Jose Ronnie Carvalho de Vasconcelos
CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Instituto de Saúde e Sociedade (ISS) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciencias Biomedicas from Universidade Federal de Pernambuco (2000) and ph.d. at Parasitology and Immunology from Universidade Federal de São Paulo (2004). Has experience in Immunology, focusing on Applied Imunology, acting on the following subjects: dna, asp-2, a/sn, interferon-g and vaccine. (Source: Lattes Curriculum)
- Multi-User Equipment approved in grant 2018/15607-1 - equipment name: realtime PCR, AP.EMU
Abstract
Natural infection by the intracellular protozoan Trypanosoma cruzi, the causative agent of Chagas' disease, induces an immune response in the mammalian host that counts on the participation of innate and adaptive immunity. Our group demonstrated that heterologous genetic immunization with ASP-2 and/or trans-sialidase from T. cruzi generates a protective response against different models...
- Role of specific CD4+ and CD8+ T cells generated by different vaccination protocols against experimental Trypanosoma cruzi infection, AP.JP2
Abstract
Natural infection by the intracellular protozoan Trypanosoma cruzi, the causative agent of Chagas' disease, induces an immune response in the mammalian host that counts on the participation of innate and adaptive immunity. Our group demonstrated that heterologous genetic immunization with ASP-2 and/or trans-sialidase from T. cruzi generates a protective response against different models...
- Migration study of specific T cells generated by vaccination or Trypanosoma cruzi infection, AP.JP
Abstract
CD8+ T cells play a key role in protective immunity against intracellular pathogens, such as Trypanosoma cruzi, the causative agent of Chagas disease. Integrins, cell adhesion molecules (CAM) and chemokine receptors may play a critical role in this process allowing these cells migrate to non-peripheral lymphoid tissues to exert their effector function. Recently, we demonstrated that tre...
- Chemokines and leucocyte trafficking in homeostasis and inflamation (A1), AR.EXT
- Role of the CX3CR1 chmokine receptor and LFA-1 integrin in the differentiation and activation of CD8 T lymphocytes during Trypanosoma cruzi infection, BP.DD
Abstract
CD8 + T lymphocytes play an important role in the control of infections by intracellular pathogens such as Trypanosoma cruzi, a causative agent of Chagas Disease. These lymphocytes control infection by the release of IFN-g and by the elimination of the target cells infected by direct cytotoxicity. To perform these functions, lymphocytes must migrate to infected tissues, establish stable...
- Role of pharmacological inhibitor mTOR rapamycin in response of memory CD8+ T cells induced by heterologous prime-boost immunization, BP.DD
Abstract
Heterologous prime-boost vaccination using plasmid DNA followed by replication defective human recombinant adenovirus type 5 - both expressing the amastigote surface protein 2 (ASP-2) of Trypanosoma cruzi- is a powerful strategy to elicit CD8+ T cells, mainly CD8+ T effector memory cells (TEM), that mediated protective immunity against the parasite protozoan Trypanosoma cruzi. Specific ...
- Role of CX3CR1 chemokine receptor and the integrin LFA-1 in the differentiation and activation of CD8 + t lymphocytes during Trypanosoma cruzi infection, BP.MS
Abstract
CD8 + T lymphocytes play an important role in the control of infections by intracellular pathogens such as Trypanosoma cruzi, the causative agent of Chagas' disease. These lymphocytes control infection through the release of IFN-g and the elimination of infected target cells by direct cytotoxicity. To perform these functions, lymphocytes must migrate to infected tissues, establish stab...
- Study of phenotype and specific CD8 + T cells function in immunized and/or infected mice by Trypanosoma cruzi after treatment with chemokine receptor blockers, BP.IC
Abstract
CD8 + T cells play a key role in protective immunity against intracellular pathogens such as, for example, Trypanosoma cruzi, the causative agent of Chagas' disease. Integrins, adhesion molecules and chemokine receptors may play a critical role in this process allowing these cells to migrate to non-lymphoid peripheral tissues to exert effector function. Some studies have shown that type...
