Oswaldo Keith Okamoto
CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1994) and doctorate at Bioquímica e Biologia Molecular from Universidade de São Paulo (2000). Has experience in Biochemistry, acting on the following subjects: células-tronco, câncer, expressao genica, antioxidantes and cancer. (Source: Lattes Curriculum)
- Aging and genetic disorders: genomics and metagenomics, AP.TEM
Abstract
Healthy aging and longevity are a growing topic of interest. They depend on the complex interplay between nuclear and mitochondrial DNA, the environment and the microbiota, that is, the whole set of bacteria living in the different parts of our body with their whole set of genes. Understanding this complex nature versus nurture balance is one of the greatest challenges in human genetics...
- CEGH-CEL - Human Genome and Stem Cell Research Center, AP.CEPID
Abstract
The Human Genome Research Center (HGRC-CEPID I) was initiated in 2000 with the main goal of increasing our basic knowledge and diagnosis of prevalent genetic diseases in the Brazilian population. The HGRC concentrated largely on Mendelian disorders, mainly neuromuscular, craniofacial, and mental disability. The scope was expanded in 2005 by incorporating stem-cell research, both as a t...
- Cancer stem cell interactome mapping, AP.R
Abstract
The Human Genome Research Center (HGRC-CEPID I) was initiated in 2000 with the main goal of increasing our basic knowledge and diagnosis of prevalent genetic diseases in the Brazilian population. The HGRC concentrated largely on Mendelian disorders, mainly neuromuscular, craniofacial, and mental disability. The scope was expanded in 2005 by incorporating stem-cells research, both as a t...
- E2F2 transcription factor and expression of proto-oncogenes in human embryonic stem cells, AP.R
Abstract
This research project addresses an important safety issue yet to be solved in the field of cell therapy and of critical relevance to the clinical applications of stem cells: the generation of tumors. Although tumors may arise from any type of stem cell, this project will adopt a pre-established human embryonic stem cell (hESC) line as a study model, given the striking association betwee...
- Cancer stem cells: functional study of genes involved in tumorigenesis in the central nervous system, AP.R
Abstract
The primary aim of this study is to better understand the underlying molecular mechanism leading to tumorigenesis and the possible link between cancer and stem cell biology. This type of knowledge is relevant for the development of alternative therapeutic approaches of tumor suppression. One fundamental issue in cancer therapeutics is the elucidation of the molecular and cellular basis ...
- Long non-coding RNA SNHG16 and neoplastic transformations in neural progenitor cells, BP.IC
Abstract
The lncRNAs are RNAs with 200 or more nucleotides, considered to be important regulatory components since they act in the transcriptional, post-transcriptional and epigenetic regulation. Changes in the expression pattern of these RNA transcripts lead to the development and/or worsening of cancer. SNHG16 is a lncRNAs described for having influence in the increase of proliferation and met...
- Caracterization of the proteic interactoma of the pluripotency factor L1TD1 in central nervous system tumour stem cells and neural stem cells, BP.IC
Abstract
Medulloblastoma is the most common type of malignant Central Nervous System (CNS) embryonal cancer in children up to 4 years of age and is one of the leading causes of childhood morbidity and mortality. Stem cells and tumor cells have been shown to have some common pluripotency properties that have been associated with tumorigenicity in several types of solid cancers. In medulloblastoma...
- Hippo signaling pathway and asymmetric division of cancer stem cells derived from human medulloblastoma, BP.PD
Abstract
Asymmetric cell division is a striking feature of stem cells. It generates two daughter cells with defined distinct fates, ensuring both stem cell self renewal and differentiation. Abnormalities in this process may affect tissue homeostasis leading to tumor formation, as first observed in Drosophila mutants for genes involved in asymmetric cell division. Failures in asymmetric cell divi...
- Modeling of embryonic tumor of the central nervous system from neuroprogenitor cells derived from human pluripotent stem cells, BP.IC
Abstract
Certain Central Nervous System (CNS) tumors, such as medulloblastoma, are caused by genetic changes in stem cells or neuronal progenitor cells, even during the embryonic stage of development. Previous studies of our group identified an abnormal expression of pluripotency factors in medulloblastoma. One such factor is OCT4A, one of the five isoforms generated by alternative splicing of t...
