CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade de São Paulo (1992), master's at Biochemistry from Universidade de São Paulo (1996) and doctorate at Biochemistry from Universidade de São Paulo (2000). Has experience in Immunology, focusing on Celular Imunology, acting on the following subjects: c-myc, fgf2, acth, papilomavírus humano and carcinoma da cérvice uterina. (Source: Lattes Curriculum)
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Immune responses are important for determination of tumor fate. My laboratory has been studying the interactions between Human Papillomavirus (HPV) associated tumors and the immune system. In the tumor microenvironment, where cytokines, metabolites and several other factors play a role, myeloid cells can display tolerogenic phenotype, inhibiting T cell responses. Tumors also display syste…
(Only some records are available in English at this moment)
Although the literature indicates that tumor cells preferentially use the glycolytic pathway, there are tumors that use other substrates for metabolism, such as fatty acids and amino acids, including glutamine. The use of glutamine, by glutaminolysis, provides metabolic intermediates for the Krebs cycle, for the synthesis of macromolecules and for the redox balance. Tumor cells and immune…
Our laboratory has been working on characterizing the interactions between tumor and immune system cells in the tumor microenvironment. Our main target has been cervical tumors, for which the main etiological factor is persistent high-risk oncogenic human papillomavirus (HPV) infection. We have described the role of interactions between tumor cells and immune system cells, involving the s…
In the tumor microenvironment, extracellular medium in which tumor cells are located, there are several factors that promote the progression of the disease. Such factors may either directly favor tumor proliferation or indirectly, by altering the local immune response. Human papillomavirus (HPV), for example, can lead to the development of cervical cancer by infecting female genital tract…
Infection with human papillomavirus (HPV) is the main etiologic factor of cervical cancer, as well as other anogenital and oropharyngeal tumors. Despite our body being able to recognize and eliminate these viruses, HPV have several escape mechanisms of the immune response, reaching remain decades in some infected individuals. In such cases, cells infected with HPV purchase: resistance to …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 13 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 15 / 8 | Completed scholarships in Brazil |
| 30 / 17 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 9 |
| Citations | 162 |
| Cit./Article | 18.0 |
| Data from Web of Science | |
STONE, SIMONE CARDOZO; MARQUES ROSSETTI, RENATA ARIZA; BOLPETTI, ALINE; BOCCARDO, ENRIQUE; DE ARAUJO SOUZA, PATRICIA SAVIO; LEPIQUE, ANA PAULA. HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells. Journal of Leukocyte Biology, v. 96, n. 4, p. 619-631, OCT 2014. Web of Science Citations: 7. (10/20010-2, 08/03232-1)
STONE, SIMONE CARDOZO; MARQUES ROSSETTI, RENATA ARIZA; FERNANDEZ ALVAREZ, KARLA LUCIA; CARVALHO, JESUS PAULA; RAMOS MARGARIDO, PAULO FRANCISCO; BARACAT, EDMUND CHADA; TACLA, MARICY; BOCCARDO, ENRIQUE; YOKOCHI, KAORI; LORENZI, NOELY PAULA; et al. Lactate secreted by cervical cancer cells modulates macrophage phenotype. Journal of Leukocyte Biology, v. 105, n. 5, p. 1041-1054, MAY 2019. Web of Science Citations: 3. (14/19326-6, 08/57889-1)
