CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Alemanha
Is currently a Full professor at UNICAMP, School of Pharmaceutical Sciences, Graduated in Biologia from Universitat Kiel (Christian-Albrechts) (1992), master's in Biology from Universitat Kiel (Christian-Albrechts) (1992) and Ph.D. in Biology from Universitat Kiel (Christian-Albrechts) (1995), Was a researcher and group leader between 1998-2014 at the CNPEM/LNBio - Campinas (former Brazilian Synchrotron laboratory), Habilitated (Privatdozent, livre docente) in 2013 at Universidade São Paulo. Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: cancer, onco-proteins, signaling, protein-protein interactions and cancer signaling. Published 101 papers. Tutored 26 PhD and 6 master students. Co-supervised 4 PhD and supervised 16 post-docs and 23 undergraduate students in the past. In the moment tutors 4 PhD students, 1 masterstudent, and 2 undergraduate student . Currently is a full professor at the school of Pharmacy UNICAMP, Brasil. Studies: signaling, Nek cinases, onco-proteins, cancer, tranformation, DDR response, DNA repair, mitochondrial metabolism and morphology. Google academic: H-factor: 34, 3557 citations (15.9.2023). (Source: Lattes Curriculum)
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Cancer is among the diseases that most kill humans and domestic animals. Depending on the tissue and cell type affected by mutations, a large number of subtypes of cancer can be differentiated. For a specific subtype of cancer the molecular causes can be quite heterogeneous and for the majority of cases are poorly mapped. This represents both a major challenge as well as an an opportunit…
Members of the family of NEK kinases (NIMA related kinases) were identified as important regulators of cell cycle checkpoints, especially at the G2 to M phase transition. Although they are among all kinases one of the least studied families, recent studies showed they can have crucial roles in mitosis, centrosome disjunction, and in the signaling of the DNA damage response. These characte…
Ki-1/57 was discovered through the cross-reactivity of the monoclonal antibody Ki-1, the first antibody which specifically detects the cells of the Hodgkin lymphome. Preliminary studies on this protein revealed several characteristics that are common to onco-proteins. Yeast-two hybrid experiments identified interacting proteins involved in the control of transcription and RNA metabolism.…
The proteín UNC-76 was identified as an essential component for axon fasciculation and elongation in the worm Caenorhabditis elegans. In the same way, the orthologue from mammalians FEZ1 presents expression in neuronal tissues and knockout mice for the FEZ1 gene present comportamental disorders which reflect light neurological defects. In previous work our group has shown that FEZq is a m…
(Only some records are available in English at this moment)
SERBP1 is described as an intrinsically disordered RNA-binding protein, active in gene regulation through different targets, genes and proteins. Some data suggests the active participation of this molecule in several types of tumor, especially in solid tumors, however there are few data regarding this molecule and this is an obstacle to clarifying the role of SERBP1 in cell signaling path…
Nek4 is a serine-threonine kinase from the Nek family that, among other functions, has a role in mRNA alternative splicing regulation. The mechanism of this regulation is not clear so far, but it is known that both Nek4 isoforms interact with numerous splicing factors. The alternative splicing of specific genes are frequently dysregulated in cancer, affecting cancer development and progre…
HABP4 is an unstructured protein that shows high plasticity and interaction with several targets, genes and proteins. Recent studies suggest that this protein is related to tumorigenesis, since the increase or decrease of its expression influences cell proliferation, cell cycle control and apoptosis. The Habp4 gene is located on chromosome 9, linked to four other genes, forming a haplotyp…
Centrioles assemble the centrosome, the microtubule organizing centre essential for cell division in proliferating cells. Centrioles also template cilia, cell organelles that act as antenna in quiescent cells and can also generate fluid flow. Because of their essential functions in human life, centrioles are highly regulated throughout the cell cycle. Among the least studied centriole cyc…
1983 Oakley and Morris identified, in a genetic cell division screen, in the filamentous fungus Aspergillus nidulans, a protein kinase named NIMA (Never In Mitosis gene A), founding member of the NEK family kinases (NIMA related kinases). The NEKs were identified in a vast spectrum of organisms, from protozoans to multicellular eukaryonts, including Drosophila, Xenopus, mice and humans. H…
(Only some records are available in English at this moment)
Nek4 is a serine-threonine kinase from the Nek family that, among other functions, has a role inmRNA alternative splicing regulation. The mechanism of this regulation is not clear so far, but it isknown that both Nek4 isoforms interact with numerous splicing factors. The alternative splicing ofspecific genes are frequently dysregulated in cancer, affecting cancer development and progressi…
NEK1 has pleiotropic functions and mutations of its gene have been reported in cancer and ciliopathies, such as polycystic kidney disease (PKD), besides some genetic diseases such as Mohr syndrome and short-rib thoracic dysplasia (SRTD). Recent studies demonstrate that loss-of-function mutations of NEK1 are related to familial ALS, however, how those mutations contribute to development of…
The eleven members of the human NEK family of serine/threonine kinases have been associated with diverse cellular processes. The function of NEK10 is poorly understood, but we have recently found that NEK10 has a role in mitochondrial morphology and function. NEK10 has several isoforms and we were able to identify at least one which is enriched in mitochondria. Immunoprecipitation followe…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 10 / 10 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 63 / 40 | Completed scholarships in Brazil |
| 14 / 14 | Completed scholarships abroad |
| 91 / 68 | All research grants and scholarships |
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