Ana Paula Lepique
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade de São Paulo (1992), master's at Biochemistry from Universidade de São Paulo (1996) and doctorate at Biochemistry from Universidade de São Paulo (2000). Has experience in Immunology, focusing on Celular Imunology, acting on the following subjects: c-myc, fgf2, acth, papilomavírus humano and carcinoma da cérvice uterina. (Source: Lattes Curriculum)
- The effect of the tumor microenvironment on myeloid cells, AP.R
Abstract
Immune responses are important for determination of tumor fate. My laboratory has been studying the interactions between Human Papillomavirus (HPV) associated tumors and the immune system. In the tumor microenvironment, where cytokines, metabolites and several other factors play a role, myeloid cells can display tolerogenic phenotype, inhibiting T cell responses. Tumors also display sys...
- Tumor immunology and immunotherapy, AR.EXT
- XLIII Congress of the Brazilian Society of immunology, AO.R
- 3rd ICGEB workshop on human papillomavirus and associated malignancies: biology, prevention and therapy, AO.R
(Only some records are available in English at this moment)
- Molecular markers of tumorigenesis and immune evasion during the natural history of cervical cancer, BP.IC
Abstract
Our laboratory has been working on characterizing the interactions between tumor and immune system cells in the tumor microenvironment. Our main target has been cervical tumors, for which the main etiological factor is persistent high-risk oncogenic human papillomavirus (HPV) infection. We have described the role of interactions between tumor cells and immune system cells, involving the...
- Analysis of PAR-2 activity ín tumor cell progression via administration of its agonist, BP.IC
Abstract
In the tumor microenvironment, extracellular medium in which tumor cells are located, there are several factors that promote the progression of the disease. Such factors may either directly favor tumor proliferation or indirectly, by altering the local immune response. Human papillomavirus (HPV), for example, can lead to the development of cervical cancer by infecting female genital tra...
- Alfa-mannosidase inhibitor effect, Swainsonina, on the phenotype of tumor associated macrophages, BP.IC
Abstract
Infection with human papillomavirus (HPV) is the main etiologic factor of cervical cancer, as well as other anogenital and oropharyngeal tumors. Despite our body being able to recognize and eliminate these viruses, HPV have several escape mechanisms of the immune response, reaching remain decades in some infected individuals. In such cases, cells infected with HPV purchase: resistance t...
- Role of HPV associated tumor metabolism on human macrophage phenotype, BP.DR
Abstract
Human papillomaviruses (HPV) are small DNA viruses that infect epithelial cells causing, depending on the virus type, benign and malignant lesions. This virus is the main etiological factor for cervical cancer, being present in virtually all cases of this disease. Cervical cancer is a serious disease that affects thousands of women each year, being the second most common cancer among wo...
- Study of activation of the CD40 pathway and interaction with Candida albicans infection in an orthotopic HPV associated mouse model, BP.DR
Abstract
Tumors associated with infection by human papillomavirus are a public health problem in developing countries. Despite the prophylactic vaccine commercially available, the study of mechanisms trigger tolerance by the tumor are very important for new immunotherapies. Our laboratory has been using a tumor model associated with HPV16, strain TC-1 injected subcutaneously in mice, which allow...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 13 / 7 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 13 / 6 | Completed scholarships in Brazil |
| 29 / 16 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 8 |
| Citations | 162 |
| Cit./Article | 20.2 |
| Data from Web of Science | |
MARQUES ROSSETTI, RENATA ARIZA; CRISTINA LORENZI, NOELY PAULA; YOKOCHI, KAORI; SARTOR DE FARIA ROSA, MARIA BEATRIZ; BENEVIDES, LUCIANA; RAMOS MARGARIDO, PAULO FRANCISCO; BARACAT, EDMUND CHADA; CARVALHO, JESUS PAULA; VILLA, LUISA LINA; LEPIQUE, ANA PAULA. B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses. PLoS One, v. 13, n. 7, JUL 5 2018. Web of Science Citations: 5. (14/19326-6, 10/20010-2, 11/11121-8)
LEPIQUE, ANA PAULA; PEREZ DAGHASTANLI, KATIA REGINA; CUCCOVIA, IOLANDA MIDEA; VILLA, LUISA LINA. HPV16 Tumor Associated Macrophages Suppress Antitumor T Cell Responses. Clinical Cancer Research, v. 15, n. 13, p. 4391-4400, JUL 1 2009. Web of Science Citations: 78.
