CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate inCiências Biológicas Modalidade Médica at Universidade de Santo Amaro (1984), Ph.D. in Molecular Microbiology at Universidade Federal de São Paulo (1995), Post-Doc at UCSF (2000) and Lecture in Molecular Microbiology at UNESP-Botucatu (2008). Has experience in Biochemistry, acting on the following subjects: telomeres, Leishmania spp telomeric proteins, telomerase, telomeric lncRNAs (Source: Lattes Curriculum)
Leishmaniasis are tropical diseases transmitted by primitive parasites of the genus Leishmania, family Trypanosomatidae. For these diseases, which can be present in different clinical forms, there are no efficient control and treatment. The actual treatment protocols are highly toxic and expensive and can lead to the resistance of parasites and vectors. Knowledge about the parasite molecu…
Leishmaniasis are tropical diseases transmitted by primitive parasites of the genus Leishmania, family Trypanosomatidae. For these diseases, which can be present in different clinical forms, there are no efficient control and treatment. The actual treatment protocols are highly toxic and expensive and can lead to the resistance of parasites and vectors. Knowledge about the parasite molecu…
Protozoan from Leishmania genus belong to the Trypanosomatidae family and present peculiar biological characteristics that are not shared with other eukaryotes. Many Leishmania species are the causative agents of a spectrum of diseases known as leishmaniases which are transmit by insects. The disease presents different clinical manifestations and in Brazil several new cases occur each yea…
The Hsp90 chaperone (heat shock protein 90 kDa) is found in all organisms and in all cellular compartments, and the two types found in the eukaryotic cytosol interact with at least 10% of all proteins produced by the cell. The Hsp90 plays a key role in the maturation of these proteins, which makes it important for many cellular processes such signaling, proteostasis, epigenetics, telomere…
(Only some records are available in English at this moment)
Leishmaniases are neglected diseases caused by parasites of the genus Leishmania, for which there is no suitable treatment or control. Available therapies are expensive, presenting high toxicity levels, and can induce drug resistance in the parasites. All of these issues highlight the need to seek new therapeutic targets and to understand the parasite life cycle and the biological issues …
Leishmaniases are severe infectious diseases of great importance in public health due to high mortality, morbidity, and incidence, wide geographical distribution, a great variety of parasite species that cause the disease and lack of efficient treatment and adequate control. Therefore, the search for new antiparasitic drugs and treatment is highly necessary. In most eukaryotes, including …
Leishmaniases are infectious diseases with high mortality and incidence rate caused by parasites of the genus Leishmania, Trypanosomatidae family. The disease has a wide geographical distribution and presents different clinical manifestations. The lack of efficient control and disease treatment classifies Leishmaniases as neglected diseases, urgently requiring the discovery of new therape…
Among the protozoa of the Leishmania genus are the causative agents of leishmaniasis, a neglected tropical disease that presents different clinical forms and that affects millions of people in Brazil and in the world. To date there are no efficient contol and treatment against leishmaniasis, therefore, studies that contribute to understand parasite biology may provide the possibility to f…
Leishmaniasis is a neglected tropical disease that presents different clinical forms and affects de poorest populations in Africa, Asia and Latin America, especially Brazil. It is caused by a protozoan parasite belonging to the genus Leishmania, which is transmitted by the bite of a sandfly. Finding therapeutic targets for the development of new drugs is indispensable, once the anti-paras…
Leishmaniasis is a neglected tropical disease caused by parasites of the family Trypanosomatidae, genus Leishmania. The current treatment protocol implies highly toxic, high cost and can lead to resistant parasites. The absence of effective treatments to combat the disease, makes it important to seek for new therapeutic targets against Leishmania. Recently, studies about telomeres have be…
