graduate at Ciências Farmacêuticas Ribeirão Preto from Universidade de São Paulo (1986), master's at Pharmacology from Universidade de São Paulo (1990) and ph.d. at Pharmacology from Universidade de São Paulo (1995). Has experience in Pharmacology, focusing on Neuropsicopharmacology, acting on the following subjects: ansiedade, labirinto em t elevado, substância cinzenta periaqueductal, serotonina and panico. (Source: Lattes Curriculum)
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Panic disorder (PD) is characterized by the occurence of recurrent panic attacks (PA), with intense fear, sensation of suffocation, and cardiovascular perturbations posing as main symptoms of PD. Both clinical and preclinical data support the dorsal periaqueductal gray (DPAG) as a key brain structure implicated in the pathophysiology of PD. Additional experiments in rodents also indicate …
Anxiety-related disorders are the most prevalent class of mental illnesses and twice as common in women compared to men. Early life adversity can significantly increase the risk of developing panic psychopathology in adulthood. At present, one-third of patients are refractory to treatment; there is a pressing need for further research to identify effective treatments. The project focuses …
The Visiting Researcher (Thelma Lovick) will work with members of the Helio Zangrossi (Principal applicant) and Norberto Coimbra (co-applicant) laboratories. The aim is to facilitate progress on a number of experiments designed to further our understanding of the way that cyclical changes in female sex hormones during the estrous cycle impact on behavior, and the mechanisms that underlie …
Glutamate is well recognized as the main excitatory neurotransmitter in the mammalian central nervous system. Its receptors are classified into ionotropic and metabotropic. Whereas 8 subtypes of the former have already bee recognized, ionotropic glutamate receptors are usually divided into NMDA, AMP A and Kainic subtypes. Glutamate activation of NMDA receptors leads to calcium influx, act…
(Only some records are available in English at this moment)
Panic disorder (PD) is a chronic, disabling pathology, characterized by the recurrence of unexpected panic attacks. Recently, a model of neonatal stress in rodents was proposed, which consists of simulating a condition of poverty, limiting the material available for lactating dams to adequately care for their offspring. It has been shown that the limited bedding and nesting experience pro…
Panic Disorder (PD) is characterized by the presence of recurrent Panic Attacks (PA), with intense fear, sensation of suffocation, and cardiovascular perturbations posing as main symptoms of PD. Both clinical and pre-clinical data support the Dorsal Periaqueductal Gray (DPAG) as a key brain structure implicated in the pathophysiology of PD. Additional exper-iments in rodents also indicate…
Panic disorder is characterized by the recurrence of unexpected panic attacks. Panic attacks can be triggered by inhalation of high CO2 concentrations or low O2 concentrations. Results recently obtained by our research group show that escape expression, a behavior associated with panic, evoked by exposure to CO2 is different among 3 mouse strains (C57BL/6, Balb cand Swiss), suggesting a d…
Panic disorder is characterized by the occurrence of unexpected panic attacks. Studies have shown that activation of the dorsal periaqueductal grey matter (dPAG) evokes behavioural and physiological reactions related to panic. Recently, we showed that administration of bradykinin into the dPAG in rats exposed to the dPAG electrical stimulation test promotes antipanic-like effect. This eff…
(Only some records are available in English at this moment)
A wealth of evidence indicates that the dorsal raphe nucleus (DR) is a heterogeneous structure with different pattern of neuronal activation observed after expression of anxiety- and panic-related defensive responses. Antidepressant (AD) drugs are the first choice in treatment of anxiety disorders, and the delay for the therapeutic effect, have consistently been associated with changes in…
Over the past years, numerous studies have identified a network of neuronal structures involved in the formation and expression of conditioned fear memories, detached the basolateral amygdala (BLA) and the hippocampus. In addition, the medial prefrontal cortex (mPFC) has also been enrolled in this neuronal circuit, through its dense interconnectivity with BLA and hippocampus. In the past …
| 1 / 1 | Ongoing research grants |
| 6 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 17 / 11 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 28 / 20 | All research grants and scholarships |
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CV Lattes
ORCID