CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Centro de Hematologia e Hemoterapia (HEMOCENTRO) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Coordinator of the Vascular Inflammation Laboratory, Hematology and Hemotherapy Center (Hemocentro), UNICAMP. B.Sc. Hons in Medical Biochemistry - University of Birmingham. PhD in Biochemistry - University of Nottingham, UK. Postdoctoral Fellowship: Department of Pharmacology, UNICAMP. Young Researcher Fellowship, FAPESP, Hemocentro, UNICAMP.Currently a researcher (Research Career Pathway, UNICAMP) at the Hemocentro, UNICAMP. Research mainly on the following subjects: Hemoglobinopathies, sickle cell anemia, vaso-occlusion, cell adhesion, nitric oxide, leukocytes, platelets, vascular inflammation.- Editor for Latin America, Experimental Biology and Medicine. Ass/Guest Editor: Hematology, Transfusion Cell Therapy and Frontiers in Immunology.- Scientific Committee for Red Cell Biology for the American Society of Hematology (member). Councillor, Society for Experimental Biology and Medicine, Washington, USA.- Coordinator: Professional Master's Degree in Hemotherapy, FCM, UNICAMP. Member of the committee, Postgraduate Program in Medical Pathophysiology Committee.- Member of the CDT Board: Colegio Doctoral Tordesillas (CDT) Agreement in Biomedicine and Metabolism between Universities in Brazil, Portugal, Spain. (Source: Lattes Curriculum)
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Sickle cell anemia (SCD) is an inherited disease characterized by alteration in red blood cells. Hemolytic processes due to the altered chemical-physical properties of the red blood cells induce vascular inflammation and eventually vaso-occlusive processes. Vaso-occlusive events result in the main clinical complications of SCD, as they obstruct the small blood vessels, causing tissue isch…
The proposed Thematic Project "Pathophysiological Mechanisms and Treatment of Red Blood Cell Abnormalities" will be developed by the Red Blood Cell Research Group at the Hematology Center, the Department of Clinical Pathology and the Center for Molecular Biology and Genetic Engineering (CBMEG), UNICAMP, in collaboration with various Brazilian and international researchers. The project aim…
Sickle cell disease (SCD) is a group of inherited disorders, caused by mutations in the gene encoding ²-globin. The disease causes alterations in the hemoglobin molecule, resulting in altered red blood cell (RBC) properties and shape, and the destruction of these cells in the circulation, leading to anemia and other complications. The pathophysiological changes incurred from this alterati…
Intravascular hemolysis, or the destruction of red blood cells, occurs in numerous pathological conditions, including the acquired hemolytic anemias and sickle cell disease, as well as during some transfusion reactions, preeclampsia, and infections, such as those caused by malaria or Clostridium perfringens. Hemolysis results in the release of large amounts of damage-associated molecular …
Angiogenesis is characterized by the formation of new capillaries, from pre-existing vessels. This process plays an important role in the supply of oxygen and nutrients to tissues and the migration of inflammatory cells to sites of inflammation. The angiogenic process involves interactions of various cell types and mediators to establish capillary formation. Endothelial cells are key to t…
(Only some records are available in English at this moment)
Sickle cell anemia (SCD) is an inherited disease characterized by alteration in red blood cells. Hemolytic processes due to the altered chemical-physical properties of the red blood cells induce vascular inflammation and eventually vaso-occlusive processes. Vaso-occlusive events result in the main clinical complications of SCD, as they obstruct the small blood vessels, causing tissue isch…
Sickle Cell Anemia (SCA) is an inherited disease caused by the production of abnormal hemoglobin(Hb)S, whose deoxygenation-induced polymerization results in Red Blood Cell (RBC) sickling and numerous pathophysiological consequences. Sickle Cell Disease (SCD) affects approximately 300 000 newborns worldwide each year and is associated with acute and chronic complications, including frequen…
Sickle cell anemia (SCA) is a genetic disease characterized by the deformation of red blood cells due to abnormal hemoglobin S polymerization. Clinical manifestations are mainly related to vaso-occlusive processes, such as painful crises and complications in various organs. In the disease there is extensive intravascular hemolysis due to the fragility of red blood cells. The release of he…
Sickle cell anemia (SCA) is a hemolytic anemia, caused by the inheritance of hemoglobin S (HbS) in homozygous. Inflammation is a fundamental component of its pathophysiology, and can occur acutely and chronically. In general, numbers and levels of leukocytes and proinflammatory cytokines are high in the disease and these are associated with the clinical severity. In this context, transfor…
(Only some records are available in English at this moment)
Sickle cell anemia (SCA) is caused by a point mutation in the ²-hemoglobin gene, producing abnormal hemoglobin S (HbS). When deoxygenated, HbS polymerizes, causing the red blood cell to become sickle shaped and to rupture more easily. As a result, the disease is characterized by anemia, intravascular hemolysis and vaso-occlusive disease, which can result in painful vaso-occlusive episodes…
Evidence suggests that haem may represent a novel DAMP. Haem generated by intra and extra-vascular haemolysis activates innate immune cells and non-hematopoietic cells, promoting pro-inflammatory activities, such as leukocyte activation, migration and infiltration, adhesion molecule activation, cytokine release and inflammasome formation. Our data suggest that haem is a potent driver of i…
Sickle cell anemia (SCA) is a hereditary hemoglobinopathy resulted from a mutation in the beta-globin gene. This simple monogenic event is responsible for a systemic disorder of enormous complexity that affects multiple organs. The vaso-occlusive crisis is a major cause of morbidity in SCA and result from the interaction of inflammatory cytokines, activated blood cells and vascular endoth…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 14 / 13 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 25 / 21 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 47 / 42 | All research grants and scholarships |
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