Vera L G Calich graduated in Biological Sciences; PhD in Immunology at the University of São Paulo and Postdoctoral training at Harvard Medical School. She joined the faculty of University of São Paulo in 1978 and is currently a Professor of Immunology. She has trained 27 predoctoral students and 8 postdoctoral fellows. Their research focus is on the immunopathogenesis of paracoccidioidomycosis, an endemic pulmonary fungal infection of Latin America. Most of her current group is involved in identifying and characterizing the mechanisms of innate and adaptive immunity that leads to protective or deleterious effects to infected hosts. Member of the editorial board, and reviewer of national and international journals. Organized conferences and lectured at national and international congresses. Member of the Advisory Committee of several Brazilian Scientific Institutions. (Source: Lattes Curriculum)
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Infectious diseases still cause one in four human deaths and are important agents of permanent dysfunction of the hosts due to tissue damage. New knowledge of the host-pathogen relationship, pathogenicity mechanisms, inflammatory patterns, and innate and adaptive immune responses have led to a wide advance in therapies aimed to modulate host homeostasis and not directed against the pathog…
Paracoccidioidomycosis (PCM) is a severe systemic mycosis that affects individuals in Latin America. Studies in the human disease and experimental models have shown that Th1/Th17 immune responses are protective while those mediated by Th2/Th3 and regulatory (Treg) T cells have been associated with disease severity Recent studies have shown that the enzyme indolamine 2, 3-dioxygenase (IDO)…
The recognition of P. brasiliensis components by pathogen recognition receptors (PRRs) present on macrophages and other cells of innate immunity plays an important role in the innate and adaptive immune response against this fungal pathogen. Toll like receptors (TLRs), C-type Lectin Receptors (CLRs) and the NOD-like receptors (NLR, Nucleotide binding Oligomerization Domain Receptors), may…
Dectin-1, the innate immune receptor that recognizes ²-glucan, plays an important role in immunity against fungal pathogens. Paracoccidioides brasiliensis, the etiological agent of paracoccidioidomycosis, has a sugar-rich cell wall mainly composed of mannans and glucans. This fact motivated us to use dectin-1-sufficient and deficient mice to investigate the role of ²-glucan recognition in…
(Only some records are available in English at this moment)
Paracoccidioidomycosis (PCM) is a severe systemic mycosis that affects individuals in Latin America. Studies in the human disease and experimental models have shown that Th1/Th17 immune responses are protective while those mediated by Th2/Th3 and regulatory (Treg) T cells have been associated with disease severity Recent studies have shown that the enzyme indolamine 2, 3-dioxygenase (IDO)…
Dendritic cells (DCs) are the main link between innate and adaptive immunities. Depending on the subclass and activation pattern, they play an important role in regulating immunological process that could be protective and deleterious to the hosts. The role of DCs in paracoccidioidomycosis (PCM), the most prevalent deep mycosis in Latin America, has been little studied, although several s…
Paracoccidioidomycosis (PCM), a relevant systemic mycosis in Latin America, is caused by Paraccoccidioides brasiliensis (Pb). The innate immunity in PCM is poorly understood but our recent studies in the murine model of PCM have demonstrated the important role of indoleamine 2,3-dioxygenase (IDO), an enzyme that controls fungal burdens but also suppresses the innate and adaptive immune re…
(Only some records are available in English at this moment)
Characterization of the mechanism by which the intestinal microbiota including Proteus mirabilis activate the NLRP3 inflammasome. P. mirabilis is a member of the Enterobacteriaceae family, and it is a robust inducer of IL-1beta release via NLRP3 and this resident bacterium induces NLRP3 activation by the production of the hemolysin hmpA. Based on studies using conventional, germ-free (GF)…
In preliminary studies Ramirez-Ortiz et al. 2011, demonstrate that plasmacytoid dendritic cells (pDCs) phagocytose Aspergillus fumigatus conidia and spread over the surface of the hyphal morphotype. In response to hyphal stimulation, pDCs directly inhibit fungal growth and release IFN-± and TNF-±. These studies together with this project challenge the prevailing dogma regarding the specia…
| 1 / 1 | Ongoing research grants |
| 21 / 12 | Completed research grants |
| 30 / 5 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 54 / 20 | All research grants and scholarships |
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CV Lattes
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