Graduate inCiências Biológicas Modalidade Médica at Universidade de Santo Amaro (1984), Ph.D. in Molecular Microbiology at Universidade Federal de São Paulo (1995), Post-Doc at UCSF (2000) and Lecture in Molecular Microbiology at UNESP-Botucatu (2008). Has experience in Biochemistry, acting on the following subjects: telomeres, Leishmania spp telomeric proteins, telomerase, telomeric lncRNAs (Source: Lattes Curriculum)
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Leishmaniasis are tropical diseases transmitted by primitive parasites of the genus Leishmania, family Trypanosomatidae. For these diseases, which can be present in different clinical forms, there are no efficient control and treatment. The actual treatment protocols are highly toxic and expensive and can lead to the resistance of parasites and vectors. Knowledge about the parasite molecu…
Leishmaniasis are tropical diseases transmitted by primitive parasites of the genus Leishmania, family Trypanosomatidae. For these diseases, which can be present in different clinical forms, there are no efficient control and treatment. The actual treatment protocols are highly toxic and expensive and can lead to the resistance of parasites and vectors. Knowledge about the parasite molecu…
Protozoan from Leishmania genus belong to the Trypanosomatidae family and present peculiar biological characteristics that are not shared with other eukaryotes. Many Leishmania species are the causative agents of a spectrum of diseases known as leishmaniases which are transmit by insects. The disease presents different clinical manifestations and in Brazil several new cases occur each yea…
The Hsp90 chaperone (heat shock protein 90 kDa) is found in all organisms and in all cellular compartments, and the two types found in the eukaryotic cytosol interact with at least 10% of all proteins produced by the cell. The Hsp90 plays a key role in the maturation of these proteins, which makes it important for many cellular processes such signaling, proteostasis, epigenetics, telomere…
(Only some records are available in English at this moment)
Leishmaniasis is a neglected vector-borne tropical disease caused by intracellular protozoan parasites of the genus Leishmania. The disease represents a major global public health problem, with 1.5 to 2 million cases annually worldwide. Leishmania infantum causes visceral leishmaniasis, which is the most fatal form of the disease and responsible for more than 90% of leishmaniasis deaths. …
Among the Leishmania genus are the causative agents of leishmaniasis, a neglected disease to which there are no effective treatment, control, and prevention. Therefore, it is important to find new parasite-specific therapeutic targets. Telomeres have been recently considered potential targets due to their role in maintaining genome stability and maintenance. The minimal parasite´s telomer…
Leishmaniasis is a set of diseases that show different outcomes and can be expressed in different clinical forms such as cutaneous, mucocutaneous, and visceral (kala-azar). The disease is transmited by the bite of a female sandfly contaminated by protozoa of the Leishmania genus. The available treatments present low efficacy, high toxicity, and high cost leading to parasite resistance, wh…
Among the Leishmania genus are the causative agents of Leishmaniasis, a neglected disease to which there are no effective treatment, control, and prevention. Therefore, it is important to find new parasite-specific therapeutic targets. Telomeres have been recently considered potential targets due to their role in maintaining genome stability and maintenance. The minimal parasite´s telomer…
Among the protozoa of the Leishmania genus are the causative agents of Leishmaniasis, a neglected tropical disease that presents different clinical forms and that affects millions of people in Brazil and in the world. To date there are no efficient control and treatment against Leishmaniasis, therefore, studies that contribute to understanding parasite biology may provide the possibility …
Leishmaniases are neglected diseases caused by parasites of the genus Leishmania, for which there is no suitable treatment or control. Available therapies are expensive, presenting high toxicity levels, and can induce drug resistance in the parasites. All of these issues highlight the need to seek new therapeutic targets and to understand the parasite life cycle and the biological issues …
(Only some records are available in English at this moment)
Leishmaniases are neglected tropical diseases caused by different species of Leishmania, a protozoa parasite belonging to the Trypanosomatidae family. Every year, about 1 million people worldwide are threatened by the disease. Besides its high incidence rate, there is still no efficient prevention and treat-ment. Therefore, a deeper understanding of parasite biology will help develop new …
Telomeres are nucleoprotein structures that protect chromosome ends from fusion and degradation. Although generally considered transcriptionally silenced, it was recently demonstrated that telomeres from different eukaryotes are transcribed into long non-coding telomeric RNAs (lncRNA). In Kinetoplastida protozoa, including Leishmania, it was previously shown that different types of RNA po…
| 2 / 2 | Ongoing grants |
| 8 / 5 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 32 / 19 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 48 / 31 | All research grants and scholarships |
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CV Lattes
ORCID