CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Instituto de Saúde e Sociedade (ISS) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciencias Biomedicas from Universidade Federal de Pernambuco (2000) and ph.d. at Parasitology and Immunology from Universidade Federal de São Paulo (2004). Has experience in Immunology, focusing on Applied Imunology, acting on the following subjects: dna, asp-2, a/sn, interferon-g and vaccine. (Source: Lattes Curriculum)
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Natural infection by the intracellular protozoan Trypanosoma cruzi, the causative agent of Chagas' disease, induces an immune response in the mammalian host that counts on the participation of innate and adaptive immunity. Our group demonstrated that heterologous genetic immunization with ASP-2 and/or trans-sialidase from T. cruzi generates a protective response against different models o…
Natural infection by the intracellular protozoan Trypanosoma cruzi, the causative agent of Chagas' disease, induces an immune response in the mammalian host that counts on the participation of innate and adaptive immunity. Our group demonstrated that heterologous genetic immunization with ASP-2 and/or trans-sialidase from T. cruzi generates a protective response against different models o…
Natural infection by the intracellular protozoan Trypanosoma cruzi, the causative agent of Chagas' disease, induces an immune response in the mammalian host that counts on the participation of innate and adaptive immunity. Our group demonstrated that heterologous genetic immunization with ASP-2 and/or trans-sialidase from T. cruzi generates a protective response against different models o…
CD8+ T cells play a key role in protective immunity against intracellular pathogens, such as Trypanosoma cruzi, the causative agent of Chagas disease. Integrins, cell adhesion molecules (CAM) and chemokine receptors may play a critical role in this process allowing these cells migrate to non-peripheral lymphoid tissues to exert their effector function. Recently, we demonstrated that treat…
CD8 + T lymphocytes play an important role in the control of infections by intracellular pathogens such as Trypanosoma cruzi, a causative agent of Chagas Disease. These lymphocytes control infection by the release of IFN-g and by the elimination of the target cells infected by direct cytotoxicity. To perform these functions, lymphocytes must migrate to infected tissues, establish stable c…
Natural infection by the intracellular protozoan Trypanosoma cruzi, the causative agent of Chagas disease, induces an immune response in the mammalian host that includes innate and adaptive immunity. Our group demonstrated that heterologous genetic immunization with T. cruzi ASP-2 and/or trans-sialidase generates a protective response against different models of experimental infection. Th…
Heterologous prime-boost vaccination using plasmid DNA followed by replication defective human recombinant adenovirus type 5 - both expressing the amastigote surface protein 2 (ASP-2) of Trypanosoma cruzi- is a powerful strategy to elicit CD8+ T cells, mainly CD8+ T effector memory cells (TEM), that mediated protective immunity against the parasite protozoan Trypanosoma cruzi. Specific TE…
CD8 + T lymphocytes play an important role in the control of infections by intracellular pathogens such as Trypanosoma cruzi, the causative agent of Chagas' disease. These lymphocytes control infection through the release of IFN-g and the elimination of infected target cells by direct cytotoxicity. To perform these functions, lymphocytes must migrate to infected tissues, establish stable…
(Only some records are available in English at this moment)
CD8+ T lymphocytes play an important role in the control of infections by intracellular pathogens such as Trypanosoma cruzi, the causative agent of Chagas disease. These lymphocytes control the infection by releasing IFN-g or by direct cytotoxicity against infected target cells. To perform such functions, the lymphocytes migrate into the infected tissues, establish a stable contact with a…
| 3 / 3 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 12 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 19 / 17 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 37 |
| Cit./Article | 3.1 |
| Data from Web of Science | |
ERSCHING, JONATAN; VASCONCELOS, JOSE R.; FERREIRA, CAMILA P.; CAETANO, BRAULIA C.; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; BARON, MONIQUE A.; FERREIRA, LUDMILA R. P.; CUNHA-NETO, EDECIO; ROCK, KENNETH L.; et al. The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8(+) T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi. PLOS PATHOGENS, v. 12, n. 4, APR 2016. Web of Science Citations: 5. (10/09361-8, 09/06820-4, 15/08814-2, 12/22514-3)