(Only some records are available in English at this moment)
Telomeres are nucleoprotein structures that protect chromosome ends from fusion and degradation. Although generally considered transcriptionally silenced, it was recently demonstrated that telomeres from different eukaryotes are transcribed into long non-coding telomeric RNAs (lncRNA). In Kinetoplastida protozoa, including Leishmania, it was previously shown that different types of RNA po…
| 2 / 2 | Ongoing research grants |
| 8 / 5 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 27 / 14 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 42 / 25 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 15 |
| Citations | 68 |
| Cit./Article | 4.5 |
| Data from Web of Science | |
MONTEIRO, JOMAR PATRICIO; NOGUEIRA CANO, MARIA ISABEL. SIRT1 Deacetylase Activity and the Maintenance of Protein Homeostasis in Response to Stress: An Overview. PROTEIN AND PEPTIDE LETTERS, v. 18, n. 2, p. 167-173, FEB 2011. Web of Science Citations: 9. (09/53336-0)
FERNANDES, CARLOS A. H.; PEREZ, ARINA M.; BARROS, ANDREA C.; DREYER, THIAGO R.; DA SILVA, MARCELO S.; MOREA, EDNA GICELA O.; FONTES, MARCOS R. M.; CANO, MARIA ISABEL N.. Dual cellular localization of the Leishmania amazonensis Rbp38 (LaRbp38) explains its affinity for telomeric and mitochondrial DNA. Biochimie, v. 162, p. 15-25, JUL 2019. Web of Science Citations: 0. (14/24170-5, 15/18641-8)
MOREA, EDNA G. O.; VIVIESCAS, MARIA ALEJANDRA; FERNANDES, CARLOS A. H.; MATIOLI, FABIO F.; LIRA, CRISTINA B. B.; FERNANDEZ, MARIBEL F.; MORAES, BARBARA S.; DA SILVA, MARCELO S.; STORTI, CAMILA B.; FONTES, MARCOS R. M.; et al. A calmodulin-like protein (LCALA) is a new Leishmania amazonensis candidate for telomere end-binding protein. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 11, A, p. 2583-2597, NOV 2017. Web of Science Citations: 1. (15/18641-8, 12/50161-8)
PAVANI, RAPHAEL SOUZA; VITARELLI, MARCELA O.; FERNANDES, CARLOS A. H.; MATTIOLI, FABIO F.; MORONE, MARIANA; MENEZES, MILENE C.; FONTES, MARCOS R. M.; CANO, MARIA ISABEL N.; ELIAS, MARIA CAROLINA. Replication Protein A-1 Has a Preference for the Telomeric G-rich Sequence in Trypanosoma cruzi. Journal of Eukaryotic Microbiology, v. 65, n. 3, p. 345-356, MAY-JUN 2018. Web of Science Citations: 2. (14/02978-0, 13/07467-1, 15/10580-0)
VIVIESCAS, MARIA ALEJANDRA; NOGUEIRA CANO, MARIA ISABEL; SEGATTO, MARCELA. Chaperones and Their Role in Telomerase Ribonucleoprotein Biogenesis and Telomere Maintenance. CURRENT PROTEOMICS, v. 16, n. 1, p. 31-43, 2019. Web of Science Citations: 0. (15/18641-8, 12/50161-8)
PAVANI, R. S.; FERNANDES, C.; PEREZ, A. M.; VASCONCELOS, E. J. R.; SIQUEIRA-NETO, J. L.; FONTES, M. R.; CANO, M. I. N.. RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain. FEBS Letters, v. 588, n. 24, p. 4740-4748, DEC 20 2014. Web of Science Citations: 6.
FERNANDES, CARLOS A. H.; MOREA, EDNA GICELA O.; DOS SANTOS, GABRIEL A.; DA SILVA, VITOR L.; VIEIRA, MARINA ROVERI; VIVIESCAS, MARIA ALEJANDRA; CHATAIN, JEAN; VADEL, AURELIE; SAINTOME, CAROLE; FONTES, MARCOS ROBERTO M.; et al. A multi-approach analysis highlights the relevance of RPA-1 as a telomere end-binding protein (TEBP) in Leishmania amazonensis. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1864, n. 7, JUL 2020. Web of Science Citations: 0. (15/17286-0, 18/04375-2, 19/11496-3)
STORTI, CAMILA BALDIN; DE OLIVEIRA, ROGERIO ANTONIO; DE CARVALHO, MARCIO; HASIMOTO, ERICA NISHIDA; CATANEO, DANIELE CRISTINA; MARIA CATANEO, ANTONIO JOSE; DE FAVERI, JULIO; VASCONCELOS, ELTON JOSE R.; DOS REIS, PATRICIA PINTOR; NOGUEIRA CANO, MARIA ISABEL. Telomere-associated genes and telomeric lncRNAs are biomarker candidates in lung squamous cell carcinoma (LUSC). Experimental and Molecular Pathology, v. 112, FEB 2020. Web of Science Citations: 0. (16/06936-6, 12/50161-8, 11/13213-7)
VASCONCELOS, ELTON J. R.; NUNES, VINICIUS S.; DA SILVA, MARCELO S.; SEGATTO, MARCELA; MYLER, PETER J.; CANO, MARIA ISABEL N.. The Putative Leishmania Telomerase RNA (LeishTER) Undergoes Trans-Splicing and Contains a Conserved Template Sequence. PLoS One, v. 9, n. 11, NOV 12 2014. Web of Science Citations: 4.
