CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate in Farmácia-Bioquímica at the Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP (1986), master's in Microbiology and Immunology at the Universidade Federal de São Paulo - UNIFESP (1989) and Ph.D. in Bioquímica at the Universidade de São Paulo - USP (1993). Part of the Ph.D. thesis was developed at the Massachusetts Institute of Technology - MIT. Pos-doc fellow at Harvard Medical School (1996-1998). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: functional characterization of eIF5A using Saccharomyces cerevisiae as an organism model. (Source: Lattes Curriculum)
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The eukaryotic translation factor 5A (eIF5A) is a highly conserved eukaryotic and archaea protein, essential for cell viability, and is involved in the control of cell proliferation, and in neoplastic and inflammatory processes. eIF5A has a unique amino acid, called hypusine, formed by a post-translational modification. The hypusine biosynthesis is dependent on the polyamine spermidine an…
One of the new challenges of Biotechnology and Pharmaceutical industries is the use of proteins as innovative therapies for the treatment of complex diseases. In order to control their production and/or to identify their applicability and eficcacy, the development of new biomarker/bioreporter proteins is required. For that purpose, the strong fluorescence and easy detection of Green Fluor…
(Only some records are available in English at this moment)
The new coronavirus pandemic (COVID-19) has caused socioeconomic impacts around the world, generating a setback that highlighted hunger and unemployment. This virus circulates in the air and secretions, so several measures were taken to control its spread. However, aiming for a more assertive control of the contaminated people, it was necessary to develop specific diagnostic tests that ar…
The new coronavirus, the cause of COVID-19, is a global threat to human health. The virus, called SARS-CoV-2, has a high transmissibility and mortality rate. In addition, there is still a growing concern about the new variants: alpha, beta, gamma, and delta, which have a higher rate of contagion and mortality and are more resistant to vaccines and medicines used. Furthermore, characterist…
The eukaryotic initiation fator 5A (eIF5A) is highly conserved in Archaea and mammals. This factor undergoes a unique and specific post-translational modification called hypusination. Although it was initially suggested a function for eIF5A in the translation initiation, it was in the elongation step that eIF5A was better demonstrated. Recent data from our group revealed a possible role f…
(Only some records are available in English at this moment)
The translation factor 5A (eIF5A) is highly conserved in Archaea and eukaryotes and is essential for cell viability. This is the only protein known to contain the amino acid residue hypusine, essential for eIF5A function, generated by a post-translational modification. Although it was initially suggested a function for eIF5A in the translation initiation, it was in the elongation step tha…
The translation factor 5A (eIF5A) is highly conserved in Archaea and eukaryotes and is essential for cell viability. This is the only protein known to contain the amino acid residue hypusine, essential for eIF5A function, generated by a post-translational modification. Although eIF5A has been extensively involved in several cellular processes, it is now clear that this factor plays a role…
The translation factor 5A (eIF5A) is highly conserved in Archaea and eukaryotes and is essential for cell viability. This is the only protein known to contain the amino acid residue hypusine, essential for eIF5A function, generated by a post-translational modification. Although eIF5A has been extensively involved in several cellular processes, it was only recently determined a role for eI…
(Only some records are available in English at this moment)
| 23 / 10 | Completed research grants |
| 63 / 10 | Completed scholarships in Brazil |
| 5 / 4 | Completed scholarships abroad |
| 91 / 24 | All research grants and scholarships |
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