Full Professor of the Department of Biophysics at the Federal University of São Paulo (UNIFESP). Visiting Professor at the Max Delbuck Institute (MDC), Berlin, Germany. He has a degree in Veterinary Medicine from the Federal University of Minas Gerais and in Sciences from the Pontifícia Católica de Minas Gerais, a master's degree in Biological Sciences from the Physiology and Pharmacology Program at the Federal University of Minas Gerais and a PhD in Biological Sciences (Molecular Biology) from the Federal University of São Paulo with. He has experience in the area of #8203;#8203;Biophysics, with an emphasis on Biophysics, working mainly on the following topics: kinins, transgenic animals, kallikrein metabolism and physical exercise. He was head of the Biophysics Department at UNIFESP for 6 years. (Source: Lattes Curriculum)
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Physical inactivity is one of the causes of the epidemic of obesity and diabetes. The World Health Organization showed in 2018 that around 28% of the world population had insufficient physical activity and Latin America has one of the highest rates of inactivity. Thus, it is important to evaluate the molecular mechanisms involved in the practice of physical exercise, the mediators involve…
Epidemiological and experimental studies with animals suggested that the first nutritional experiences of an individual; i.e., any uterine nutritional alteration, may affect the susceptibility of the fetus to develop chronic diseases related to the Metabolic Syndrome when adult, as obesity, hypertension, cardiovascular disease and Type 2 diabetes. This process is known as metabolic imprin…
Kallikrein-kinin system (KKS) participates in inflammatory processes, pain mediation and control of blood pressure. Recent evidences suggest the involvement of this system in the modulation of physical exercise, metabolism and obesity. Such involvement could be partly mediated by interaction with the immune system, with glycemic control and cardiovascular homeostasis. To evaluate the role…
The kallikrein-kinin system (KKS) participates in inflammatory processes, pain mediation and control of blood pressure. Recent evidences suggest the involvement of this system in the modulation of physical exercise, metabolism and obesity. Such involvement could be partly mediated by interaction with the immune system, with glycemic control and cardiovascular homeostasis. To evaluate the …
(Only some records are available in English at this moment)
INTRODUCTION: Due to the structural diversity of molecules, there are several biological systems essential to regulate the organism's homeostasis, which are capable of triggering a variety of important events in different types of tissues. One of these systems is the kallikrein-kinin (KKS). The actions of the KKS are mediated by molecules (peptides) called kinins, which exert their biolog…
Chronic kidney disease represents a significant public health problem. At the histological level, tubulointerstitial fibrosis is the common final consequence of the progression of kidney disease, regardless of the initial insult. Evidence shows that renal inflammation plays a central role both in the initiation and the progression of chronic kidney disease. Some of the inflammatory molecu…
Clinical and experimental studies have consistently demonstrated that low birth weight may contribute to the late development of cardiovascular disease. Although the factors involved in this effect have not yet been fully elucidated, changes such as reduced vascular compliance, incomplete vasculogenesis characterized by microvascular rarefaction and alteration of the endothelial cell modu…
Evidence indicates that the incidence of acute kidney injury (AKI) is increasing rapidly, particularly among patients hospitalized with other acute diseases and those undergoing major surgeries. The sequelae are severe and are characterized by an increased risk of short- and long-term mortality. Although mortality associated with AKI is declining, it remains unacceptably high. This decrea…
(Only some records are available in English at this moment)
Cisplatin is a chemotherapeutic agent applied in treatment protocols of numerous cancer entities. However, cisplatin and other platinum agents can cause severe adverse side effects, such as nephro-, oto- and peripheral neurotoxicity. Mechanisms of platinum- induced nephrotoxicity have been analyzed in rodents and human cell lines revealing that cisplatin is accumulated intracellularly in …
The glucose metabolism is closely related to an impairment of several chronic diseases, as obesity, diabetes and the metabolic syndrome. Kallikrein-kinin system (KKS) has been involved in different metabolic processes, demonstrated by knockout mice that are resistant to obesity. The kinin receptors, B1 (B1R) and B2 (B2R) are responsible for mediating the biological responses from the prec…
| 1 / 1 | Ongoing grants |
| 16 / 10 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 21 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 41 / 25 | All research grants and scholarships |
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CV Lattes
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