graduate at Ciencias Biomedicas from Universidade Federal de Pernambuco (2000) and ph.d. at Parasitology and Immunology from Universidade Federal de São Paulo (2004). Has experience in Immunology, focusing on Applied Imunology, acting on the following subjects: dna, asp-2, a/sn, interferon-g and vaccine. (Source: Lattes Curriculum)
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Natural infection by the intracellular protozoan Trypanosoma cruzi, the causative agent of Chagas' disease, induces an immune response in the mammalian host that counts on the participation of innate and adaptive immunity. Our group demonstrated that heterologous genetic immunization with ASP-2 and/or trans-sialidase from T. cruzi generates a protective response against different models o…
Natural infection by the intracellular protozoan Trypanosoma cruzi, the causative agent of Chagas' disease, induces an immune response in the mammalian host that counts on the participation of innate and adaptive immunity. Our group demonstrated that heterologous genetic immunization with ASP-2 and/or trans-sialidase from T. cruzi generates a protective response against different models o…
Natural infection by the intracellular protozoan Trypanosoma cruzi, the causative agent of Chagas' disease, induces an immune response in the mammalian host that counts on the participation of innate and adaptive immunity. Our group demonstrated that heterologous genetic immunization with ASP-2 and/or trans-sialidase from T. cruzi generates a protective response against different models o…
CD8+ T cells play a key role in protective immunity against intracellular pathogens, such as Trypanosoma cruzi, the causative agent of Chagas disease. Integrins, cell adhesion molecules (CAM) and chemokine receptors may play a critical role in this process allowing these cells migrate to non-peripheral lymphoid tissues to exert their effector function. Recently, we demonstrated that treat…
Natural infection by the intracellular protozoan Trypanosoma cruzi, the causative agent of Chagas disease, induces an immune response in the mammalian host that includes innate and adaptive immunity. Our group demonstrated that heterologous genetic immunization with T. cruzi ASP-2 and/or trans-sialidase generates a protective response against different models of experimental infection. Th…
CD8 + T lymphocytes play an important role in the control of infections by intracellular pathogens such as Trypanosoma cruzi, a causative agent of Chagas Disease. These lymphocytes control infection by the release of IFN-g and by the elimination of the target cells infected by direct cytotoxicity. To perform these functions, lymphocytes must migrate to infected tissues, establish stable c…
Heterologous prime-boost vaccination using plasmid DNA followed by replication defective human recombinant adenovirus type 5 - both expressing the amastigote surface protein 2 (ASP-2) of Trypanosoma cruzi- is a powerful strategy to elicit CD8+ T cells, mainly CD8+ T effector memory cells (TEM), that mediated protective immunity against the parasite protozoan Trypanosoma cruzi. Specific TE…
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CD8+ T lymphocytes play an important role in the control of infections by intracellular pathogens such as Trypanosoma cruzi, the causative agent of Chagas disease. These lymphocytes control the infection by releasing IFN-g or by direct cytotoxicity against infected target cells. To perform such functions, the lymphocytes migrate into the infected tissues, establish a stable contact with a…
| 3 / 3 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 13 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 19 / 17 | All research grants and scholarships |
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CV Lattes
ORCID