CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Alemanha
Is currently a Full professor at UNICAMP, School of Pharmaceutical Sciences, Graduated in Biologia from Universitat Kiel (Christian-Albrechts) (1992), master's in Biology from Universitat Kiel (Christian-Albrechts) (1992) and Ph.D. in Biology from Universitat Kiel (Christian-Albrechts) (1995), Was a researcher and group leader between 1998-2014 at the CNPEM/LNBio - Campinas (former Brazilian Synchrotron laboratory), Habilitated (Privatdozent, livre docente) in 2013 at Universidade São Paulo. Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: cancer, onco-proteins, signaling, protein-protein interactions and cancer signaling. Published 101 papers. Tutored 27 PhD and 6 master students. Co-supervised 4 PhD and supervised 16 post-docs and 23 undergraduate students in the past. In the moment tutors 3 PhD students, 2 masterstudent, and 2 undergraduate student . Supervises 1 pos-doc. Currently is a full professor at the school of Pharmacy UNICAMP, Brasil. Studies: signaling, Nek cinases, onco-proteins, cancer, tranformation, DDR response, DNA repair, mitochondrial metabolism and morphology. Google academic: H-factor: 34, 3641 citations (11.1.24) (Source: Lattes Curriculum)
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The Faculty of Pharmaceutical Sciences is one of the newest units at UNICAMP, having started its activities in the second semester of 2014. It has a teaching staff made up of 18 professors, all full-time, as well as 1 researcher. Currently, it has around 250 students enrolled in the undergraduate Pharmacy course and 103 in the Postgraduate Program in Pharmaceutical Sciences, 43 in the Mas…
The presente proposal envisions the aquisition of a Luminex 200 equipment as a platform to identify and Analyse up to 100 analites (proteins in biological samples) simultâneos per well, in substitution for traditional western blot techniques. The platform works with custom made or comercial kits, that allow a complete investigation of diverse molecular contexts like signaling pathways, im…
Cancer is among the diseases that most kill humans and domestic animals. Depending on the tissue and cell type affected by mutations, a large number of subtypes of cancer can be differentiated. For a specific subtype of cancer the molecular causes can be quite heterogeneous and for the majority of cases are poorly mapped. This represents both a major challenge as well as an an opportunit…
The Faculty of Pharmaceutical Sciences is one of the most recent UNICAMP's Units, having started operating in the second half of 2014. It operates with a teaching staff of 17 professors, all full and exclusive dedication and 1 researcher. It has approximately 260 students enrolled in the undergraduate course in Pharmacy and 103 in the Graduate Program in Pharmaceutical Sciences, 47 in the…
The Faculty of Pharmaceutical Sciences is the youngest of the UNICAMP Units, having started operating in the second half of 2014. It operates with a faculty of 17 professors, 3 of which are full-time professors, 8 associate professors and 5 PhD professors, all on a full-time basis and exclusive and 1 researcher. It currently has 268 students enrolled in the undergraduate course in Pharmac…
Members of the family of NEK kinases (NIMA related kinases) were identified as important regulators of cell cycle checkpoints, especially at the G2 to M phase transition. Although they are among all kinases one of the least studied families, recent studies showed they can have crucial roles in mitosis, centrosome disjunction, and in the signaling of the DNA damage response. These characte…
(Only some records are available in English at this moment)
In general, Neks (NIMA-related kinases) are a family of serine/threonine/tyrosinekinases that regulate the cell cycle of eukaryotic cells. Neks consist of enzymesconsidered relevant targets in several pathologies, including cancer. From datacarried out by the Pan American Health Organization (PAHO/WHO) in 2020, colorectal cancer isconsidered one of the most lethal. This work will have as …
Cancer is one of the most devastating diseases of man and domestic animals. Depending on the type of tissue or cell affected by mutations, a great number of cancer sub-types can de established. These sub-types are only marginally mapped and tend to be quite heterogeneous. This scenario representes one of the major frontiers of the cancer field but may lead to numerous new diagnostic a…
(Only some records are available in English at this moment)
Nek4 is a serine-threonine kinase from the Nek family that, among other functions, has a role in mRNA alternative splicing regulation. The mechanism of this regulation is not clear so far, but it is known that both Nek4 isoforms interact with numerous splicing factors. The alternative splicing of specific genes are frequently dysregulated in cancer, affecting cancer development and progre…
HABP4 is an unstructured protein that shows high plasticity and interaction with several targets, genes and proteins. Recent studies suggest that this protein is related to tumorigenesis, since the increase or decrease of its expression influences cell proliferation, cell cycle control and apoptosis. The Habp4 gene is located on chromosome 9, linked to four other genes, forming a haplotyp…
(Only some records are available in English at this moment)
The eukaryotic cell cycle is regulated by a cascade of mechanisms that ensure its integrity,in particular, the interphase (G1, S, and G2 phases) and mitosis. Protein kinases, including NIMA-related kinases (Neks), play crucial roles in cell cycle regulation. Nek8, a member of the Nek family, is involved in centrosomal organization and primary cilium formation, with mutations linked to dis…
Retrotransposons are mobile genetic elements that copy their sequences and insert them in new genomic location through RNA intermediates using a "copy and paste" mechanism called retrotransposition. Long-Interspersed Element-1 (L1) is the only autonomous functional retrotransposon in humans. When L1 is transcript, two proteins are translated: ORF1p and ORF2p, in the cytosol they can form …
Hyaluronic Acid Binding Protein 4 (HABP4) is a key intracellular protein involved in regulating various cellular processes, including transcriptional and translational control, as well as cell cycle progression. Its role in tumor suppression has been extensively studied, with interactions and microarray analyses linking it to important pathways like chromatin remodeling, apoptosis, and mR…
Nek4 is a serine-threonine kinase from the Nek family that, among other functions, has a role inmRNA alternative splicing regulation. The mechanism of this regulation is not clear so far, but it isknown that both Nek4 isoforms interact with numerous splicing factors. The alternative splicing ofspecific genes are frequently dysregulated in cancer, affecting cancer development and progressi…
NEK1 has pleiotropic functions and mutations of its gene have been reported in cancer and ciliopathies, such as polycystic kidney disease (PKD), besides some genetic diseases such as Mohr syndrome and short-rib thoracic dysplasia (SRTD). Recent studies demonstrate that loss-of-function mutations of NEK1 are related to familial ALS, however, how those mutations contribute to development of…
The eleven members of the human NEK family of serine/threonine kinases have been associated with diverse cellular processes. The function of NEK10 is poorly understood, but we have recently found that NEK10 has a role in mitochondrial morphology and function. NEK10 has several isoforms and we were able to identify at least one which is enriched in mitochondria. Immunoprecipitation followe…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 12 / 12 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 65 / 42 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 14 / 14 | Completed scholarships abroad |
| 102 / 79 | All research grants and scholarships |
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