STONE, SIMONE CARDOZO; MARQUES ROSSETTI, RENATA ARIZA; BOLPETTI, ALINE; BOCCARDO, ENRIQUE; DE ARAUJO SOUZA, PATRICIA SAVIO; LEPIQUE, ANA PAULA. HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells. Journal of Leukocyte Biology, v. 96, n. 4, p. 619-631, OCT 2014. Web of Science Citations: 7. (08/03232-1, 10/20010-2)
STONE, SIMONE CARDOZO; MARQUES ROSSETTI, RENATA ARIZA; FERNANDEZ ALVAREZ, KARLA LUCIA; CARVALHO, JESUS PAULA; RAMOS MARGARIDO, PAULO FRANCISCO; BARACAT, EDMUND CHADA; TACLA, MARICY; BOCCARDO, ENRIQUE; YOKOCHI, KAORI; LORENZI, NOELY PAULA; et al. Lactate secreted by cervical cancer cells modulates macrophage phenotype. Journal of Leukocyte Biology, v. 105, n. 5, p. 1041-1054, MAY 2019. Web of Science Citations: 3. (08/57889-1, 14/19326-6)
FERNANDEZ ALVAREZ, KARLA LUCIA; BELDI, MARIANA; SARMANHO, FABIANE; MARQUES ROSSETTI, RENATA ARIZA; FARINA SILVEIRA, CAIO RAONY; MOTA, GIANA RABELLO; ANDREOLI, MARIA ANTONIETA; DE CARVALHO CARUSO, ELIANA DIAS; KAMILLOS, MARCIA FERREIRA; SOUZA, ANA MARTA; et al. Local and systemic immunomodulatory mechanisms triggered by Human Papillomavirus transformed cells: a potential role for G-CSF and neutrophils. SCIENTIFIC REPORTS, v. 7, AUG 21 2017. Web of Science Citations: 12. (08/57889-1, 14/19326-6)
FARINA SILVEIRA, CAIO RAONY; CIPELLI, MARCELLA; MANZINE, CAROLINA; RABELO-SANTOS, SILVIA HELENA; ZEFERINO, LUIZ CARLOS; RODRIGUEZ, GRETEL RODRIGUEZ; DE ASSIS, JOSIANE BETIM; HEBSTER, SUELLEN; BERNADINELLI, ISABEL; LAGINHA, FABIO; et al. Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population. PLoS One, v. 14, n. 3, MAR 6 2019. Web of Science Citations: 1. (14/19326-6, 08/57889-1)
BOLPETTI, ALINE; SILVA, JOAO S.; VILLA, LUISA L.; LEPIQUE, ANA PAULA. Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth. BMC IMMUNOLOGY, v. 11, JUN 7 2010. Web of Science Citations: 47.
NASCIMENTO, FLAVIA R. F.; GOMES, ELIANE A.; RUSSO, MOMTCHILO; LEPIQUE, ANA P.. Interferon Regulatory Factor (IRF)-1 Is a Master Regulator of the Cross Talk between Macrophages and L929 Fibrosarcoma Cells for Nitric Oxide Dependent Tumoricidal Activity. PLoS One, v. 10, n. 2, FEB 6 2015. Web of Science Citations: 9. (10/20010-2, 13/24694-1)
(References retrieved automatically from State of São Paulo Research Institutions)
FERNÁNDEZ, Karla Lucía Alvarez. Caracterização do infiltrado inflamatório no carcinoma cervical e em suas lesões precursoras.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/20499-4)
STONE, Simone Cardozo. Papel do metabolismo de tumores associados ao papilomavírus humano na modulação do fenótipo de macrófagos humanos.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (13/26856-9)
ROSSETTI, Renata Ariza Marques. Estudo do estado de ativação de vias de sinalização no microambiente tumoral e leucócitos circulantes em pacientes com tumor do colo do útero.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/11121-8)