CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Master and PhD studies in Genetics at IB/USP. Former pos-doc of Columbia University (NY-USA) and Biochemistry Department -IQ/USP. Nowadays is an Associate Professor at the Department of Microbiology - ICB/USP, using Saccharomyces cerevisiae as model for studies related to mitochondria bioenergetics and biogenesis. (Source: Lattes Curriculum)
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In most eukaryotes, the mitochondrial respiratory complexes, ATP synthase, and mitoribosome are genetic hybrids encoded by nuclear and mitochondrial genes. An emerging area of mitochondrial research seeks to decipher mechanisms by which these genetic, hetero-oligomeric hybrids are coordinately formed achieving optimal stoichiometry between them. In recent years, this laboratory has contri…
Mitochondria are essential for life; they are critical subcellular compartments that generate the power driving most cellular reactions. We use the common model organism, baker's yeast, to study the genetics and biochemistry of mitochondrial function. Yeast, like all eukaryotes, has an 80,000 base pair mitochondrial genome in addition to 12 million base pairs in nuclear chromosomes. Trans…
Mitochondrial mitoribosomes are responsible for the translation of mitochondrially encoded mRNAs. The mitoribosome was adapted along evolution to optimize the expression of highly hydrophobic membrane proteins. Studies involving mitochondrial translation have revealed numerous factors involved in mitoribosome biogenesis, including several uncharacterized components of the mitochondrial ge…
The assembly of the mitochondrial respiratory complexes depends on proteins encoded by two different genomes, an unique situation in human cells that arise our interest on regulatories mechanisms involved in the proper steichiometric assembly of the respiratory complexes. Here, we propose to study a possible regulatory interconnection between cytochrome c oxidase (COX) assembly and the mi…
(Only some records are available in English at this moment)
The yeast Saccharomyces cerevisiae is widely used as a model organism in genetic and biochemical studies due to its molecular accessibility and flexible metabolism. In respiratory metabolism, an essential component is the protein Sal1p, a mitochondrial adenine nucleotide transporter belonging to the MCF (Mitochondrial Carrier Family). Sal1p enables the electroneutral import of mitochondri…
Oxidative phosphorylation is a central mechanism of ATP synthesis that in Eukaryota occurs compartmentalized in the mitochondria. These organelles of endosymbiotic origin have their own DNA, called mtDNA, which replicates independently of the cell cycle and is packaged with proteins, forming spheroid granules physically associated with the inner membrane called nucleoids. mtDNA encodes fe…
Mitochondria are responsible for several biochemical processes in eukaryotic cells. Due to its endosymbiotic origin, it contains a genetic system encoding subunits of the oxphos system and the mitoribosome. We have been using the yeast Saccharomyces cerevisiae as a model to study and characterize mitochondria proteins required for respiration, particularly those involved in regulating th…
(Only some records are available in English at this moment)
This project seeks to evaluate the relationship between the product of the nuclear gene AIM34 and essential components of the mitochondrial metabolism of Saccharomyces cerevisia. Functional studies indicate that the protein Aim34p is located in the mitochondrion, with probable activity over the stability of mitDNA, and indeed, our team has verified that the excess of Aim34p causes instabi…
Mitochondria are essential for the energy production in eukaryotic cells. Mitochondria contain its own genetic material that relies on a genetic expression system and mitoribosome whose subunits are imported and assembled inside the organelle. The yeast Saccharomyces cerevisiae is an excellent tool for genetic and biochemical studies involved in mitochondria biogenesis, its studies has fa…
The translation of mitochondrially encoded mRNAs is done by mitoribosomes. Mitochondrial translation involves several factors, including translation activators, which bind to a site in the 5 'UTR region of the mitochondrial mRNA and a site in the coding region. The factors Pet309, Pet111 and Pet494 have already been observed for the COX1, COX2 and COX3 genes, respectively. Several unchara…
(Only some records are available in English at this moment)
Mitochondrial gene expression in Saccharomyces cerevisiae has been studied for manyyears, providing fundamental insights into the mechanisms and regulation of thisprocess in multicellular organisms. In most eukaryotes, mitochondria contain their owngenetic system encoding a small set of subunits involved in the assembly of oxidationphosphorylation complexes in the inner mitochondrial memb…
In Saccharomyces cerevisiae, the mitochondrial DNA (mtDNA) is responsible for coding seven proteins that are subunits of the OXPHOS complexes. Cox2p, encoded by the mtDNA, is one of the proteins comprising the catalytic core of cytochrome c oxidase, and it is associated with two atoms of copper (CuA center). Cox2p has two transmembrane domains that count on several proteins to be correctl…
Fungal and mammalian ATP Synthase and Cytochrome c oxidase (COX) are examples ofmitochondrial hetero-oligomeric complexes whose assembly depends on the expression ofmitochondrial and nuclear genes. In prior studies, yeast ATP synthase was shown to be assembledfrom three modules, each formed by a separate pathway. The simplest module is a ring, which inyeast consists of 10 identical copies…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 10 / 8 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 22 / 11 | Completed scholarships in Brazil |
| 5 / 4 | Completed scholarships abroad |
| 42 / 28 | All research grants and scholarships |
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