graduation at Ciências Biológicas from Universidade de São Paulo (1985), master's at Physiology from Universidade de São Paulo (1988) and doctorate at Physiology from Universidade de São Paulo (1992). Has experience in Physiology, focusing on Endocrinal Physiology, acting on the following subjects: cetp, mitochondria, oxidative stress, atherosclerosis and hipercolesterolemia. (Source: Lattes Curriculum)
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In the last 40 years, it has become evident that mitochondria are involved in many cell functions besides energy conversion, such as the control of cell death via calcium and oxygen and nitrogen reactive species signaling. Elevated levels of calcium in the mitochondrial matrix stimulate the generation of reactive oxygen which promote the opening of an unspecific pore in the inner mitochon…
Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected t…
This project aims to confirm that environmental contamination in the Mundaú-Manguaba Lagoon Complex (CELMM, Maceió-AL) affects the health of the local population. In order to test this hypothesis and increase knowledge about this environment, previous data on environmental and biochemical indicators of volunteers living in CELMM were taken as reference. Thus, regarding the environmental s…
This is a proposal to set up a facility in Cell and Molecular Biology at the Biology Institute, State University of Campinas (Unicamp). Most equipment's required will provide high technology to obtain high resolution images associated with data acquisition from a large number of biological phenomena in real time on a straight-through-processing basis. In response to the FINEP call, we req…
In addition to be the cell’s powerhouse, mitochondria also contains a cell death machinery. Indeed, after a number of new mitochondrial proteins and modulator metabolites have been discovered, this organelle has emerged as a center of attention in processes of cell signaling, cell injury and cell death. Evidence has been provided that mitochondria comprise one of the main pathways for cel…
(Only some records are available in English at this moment)
Cholesteryl Ester Transfer Protein (CETP) promotes cholesterol transfer from the HDL fraction to lipoproteins containing apolipoprotein B. By reducing HDL, CETP is considered an atherogenic protein. A previous study showed that high plasma concentrations of CETP during the acute phase of myocardial infarction are associated with endothelial dysfunction and increased lethality and recurren…
The excess of fat accumulation causes cardio-metabolic disorders, which harm individual health. Previous data from our lab have shown that cholesteryl ester transfer protein (CETP) expression may play a relevant role in reducing adiposity. CETP promotes the exchange of triglycerides by cholesterol between HDL and lipoproteins containing apoB in plasma. This action may enhance the atherosc…
Atherosclerosis is the main cause of all cardiovascular diseases and related mortality. Elevated LDL-cholesterol in the plasma and local oxidative stress are early events in the atherogenesis process. Besides, macrophages recruited from the circulating blood monocytes and resident in the subendothelial space are key cells involved in the initiation and progression of atherosclerosis. Mark…
The increasing of the obesity epidemic indicates that the study of the physiological and molecular mechanisms can be useful in the identification of targets to fight it. Several proteins have been directly or indirectly associated with adipogenesis. CETP, a protein that promotes the exchange of neutral lipids, classically known for its role in reverse cholesterol transport, has been studi…
(Only some records are available in English at this moment)
Despite remarkable progress, cardiovascular disease (CVD) remains a major cause of morbidity, mortality, and impaired quality of life worldwide. Endothelial dysfunction is a central feature of the pathophysiology of numerous CVDs and manifests in patients with CV risk factors such as atherosclerosis, hypertension, and diabetes mellitus. For this reason, the endothelium may represent a pow…
Despite many recent breakthroughs to prevent or limit cardiovascular disease, heart attacks and congestive heart failure remain among the world's most prominent health challenges. In fact, despite successful approaches, the restoration of function to the damaged heart remains a formidable challenge. Oxidative stress results in excessive accumulation of reactive oxygen species (ROS) and co…
Obesity can be defined as a state in which excess body fat accumulated adversely affects one's health. Several evidences have suggested that proteins primarily related to lipoprotein plasma transport, such as apolipoprotein CIII and E, may significantly affect the process of body fat accumulation. CETP mediates the exchange of triglycerides for esterified cholesterol from HDL to apo B con…
| 2 / 2 | Ongoing research grants |
| 11 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 29 / 10 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 46 / 22 | All research grants and scholarships |
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