graduation at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1994) and doctorate at Bioquímica e Biologia Molecular from Universidade de São Paulo (2000). Has experience in Biochemistry, acting on the following subjects: células-tronco, câncer, cancer, expressao genica and terapia celular. (Source: Lattes Curriculum)
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The Human Genome Research Center (HGRC-CEPID I) was initiated in 2000 with the main goal of increasing our basic knowledge and diagnosis of prevalent genetic diseases in the Brazilian population. The HGRC concentrated largely on Mendelian disorders, mainly neuromuscular, craniofacial, and mental disability. The scope was expanded in 2005 by incorporating stem-cell research, both as a too…
The Human Genome Research Center (HGRC-CEPID I) was initiated in 2000 with the main goal of increasing our basic knowledge and diagnosis of prevalent genetic diseases in the Brazilian population. The HGRC concentrated largely on Mendelian disorders, mainly neuromuscular, craniofacial, and mental disability. The scope was expanded in 2005 by incorporating stem-cells research, both as a too…
This research project addresses an important safety issue yet to be solved in the field of cell therapy and of critical relevance to the clinical applications of stem cells: the generation of tumors. Although tumors may arise from any type of stem cell, this project will adopt a pre-established human embryonic stem cell (hESC) line as a study model, given the striking association between …
The primary aim of this study is to better understand the underlying molecular mechanism leading to tumorigenesis and the possible link between cancer and stem cell biology. This type of knowledge is relevant for the development of alternative therapeutic approaches of tumor suppression. One fundamental issue in cancer therapeutics is the elucidation of the molecular and cellular basis of…
Embryonic tumors of the Central Nervous System (CNS), including Medulloblastomas (MEDs) and Atypical Rabatoid Teratoid Tumors (ATRTs), are extremely aggressive tumors that threaten the lives of children, being the main cause of Cancer-related death in the age group 0-4 years. Despite the aggressive therapeutic strategies used to treat these neoplasms (i.e. surgery, radio and chemotherapy)…
Gliomas are the most common Central Nervous System tumors around the globe and comprehend up to 80% of all malignant primary brain tumors. Throughout the types of gliomas, glioblastomas multiforme stand out as the most aggressive and common type. The currently available therapies for glioblastoma treatment are insufficient, and consist of medical resection followed by chemo/radiotherapy a…
Cancer is one of the leading causes of death in the world. In Brazil, there is an estimated 5,810 new cases of central nervous system (CNS) cancer in men and 5,510 new cases in women, by 2019. Although relatively rare, these CNS neoplasms are responsible for high morbidity and mortality rates. Gliomas are primary brain tumors originating from stem cells or neuroglial progenitors. Among th…
Certain Central Nervous System (CNS) tumors, such as medulloblastoma, are caused by genetic changes in stem cells or neuronal progenitor cells, even during the embryonic stage of development. Previous studies of our group identified an abnormal expression of pluripotency factors in medulloblastoma. One such factor is OCT4A, one of the five isoforms generated by alternative splicing of the…
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Hippo pathway is a phosphorylation cascade that culminates in YAP inactivation, inhibiting its activity as a transcription factor. Initially, Hippo pathway was related to the control of cell proliferation, tissue growth and stem cells phenotype. In addition, the inhibition of this pathway and hyperactivation of YAP have been related to several types of cancer. Efforts have been done to el…
Neural stem cells are regarded as new therapeutic potential for neurodegenerative diseases and injuries marrow by their ability to self-renew, proliferate and differentiate giving rise to new neural cells able to migrate to areas of injury and replacing damaged tissue. However, understanding the process of differentiation of neural stem cells is crucial to develop new cellular therapies. …
| 1 / 1 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 22 / 19 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 32 / 27 | All research grants and scholarships |
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CV Lattes
ORCID