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Deborah Schechtman

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Universidade de São Paulo (USP). Instituto de Química (IQ)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Undergraduate studies in Biomedicine at the Universidade Federal do Estado do Rio de Janeiro (Uni-Rio) (1988), masters in biophysics at the Universidade Federal do Rio de Janeiro (1992) e PhD obtained from The Weizmann Institute Of Science (1998). Pos-doctoral studies at Stanford University (2005-2009). Young Investigator (FAPESP) at the Heart Institue (InCor/ HCFMUSP) at the Laboratory of de Genetics and Molecular Cardiology. Has experience in biochemistry, emphasis in molecular and celular biology, working mainly with: signal transduction, proteomics, rational design of farmacological peptide modulators of protein-protein interactions and of conformational antibodies. . Atualmente é profa. Currently Associate Professor of the Chemistry Institute, Department of Biochemistry of the University of São Paulo, working on signaling pathways related to pain. The main goal of the laboratory is to study signal transduction pathways involved in embriogenesis of the pain pathway, and in the transmission of signals of pain transmitted by nerve growth factor, NGF, activating the kinase TrkA, and the role of the kinase PKMzeta in synaptic remodeling and in chronic pain. (Source: Lattes Curriculum)

Articles published in Pesquisa FAPESP Magazine about the researcher:
Molecular origami 
Un origami molecular 
News published in Agência FAPESP Newsletter about the researcher
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FAPESP support in numbers * Updated July 24, 2021
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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (20)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Data from Web of Science

MAGALHAES, YULI T.; SILVA, GISELE E. T.; OSAKI, JULIANA H.; ROCHA, CLARISSA R. R.; FORTI, FABIO L.. RHOAming Through the Nucleotide Excision Repair Pathway as a Mechanism of Cellular Response Against the Effects of UV Radiation. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 8, . Web of Science Citations: 0. (11/05822-3, 10/09453-0, 18/01753-6, 15/03983-0, 10/20506-8, 17/01451-7)

DE OLIVEIRA, PAULO SERGIO L.; FERRAZ, FELIPE AUGUSTO N.; PENA, DARLENE A.; PRAMIO, DIMITRIUS T.; MORAIS, FELIPE A.; SCHECHTMAN, DEBORAH. Revisiting protein kinase-substrate interactions: Toward therapeutic development. Science Signaling, v. 9, n. 420, . Web of Science Citations: 18. (15/17812-3, 12/24154-4, 11/10321-3, 15/21786-8)

MONTEIRO, LUCAS FALCAO; FORTI, FABIO LUIS. Network analysis of DUSP12 partners in the nucleus under genotoxic stress. JOURNAL OF PROTEOMICS, v. 197, p. 42-52, . Web of Science Citations: 0. (18/01753-6)

FACHI, JOSE LUIS; FELIPE, JAQUELINE DE SOUZA; PRAL, LAIS PASSARIELLO; DA SILVA, BRUNA KARADI; CORREA, RENAN OLIVEIRA; PEREIRA DE ANDRADE, MIRELLA CRISTINY; DA FONSECA, DENISE MORAIS; BASSO, PAULO JOSE; SARAIVA CAMARA, NIELS OLSEN; DE SALES E SOUZA, ERICKA LORENNA; et al. Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism. CELL REPORTS, v. 27, n. 3, p. 750+, . Web of Science Citations: 3. (17/06577-9, 17/25679-7, 14/03002-7, 18/01753-6, 18/02208-1, 12/10653-9, 17/01451-7, 13/06810-4, 17/16280-3, 16/23142-3, 15/01507-7, 17/26366-2, 15/06134-4)

PENA, DARLENE A.; DUARTE, MARIANA LEMOS; PRAMIO, DIMITRIUS T.; DEVI, LAKSHMI A.; SCHECHTMAN, DEBORAH. Exploring Morphine-Triggered PKC-Targets and Their Interaction with Signaling Pathways Leading to Pain via TrkA. PROTEOMES, v. 6, n. 4, . Web of Science Citations: 2. (15/21786-8)

GARAVELLO, NICOLE MILARE; PENA, DARLENE APARECIDA; CAMARGO BONATTO, JOSE MATHEUS; DUARTE, MARIANA LEMOS; COSTA-JUNIOR, HELIO MIRANDA; SCHUMACHER, ROBERT IVAN; FORTI, FABIO LUIS; SCHECHTMAN, DEBORAH. Activation of protein kinase C delta by psi delta RACK peptide promotes embryonic stem cell proliferation through ERK 1/2. JOURNAL OF PROTEOMICS, v. 94, p. 497-512, . Web of Science Citations: 5. (10/18640-8, 09/04067-7, 11/10321-3, 10/08798-3)

COSTA-JUNIOR, HELIO MIRANDA; SUETSUGU, MARIANA J.; KRIEGER, JOSE EDUARDO; SCHECHTMAN, DEBORAH. Specific modulation of protein kinase activity via small peptides. Regulatory Peptides, v. 153, n. 1-3, p. 11-18, . Web of Science Citations: 6. (05/54188-4)

MAGALHAES, YULI T.; FARIAS, JESSICA O.; SILVA, LUIZ E.; FORTI, FABIO L.. GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms. DNA Repair, v. 100, . Web of Science Citations: 0. (18/01753-6, 17/16491-4, 15/03983-0, 17/01451-7)

HEIMANN, ANDREA S.; DALE, CAMILA S.; GUIMARAES, FRANCISCO S.; REIS, RICARDO A. M.; NAVON, AMI; SHMUELOV, MICHAL A.; RIOLI, VANESSA; GOMES, IVONE; DEVI, LAKSHMI L.; FERRO, EMER S.. Hemopressin as a breakthrough for the cannabinoid field. Neuropharmacology, v. 183, . Web of Science Citations: 0. (16/04000-3, 19/06982-6, 17/24304-0)

