Marcelo Nicolas Muscara

• Abstract

  In view of the relevance of cardiovascular diseases in public health, the development of new therapeutic strategies is a high-priority issue. Studies carried out over the last decade show the participation of hydrogen sulphide (H2S) in several physiological systems, including the cardiovascular system. In blood vessels, H2S can act on both smooth muscle cells and endothelial cells resulti…

  Study on the participation and effects of hydrogen sulfide (H2S) on the in vitro vasomotor response of mouse mesenteric artery, AP.R

• Abstract

  Over the last decade, the endogenous production of hydrogen sulfide (H2S), a well known environmental pollutant, has been characterized in mammals, as well as its participation in several organic functions, such as vascular reactivity, mitochondrial activity and inflammatory response. Regarding the latter aspect, and despite some divergences that appear in the literature concerning the pr…

  Role of hydrogen sulfide (H2S) in the inflammatory and nociceptive responses induced by carrageenan in the rat temporomandibular joint, AP.R

• Abstract

  Inflammation is an adaptive response triggered by noxious stimuli such as infections and tissue damage that aims to restore homeostasis. Chronic destruction of periodontal attachment apparatus due to an intense inflammatory response to bacteria leads to a clinical condition known as periodontal disease. Periodontal inflammation usually causes superficial ulcers in the gingival sulcus, whe…

  Consequences of the presence of ligature-induced periodontitis on rat blood pressure and in vitro vasomotor response, AP.R

(Only some records are available in English at this moment)

• Abstract

  Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease characterized by eczematous lesions associated with severe pruritus and immunoglobulin E (IgE) overproduction that affects children and adults with a high prevalence. Even though some patients respond satisfactorily to topical treatments, this type of therapies are not always effective, and systemic treatments are of…

  Effect of hydrogen sulfide (H2S) donors on experimental atopic dermatitis in mice., BP.DR

• Abstract

  Hydrogen sulfide (H2S) is a gaseous mediator endogenously produced in mammals mainly by the enzymes cystathionine ³-lyase enzyme (CSE) and cystathionine-²-synthase (CBS) using L-cysteine as substrate. A recent work from our laboratory shows that H2S donors, such as the compound GYY-4137 (slow release) or NaHS (spontaneous release), have anti-nociceptive and antiinflammatory effects on the…

  Evaluation of the nociceptive response secondary to the individual and combined administration of hydrogen sulfide (H2S) and nitric oxide (no) donors into the rat temporomandibular joint (TMJ), BP.IC