Bachelor in Chemistry from the Federal University of Paraná (1998), Master in Chemistry from the Federal University of Paraná (2001) and doctorate in Organic Chemistry from the University of São Paulo (2005). He completed a doctoral internship at the University of California-Santa Barbara (2003-2004) in addition to postdoctoral internships at the State University of Campinas (2005) in the area of Biocatalysis and at Ludwig Maximilians Universität (Munich, Germany) in the area of Organometallics ( 2006-2008). He is currently an Associate Professor of Organic Chemistry at the Department of BioMolecular Sciences at the Faculty of Pharmaceutical Sciences of Ribeirão Preto - USP. He has experience in the area of Chemistry, with an emphasis on Organic Synthesis, working mainly on the following topics: Development of new synthetic methods aimed at the preparation of bioactive substances, development and application of new organometallic reagents, synthesis of drugs and pharmochemicals. (Source: Lattes Curriculum)
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²-Carboline based chemical scaffolds are potential ligands for the ±+/² binding site of GABAA receptors. In particular, ²-carbolines belong to the ''ZK series'' such as ZK 91085 have been suggested to exert their second phase of action at the extracellular ±+/² interface. However, their chemical synthesis demand multi-step which prevents the access to large set of molecular libraries for …
Pharmaceutical impurities are unwanted chemicals present in pharmaceutical products. In finished products, their origin can be related both to their presence in the aforementioned inputs used in the manufacturing process, and to their development during the product formulation, in the packaging process or with its aging (degradation). In recent decades, the modernization of pharmaceutical…
New techniques that combine artificial intelligence and robotics are increasingly impacting the Organic Synthesis and, consequently, the Medicinal Chemistry, especially with regard to the implementation of new synthetic approaches and process automation for the preparation of innovative libraries of drug candidates. These new technologies have created great opportunities for the use of me…
In the present project we intend to study the potential of organometallic reagents in the development of methodologies for selective functionalization of aromatic and heterocyclic substrates of great scientific and technological interest, mainly for Medicinal Chemistry. In this sense, directed metalation or halogen/metal exchange reactions in a series of aryl nitriles, quinolines, indoliz…
(Only some records are available in English at this moment)
Indolizines are aromatic heterocyclic molecules composed of a five-membered pyrrolic ring fused to a six-membered pyridinic ring, with a nitrogen atom being shared by the two. These heterocycles have electron-deficient characteristics in their six-membered ring and electron-rich characteristics in their five-membered ring, so they can react both as nucleophiles and electrophiles. This cla…
Indolizines are heteroaromatic molecules that have a six-membered ring fused with a five-membered ring, with a nitrogen atom in the center, they are also called pyrrolo[1,2-a]pyridine. Due to their electronic and fluorescent characteristics, they have also been used for photoresponsive materials and dyes. Amino groups are very interesting substituents for different scaffols, as they can a…
Among the N-heterocyclic compounds, indolizines stand out for their great scientific and technological potential, especially in the field of Medicinal Chemistry. This nucleus has as its main structural characteristic, two fused rings, one of the pyridine type and the other of the pyrrole type. Indolizine is an important bioisostere of the indole nucleus, being considered a pharmacological…
(Only some records are available in English at this moment)
Pharmaceutical impurities are unwanted chemicals present in pharmaceutical products. In finished products, their origin can be related both to their presence in the aforementioned inputs used in the manufacturing process, and to their development during the product formulation, in the packaging process or with its aging (degradation). In recent decades, the modernization of pharmaceutical…
Heterocycles are structures present in the vast majority of drugs, promoting the medicinal action of these compounds. Within this class of compounds, those that present Nitrogen as the heteroatom in their structure predominate, which usually contain fused rings. Indolizine is a representative compound of this group, which has already been the subject of studies for antitumor drugs, howeve…
Chalcones are organic molecules commonly found in the molecular structure of natural and synthetic products of high added value, including clinically approved drugs, being considered privileged units in medicinal chemistry for presenting a wide spectrum of biological properties. These aspects make the development of synthetic methodologies relevant for the preparation of this class of com…
(Only some records are available in English at this moment)
Aromatic indolizines are important scaffolds in organic synthesis, with several applications on both medicinal and material chemistry. However, only the saturated indolizidine scaffold is found in nature, with diverse examples of alkaloids displaying remarkable biological activities. Therefore, various synthetic approaches to obtain the saturated version of this heterocycle, based on the …
In light of the ongoing public health challenge posed by cancer, there is a continuous need to explore novel approaches for treating and diagnosis of different cancer types. Of particular interest in our research is CD73, an enzyme that is often overexpressed in cancer tissues . Our research proposal focuses on exploring ligands designed to inhibit CD73's functionality, addressing the all…
Sulfonamides compounds represent and important class of compounds due to their wide range of biological and pharmaceutical applications, including in the first generation of antibiotics. Despite their recognized importance, several classical methodologies to synthesize sulfonamides derivatives have limitations regarding the sustainability aspect, which is an increasingly concern for econo…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 7 / 6 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 25 / 18 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 45 / 37 | All research grants and scholarships |
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CV Lattes
ORCID