graduate at Medicina from Universidade de São Paulo (1988), master's at Parasitologia from Universidade de São Paulo (1993) and ph.d. at Parasitologia from Universidade de São Paulo (1997). Has experience in Parasitology, focusing on Human Parasite Protozoology, acting on the following subjects: malaria, plasmodium falciparum, epidemiologia, diversidade antigenica and genetica de populacoes. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Una ciudad convertida en laboratorio |
| A town turned laboratory |
| The uncertainty of herd immunity |
| La incertidumbre acerca de la inmunidad colectiva |
| A versatile parasite |
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| News published in Agência FAPESP Newsletter about the researcher |
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Plasmodium vivax causes 14.3 million infections annually, with 3.3 billion people at risk worldwide. No effective vaccine is available. P. vivax can only invade immature reticulocytes, expressing high levels of CD71, and <1.5% of circulating red blood cells (RBCs). CD71 is the receptor for PvRBP2b, a member of the P. vivax reticulocyte-binding protein (PvRBP) family. Another member, PvRBP…
Extensive research has examined why some people have repeated Plasmodium falciparum malaria attacks in Sub-Saharan Africa while others remain free of disease most of the time. In contrast, malaria risk heterogeneity remains little studied in regions where P. vivax is the dominant species. Are repeatedly infected people in vivax malaria settings such as the Amazon just unlucky? Here we aim…
Pyruvate kinase (PK) is the glycolytic enzyme responsible for catalyzing the transphosphorylation of phosphoenolpyruvate into adenosine diphosphate in human red blood cells, producing pyruvate and ATP as the final product of the second step of glycolysis. Pyruvate kinase deficiency (PKD), with autosomal recessive inheritance, is the most common defect associated with hereditary non-sphero…
Drug resistance has been for more than a century the hallmark of Plasmodium falciparum. This capacity has driven its expansion worldwide, in particular during the long period of established chloroquine (CQ) resistance. P. vivax is the other species well established to be capable of evasion from antimalarial drug action. P. vivax drug resistance has been initially described against anti-fo…
Despite the major recent progress towards malaria elimination in Latin America and the Caribbean, focal transmission persists mostly across the Amazon Basin and the Pacific and Atlantic Coast of Colombia and Central America, where Plasmodium vivax accounts for nearly 80% if the cases. One distinctive feature of P. vivax associated with its increased resilience is the ability to stay in th…
(Only some records are available in English at this moment)
Numerous genetic and behavioral factors influence the risk of acquiring malaria. Evidence suggests that certain naturally acquired antibodies are linked to reduced clinical malaria risk in endemic areas. Conversely, specific work activities are known to increase the risk of malaria. In this context, we have demonstrated that components of vivax malaria transmission dynamics in the Amazon …
Recently, the PvRBP2b protein was identified as a key invasion ligand for the malaria parasite Plasmodium vivax, as it binds to the transferrin-1 receptor (CD71) on the surface of immature red blood cells, known as reticulocytes, targeted by the parasite for invasion. Evidence has emerged that naturally acquired antibodies to PvRBP2b are associated with reduced malaria risk in both high- …
Nearly 130,000 cases of malaria are reported in Brazil each year, 99.9% of them in the Amazon Basin. Despite control measures, Mâncio Lima, the main urban hotspot of Brazil, has a high incidence and half of the cases are reportedly acquired in its urban area. We hypothesize that the residual malaria transmission can be sustained by a minority of high-risk people who are more likely to ori…
(Only some records are available in English at this moment)
With 143,910 laboratory-confirmed cases and 41 malaria-related deaths in 2014, Brazil has now the lowest malaria burden in 35 years, with transmission virtually limited to the Amazon Basin. Accordingly, the Ministry of Health of Brazil has launched, in November 2015, the Malaria Elimination Plan, with the short-term goal of interrupting Plasmodium falciparum transmission countrywide over …
SARS-CoV-2 has now spread globally and poses a major challenge for low- and middle-income countries, where local health infrastructure can be quickly overwhelmed. This proposal builds upon ongoing, FAPESP-supported field research to address the microepidemiology and control of SARS-CoV-2 infection in Mâncio Lima, an urban community in the Amazon. The overarching goal is translating field-…
P. vivax challenges Malaria control, surpasses P. falciparum distribution and subjects 2,5 billion people to the risk of being infected. Naturally acquired immunity, observed on individuals exposed to several Malaria episodes, does not prevents infection but limits parasitaemia, preventing it´s escalation and the manifestation of symptoms. Clinical immunity to Malaria in P. falciparum end…
(Only some records are available in English at this moment)
Malaria caused by Plasmodium vivax, the most common form of the disease in the Americas, continues to be a major public health problem, including in Brazil. In order to develop new strategies for controlling and treating vivax malaria, it is essential to gain a better understanding on red blood cell (RBC) invasion mechanisms used by the parasite. One of the key ligand-receptor interaction…
This is a proposal for a research internship - lasting 12 months - at the University of Maryland School of Medicine, under the supervision of Dra. Joana Carneiro da Silva. The main objective of this internship is to obtain training in population genomic analysis techniques in order to determine the probable origin populations of current populations of Plasmodium spp. that were introduced …
This is a proposal for a 12-month research internship at the Harvard T. H. Chan School of Public Health, under the supervision of Dr. Marcia Caldas de Castro. The main aim is obtaining further training in statistical and geospatial methods for data analysis to test whether the periodic application of an environmentally safe biolarvicide (VectoMax FG, 20 kg/ha) in fish farming ponds can re…
This is a proposal for a twelve-month internship at the Department of Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health, under the supervision of Prof. Duraisingh, who is an international expert in the area of investigation of the biology of the blood stages of Plasmodium. The central objective of this stage will be to investigate the biological activity of a…
This a proposal for a seven month period internship at the Department of Parasitology in Leiden University Medical Center (LUMC) under the supervision of Dr. Maria Yazdanbakhsh, who exercises leadership and recognized international excellence in immunology of filariasis. The main objective of this short-term research project is analyze field-collected peripheral blood mononuclear cell sam…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 33 / 22 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 31 / 15 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 76 / 49 | All research grants and scholarships |
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