She has a licentiate and a bachelor's degree in Biological Sciences from the University of São Paulo (USP), a PhD in Sciences (Cell Biology and Histology) from the Institute of Biomedical Sciences at USP and a Post-Doctorate in Biochemistry and Molecular Biology (Institute of Chemistry- USP and Michigan University-USA). She is currently Associate Professor 3 at the Department of Anatomy at the ICB/USP, where she has been employed since 2001. She has experience in the area of Cellular and Molecular Biology in the subjects: action of hormones and growth factors on the adrenal gland, HPA axis, differentiation, proliferation, and renewal of normal and tumoral adrenocortical cortex. She develops research projects: 1 Young Researcher, Regular Grants and 2 Thematic as main researcher, supported by FAPESP, and CAPES and CNPq. In teaching, she works at undergraduate and graduate levels as well as in extension activities. The main roles in management were as president of the ICB Research Commission and as head of the Department of Anatomy at the ICB/USP. (Source: Lattes Curriculum)
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The Multi-User Laboratory of Anatomy Department, Multi-ICB3, was opened in 2001 through FAPESP funding (process 2000/05530-8) as a proposal to modernize the Anatomy Department. Equipment for histology, electron and light microscopy, molecular biology, analytical equipment, among others, was acquired. Since then, MULTI-ICB3 has been part of the department's research routine and aims to pro…
The Extracellular Matrix (ECM) differs greatly across organs owing to complex variations required for specific organ structure and function. ECM modulates cell behavior and regulates cell-cell interactions in physiological mechanisms, processes largely dependent on modulation of cell signaling pathways. Disruptions of these mechanisms may lead to disease. In the current project we propose…
The development of the adrenal starts with the bilateral formation of the adrenogonadal primordium (AGP) marked by the expression of steroidogenic factor 1 (SF-1). SF-1 positive cells will form the adrenal (AP) primordium that will give rise to the fetal adrenal. The fetal adrenal expands rapidly due to fetal zone growth (ZFe) followed by the definitive zone (ZDe), which will give rise to…
POD-1/TCF21 can inhibit the transcription factor SF-1/NR5A1 adrenal during development. Such inhibition may lead to alterations in the development of adrenal, however its increase is associated with increased proliferation and adrenal tumorigenesis. A previous study from our group showed that overexpression of POD-1 inhibits the expression of endogenous SF-1 by binding in the E-box site o…
Cushing syndrome (CS) results from chronic excess of cortisol production and represents and archetype of metabolic syndrome (MS). The MS is a condition defined as a complex of interconnected cardiovascular risk factors such as (obesity, diabetes, blood hypertension and dyslipidemia). It is estimated that 2/3 of CS patients fulfill the criteria for MS. PMAH is a cause of CS, usually diagno…
(Only some records are available in English at this moment)
The adrenal gland is an endocrine gland composed of cortex and medulla. The adrenal cortex presents a structural and functional zonation, whose processes of differentiation, migration, and cell renewal are dependent on interactions betweenligands and intracellular activation pathways. In addition, also to probable interactions between cells and components of the extracellular matrix (ECM)…
The extracellular matrix (ECM) is responsible for structural integrity, cellular communication, transport of molecules and differs biochemically, according to the tissue microenvironment. Biochemical changes in this composition promote different cell signaling in normal tissues and in pathological conditions, such as in the tumor, with impacts on tumor progression. The adrenal gland consi…
The extracellular matrix (ECM) is defined as the non-cellular component of the tissue. It is responsible for the structural integrity of the organ, as well as for cellular communication and transport of molecules. Changes in the composition of the ECM induce different cell signaling in normal tissues, and in pathological conditions, such as in the tumor, impact on tumor progression. The a…
The extracellular matrix (MEC), defined as non-cellular component of the tissue, is responsible for structural integrity, cellular communication, transport of molecules and biochemically distinct, according to the tissue microenvironment. Biochemical changes in this composition promote different cell signaling in normal tissues and in pathological conditions, such as in the tumor, with im…
(Only some records are available in English at this moment)
This study aims to understand how the Wnt pathway contributes to the formation of the adrenal microenvironment by regulating the extracellular matrix (ECM) using primary 3D culture models of normal rat adrenal gland cells. The adrenal gland, composed of differentiated histological zones, is regulated by various factors, including ECM composition and paracrine signaling. Previous studies i…
The adrenocorticotropic hormone (ACTH) is considered the main peptide derived from POMC acting on the adrenal gland promoting development, maintenance and corticosteroidogenesis. However, there is considerable evidence that other peptides derived from POMC, such as those from the N-terminal (N-POMC), might act to maintain the adrenal gland. However, it remains unknown the receptor for the…
| 2 / 2 | Ongoing grants |
| 14 / 10 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 37 / 20 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 56 / 35 | All research grants and scholarships |
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CV Lattes
ORCID