Graduated in Biological Sciences Medical (Biomedicine) from the Federal University of the State of Rio de Janeiro (1988), masters degree in Cellular and Molecular Biology in Pharmacology from the Oswaldo Cruz Foundation (1994), and PhD in Sciences in the area of Pharmacology from the Ribeirão Preto Medical School, University of São Paulo (1998). Post-doctorate at the University of Michigan in immunopharmacology (2000). CNPq researcher. She is a Full Professor in the Department of Basic Sciences at the School of Dentistry of Araçatuba, São Paulo State University, and local coordinator of the Multicentre Postgraduate Program in Physiological Sciences-SBFis. She has experience in teaching and research in Pharmacology, with an emphasis on Immunopharmacology, working mainly on the following topics: renin-angiotensin system in models of inflammation in the presence of systemic diseases, 2D and 3D cell culture, mechanisms involved in bone metabolism, the release of inflammatory mediators and intracellular signaling. (Source: Lattes Curriculum)
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An outbreak of new coronavirus-related pneumonia was identified in December 2019, and has expanded rapidly, with cases now confirmed in more than 211 countries or more areas. This constant transmission of a new SARS-CoV-2 and its ability to spread from human to human led scientists to develop new approaches to the treatment of COVID-19. One of the main targets of this virus is to drastica…
In dentistry, there is growing interest in understanding the relationship between the inflammatory response and bone metabolism, especially regarding chronic and infectious diseases. The exploration of possible interactions between oral and systemic health has been shown to be relevant for enabling the understanding of modulators of the inflammatory process, such as the renin-angiotensin …
Professor Maria Helena Raposo Fernandes will give a course called metabolism and bone regeneration that is part of all subjects of the Multicenter Graduate Program in Physiological Sciences. This course is held every two years, and in 2012 Professor Maria Helena was in the Faculty of Dentistry of Araçatuba teaching the course for the first time. This visit was made at my request, since in…
(Only some records are available in English at this moment)
Squamous cell carcinoma (SCC) is a malignant neoplasm that corresponds to approximately 95% of cases of oral cancers. In addition to smoking and alcoholism, stress also contributes to the development of cancer. Data in our group demonstrated that the treatment of squamous cell carcinoma (SCC-25) cells stimulated by norepinephrine (NOR) induces the production of higher levels of interleuki…
Arterial hypertension and osteoporosis represent multifactorial disorders, where genetic and environmental factors culminate in pathogenesis development. Recent studies suggest that angiotensin II, the main active peptide produced by the renin-angiotensin system (RAS), stimulates the differentiation and activity of osteoclasts, influencing bone metabolism and contributing to the imbalance…
The periodontal ligament is a soft tissue located between the cementum and the alveolar bone, which acts on bone remodeling and orthodontic tooth movement. Some cells in this tissue are capable of self-renewal and differentiation into multiple lineages, which are called periodontal ligament stem cells. Such cells have already demonstrated a strong ability to form structures similar to cem…
Periodontal disease (PD) is considered an inflammation that destroys the tissue supporting the teeth - alveolar bone, periodontal ligament, cementum and gums. There are several studies that link periodontitis to diabetes mellitus, since diabetes mellitus increases the severity of PD. One of the mediators involved in the inflammatory process of PD is angiotensin. The renin-angiotensin syst…
(Only some records are available in English at this moment)
Inflammatory diseases can impair proper bone homeostasis by decreasing osteoblast activity and/or increasing osteoclast activity, thereby favoring bone mass loss as well as structural and functional damage. Periodontal disease (PD) is an inflammatory disorder affecting the tissues surrounding and supporting the teeth that can lead to alveolar bone resorption resulting in loss of teeth, an…
Recent studies demonstrate that the stress hormone norepinephrine (NE) exerts a pivotal role in the progression and in the chemoresistance of different types of cancer but its epigenetic mechanisms remain poorly understood. Moreover, the participation of cancer stem cells (CSC) in such processes is also a mystery. In fact, those questions have not been addressed in head and neck squamous …
| 1 / 1 | Ongoing research grants |
| 16 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 44 / 27 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 66 / 40 | All research grants and scholarships |
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CV Lattes
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