graduation at Fisioterapia from Universidade Federal de São Carlos (2001), ph.d. at Doutorado sanduíche from Loyola University of Chicago (2005) and ph.d. at Histology from Universidade de São Paulo (2005). Has experience in Morfologia, focusing on Morfologia, acting on the following subjects: lesão muscular esquelética sistêmica, crotoxina, orientações fisioterapêuticas, questionário de qualidade de vida para asmáticos and plasticidade muscular esquelética. (Source: Lattes Curriculum)
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Satellite cells, a post-natal population of muscle stem cells, are important for post-natal muscle development because they fuse in order to promote the myofiber growth. In addition, satellite cells contribute to the maintenance of muscle mass integrity and are essential for the success of the remarkable regenerative process of skeletal muscle. Overall, skeletal muscle regeneration involv…
Marfan syndrome (SMF) is characterized by an autosomal dominant systemic disorder that affects connective tissue, since mutation occurs in the fibrillin-1 gene, with consequent alteration in the fibrillin-1 protein. Such protein is the main component of microfibrils present in the extracellular matrix of elastic and non-elastic connective tissues. Considering that: 1) the molecular mechan…
Marfan syndrome (SMF) is an autosomal-dominant systemic disorder of connective tissue, caused by a mutation of fibrillin-1 gene, resulting in changes in the protein fibrillin-1, the major component of microfibrils of the extracellular matrix, present in elastic and non-elastic connective tissues. Although poorly studied, alterations in skeletal muscles from fibrillin-1-deficient mice and …
Skeletal muscle regeneration is essential for muscle integrity, however the intracelular mechanism involved in this process are still not totally understood. A possible regulator of the muscle regenerative process could be the beta2 adrenoceptor, because it has been described that synthetic beta2-adrenoceptor agonists are able to maximize the recovery of the size of regenerating myofibers…
(Only some records are available in English at this moment)
Skeletal muscle has a remarkable ability to regenerate after injury, which is attributed to the presence of muscle stem cells called satellite cells. In addition, after muscle injury, fibro- adipogenic progenitors (FAPs), mesenchymal interstitial cells residing in the skeletal muscle, are activated, proliferate and expand, and provide a transient favorable environment to promote satellite…
Skeletal muscle tissue has the ability to regenerate after injury. Satellite cells are stem cells specific of the skeletal muscle and play a fundamental role in the regeneration of this organ. Although the morphological aspects of skeletal muscle regeneration are well known, the molecular mechanisms of this process are still not completely understood. Considering that the Set1/Trithorax-t…
Marfan syndrome (SMF) is an autosomal dominant systemic disease that affects connective tissue due to mutations in the fibrillin-1 gene that cause alteration in fibrillin-1 protein, one of the major microfibril components of the extracellular matrix of connective tissue. Individuals with SMF have lower muscle mass characterized by reduced size and number of muscle fibers and consequent lo…
Skeletal muscle tissue has a remarkable regenerative capacity due to the presence of muscle stem cells called satellite cells. The regeneration of injured myofibers includes the inflammatory process installation, the satellite cell activation and subsequent proliferation. Subsequently, a small population of satellite cells returns to the quiescence state and most of them differentiate to …
Satellite cells have the capacity to originate differentiated cells, as well as to replenish the quiescent satellite cell pool, a process called self-renewal. In response to the injury of myofibers, satellite cells are activated, proliferate, some of them undergo self-renewal and most of them differentiate into myofibers. Considering that the mechanisms involved in the satellite cell self…
(Only some records are available in English at this moment)
Marfan syndrome is caused by mutations in an autosomal dominant gene encoding fibrillin-1, which is the key structural glycoprotein for microfibrils and act as scaffolding proteins for formation of elastic fibers and elastin deposition. Skeletal muscle alterations are also found in Marfan syndrome, such as reduction in the number and size of myofibers, combined with fibrosis, deposition o…
Skeletal muscle tissue has a remarkable capacity of repairing itself after injury. This regenerative capacity depends on satellite cells, the muscle stem cells that are crucial players in the regeneration process of the damaged myofibers. During aging this process is impaired, which is associated with the reduction in the number and the function of satellite cells in aged mice. The satell…
| 1 / 1 | Ongoing research grants |
| 10 / 8 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 17 / 9 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 33 / 22 | All research grants and scholarships |
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CV Lattes
ORCID