Valdecir Farias Ximenes

• Abstract

  Detection, monitoring and quantification of molecular processes in simple systems, such as biochemical reactions in isolated systems, or complex ones, such as those occurring within cells or supramolecular systems, occurs by contrasting between what is wanted and what is not wanted to see. In other words, by increasing the signal to noise ratio. In this scenario, fluorescence-based techni…

  Synthesis, studies and applications of fluorescent and circular dichroic probes for characterization of interactions with proteins, DNA and determination of enzymatic activity, AP.R

• Abstract

  Mounting evidence has demonstrated the role of hypohalous acids as hypochlorous acid (HOCl) and hypobromous acid (HOBr) as agents involved in biomolecules degradation. Indeed, the identification of biomarkers as chlorotyrosine and HOCl and HOBr modified proteins and nucleic acid has been widely demonstrated and correlated with pathologies as Alzheimer`s disease, Parkinson`s disease, chron…

  Development and application of fluorescent probes and probes based on circular dichroism for the interaction studies of ligands with protein, characterization of amyloid proteins and determination of enzymatic activity, AP.R

• Abstract

  Mounting evidence has demonstrated the role of hypohalous acids as hypochlorous acid (HOCl) and hypobromous acid (HOBr) as agents involved in biomolecules degradation. Indeed, the identification of biomarkers as chlorotyrosine and HOCl and HOBr modified proteins and nucleic acid has been widely demonstrated and correlated with pathologies as Alzheimer`s disease, Parkinson`s disease, chron…

  Kinetic studies of reactions mediated by oxidants produced by neutrophils: mechanism of deleterious action and development of enzyme inhibitors, AP.R

(Only some records are available in English at this moment)

• Abstract

  The N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) is a compound derived from melatonin (MEL), generated from the oxidative cleavage of the pyrrolic nucleus via enzymatic, pseudo-enzymatic and nonenzymatic pathways. As MEL, AFMK is also an excellent antioxidant, being a great hydroxyl radical (*OH) scavenger and capable of inhibiting the production of pro-oxidant enzymes, pro-inflammatory…

  Obtaining the metabolite N1-acetyl-n2-formil-5-metoxykynuramine (AFMK) from the photooxidation of melatonin catalyzed by nanostructured metal oxides, BP.IC

• Abstract

  The human serum albumin, HSA, is a major protein constituent from blood plasma. Among its functions, it highlights its performance in the transport of drugs. This property is particularly relevant in the context pharmacokinetic, since the HSA-drug interaction may interfere with the bioavailability of the drug in the body, affecting its therapeutic action. Therefore, evaluate the interacti…

  Development of Fluorescent Probes for the Determination of Binding Sites on Albumin: Studies of the Relationship of the Molecular Structure, Association Constant and Specificity, BP.DR

• Abstract

  Helicobacter pylori is one of major cause of chronic gastritis and peptic ulcer disease, increasing the probability of the onset of stomach cancer if the infection is left untreated. Although the mechanism involved in gastric inflammation by this bacterium is not fully understood, it is known the important role of reactive oxygen species (ROS) produced by polymorphonuclear neutrophils (PM…

  Gallic acid and its esters as anti-Helicobacter pylori agents and scavenger of oxidants produced by neutrophils, BP.MS

(Only some records are available in English at this moment)