Cleopatra da Silva Planeta

• Abstract

  The aim of the present project is to describe the application plan of the School of Pharmaceutical Sciences for the grant related to the "Reserva Técnica Institucional" da Fapesp - 2014 (AU)

  Project for the Reserva Técnica Institucional of Faculdade de Ciências Farmacêuticas - UNESP, AP.RT.INST

• Abstract

  The aim of the present project is to describe the application plan of the School of Pharmaceutical Sciences for the grant related to the "Reserva Técnica Institucional" da Fapesp - 2013. (AU)

  Project for the Reserva Técnica Institucional da Faculdade de Ciências Farmacêuticas - UNESP, AP.RT.INST

• Abstract

  Drug abuse is considered a public health problem worldwide. In Brazil, epidemiological data have shown an increase in the consumption of licit and illicit drugs, among them anabolic androgenic steroids (AAS) and ethanol. Studies have shown a relationship between use of AAS, ethanol consumption and physical exercise. Although the relevance of the theme, a comprehensive review of the litera…

  Effects of physical training and testosterone on ethanol - induced changes in the central and cardiovascular systems, AP.R

(Only some records are available in English at this moment)

• Abstract

  Several evidences in the literature have demonstrated the deleterious effects that acute and chronic stress can trigger in individuals. The emergence of depression and anxiety disorder are possible consequences of these effects. The social defeat (SD) stress is an animal model that can be used to investigate the effects of acute and chronic stress on anxiety-related behavior in mice submi…

  Evaluation of the possible prophylactic role of ketamine in anxiety induced by social defeat in mice, BP.IC

• Abstract

  The medial prefrontal cortex (mPFC) is ivolved in the modulation of different behaviors, which include those associated with the use of ethanol and response to stressors. This brain region is predominantly composed of glutamatergic neurons and GABAergic interneurons, in addition to receiving dopaminergic afferents from the ventral tegmental area. Recently, it has been proposed that the mP…

  Evaluation of left and right medial prefrontal cortex glutamatergic and GABAergic neurotransmissions in ethanol-induced consumption by social defeat stress in mice, BP.PD

• Abstract

  Learned associations play an important role in addiction. With repeated drug use, addicts learn to associate drug effects with stimuli or cues in the drug environment, such as drug paraphernalia, context, and people. Over time, these cues can promote drug craving and relapse. These drug-related cues are complex combinations of different stimuli that are recognized with a high degree of r…

  Pharmacogenetics Manipulation and Research of Molecular Changes in Synapses between Selectively Activated Neurons in the Reinstatement of Ethanol Self-Administration, BP.PD

(Only some records are available in English at this moment)

• Abstract

  Rats submitted to the single prolonged stress (SPS) procedure demonstrate impaired fear extinction and increased anxiety, similar to those behavioral and physiological symptoms observed in posttraumatic stress disorder (PTSD) patients. The prefrontal cortex (PFC) plays a role in the modulation of emotional memory consolidation through its interactions with other brain regions like the amy…

  Testing the role of the left and right medial prefrontal cortex in fear extinction and anxiety with optogenetic manipulations, BE.EP.PD

• Abstract

  Alcohol abuse is a worldwide problem with concomitant medical, social and economic costs for which pharmacotherapeutic approaches are limited. As a result, most patients relapse within the first months of treatment (MILLER and HESTER, 1986; SINHA, 2011). In particular, cues that have been associated with alcohol can trigger alcohol-related memories, leading to craving and relapse to alcoh…

  Elucidating the role of ribosomal translation machinery in alcohol abuse disorders, BE.EP.DR

• Abstract

  Tobacco is considered a licit drug in the majority of countries around the world. Adolescence is considered a risk factor for drug abuse and dependence. High rates of nicotine dependence are seen among adolescents. The withdrawal effects of nicotine are considered as an important factor related to relapse to nicotine seeking. Previous studies indicate that specific patterns of sparsely di…

  Characterization of neural ensembles mediating nicotine withdrawal in adolescent rats, BE.EP.MS