CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade de São Paulo (1992), master's at Biochemistry from Universidade de São Paulo (1996) and doctorate at Biochemistry from Universidade de São Paulo (2000). Has experience in Immunology, focusing on Celular Imunology, acting on the following subjects: c-myc, fgf2, acth, papilomavírus humano and carcinoma da cérvice uterina. (Source: Lattes Curriculum)
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Immune responses are important for determination of tumor fate. My laboratory has been studying the interactions between Human Papillomavirus (HPV) associated tumors and the immune system. In the tumor microenvironment, where cytokines, metabolites and several other factors play a role, myeloid cells can display tolerogenic phenotype, inhibiting T cell responses. Tumors also display syste…
(Only some records are available in English at this moment)
HPV-associated cancer is still a relevant public health burden in low-income countries. HPV infection is necessary but not sufficient to induce tumor development in various anatomical sites, such as the uterine cervix, anus, penis, and oropharynx. HPV genome codifies oncoproteins with various known mechanisms as part of cellular transformation and immune system evasion. It is also known t…
The presence of immune cells in the tumor microenvironment is a well known feature. In some cancers, the microenvironment promotes progression tumor progression and immune responses suppression. Cells with this characteristics are myeloid derived suppressor cells, alternative macrophages, N2 neutrophils and others. Under this perspective, our laboratory has been investigating how myeloid …
Although the literature indicates that tumor cells preferentially use the glycolytic pathway, there are tumors that use other substrates for metabolism, such as fatty acids and amino acids, including glutamine. The use of glutamine, by glutaminolysis, provides metabolic intermediates for the Krebs cycle, for the synthesis of macromolecules and for the redox balance. Tumor cells and immune…
Our laboratory has been working on characterizing the interactions between tumor and immune system cells in the tumor microenvironment. Our main target has been cervical tumors, for which the main etiological factor is persistent high-risk oncogenic human papillomavirus (HPV) infection. We have described the role of interactions between tumor cells and immune system cells, involving the s…
In the tumor microenvironment, extracellular medium in which tumor cells are located, there are several factors that promote the progression of the disease. Such factors may either directly favor tumor proliferation or indirectly, by altering the local immune response. Human papillomavirus (HPV), for example, can lead to the development of cervical cancer by infecting female genital tract…
Infection with human papillomavirus (HPV) is the main etiologic factor of cervical cancer, as well as other anogenital and oropharyngeal tumors. Despite our body being able to recognize and eliminate these viruses, HPV have several escape mechanisms of the immune response, reaching remain decades in some infected individuals. In such cases, cells infected with HPV purchase: resistance to …
(Only some records are available in English at this moment)
| 14 / 8 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 15 / 8 | Completed scholarships in Brazil |
| 32 / 19 | All research grants and scholarships |
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