bachelor's at Medicina from Universidade Federal do Pará (1993), master's at Physiology from Universidade de São Paulo (1998) and doctorate at Physiology from Universidade de São Paulo (2002). Has experience in Physiology, acting on the following subjects: músculo esquelético, catecolaminas, proteólise, simpatectomia and metabolismo de proteínas. (Source: Lattes Curriculum)
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Autophagy is a ubiquitous catabolic process that causes intracellular degradation through vesicular engulfment of dysfunctional, damaged, or harmful cytoplasmic components. Although it is well established that autophagy and the Ub-proteasome system regulate cellular homeostasis, the exacerbation of these processes leads to muscle atrophy and several pathologies. Previous work from our lab…
The second messenger cAMP mediates the hyperglycemic effects of sympathetic catecholamines in response to stress. Recent studies indicate that the cyclic AMP-responsive element-binding protein (CREB) binds to a family of cAMP-regulated transcriptional co-activators (CRTCs), whose regulation and physiological role are still unknown. Thus, we hypothesized that the CRTC-2 is a critical signa…
In our previous thematic project, we have shown that the sympathetic nervous system through the beta 2-adrenoceptors activation inhibits the activity of ubiquitin-proteasome system (UPS), the major proteolytic system involved in muscle wasting. This effect is due to the suppression of "atrophy program" (atrophy-related genes or atrogenes) and involves the cAMP signaling pathway. However, …
The main goal of the activities developed by Dr. Rudiger Rudolf will be the learning and application of new imaging techniques that can assist in the elucidation of signaling pathways by which the sympathetic nervous system controls the metabolism of proteins in skeletal muscle. Additionaly, the researcher's visit will contribute to the viability of the research project entitled "Function…
(Only some records are available in English at this moment)
Liraglutide (LIRA) is a GLP-1 (Glucagon Peptide Type I) analog drug widely used for treating Type 2 Diabetes Mellitus and obesity that results in improved glycemic control, satiety, and intense weight loss. Although there is evidence that central actions of LIRA mediate part of these effects, very little is known about the role of the Sympathetic Nervous System (SNS) in the loss of fat ma…
Autophagy is one of the main processes of degradation of intracellular components, such as lipids (lipophagy), and essential for the maintenance of cellular homeostasis. In the liver, dysregulation of the autophagic process leads to the accumulation of hepatic triglycerides and the development of steatosis. It is known that the cAMP responsive element-binding protein (CREB) and its co-act…
The loss of muscle mass is a consequence of neuromuscular and metabolic diseases and remain untreated. Previous experiments in our laboratory have shown that the Sympathetic Nervous System, by activating the cAMP cascade, positively modulates the protein balance in skeletal muscle by stimulating synthesis and inhibiting proteolytic pathways such as lysosomal/autophagic, dependent on Ca++ …
Vitamin D acts on differents body tissues and your deficiency increases the risk of development several chronic diseases, such as diabetes mellitus and obesity. Although there is evidence that vitamin D receptor (VDR) knockout animals show increased energy expenditure, the physiological importance of this hormone in brown adipose tissue (TAM), the main heat producing site in the body, is …
(Only some records are available in English at this moment)
Autophagy is one of the main degradation processes of intracellular components, such as lipids (lipophagy), and it is essential for the maintenance of cellular homeostasis. In the liver, dysregulation of the autophagic process leads to the accumulation of triglycerides and the development of steatosis. Despite its importance, the role of autophagy in hepatic metabolism is still poorly und…
The escalating prevalence of obesity and Type II diabetes mellitus (T2DM) has prompted an urgent need for effective therapeutic strategies. Liraglutide (LIRA), a Glucagon-like peptide-1 (GLP-1) analogue, has shown promise in addressing metabolic dysfunctions associated with these conditions. Initial findings suggest that LIRA not only aids in weight and adipose tissue reduction but also p…
The description of the neural circuitry and brain network involved in the regulation of liver metabolism is of great importance for the understanding of liver physiology and pathophysiology of different metabolic diseases including diabetes and obesity. In the master´s project linked with this present project, it was observed that the chemical sympathectomy of liver induced by neonatal tr…
During the acute stress response, the Sympathetic Nervous System (SNS) induces rapid catabolism of energy reserves through the release of catecholamines and activation of the cAMP/PKA/CREB signaling. However, the molecular mechanism by which catecholamines control skeletal muscle protein balance remains to be elucidated. Diverse stresses conditions induce reduction of protein synthesis in…
| 1 / 1 | Ongoing research grants |
| 7 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 13 / 10 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 26 / 21 | All research grants and scholarships |
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CV Lattes
ORCID