- Regulation between hsa-miR-4719 and nucleostemin in meduloblastoma, BP.IC
Abstract
The POU5F1 gene is responsible for expression of the OCT4 protein, which is found with higher expression than normal in embryonic and tumor stem cells, and is related to maintenance of the undifferentiated state. Our group detected a correlation between increased POU5F1 expression and decreased survival of patients with medulloblastoma, increased tumor aggressiveness by faster cell grow...
- Expression and mechanism of hsa-miR-367 in neurogenesis and aggressiveness of human medulloblastoma, BP.IC
Abstract
Medulloblastoma is an embryonic tumor from Central Nervous System (CNS) and the most common among children from zero to four years old. The origin of this malignat pediatric tumor is still undefined, but believed to be derived from cells with stem cells characteristics during the development of cerebellum. This tumor is classified as being highly aggressive, with rapid growth and capaci...
(Only some records are available in English at this moment)
- The Hippo pathway, asymmetric cell division and the tolerance to aneuploidy in cancer cells, BE.EP.PD
Abstract
Hippo pathway is a phosphorylation cascade that culminates in YAP inactivation, inhibiting its activity as a transcription factor. Initially, Hippo pathway was related to the control of cell proliferation, tissue growth and stem cells phenotype. In addition, the inhibition of this pathway and hyperactivation of YAP have been related to several types of cancer. Efforts have been done to ...
- Functional characterization of RNA binding proteins Lin28 and Msi1 in neurogenesis, BE.EP.PD
Abstract
Neural stem cells are regarded as new therapeutic potential for neurodegenerative diseases and injuries marrow by their ability to self-renew, proliferate and differentiate giving rise to new neural cells able to migrate to areas of injury and replacing damaged tissue. However, understanding the process of differentiation of neural stem cells is crucial to develop new cellular therapies...
| 2 / 2 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 17 / 14 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 29 / 24 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 10 |
| Citations | 150 |
| Cit./Article | 15.0 |
| Data from Web of Science | |
OKAMOTO, OSWALDO KEITH; CARVALHO, ANA CAROLINA S. R.; MARTI, LUCIANA C.; VENCIO, RICARDO Z.; MOREIRA-FILHO, CARLOS A.. Common molecular pathways involved in human CD133+/CD34+progenitor cell expansion and cancer. CANCER CELL INTERNATIONAL, v. 7, 2007. Web of Science Citations: 13.
GONCALVES DA SILVA, PATRICIA BENITES; TEIXEIRA DOS SANTOS, MARCIA CRISTINA; RODINI, CAROLINA OLIVEIRA; KAID, CAROLINI; LEITE PEREIRA, MARCIA CRISTINA; FURUKAWA, GABRIELA; GIMENES DA CRUZ, DANIEL SANZIO; GOLDFEDER, MAURICIO BARBUGIANI; REILY ROCHA, CLARISSA RIBEIRO; ROSENBERG, CARLA; et al. High OCT4A levels drive tumorigenicity and metastatic potential of medulloblastoma cells. ONCOTARGET, v. 8, n. 12, p. 19192-19204, 2017. Web of Science Citations: 2. (13/08028-1, 11/05534-8, 13/17566-7, 13/02983-1, 11/10001-9, 10/52686-5, 11/51588-2)
KAID, CAROLINI; SILVA, PATRICIA B. G.; CORTEZ, BEATRIZ A.; RODINI, CAROLINA O.; SEMEDO-KURIKI, PATRICIA; OKAMOTO, OSWALDO K.. miR-367 promotes proliferation and stem-like traits in medulloblastoma cells. Cancer Science, v. 106, n. 9, p. 1188-1195, SEP 2015. Web of Science Citations: 25. (13/08028-1, 14/10519-6, 13/17566-7, 13/02983-1, 11/10001-9, 10/52686-5)
