CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Cláudio Francisco Tormena is Associate Professor of the Institute of Chemistry at University of Campinas Campinas - São Paulo - Brazil. He received his PhD (in chemistry) from University of Campinas in 2000, under supervision of Professor Roberto Rittner. Part of his doctoral was developed at the University of Liverpool from 1998 to 1999 under supervision of Professor R. J. Abraham. He was a postdoctoral fellow at the University of Campinas from 2000 to 2003. From 2009 to 2010 during a sabbatical period, Dr. Tormena stayed in the School of Chemistry at the University of Manchester working with Prof. Gareth A. Morris. He has published more than 145 peer-review papers and more than 100 communications in national and international meetings. His research interests are focused on the experimental and theoretical NMR parameters, conformational analysis and Matrix-Assisted DOSY for mixtures analyses and pulse sequence development. He is a member of Advisory board of Magnetic Resonance in Chemistry and member of São Paulo Academy of Science (Source: Lattes Curriculum)
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Since most of the adverse effects are dose-related, ²-lactams have been the drug of choice for the treatment of bacterial infection. However, the misuse of these antimicrobial drugs speeded up the emergence of drug-resistant bacteria. It is important to emphasize that 9 of the 12 most dangerous families of bacteria, data released by WHO, has the presence of ²-lactamase as the main mechani…
Since 2015 a thematic proposal (2015/08541-6) is in progress, related to the application of NMR beyond to structure assignments. During this period, our group developed and applied new pulse sequences, including those for DOSY and FESTA experiments to deal with structure assignment of compounds in mixtures, without the need for any physical separation. DOSY experiments were also used to s…
In order to commercialize beef, quality and tenderness are fundamental and several factors can influence, such as post-mortem treatments. There are several studies on meat tenderness, however, the biomarkers that express this quality attribute and may contribute to the rapid tenderness classification soon after slaughter, as well as genetic selection, are not well known. In beef commercia…
(Only some records are available in English at this moment)
Nuclear Magnetic Resonance (NMR) is the most powerful spectroscopic technique for detailed chemical information in solution. Fundamental parameters such as chemical shifts (d) and coupling constants (J) are the most important sources of information to achieve unequivocal molecular structure assignment. These two parameters can also be applied to determine the conformation adopted by a mol…
In the present project 1H and 19F Diffusion-Ordered Spectroscopy (DOSY) will be applied with or without surfactant addition to evaluate the effect of surfactant to complex mixture separation, dubbed MAD (Matrix Assisted DOSY). Several molecular systems are chosen to these purposes, where target molecules possess acidic or basic groups and in some cases at least one fluorine atom is presen…
The project under evaluation involves the effects of stereoelectronic interactions on 13C NMR chemical shifts for molecules containing heavy atoms. It is proposed a description about how stereoelectronic interactions affect the Spin-Orbit component of the nuclear shielding tensor, which may be ascribed as responsible for heavy atom effects on 13C NMR. It is also highlighted in this projec…
(Only some records are available in English at this moment)
Matrix-Assisted DOSY (MAD) has been used to differentiate molecules that diffuse at a similar rate, as it is often the case for isomers. The differentiation is based on modifying the solution matrix (i.e. the medium), by adding large compounds that interact with each isomer present in the sample with different strengths. Surfactants are typically used for this purpose. Our group has made …
It is proposed to develop a new NMR pulse sequence base on Pure Shift approach to simultaneously determine the magnitude and sign of JFH couplings. The new pulse sequence will be based on combination of heteronuclear modulated echo, concatenated with zTOCSY and suitable Pure Shift elements. The compounds to be used in this study are in some cases commercially available, some are already p…
This proposal intents to evaluate the stereoelectronic effect responsible for the experimental variation around 20 Hz observed for 2JCH coupling constants in some substituted ethenes. To achieve this aim, the signs and magnitudes of 2JCH coupling for several mono- di- and tri-substituted ethenes derivatives will be experimentally measured and theoretically calculated through ab initio SOP…
The analysis of natural products, often as part of complex mixtures, is very challenging, but identifying the structure of their components is essential for drug discovery and development. In the context of molecular structure assignment of mixture components, Nuclear Magnetic Resonance (NMR) is one of the most suitable non-destructive analytical methods. Its advances in the last decade h…
The aim of this proposal is to evaluate the influence and strength of possible intramolecular hydrogen bonding (IntraHB) involving N-H---O, O-H---N, O-H---F and N-H---F molecular moieties as a driving force on the conformational preferences of some fluorinated amino-alcohols. To achieve our purpose we intent to merge experimental information from Nuclear Magnetic Resonance Spectroscopy wi…
(Only some records are available in English at this moment)
The present proposal intents to study the strength of intramolecular hydrogen bonds involving fluorine atom and its effect in the conformational preference of fluorinated amino alcohols. The BEPE project was motivated by the results obtained in the project (FAPESP 2018/02634-0) involving compound trans-2-((2-fluorophenyl)amino)-cyclohexanol. A long range JHF coupling between the fluorine …
Stereoelectronic interactions are commonly required to explain the stability of different compounds or the reactivity of some substrates. Moreover, these interactions are important to understand the effects of electron-donating and electron-withdrawing groups in aromatic systems, mainly related to resonance effects. Despite of these known interactions, the effect of some groups (e.g. nitr…
The present postdoctoral project involves the potential use of DOSY techniques to separate the NMR spectra of complex mixtures of isomers using micellar solutions of surfactants as separation agents.The initial aim of this project will be to study the effects of surfactants on diffusion-weighted NMR spectra of mixtures of isomers of differing polarities. The first question is: to what ext…
| 4 / 4 | Ongoing research grants |
| 7 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 16 / 12 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 32 / 25 | All research grants and scholarships |
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