Abstract
²-Carboline based chemical scaffolds are potential ligands for the ±+/² binding site of GABAA receptors. In particular, ²-carbolines belong to the ''ZK series'' such as ZK 91085 have been suggested to exert their second phase of action at the extracellular ±+/² interface. However, their chemical synthesis demand multi-step which prevents the access to large set of molecular libraries for …