CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade de São Paulo (1992), master's at Biochemistry from Universidade de São Paulo (1996) and doctorate at Biochemistry from Universidade de São Paulo (2000). Has experience in Immunology, focusing on Celular Imunology, acting on the following subjects: c-myc, fgf2, acth, papilomavírus humano and carcinoma da cérvice uterina. (Source: Lattes Curriculum)
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Signals generated in the tumor microenvironment (TEM) are important for cell communication within the TME and systemically. STAT3 (Signal Transducer and Activator of Transcription 3) is considered an oncogene, with direct roles on tumor cells, promoting proliferation, survival, epithelial-mesenchymal transition, and with roles on the TME, mostly by promoting tolerogenic responses. Gynecol…
Immune responses are important for determination of tumor fate. My laboratory has been studying the interactions between Human Papillomavirus (HPV) associated tumors and the immune system. In the tumor microenvironment, where cytokines, metabolites and several other factors play a role, myeloid cells can display tolerogenic phenotype, inhibiting T cell responses. Tumors also display syste…
(Only some records are available in English at this moment)
Ovarian cancer (OC) is one of the most common and lethal gynecological tumors in the global female population. The high-grade serous type is the most frequent and the major contributor to the high mortality rates of the disease. The etiology of OC is multifactorial, but about 10 to 15% of cases are related to mutations in DNA repair genes, especially BRCA1 and BRCA2. The treatment of OC i…
Cervical cancer is a tumor caused by the infection with Human Papiloma Virus (HPV), it hasa worldwide impact, while having a stronger presence in developing countries. Although theHPV infection is a fundamental factor for the developing of tumors, it has been shown thatchanges in the genital microbiota can take part in this process. Literature data have shownthat the reduction of bacteria…
The tumor microenvironment (TME) is complex and consists of different cell lineages besides the tumor cells, including endothelial cells, cancer-associated fibroblasts (CAFS), immune cells, as well as soluble components such as cytokines and metabolites, and extracellular matrix components. Reprogramming of energy metabolism is an important hallmark of neoplastic diseases. Compared to nor…
(Only some records are available in English at this moment)
The presence of immune cells in the tumor microenvironment is a well known feature. In some cancers, the microenvironment promotes progression tumor progression and immune responses suppression. Cells with this characteristics are myeloid derived suppressor cells, alternative macrophages, N2 neutrophils and others. Under this perspective, our laboratory has been investigating how myeloid …
Although the literature indicates that tumor cells preferentially use the glycolytic pathway, there are tumors that use other substrates for metabolism, such as fatty acids and amino acids, including glutamine. The use of glutamine, by glutaminolysis, provides metabolic intermediates for the Krebs cycle, for the synthesis of macromolecules and for the redox balance. Tumor cells and immune…
Our laboratory has been working on characterizing the interactions between tumor and immune system cells in the tumor microenvironment. Our main target has been cervical tumors, for which the main etiological factor is persistent high-risk oncogenic human papillomavirus (HPV) infection. We have described the role of interactions between tumor cells and immune system cells, involving the s…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 14 / 8 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 17 / 10 | Completed scholarships in Brazil |
| 37 / 24 | All research grants and scholarships |
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