CV Lattes
Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciencves Medical Modality at the Centro Universitário Barão de Mauá (1975), master (1979) and PhD (1984) degrees at the Dept. of Pharmacology, FMRP-USP. The field of investigation is related to the mediation and modulation of the febrile and acute phase response. Also colaborates with the investigators of the Dept. searching the antiinflammatorty, antialgesic and antipyretic effects of substances derived from plants. (Source: Lattes Curriculum)
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(Only some records are available in English at this moment)
The prodrug dipyrone is an important antipyretic drug. After its administration, dipyrone is rapidly converted by hydrolysis in 4- methylaminoantipyrine (4-MAA), which is then metabolized to 4- formylaminoantipyrine 4-(4-FAA), 4- aminoantipyrine ( 4-AA) and 4- acetylaminoantipyrine (4-AAA). However, the metabolites of dipyrone with antipyretic activity, as well as the mechanism of action …
Fever is a highly complex response in mammalian host defense systems that results in a temporary rise of basal temperature and seems to be mediated by action of endogenous pyrogens including interleukin (IL)-1± and -1beta, IL-6, tumor necrosis factor-± (TNF-±), IL-8, C-C-ligands/macrophage inflammatory protein-1± and beta (CCL3 /MIP-1± and CCL4/MIP-1beta) and pre-formed pyrogenic factor (…
| 15 / 9 | Completed research grants |
| 22 / 3 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 38 / 12 | All research grants and scholarships |
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