CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor in Chemistry from the Federal University of Paraná (1998), Master in Chemistry from the Federal University of Paraná (2001) and doctorate in Organic Chemistry from the University of São Paulo (2005). He completed a doctoral internship at the University of California-Santa Barbara (2003-2004) in addition to postdoctoral internships at the State University of Campinas (2005) in the area of Biocatalysis and at Ludwig Maximilians Universität (Munich, Germany) in the area of Organometallics ( 2006-2008). He is currently an Associate Professor of Organic Chemistry at the Department of BioMolecular Sciences at the Faculty of Pharmaceutical Sciences of Ribeirão Preto - USP. He has experience in the area of Chemistry, with an emphasis on Organic Synthesis, working mainly on the following topics: Development of new synthetic methods aimed at the preparation of bioactive substances, development and application of new organometallic reagents, synthesis of drugs and pharmochemicals. (Source: Lattes Curriculum)
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New techniques that combine artificial intelligence and robotics are increasingly impacting the Organic Synthesis and, consequently, the Medicinal Chemistry, especially with regard to the implementation of new synthetic approaches and process automation for the preparation of innovative libraries of drug candidates. These new technologies have created great opportunities for the use of me…
In the present project we intend to study the potential of organometallic reagents in the development of methodologies for selective functionalization of aromatic and heterocyclic substrates of great scientific and technological interest, mainly for Medicinal Chemistry. In this sense, directed metalation or halogen/metal exchange reactions in a series of aryl nitriles, quinolines, indoliz…
In this project we intend to study the application of mixed lithium, magnesium and zinc organometallic reagents in the directed functionalization of aromatic and heterocyclic substrates of great scientific and technological interest, mainly for Medicinal Chemistry. In this sense, directed metalation or halogen/metal exchange reactions in a series of indolizines, imidazo-pyridines, quinazo…
Magnesium and zinc organometallic reagents complexed with lithium chloride were recently introduced in the literature and have show a great potential in the funcionalization of aromatic and heterocyclic substrates. However, until now, their reactivity with many important substrates was not properly studied. This is the case of aromatic indolizines, quinoxalines, isoquinolines and nitriles…
(Only some records are available in English at this moment)
Indolizines are heteroaromatic molecules that have a six-membered ring fused with a five-membered ring, with a nitrogen atom in the center, they are also called pyrrolo[1,2-a]pyridine. Due to their electronic and fluorescent characteristics, they have also been used for photoresponsive materials and dyes. Amino groups are very interesting substituents for different scaffols, as they can a…
Heterocycles are structures present in the vast majority of drugs, promoting the medicinal action of these compounds. Within this class of compounds, those that present Nitrogen as the heteroatom in their structure predominate, which usually contain fused rings. Indolizine is a representative compound of this group, which has already been the subject of studies for antitumor drugs, howeve…
Among the N-heterocyclic compounds, indolizines stand out for their great scientific and technological potential, especially in the field of Medicinal Chemistry. This nucleus has as its main structural characteristic, two fused rings, one of the pyridine type and the other of the pyrrole type. Indolizine is an important bioisostere of the indole nucleus, being considered a pharmacological…
Chalcones are organic molecules commonly found in the molecular structure of natural and synthetic products of high added value, including clinically approved drugs, being considered privileged units in medicinal chemistry for presenting a wide spectrum of biological properties. These aspects make the development of synthetic methodologies relevant for the preparation of this class of com…
N-hereterocycle compounds containing fused rings, such as pyrido [1,2-a] indoles, have been attracting interest from researchers due to the great pharmacological potential they present, being used as leishmanicidal, antiviral, anti-inflammatory, antibacterial and anti-tumor agents. On the other hand, many derivatives stand out for their luminescent properties, thus envisioning different t…
In the past few years, organic synthesis in continuous flow has become a powerful tool in mid and large-scale production of Active Pharmaceutical Ingredients (APIs) in reduced spaces. In this context, the following project focus in the search for solutions in the synthesis of API precursors scaffolds by developing continuous flow protocols compatible with classic organic synthesis strateg…
(Only some records are available in English at this moment)
Sulfonamides compounds represent and important class of compounds due to their wide range of biological and pharmaceutical applications, including in the first generation of antibiotics. Despite their recognized importance, several classical methodologies to synthesize sulfonamides derivatives have limitations regarding the sustainability aspect, which is an increasingly concern for econo…
Flow chemistry has been employed as new synthetic tool in order to optimize reaction conditions, improve the atom economy, allow to handle hazardous reagents, promote safety process and to support scale-up. A number of classical reactions have been performed under flow conditions in good yields and some synthetic challenges have already been solved. However, the formation of solids and pr…
The directed metalation and halogen-metal exchange are among the most used strategies to generate polyfunctionalized organometallic compounds. However, the high ionic character of the species involved require specific reaction conditions, e. g., low temperature. In this context, continuous flow micro-reactors have become an important tool for this purpose, since this equipment allows a mo…
The direct C-H functionalization catalyzed by transition metal has emerged as an important and versatile strategy for the synthesis/functionalization of heterocyclic compounds. The ability of transition metals such as Cu, Ru, Ir, Rh, Pd, Pt, to activate C-H bonds has been used extensively to construct C-heteroatom and C-C bonds in organic synthesis. However, despite the applicabilit…
| 2 / 2 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 24 / 17 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 38 / 30 | All research grants and scholarships |
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