SBRANA, MARIANA FERREIRA; FORNAZIERI, MARCO AURELIO; BRUNI-CARDOSO, ALEXANDRE; AVELINO-SILVA, I, VIVIAN; SCHECHTMAN, DEBORAH; VOEGELS, RICHARD LOUIS; MALNIC, BETTINA; GLEZER, ISAIAS; PINNA, FABIO DE REZENDE. Olfactory Dysfunction in Frontline Health Care Professionals During COVID-19 Pandemic in Brazil. FRONTIERS IN PHYSIOLOGY, v. 12, . Web of Science Citations: 0. (18/18633-3, 19/06982-6, 16/24471-0, 13/07937-8, 19/26767-2)

GLEZER, ISAIAS; BRUNI-CARDOSO, ALEXANDRE; SCHECHTMAN, DEBORAH; MALNIC, BETTINA. Viral infection and smell loss: The case of COVID-19. Journal of Neurochemistry, v. 157, n. 4, p. 930-943, . Web of Science Citations: 7. (18/18633-3, 19/26767-2, 19/06982-6, 13/07937-8)

RUSSO, LILIAN CRISTINA; FARIAS, JESSICA OLIVEIRA; FORTI, FABIO LUIS. DUSP3 maintains genomic stability and cell proliferation through modulation of the NER pathway and cell cycle regulatory proteins. CELL CYCLE, v. 19, n. 12, . Web of Science Citations: 0. (17/16491-4, 15/03983-0, 18/01753-6)

MAGALHAES, YULI T.; CARDELLA, GIOVANNA D.; FORTI, FABIO L.. Exoenzyme C3 transferase lowers actin cytoskeleton dynamics, genomic stability and survival of malignant melanoma cells under UV-light stress. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 209, . Web of Science Citations: 0. (17/01451-7, 19/05736-1, 15/03983-0, 18/01753-6)

SILVA, LUIZ E.; SOUZA, RENAN C.; KITANO, EDUARDO S.; MONTEIRO, LUCAS F.; IWAI, LEO K.; FORTI, FABIO L.. Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3 eta as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. JOURNAL OF PROTEOME RESEARCH, v. 18, n. 10, p. 3597-3614, . Web of Science Citations: 0. (13/07467-1, 18/01753-6)

DUARTE, MARIANA LEMOS; PENA, DARLENE APARECIDA; NUNES FERRAZ, FELIPE AUGUSTO; BERTI, DENISE APARECIDA; PASCHOAL SOBREIRA, TIAGO JOSE; COSTA-JUNIOR, HELIO MIRANDA; ABDEL BAQUI, MUNIRA MUHAMMAD; DISATNIK, MARIE-HELENE; XAVIER-NETO, JOSE; LOPES DE OLIVEIRA, PAULO SERGIO; et al. Protein folding creates structure-based, noncontiguous consensus phosphorylation motifs recognized by kinases. Science Signaling, v. 7, n. 350, . Web of Science Citations: 20. (10/18640-8, 10/15424-2, 11/10321-3, 12/24154-4)

PENA, DARLENE APARECIDA; DE ANDRADE, VICTOR PIANA; FERNANDES SILVA, GABRIELA AVILA; NEVES, JOSE IVANILDO; LOPES DE OLIVEIRA, PAULO SERGIO; MANSO ALVES, MARIA JULIA; DEVI, LAKSHMI A.; SCHECHTMAN, DEBORAH. Rational design and validation of an anti-protein kinase C active-state specific antibody based on conformational changes. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 1. (12/24154-4, 11/10321-3, 12/17279-5)

RUSSO, LILIAN C.; FERRUZO, PAULT Y. M.; FORTI, FABIO L.. Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 9, . Web of Science Citations: 0. (18/01753-6, 15/03983-0)

PEREIRA, NADINE RANIERI; RUSSO, LILIAN CRISTINA; FORTI, FABIO LUIS. UV Radiation-induced Impairment of Cellular Morphology and Motility is Enhanced by DUSP3/VHR Loss and FAK Activation. Cell Biochemistry and Biophysics, v. 79, n. 2, . Web of Science Citations: 1. (15/03983-0, 18/01753-6)

BUDAS, GRANT; COSTA, JR., HELIO MIRANDA; BATISTA FERREIRA, JULIO CESAR; DA SILVA FERREIRA, ANDRE TEIXEIRA; PERALES, JONAS; KRIEGER, JOSE EDUARDO; MOCHLY-ROSEN, DARIA; SCHECHTMAN, DEBORAH. Identification of epsilon PKC Targets During Cardiac Ischemic Injury. CIRCULATION JOURNAL, v. 76, n. 6, p. 1476-1485, . Web of Science Citations: 22. (09/03143-1, 05/54188-4)

COSTA-JUNIOR, HELLO MIRANDA; GARAVELLO, NICOLE MILARE; DUARTE, MARIANA LEMOS; BERTI, DENISE APARECIDA; GLASER, TALITA; DE ANDRADE, ALEXANDER; LABATE, CARLOS A.; DA SILVA FERREIRA, ANDRE TEIXEIRA; AGUILAR PERALES, JONAS ENRIQUE; XAVIER-NETO, JOSE; et al. Phosphoproteomics Profiling Suggests a Role for Nuclear beta IPKC in Transcription Processes of Undifferentiated Murine Embryonic Stem Cells. JOURNAL OF PROTEOME RESEARCH, v. 9, n. 12, p. 6191-6206, . Web of Science Citations: 7. (05/54188-4)

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