graduation at Medicina from Universidade de Pernambuco (1994) and doctorate at Clinical Medicine from Universidade Estadual de Campinas (2002). Has experience in Medicine, focusing on Cancerology, acting on the following subjects: câncer, transmissão do sinal, resistência à insulina, hipotálamo and exercício. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Living with Cancer |
| Conviviendo con el cáncer |
| News published in Agência FAPESP Newsletter about the researcher |
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Cancer is a major public health problem worldwide and ranks among the leading causes of death. Identifying new agents for the diagnosis and treatment of patients with cancer is highly desirable. For many centuries, metals have been used empirically to treat various diseases. Nowadays, metals and their compounds - stable or radioactive - are rationally applied in both the diagnosis and tre…
Obesity affects more than 400 million subjects in the world and projections for the next 15 years predict an overall prevalence of up to 20%. In developing countries, such as Brazil a rapid nutritional transition provided by the recent economical growth has led to a unique condition on which the malnourished persist in parallel with an increasing number of obese subjects. It is expected t…
Recent studies indicate that the muscular depletion (sarcopenia) is a risk factor associated with worse prognosis in CCR patients. Insulin resistance is a common phenomenon in neoplasms and it has been implicated in the development of sarcopenia associated with aging. In spite of the advances in the knowledge about pathophysiological mechanisms of muscle wasting, the biological and molecu…
The hypothalamus is a brain region that gathers information on the body's nutritional status and governs the release of multiple metabolic signaling molecules such as insulin and leptin to maintain homeostasis. Obesity is associated with insulin and leptin resistance in the hypothalamus. However, despite it was recently demonstrated that the insulin resistance is associated with the incre…
Annually more than 14000 new cases of head and neck cancer are diagnosed in Brazil. Despite the advances in the therapeutic options to head and neck cancer, the survival rates have not significantly ameliorated in the last 30 years. Pre-clinical data from our laboratory demonstrated a synergic effect of paclitaxel associated to metformin in the growth inhibition of A549 cells xenograft in…
(Only some records are available in English at this moment)
Recent studies show that colon cancer and obesity may be associated to subclinical low-grade inflammation and saturated fatty acid-induced lipotoxicity. Previous study from our laboratory demonstrated that diet-induced obesity increases the secretion of TNF inducing colon carcinogenesis (Flores et al., 2012). On the other hand, anti-inflammatory effects of Omega 3 fatty acids through both…
The theory of diseases generated by inflammatory cytokines brought over the years evidence that the body may produce through cytokine biological or detrimental responses. In the mid-19th century, Rudolf Virchow suggested a possible association between inflammation and development of diseases. Thus, believed that inflammation is a key mechanism in the pathogenesis of some diseases such as…
(Only some records are available in English at this moment)
Studies suggest that AMPK is a key protein in inflammation control. Preliminary data of this study suggest that inhibition of the hypothalamic AMPK with compound C leads to central and systemic inflammation in control rodents with and without tumor. Moreover, loss of function of AMPK using genetic techniques is of great relevance. Therefore, the aim of this study will be to assess the rol…
| 2 / 2 | Ongoing research grants |
| 6 / 4 | Completed research grants |
| 17 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 26 / 16 | All research grants and scholarships |
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CV Lattes
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