TEIXEIRA SANTOS, MARCIA CRISTINA; GONCALVES SILVA, PATRICIA BENITES; RODINI, CAROLINA OLIVEIRA; FURUKAWA, GABRIELA; MARCO ANTONIO, DAVID SANTOS; ZANOTTO-FILHO, ALFEU; MOREIRA, JOSE C. F.; OKAMOTO, OSWALDO KEITH. Embryonic Stem Cell-Related Protein L1TD1 Is Required for Cell Viability, Neurosphere Formation, and Chemoresistance in Medulloblastoma. STEM CELLS AND DEVELOPMENT, v. 24, n. 22, p. 2700-2708, NOV 15 2015. Web of Science Citations: 5. (10/52686-5, 13/17566-7, 13/08028-1, 11/51588-2, 11/10001-9)
SANTOS, MARCIA C. T.; TEGGE, ALLISON N.; CORREA, BRUNA R.; MAHESULA, SWETHA; KOHNKE, LUANA Q.; QIAO, MEI; FERREIRA, MARCO A. R.; KOKOVAY, ERZSEBET; PENALVA, LUIZ O. F.. miR-124,-128, and-137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network. Stem Cells, v. 34, n. 1, p. 220-232, JAN 2016. Web of Science Citations: 31. (11/51588-2, 13/25483-4, 12/22950-8)
GONCALVES DA SILVA, PATRICIA BENITES; RODINI, CAROLINA OLIVEIRA; KAID, CAROLINI; NAKAHATA, ADRIANA MITI; LEITE PEREIRA, MARCIA CRISTINA; MATUSHITA, HAMILTON; DA COSTA, SILVIA SOUZA; OKAMOTO, OSWALDO KEITH. Establishment of a novel human medulloblastoma cell line characterized by highly aggressive stem-like cells. Cytotechnology, v. 68, n. 4, p. 1545-1560, AUG 2016. Web of Science Citations: 3. (10/52686-5, 13/08028-1)
KAID, CAROLINI; GOULART, ERNESTO; CAIRES-JUNIOR, LUIZ C.; ARAUJO, BRUNO H. S.; SOARES-SCHANOSKI, ALESSANDRA; BUENO, HELOISA M. S.; TELLES-SILVA, KAYQUE A.; ASTRAY, RENATO M.; ASSONI, AMANDA F.; JUNIOR, ANTONIO F. R.; et al. Zika Virus Selectively Kills Aggressive Human Embryonal CNS Tumor Cells In Vitro and In Vivo. Cancer Research, v. 78, n. 12, p. 3363-3374, JUN 15 2018. Web of Science Citations: 6. (13/08028-1, 17/16283-2, 15/14821-1, 16/09707-8, 14/08049-1)
OKAMOTO, OSWALDO K.; JANJOPPI, LUCIANA; BONONE, FELIPE M.; PANSANI, ALINE P.; DA SILVA, ALEXANDRE V.; SCORZA, FULVIO A.; CAVALHEIRO, ESPER A.. Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis. BMC Genomics, v. 11, APR 8 2010. Web of Science Citations: 55.
PAVON, L. F.; GAMARRA, L. F.; MARTI, L. C.; AMARO JUNIOR, E.; MOREIRA-FILHO, C. A.; CAMARGO-MATHIAS, M. I.; OKAMOTO, O. K.. Ultrastructural characterization of CD133(+) stem cells bound to superparamagnetic nanoparticles: possible biotechnological applications. JOURNAL OF MICROSCOPY, v. 231, n. 3, p. 374-383, SEP 2008. Web of Science Citations: 10.
OKAMOTO, OSWALDO K.; OBA-SHINJO, SUELI M.; LOPES, LUCIANA; MARIE, SUELY K. NAGAHASHI. Expression of HOXC9 and E2F2 are up-regulated in CD133+ cells isolated from human astrocytomas and associate with transformation of human astrocytes. Biochimica et Biophysica Acta (BBA) : Gene Structure and Expression, v. 1769, n. 7/8, p. 437-442, July 2007.
KAID, CAROLINI; JORDAN, DIONE; DE SIQUEIRA BUENOS, HELOISA MARIA; SILVA ARAUJO, BRUNO HENRIQUE; ASSONI, AMANDA; OKAMOTO, OSWALDO KEITH. miR-367 as a therapeutic target in stem-like cells from embryonal central nervous system tumors. MOLECULAR ONCOLOGY, AUG 2019. Web of Science Citations: 0. (13/08028-1, 13/02983-1, 16/09707-8, 14/08049-1)
(References retrieved automatically from State of São Paulo Research Institutions)
RODINI, Carolina de Oliveira. Contribuição das células-tronco mesenquimais para as propriedades tumorigênicas de células de glioblastoma humano. 2016. Tese (Doutorado) – Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (11/10001-9)
DÁVILA, Carolini Kaid. Expressão de hsa-miR-367 e agressividade de meduloblastoma humano. 2015. Dissertação (Mestrado) - Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (13/02983-1)
SILVA, Patrícia Benites Gonçalves da. Fator de pluripotência OCT4A e agressividade de meduloblastoma humano. 2016. Tese (Doutorado) – Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (13/17566-7)