Graduated in Nursing from the University of São Paulo (1988), Master in Physiology from the Faculty of Medicine of Ribeirão Preto (1990), Ph.D. in Physiology from the Faculty of Medicine of Ribeirão Preto (1997), complemented by an internship at the University of Montreal (Canada ), in the Cellular and Molecular Biology laboratory, provided by the sandwich program-CAPES (1994-1995). Postdoctoral internships at the Hotchkiss Brain Institute at the University of Calgary - Canada (2004 to 2005). Currently, since 2018, he has been a Full Professor at the University of São Paulo - Ribeirão Preto College of Nursing. He has experience in Neuroendocrine Physiology, focusing on the vasoactive actions of these mediators in systemic inflation, especially in control pathways that involve central mechanisms in animal models that mimic sepsis and septic shock. He is responsible for the Physiology of Systemic Inflammation laboratory at EERP/USP. The laboratory employs contemporary methodologies analyzing the action of different proteins and peptides in the modulation of the inflammatory process. It is accredited in the Graduate Program in Physiology at the Faculty of Medicine of Ribeirão Preto and in the Fundamental Nursing Program, both grade 7.0 Capes. It carries out national collaborations (Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais) and international collaborations (Center for Perioperative Organ Protection of the Department of Anesthesiology, Duke University Medical Center) developing projects that assess the action of system mediators renin-angiotensin in the modulation of the inflammatory reflex. (Source: Lattes Curriculum)
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Neuroimmune interactions have been extensively explored in order to find new therapeutic targets for inflammatory diseases. With the discovery of the "cholinergic anti-inflammatory pathway", several studies were conducted exploring the anti-inflammatory potential of the vagus nerve. However, more recently, evidence has suggested that baroreceptors (essential for arterial pressure control)…
The systemic inflammatory response syndrome (SIRS) is an inflammatory condition that affects the whole body and represents a serious threat. Endotoxemia, sepsis and its complications (septic shock and multiple organ failure) are the major cause of death in intensive care units worldwide, despite recent major technological advances. Lack of knowledge of the pathophysiological mechanisms of…
The most widely accepted hypothesis to explain the biphasic response in the synthesis and release of vasopressin (AVP) observed during the change of homeostasis induced systemic inflammatory processes refers to the excessive production of inflammatory mediators. Among the main mediators there is the activation of the renin central angiotensin system (RAS) and the increase in pro-inflammat…
(Only some records are available in English at this moment)
Neuroimmune interactions have been extensively explored in order to find new therapeutic targets for inflammatory diseases. With the discovery of the "cholinergic anti-inflammatory pathway", several studies were conducted exploring the anti-inflammatory potential of the vagus nerve. However, more recently, evidence has suggested that baroreceptors (essential for arterial pressure control)…
Recent studies have been shown an increased incidence of Cardiovascular Diseases (CVDs) in surviving patients of Sepsis and septic shock. Several inflammatory mediators have been considered to be responsible for this cardiovascular changes which can occurs between 1 and 5 years after the previous infection. The activation of the Renin Angiotensin System (RAS) and the increase of proinflam…
Mental health currently stands out for its benefits in host immunometabolic profile, and serotonin has a fundamental role in this neuroimmune response. More recently, new evidence has been obtained indicating that intestinal microbiota can alter the host's mood. Along with this new knowledge, the search and evaluation of microorganisms with potential mental health benefits increases more …
Syndromes associated with systemic inflammation (for example, sepsis and septicshock) generally have high mortality and remain a challenge in emergency medicine.Systemic inflammation is usually accompanied by changes in body temperature: fever orhypothermia. In animal studies, systemic inflammation is often modeled after the use of CecalLigation and Puncture (CLP), which consists of perfo…
(Only some records are available in English at this moment)
Angiotensin-(1-7) has demonstrated potential anti-inflammatory effects in cardiovascular and inflammatory diseases, including atherosclerosis. Excessive inflammation contributes to the development and progression of atherosclerosis and cardiovascular diseases. Clinical trials have shown that therapeutic reduction of pro-inflammatory cytokines can decrease adverse cardiovascular events. Wh…
Angiotensin (Ang)-(1-7) is a major component of the renin-angiotensin system and acts predominantly through G protein-coupled receptor (GPCR) Mas. Studies previously demonstrated that in endothelial cells, there is important cross-talk between Ang-(1-7)/Mas and the endothelin-1/ETBR system, which is vasoprotective. However, the importance of this cross talk between the Ang-(1-7)/Mas and e…
| 1 / 1 | Ongoing research grants |
| 16 / 8 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 33 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 1 | Completed scholarships abroad |
| 54 / 20 | All research grants and scholarships |
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CV Lattes
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