VIVEIROS DA SILVEIRA, RITA DE CASSIA; DA SILVA, MARCELO SANTOS; NUNES, VINICIUS SANTANA; PEREZ, ARINA MARINA; NOGUEIRA CANO, MARIA ISABEL. The natural absence of RPA1N domain did not impair Leishmania amazonensis RPA-1 participation in DNA damage response and telomere protection. Parasitology, v. 140, n. 4, p. 547-559, APR 2013. Web of Science Citations: 9. (09/53336-0)
FERNANDES, CARLOS A. H.; PEREZ, ARINA M.; BARROS, ANDREA C.; DREYER, THIAGO R.; DA SILVA, MARCELO S.; MOREA, EDNA GICELA O.; FONTES, MARCOS R. M.; CANO, MARIA ISABEL N.. Dual cellular localization of the Leishmania amazonensis Rbp38 (LaRbp38) explains its affinity for telomeric and mitochondrial DNA. Biochimie, v. 162, p. 15-25, JUL 2019. Web of Science Citations: 0. (14/24170-5, 15/18641-8)
MOREA, EDNA G. O.; VIVIESCAS, MARIA ALEJANDRA; FERNANDES, CARLOS A. H.; MATIOLI, FABIO F.; LIRA, CRISTINA B. B.; FERNANDEZ, MARIBEL F.; MORAES, BARBARA S.; DA SILVA, MARCELO S.; STORTI, CAMILA B.; FONTES, MARCOS R. M.; et al. A calmodulin-like protein (LCALA) is a new Leishmania amazonensis candidate for telomere end-binding protein. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 11, A, p. 2583-2597, NOV 2017. Web of Science Citations: 1. (15/18641-8, 12/50161-8)
VIVIESCAS, MARIA ALEJANDRA; NOGUEIRA CANO, MARIA ISABEL; SEGATTO, MARCELA. Chaperones and Their Role in Telomerase Ribonucleoprotein Biogenesis and Telomere Maintenance. CURRENT PROTEOMICS, v. 16, n. 1, p. 31-43, 2019. Web of Science Citations: 0. (15/18641-8, 12/50161-8)
MONTEIRO, JOMAR PATRICIO; NOGUEIRA CANO, MARIA ISABEL. SIRT1 Deacetylase Activity and the Maintenance of Protein Homeostasis in Response to Stress: An Overview. PROTEIN AND PEPTIDE LETTERS, v. 18, n. 2, p. 167-173, FEB 2011. Web of Science Citations: 9. (09/53336-0)
FERNANDES, CARLOS A. H.; MOREA, EDNA GICELA O.; DOS SANTOS, GABRIEL A.; DA SILVA, VITOR L.; VIEIRA, MARINA ROVERI; VIVIESCAS, MARIA ALEJANDRA; CHATAIN, JEAN; VADEL, AURELIE; SAINTOME, CAROLE; FONTES, MARCOS ROBERTO M.; et al. A multi-approach analysis highlights the relevance of RPA-1 as a telomere end-binding protein (TEBP) in Leishmania amazonensis. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1864, n. 7, JUL 2020. Web of Science Citations: 0. (15/17286-0, 18/04375-2, 19/11496-3)
STORTI, CAMILA BALDIN; DE OLIVEIRA, ROGERIO ANTONIO; DE CARVALHO, MARCIO; HASIMOTO, ERICA NISHIDA; CATANEO, DANIELE CRISTINA; MARIA CATANEO, ANTONIO JOSE; DE FAVERI, JULIO; VASCONCELOS, ELTON JOSE R.; DOS REIS, PATRICIA PINTOR; NOGUEIRA CANO, MARIA ISABEL. Telomere-associated genes and telomeric lncRNAs are biomarker candidates in lung squamous cell carcinoma (LUSC). Experimental and Molecular Pathology, v. 112, FEB 2020. Web of Science Citations: 0. (16/06936-6, 12/50161-8, 11/13213-7)
(References retrieved automatically from State of São Paulo Research Institutions)
STORTI, Camila Baldin. Perfil de expressão de genes associados aos telômeros em carcinoma pulmonar de células não pequenas (NSCLC). Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu). (16/06936-6)
MOREA, Edna Gicela Ortiz. Caracterização molecular de RNAs teloméricos não codantes em Leishmania major. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu). (16/06883-0)
CONTE, Fábio Frangiotti. Organização genomica das sequencias subtelomericas (TAS - "Telomere associated sequences") de Leishmania (Leishmania) amazonensis e identificação de proteinas que reconhecem especificamente estas sequencias. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas. (02/05707-0)
GIARDINI, Miriam Aparecida. Caracterização bioquimica e molecular do componente transcriptase reversa da telomerase de Leishmania spp. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (03/01783-7)
LIRA, Cristina Braga de Brito. Identificação e isolamento de proteinas que se ligam aos telomeros de Leishmania (L.) amazonensis. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (03/00650-3)
PEREZ, Arina Marina. Caracterização da proteina LaRbp38 : mapeamento do domínio de interação com ácidos nucléicos e identificação de possíveis proteínas parceiras. 80 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu). Botucatu. (07/50620-4)
PEREZ, Arina Marina. Caracterização funcional da proteína LaRbp38 nos telômeros e no cinetoplasto de Leishmania spp. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/50566-5)
SILVA, Marcelo Santos da. Estresse oxidativo em Leishmania amazonensis : do encurtamento dos telômeros ao deslocamento de LaRPA-1 do complexo telomérico = Oxidative stress in Leishmania amazonensis : from telomere shortening to displacement of LaRPA-1 from telomeric complex. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (10/50207-2)