MARQUES ROSSETTI, RENATA ARIZA; CRISTINA LORENZI, NOELY PAULA; YOKOCHI, KAORI; SARTOR DE FARIA ROSA, MARIA BEATRIZ; BENEVIDES, LUCIANA; RAMOS MARGARIDO, PAULO FRANCISCO; BARACAT, EDMUND CHADA; CARVALHO, JESUS PAULA; VILLA, LUISA LINA; LEPIQUE, ANA PAULA. B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses. PLoS One, v. 13, n. 7, JUL 5 2018. Web of Science Citations: 5. (14/19326-6, 10/20010-2, 11/11121-8)
FARINA SILVEIRA, CAIO RAONY; CIPELLI, MARCELLA; MANZINE, CAROLINA; RABELO-SANTOS, SILVIA HELENA; ZEFERINO, LUIZ CARLOS; RODRIGUEZ, GRETEL RODRIGUEZ; DE ASSIS, JOSIANE BETIM; HEBSTER, SUELLEN; BERNADINELLI, ISABEL; LAGINHA, FABIO; et al. Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population. PLoS One, v. 14, n. 3, MAR 6 2019. Web of Science Citations: 1. (14/19326-6, 08/57889-1)
FERNANDEZ ALVAREZ, KARLA LUCIA; BELDI, MARIANA; SARMANHO, FABIANE; MARQUES ROSSETTI, RENATA ARIZA; FARINA SILVEIRA, CAIO RAONY; MOTA, GIANA RABELLO; ANDREOLI, MARIA ANTONIETA; DE CARVALHO CARUSO, ELIANA DIAS; KAMILLOS, MARCIA FERREIRA; SOUZA, ANA MARTA; et al. Local and systemic immunomodulatory mechanisms triggered by Human Papillomavirus transformed cells: a potential role for G-CSF and neutrophils. SCIENTIFIC REPORTS, v. 7, AUG 21 2017. Web of Science Citations: 12. (14/19326-6, 08/57889-1)
LEPIQUE, ANA PAULA; PEREZ DAGHASTANLI, KATIA REGINA; CUCCOVIA, IOLANDA MIDEA; VILLA, LUISA LINA. HPV16 Tumor Associated Macrophages Suppress Antitumor T Cell Responses. Clinical Cancer Research, v. 15, n. 13, p. 4391-4400, JUL 1 2009. Web of Science Citations: 78.
BOLPETTI, ALINE; SILVA, JOAO S.; VILLA, LUISA L.; LEPIQUE, ANA PAULA. Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth. BMC IMMUNOLOGY, v. 11, JUN 7 2010. Web of Science Citations: 47.
ROSSETTI, RENATA A. M.; DA SILVA-JUNIOR, ILDEFONSO A.; R RODRIGUEZ, GRETEL; ALVAREZ, KARLA L. F.; STONE, SIMONE C.; CIPELLI, MARCELLA; SILVEIRA, CAIO R. F.; BELDI, MARIANA CARMEZIM; MOTA, GIANA R.; MARGARIDO, PAULO F. R.; et al. Local and Systemic STAT3 and p65 NF-KappaB Expression as Progression Markers and Functional Targets for Patients With Cervical Cancer. FRONTIERS IN ONCOLOGY, v. 10, NOV 19 2020. Web of Science Citations: 0. (14/19326-6, 13/26856-9, 16/16149-1, 18/16989-5, 11/20499-4)
NASCIMENTO, FLAVIA R. F.; GOMES, ELIANE A.; RUSSO, MOMTCHILO; LEPIQUE, ANA P.. Interferon Regulatory Factor (IRF)-1 Is a Master Regulator of the Cross Talk between Macrophages and L929 Fibrosarcoma Cells for Nitric Oxide Dependent Tumoricidal Activity. PLoS One, v. 10, n. 2, FEB 6 2015. Web of Science Citations: 9. (13/24694-1, 10/20010-2)
(References retrieved automatically from State of São Paulo Research Institutions)
STONE, Simone Cardozo. Papel do metabolismo de tumores associados ao papilomavírus humano na modulação do fenótipo de macrófagos humanos.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (13/26856-9)
FERNÁNDEZ, Karla Lucía Alvarez. Caracterização do infiltrado inflamatório no carcinoma cervical e em suas lesões precursoras.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/20499-4)
ROSSETTI, Renata Ariza Marques. Estudo do estado de ativação de vias de sinalização no microambiente tumoral e leucócitos circulantes em pacientes com tumor do colo do útero.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/11121-8)