Associate Professor at FCFRP-USP, Immunology. Bachelor's degree in Biomedical Sciences from Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) obtained in 2001. Master's degree (2004) and Ph.D. (2008) in Basic and Applied Immunology from the University of São Paulo at Ribeirão Preto Medical School (USP). Postdoctoral degree in the Department of Pathology of the University of Michigan (UMICH), USA and at the Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP. Biociences and Biotecnology Graduate Program Director. Adviser of masters and doctorate in the Graduate programs in Biosciences and Biotechnology of FCFRP-USP and in Basic and Applied Immunology at FMRP-USP. Has experience in Immunology, with emphasis on epigenetic modifiers of the innate immune response in HIV infection and Mycobacterium tuberculosis. (Source: Lattes Curriculum)
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Epigenetic mechanisms are associated with training/programming and polarization of immune cells, which can be induced by the presence of cytokines and molecules present in the microenvironment, like PAMPs (Pathogen-associated molecular pattern) or other mediators of inflammation. Our hypothesis is that during chronic infections such as HIV and TB, PAMPs, cytokines or extracellular vesicle…
Tuberculosis (TB) is a bacterial infectious disease caused by Mycobacterium tuberculosis, still considered a serious public health problem. It is estimated that one-third of the world's population is infected with M. tuberculosis, with the latent form of the disease which can be reactivated. Moreover, the lack of rapid and sensitive diagnostic, inadequate adherence to treatment and the ac…
Basic researches can help to solve clinical problems, providing tools to transfer results from the bench to the bedside. In developing countries including Brazil, the HIV-1 infection is a major cause of death attributed to infectious diseases, especially when associated with opportunistic co-infections, such as tuberculosis, which affects one third of patients infected with HIV. Multiple …
HIV is a retrovirus that currently infects about 40 million people. Combined antiretroviral therapy has increased the life expectancy and health of virus-infected patients, but has turned the infection into a chronic condition. Patients living with HIV exhibit early senescence of the innate immune system, directly related to immune exhaustion and cellular dysfunction. Extracellular vesicl…
Epigenetics study modifications in the pattern of gene expression, although they do not promote direct changes to the DNA nucleotide sequence. Several studies have demonstrated its role in the regulation of cellular processes, including the modulation of the activation and polarization profile of cells of the immune system, such as T cells, monocytes, dendritic cells and macrophages. The …
The activation of the innate immune response in tuberculosis, a disease caused by Mycobacterium tuberculosis (Mtb), is associated with the course of infection and the development of the disease in its active or latent form. Understanding the role of extracellular vesicles (EV) in modulating the immune response and activating antigen-presenting cells can help elucidate unsolved questions. …
Cells release extracellular vesicles (EVs) by different mechanisms that involve cell membrane turnover in response to stimuli or during apoptosis. These are important for intercellular communication as they carry membrane, cytoplasmic, and nuclear components, which contain proteins, lipids, messenger RNAs, and metabolically active microRNAs. The involvement of EVs in the immune system mod…
(Only some records are available in English at this moment)
With the emergence of Antiretroviral Therapy (ART), there was an improvement in the quality of life and reduction in mortality of people infected with HIV. However, HIV has become a chronic disease since treatment is not able to eliminate the virus, which remains in a latent state in cells and tissues. In this way, ideally, the treatment of people living with HIV should be continuous and …
The Human Immunodeficiency Virus (HIV), which causes the acquired immunodeficiency syndrome (AIDS) is considered a major public health problem worldwide. More recent data made available by the World Health Organization (WHO) has shown that in 2020, about 37.7 million people are living with HIV worldwide. With the emergence of antiretroviral therapy (ART), the infection was no longer consi…
| 1 / 1 | Ongoing grants |
| 3 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 17 / 13 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 26 / 21 | All research grants and scholarships |
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