VIRGILIO, FERNANDO DOS SANTOS; PONTES, CAMILA; DOMINGUEZ, MARIANA RIBEIRO; ERSCHING, JONATAN; RODRIGUES, MAURICIO MARTINS; VASCONCELOS, JOSE RONNIE. CD8(+) T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?. Mediators of Inflammation, 2014. Web of Science Citations: 12. (13/13668-0, 09/06820-4, 12/22514-3)
ARAUJO, ADRIANO FERNANDO; DE OLIVEIRA, GABRIEL; VASCONCELOS, JULIANA FRAGA; ERSCHING, JONATAN; DOMINGUEZ, MARIANA RIBEIRO; VASCONCELOS, JOSE RONNIE; MACHADO, ALEXANDRE VIEIRA; GAZZINELLI, RICARDO TOSTES; BRUNA-ROMERO, OSCAR; SOARES, MILENA BOTELHO; et al. Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma cruzi. Mediators of Inflammation, 2014. Web of Science Citations: 0. (09/06820-4, 12/22514-3)
DOMINGUEZ, MARIANA R.; ERSCHING, JONATAN; LEMOS, RAMON; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; RODRIGUES, MAURICIO M.; DE VASCONCELOS, JOSE RONNIE C.. Re-circulation of lymphocytes mediated by sphingosine-1-phosphate receptor-1 contributes to resistance against experimental infection with the protozoan parasite Trypanosoma cruzi. Vaccine, v. 30, n. 18, p. 2882-2891, APR 16 2012. Web of Science Citations: 12. (09/06820-4)
PONTES FERREIRA, CAMILA; MORO CARISTE, LEONARDO DE; HENRIQUE NORONHA, ISAU; FERNANDES DURSO, DANIELLE; LANNES-VIEIRA, JOSELI; RAMALHO BORTOLUCI, KARINA; ARAKI RIBEIRO, DANIEL; GOLENBOCK, DOUGLAS; GAZZINELLI, RICARDO TOSTES; VASCONCELOS, JOSE RONNIE CARVALHO DE. CXCR3 chemokine receptor contributes to specific CD8(+) T cell activation by pDC during infection with intracellular pathogens. PLoS Neglected Tropical Diseases, v. 14, n. 6, JUN 2020. Web of Science Citations: 0. (18/15607-1, 15/08814-2, 19/17994-5, 16/02840-4)
VASCONCELOS, JOSE RONNIE; DOMINGUEZ, MARIANA R.; NEVES, RAMON L.; ERSCHING, JONATAN; ARAUJO, ADRIANO; SANTOS, LUARA I.; VIRGILIO, FERNANDO S.; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; GAZZINELLI, RICARDO T.; et al. Adenovirus Vector-Induced CD8(+) T Effector Memory Cell Differentiation and Recirculation, But Not Proliferation, Are Important for Protective Immunity Against Experimental Trypanosoma cruzi Infection. Human Gene Therapy, v. 25, n. 4, p. 350-363, APR 1 2014. Web of Science Citations: 10. (09/06820-4, 12/22514-3)
DOMINGUEZ, MARIANA R.; SILVEIRA, EDUARDO L. V.; DE VASCONCELOS, JOSE RONNIE C.; DE ALENCAR, BRUNA C. G.; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; GAZZINELLI, RICARDO T.; RODRIGUES, MAURICIO M.. Subdominant/cryptic CD8 T cell epitopes contribute to resistance against experimental infection with a human protozoan parasite. PLoS One, v. 6, n. 7, p. e22011, 2011. Web of Science Citations: 26. (09/06820-4)
ERSCHING, JONATAN; BASSO, ALEXANDRE SALGADO; GARCIA KALICH, VERA LUCIA; BORTOLUCI, KARINA RAMALHO; RODRIGUES, MAURICIO M.. A Human Trypanosome Suppresses CD8(+) T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4(+) Foxp3(+) T Cells. PLOS PATHOGENS, v. 12, n. 6, JUN 2016. Web of Science Citations: 4. (12/22514-3, 12/13032-5, 09/06820-4)
EICKHOFF, CHRISTOPHER S.; ZHANG, XIULI; VASCONCELOS, JOSE R.; MOTZ, R. GEOFFREY; SULLIVAN, NICOLE L.; O'SHEA, KELLY; POZZI, NICOLA; GOHARA, DAVID W.; BLASE, JENNIFER R.; DI CERA, ENRICO; et al. Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity. PLOS PATHOGENS, v. 12, n. 9, SEP 2016. Web of Science Citations: 2. (12/22514-3)
FERREIRA, CAMILA PONTES; CARISTE, LEONARDO MORO; VIRGILIO, FERNANDO DOS SANTOS; MORASCHI, BARBARA FERRI; MONTEIRO, CAROLINE BRANDAO; VIEIRA MACHADO, ALEXANDRE M.; GAZZINELLI, RICARDO TOSTES; BRUNA-ROMERO, OSCAR; MENIN RUIZ, PEDRO LUIZ; RIBEIRO, DANIEL ARAKI; et al. LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8(+) T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection. FRONTIERS IN IMMUNOLOGY, v. 8, OCT 13 2017. Web of Science Citations: 3. (12/22514-3, 17/11499-7, 14/19422-5, 15/08814-2)
PIDONE RIBEIRO, FLAVIA ANDRESSA; PONTES, CAMILA; MACHADO, ALEXANDRE DE M. V.; BRUNA-ROMERO, OSCAR; QUINTANA, HANANIAH T.; DE OLIVEIRA, FLAVIA; CARVALHO DE VASCONCELOS, JOSE RONNIE; RIBEIRO, DANIEL ARAKI. Therapeutical effects of vaccine from Trypanosoma cruzi amastigote surface protein 2 by simultaneous inoculation with live parasites. Journal of Cellular Biochemistry, v. 120, n. 3, p. 3373-3383, MAR 2019. Web of Science Citations: 0. (12/22514-3)
FERREIRA, CAMILA PONTES; CARISTE, LEONARDO MORO; MORASCHI, BARBARA FERRI; ZANETTI, BIANCA FERRARINI; HAN, SANG WON; RIBEIRO, DANIEL ARAKI; MACHADO, ALEXANDRE VIEIRA; LANNES-VIEIRA, JOSELI; GAZZINELLI, RICARDO TOSTES; CARVALHO VASCONCELOS, JOSE RONNIE. CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge. PLoS Neglected Tropical Diseases, v. 13, n. 7, JUL 2019. Web of Science Citations: 0. (16/02840-4, 17/11499-7, 12/22514-3, 18/15607-1, 15/08814-2)