(Only some records are available in English at this moment)
- Role of the CXCR3 chemokine receptor in the differentiation,migration, activation and functionality of t lymphocytes during Trypanosoma Cruzi infection, BE.EP.DD
Abstract
CD8+ T lymphocytes play an important role in the control of infections by intracellular pathogens such as Trypanosoma cruzi, the causative agent of Chagas disease. These lymphocytes control the infection by releasing IFN-g or by direct cytotoxicity against infected target cells. To perform such functions, the lymphocytes migrate into the infected tissues, establish a stable contact with...
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 11 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 17 / 15 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 13 |
| Citations | 113 |
| Cit./Article | 8.7 |
| Data from Web of Science | |
DOMINGUEZ, MARIANA R.; SILVEIRA, EDUARDO L. V.; DE VASCONCELOS, JOSE RONNIE C.; DE ALENCAR, BRUNA C. G.; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; GAZZINELLI, RICARDO T.; RODRIGUES, MAURICIO M.. Subdominant/cryptic CD8 T cell epitopes contribute to resistance against experimental infection with a human protozoan parasite. PLoS One, v. 6, n. 7, p. e22011, 2011. Web of Science Citations: 26. (09/06820-4)
VIRGILIO, FERNANDO DOS SANTOS; PONTES, CAMILA; DOMINGUEZ, MARIANA RIBEIRO; ERSCHING, JONATAN; RODRIGUES, MAURICIO MARTINS; VASCONCELOS, JOSE RONNIE. CD8(+) T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?. Mediators of Inflammation, 2014. Web of Science Citations: 12. (09/06820-4, 13/13668-0, 12/22514-3)
VASCONCELOS, JOSE RONNIE; DOMINGUEZ, MARIANA R.; NEVES, RAMON L.; ERSCHING, JONATAN; ARAUJO, ADRIANO; SANTOS, LUARA I.; VIRGILIO, FERNANDO S.; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; GAZZINELLI, RICARDO T.; et al. Adenovirus Vector-Induced CD8(+) T Effector Memory Cell Differentiation and Recirculation, But Not Proliferation, Are Important for Protective Immunity Against Experimental Trypanosoma cruzi Infection. Human Gene Therapy, v. 25, n. 4, p. 350-363, APR 1 2014. Web of Science Citations: 12. (09/06820-4, 12/22514-3)
ERSCHING, JONATAN; VASCONCELOS, JOSE R.; FERREIRA, CAMILA P.; CAETANO, BRAULIA C.; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; BARON, MONIQUE A.; FERREIRA, LUDMILA R. P.; CUNHA-NETO, EDECIO; ROCK, KENNETH L.; et al. The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8(+) T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi. PLOS PATHOGENS, v. 12, n. 4, APR 2016. Web of Science Citations: 6. (09/06820-4, 10/09361-8, 12/22514-3, 15/08814-2)
ERSCHING, JONATAN; BASSO, ALEXANDRE SALGADO; GARCIA KALICH, VERA LUCIA; BORTOLUCI, KARINA RAMALHO; RODRIGUES, MAURICIO M.. A Human Trypanosome Suppresses CD8(+) T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4(+) Foxp3(+) T Cells. PLOS PATHOGENS, v. 12, n. 6, JUN 2016. Web of Science Citations: 5. (09/06820-4, 12/22514-3, 12/13032-5)
ARAUJO, ADRIANO FERNANDO; DE OLIVEIRA, GABRIEL; VASCONCELOS, JULIANA FRAGA; ERSCHING, JONATAN; DOMINGUEZ, MARIANA RIBEIRO; VASCONCELOS, JOSE RONNIE; MACHADO, ALEXANDRE VIEIRA; GAZZINELLI, RICARDO TOSTES; BRUNA-ROMERO, OSCAR; SOARES, MILENA BOTELHO; et al. Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma cruzi. Mediators of Inflammation, 2014. Web of Science Citations: 0. (09/06820-4, 12/22514-3)
