Cláudio Francisco Tormena is Full Professor of the Institute of Chemistry at University of Campinas Campinas - São Paulo - Brazil. He received his PhD (in chemistry) from University of Campinas in 2000, under supervision of Professor Roberto Rittner. Part of his doctoral was developed at the University of Liverpool from 1998 to 1999 under supervision of Professor R. J. Abraham. He was a postdoctoral fellow at the University of Campinas from 2000 to 2003. From 2009 to 2010 during a sabbatical period, Dr. Tormena stayed in the School of Chemistry at the University of Manchester working with Prof. Gareth A. Morris. He has published more than 166 peer-review papers and more than 100 communications in national and international meetings. His research interests are focused on the experimental and theoretical NMR parameters, conformational analysis and Matrix-Assisted DOSY for mixtures analyses and pulse sequence development. He is a member of Advisory board of Magnetic Resonance in Chemistry and member of São Paulo Academy of Science (Source: Lattes Curriculum)
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The technical reserve for research, granted by FAPESP, concerning the year of 2022 goals of applicaton were approved by the Congregation of the Institute of Chemisty on September 28, 2022 and are described below: maintenance/repair of multi-user institucional equipments / complementation of the Research Labs structured cabling construction / consumables for multi-user institucional e…
The purpose of the application of the technical reserve for research granted by FAPESP for the year 2021 was approved by the Institute of Chemistry Congregation on September 30, 2021 as described below:- Maintenance / repairs of institutional multi-user equipment;- Electrical adjustments in order to tranfer the FRX equipment to the DRX lab;- Complement of the structured cabling constructi…
Since most of the adverse effects are dose-related, ²-lactams have been the drug of choice for the treatment of bacterial infection. However, the misuse of these antimicrobial drugs speeded up the emergence of drug-resistant bacteria. It is important to emphasize that 9 of the 12 most dangerous families of bacteria, data released by WHO, has the presence of ²-lactamase as the main mechani…
(Only some records are available in English at this moment)
In order to commercialize beef, quality and tenderness are fundamental and several factors can influence, such as post-mortem treatments. There are several studies on meat tenderness, however, the biomarkers that express this quality attribute and may contribute to the rapid tenderness classification soon after slaughter, as well as genetic selection, are not well known. In beef commercia…
Nuclear Magnetic Resonance (NMR) is the most powerful spectroscopic technique for detailed chemical information in solution. Fundamental parameters such as chemical shifts (d) and coupling constants (J) are the most important sources of information to achieve unequivocal molecular structure assignment. These two parameters can also be applied to determine the conformation adopted by a mol…
In the present project 1H and 19F Diffusion-Ordered Spectroscopy (DOSY) will be applied with or without surfactant addition to evaluate the effect of surfactant to complex mixture separation, dubbed MAD (Matrix Assisted DOSY). Several molecular systems are chosen to these purposes, where target molecules possess acidic or basic groups and in some cases at least one fluorine atom is presen…
(Only some records are available in English at this moment)
The increasing demand for compounds enantiomerically pure in various fields of chemistry, biology, material science and especially in the pharmaceutical industry has highlighted the lack of a simple, easy to use, cost-effective and reliable technique to analyze such compounds. Gas chromatography (GC) and high-performance liquid chromatography (HPLC) are the most common methods used for th…
It is proposed to investigate the stability of non-classical carbocations formed by the opening reaction of alpha-pinene oxide in acidic medium in solvents of different polarities and at different temperatures. The structures and stability of the possible carbocations (Scheme 1) will be experimentally determined indirectly through the unequivocal determination of the structures and propor…
The measuring Kinetic Isotope Effect (KIE) at the natural isotopic abundance of 13C NMR is a time-consuming task, as it requires very high signal-to-noise ratio quantitative 13C NMR spectra, necessary to reduce systematic errors in the integration procedure. Typically, each quantitative 13C NMR experiment takes at least 30 hours, for a highly concentrated sample and considering that quin…
(Only some records are available in English at this moment)
In the last two decades, many advances have been made in the conformational study of molecules and NMR parameters such as shielding constants (Ã), chemical shifts (´), and coupling constants (J) using quantum calculations. Most of these studies were and still are carried out in the gas phase. However, understanding the molecular behavior and experimental trends of NMR parameters in soluti…
This proposal intents to evaluate the stereoelectronic effect responsible for the experimental variation around 20 Hz observed for 2JCH coupling constants in some substituted ethenes. To achieve this aim, the signs and magnitudes of 2JCH coupling for several mono- di- and tri-substituted ethenes derivatives will be experimentally measured and theoretically calculated through ab initio SOP…
The analysis of natural products, often as part of complex mixtures, is very challenging, but identifying the structure of their components is essential for drug discovery and development. In the context of molecular structure assignment of mixture components, Nuclear Magnetic Resonance (NMR) is one of the most suitable non-destructive analytical methods. Its advances in the last decade h…
(Only some records are available in English at this moment)
Enantiomers are chiral molecules that are specular mirror images of each other but cannot be superimposed. These compounds have gained attention for their applications in various fields, including pharmaceuticals, agriculture, and food. The importance of enantiomers is due to their distinct interactions with other chiral molecules, which can result in different biological or pharmaceutica…
Understanding the solvent effect on the chemical processes and reaction mechanisms is a hard task that has been intensively investigated for many years. Several experimental and theoretical studies have been showing how solvent dynamics dramatically change the reaction rate, yield, and selectivity. However, due to the computational treatment of explicit solvent molecules being difficult a…
The present proposal intents to study the strength of intramolecular hydrogen bonds involving fluorine atom and its effect in the conformational preference of fluorinated amino alcohols. The BEPE project was motivated by the results obtained in the project (FAPESP 2018/02634-0) involving compound trans-2-((2-fluorophenyl)amino)-cyclohexanol. A long range JHF coupling between the fluorine …
Stereoelectronic interactions are commonly required to explain the stability of different compounds or the reactivity of some substrates. Moreover, these interactions are important to understand the effects of electron-donating and electron-withdrawing groups in aromatic systems, mainly related to resonance effects. Despite of these known interactions, the effect of some groups (e.g. nitr…
The present postdoctoral project involves the potential use of DOSY techniques to separate the NMR spectra of complex mixtures of isomers using micellar solutions of surfactants as separation agents.The initial aim of this project will be to study the effects of surfactants on diffusion-weighted NMR spectra of mixtures of isomers of differing polarities. The first question is: to what ext…
| 5 / 5 | Ongoing research grants |
| 8 / 5 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 16 / 13 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 41 / 34 | All research grants and scholarships |
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