Abstract
The activation of canonical Wnt pathway results in expression of genes related tocellular differentiation, proliferation and development. When it is inactivated, theeffector of this pathway - ²-catenin - is located in a destruction complex, constitutedby several proteins, including GSK3² (glycogen-synthase kinase-3 beta), CSNK1µ(casein kinase Iµ) and ²TRCP (²-transducin repeat containing)…