FERREIRA, CAMILA PONTES; CARISTE, LEONARDO MORO; MORASCHI, BARBARA FERRI; ZANETTI, BIANCA FERRARINI; HAN, SANG WON; RIBEIRO, DANIEL ARAKI; MACHADO, ALEXANDRE VIEIRA; LANNES-VIEIRA, JOSELI; GAZZINELLI, RICARDO TOSTES; CARVALHO VASCONCELOS, JOSE RONNIE. CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge. PLoS Neglected Tropical Diseases, v. 13, n. 7, JUL 2019. Web of Science Citations: 0. (16/02840-4, 17/11499-7, 12/22514-3, 18/15607-1, 15/08814-2)
RIGATO, PAULA ORDONHEZ; DE ALENCAR, BRUNA C.; DE VASCONCELOS, JOSE RONNIE C.; DOMINGUEZ, MARIANA R.; ARAUJO, ADRIANO F.; MACHADO, ALEXANDRE V.; GAZZINELLI, RICARDO T.; BRUNA-ROMERO, OSCAR; RODRIGUES, MAURICIO M.. Heterologous Plasmid DNA Prime-Recombinant Human Adenovirus 5 Boost Vaccination Generates a Stable Pool of Protective Long-Lived CD8(+) T Effector Memory Cells Specific for a Human Parasite, Trypanosoma cruzi. Infection and Immunity, v. 79, n. 5, p. 2120-2130, MAY 2011. Web of Science Citations: 34. (09/06820-4)
EICKHOFF, CHRISTOPHER S.; ZHANG, XIULI; VASCONCELOS, JOSE R.; MOTZ, R. GEOFFREY; SULLIVAN, NICOLE L.; O'SHEA, KELLY; POZZI, NICOLA; GOHARA, DAVID W.; BLASE, JENNIFER R.; DI CERA, ENRICO; et al. Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity. PLOS PATHOGENS, v. 12, n. 9, SEP 2016. Web of Science Citations: 3. (12/22514-3)
FERREIRA, CAMILA PONTES; CARISTE, LEONARDO MORO; VIRGILIO, FERNANDO DOS SANTOS; MORASCHI, BARBARA FERRI; MONTEIRO, CAROLINE BRANDAO; VIEIRA MACHADO, ALEXANDRE M.; GAZZINELLI, RICARDO TOSTES; BRUNA-ROMERO, OSCAR; MENIN RUIZ, PEDRO LUIZ; RIBEIRO, DANIEL ARAKI; et al. LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8(+) T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection. FRONTIERS IN IMMUNOLOGY, v. 8, OCT 13 2017. Web of Science Citations: 3. (12/22514-3, 17/11499-7, 14/19422-5, 15/08814-2)
DOMINGUEZ, MARIANA R.; ERSCHING, JONATAN; LEMOS, RAMON; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; RODRIGUES, MAURICIO M.; DE VASCONCELOS, JOSE RONNIE C.. Re-circulation of lymphocytes mediated by sphingosine-1-phosphate receptor-1 contributes to resistance against experimental infection with the protozoan parasite Trypanosoma cruzi. Vaccine, v. 30, n. 18, p. 2882-2891, APR 16 2012. Web of Science Citations: 12. (09/06820-4)
PIDONE RIBEIRO, FLAVIA ANDRESSA; PONTES, CAMILA; GAZZINELLI, RICARDO T.; ROMERO, OSCAR-BRUNA; LAZZARIN, MARIANA CRUZ; DOS SANTOS, JOSE FONTES; DE OLIVEIRA, FLAVIA; PISANI, LUCIANA PELLEGRINI; CARVALHO DE VASCONCELOS, JOSE RONNIE; RIBEIRO, DANIEL ARAKI. Therapeutic effects of vaccine derived from amastigote surface protein-2 (ASP-2) against Chagas disease in mouse liver. CYTOKINE, v. 113, p. 285-290, JAN 2019. Web of Science Citations: 0. (12/22514-3)
PIDONE RIBEIRO, FLAVIA ANDRESSA; PONTES, CAMILA; MACHADO, ALEXANDRE DE M. V.; BRUNA-ROMERO, OSCAR; QUINTANA, HANANIAH T.; DE OLIVEIRA, FLAVIA; CARVALHO DE VASCONCELOS, JOSE RONNIE; RIBEIRO, DANIEL ARAKI. Therapeutical effects of vaccine from Trypanosoma cruzi amastigote surface protein 2 by simultaneous inoculation with live parasites. Journal of Cellular Biochemistry, v. 120, n. 3, p. 3373-3383, MAR 2019. Web of Science Citations: 0. (12/22514-3)