Maria Luiza de Morais Barreto de Chaves

• Abstract

  Thyroid Hormones (TH) exert numerous effects in the cardiovascular system.In this way, the hyperthyroidism is associated to elevated cardiac function and morphologic alterations in the heart as cardiac hypertrophy. We have described that the increase of cardiac mass induced by TH is mediated, at least in part by activation of Renin-Angiotensin System, mainly by AT1 Receptor (AT1R). This...

  AT1R internalization and Ras/Raf/MEK/ERK signaling in the cardiomyocyte hypertrophy induced by thyroid hormone. role of beta-arrestins, AP.R

• Abstract

  Elevated levels of Thyroid Hormones promote a series of cardiovascular changes including cardiac hypertrophy, which may be assessed directly by in vitro or in vivo approaches. We and other authors have evidenced in diverse studies a close relationship between the cardiac effects of Thyroid Hormones and Renin-Angiotensin System (RAS) activation. However, some molecular mechanisms involvi...

  Inflammation and cardiac hypertrophy induced by thyroid hormones: contribution of renin-angiotensin system, AP.R

• Abstract

  Several endocrine systems, such as the renin-angiotensin system (RAS) and thyroid hormones (TH) alter the cardiac function, directly or indirectly modulating the heart trophism and protecting against cardiac stress. Besides their regulatory role under situations of cardiac damage, the endocrine systems are able to interact in many of their actions. The TH promote a phenotype of cardiopr...

  Effect of thyroid hormone on cardiac function on ischemia-reperfusion model: role of angiotensin type 2 receptor and AMPK signaling pathway, AP.R

(Only some records are available in English at this moment)

• Abstract

  Cardiac hypertrophy, despite being an adaptive response may contribute to cardiomyopathy development and progression. It is well established that thyroid hormones exert direct and indirect effects on the heart, which result on an hypertrophic state of this organ. In this sense, our research group has been studying the various cellular and molecular mechanisms involved in this process. R...

  Role of cardiac MyD88 on cardiac hypertrophy induced by tyroid hormone: model of specific tissue deletion induced by tamoxifen (Cre-Lox system), BP.IC

• Abstract

  High levels of thyroid hormones (TH) are responsible for promoting changes in the cardiovascular system, which culminate in the development of cardiac arrhythmias and the installation of a hypertrophic process (Cappola et al., 2006). We have previously demonstrated that TH is able to promote cardiac hypertrophy and other cardiovascular manifestations through Renin-Angiotensin-System (RA...

  Evaluation of therapeutic role of angiotensin 1-7 in the prevention of the cardiovascular effects induced by thyroid hormone in wistar rats, BP.MS

• Abstract

  In order to better understand the previously described interaction between the renin angiotensin system (RAS), specifically the angiotensin II receptor type 1 (AT1R), and the effects of thyroid hormone (T3) administration in cardiac muscle cells, this study proposes the analysis of receptor internalization - an important mechanism of signal transduction regulation. The ²-arrestins (²ARR...

  Thyroid hormone effect in Angiotensin II type 1 receptor (AT1R) internalization and activation of Ras/Raf/MEK/ERK in cardiomyocyte hypertrophy. beta-arrestins involvement, BP.DR

(Only some records are available in English at this moment)

• Abstract

  Although most of effects of nuclear factor ›kappaB (NF-k›B) is related to inflammatoryresponse, this nuclear factor has been shown to be involved in the development ofcardiac hypertrophy resulted by diverse stimuli. In the present study, we willinvestigate whether the thyroid hormone (TH) action leading to cardiac hypertrophy ismediated by NF-k›B. Transgenic mice that contain specific m...

  Effect of cardiac specific inhibition of NF-kB in cardiac hypertrophy induced by thyroid hormone, BE.EP.DR

• Abstract

  The heart corresponds to main target of TH and many of the classic signs and symptoms of hyperthyroidism are the cardiac and hemodynamic manifestations which include heart rhythm disorders. The present study has as aim to define the role of Caveolin-1 (Cav-1) depletion and oxidative stress in the pro-arrhythmic effects of hyperthyroidism. We will define whether Cav-1 deletion in mice le...

  Does Caveolin-1 (Cav-1) modulate arrhythmogenecity by regulating cSrc tyrosine kinase and cardiac gap junction homeostasis? Role of thyroid hormone, BE.EP.DD