Undergraduate studies in Biomedicine at the Universidade Federal do Estado do Rio de Janeiro (Uni-Rio) (1988), masters in biophysics at the Universidade Federal do Rio de Janeiro (1992) e PhD obtained from The Weizmann Institute Of Science (1998). Pos-doctoral studies at Stanford University (2005-2009). Young Investigator (FAPESP) at the Heart Institue (InCor/ HCFMUSP) at the Laboratory of de Genetics and Molecular Cardiology. Has experience in biochemistry, emphasis in molecular and celular biology, working mainly with: signal transduction, proteomics, rational design of farmacological peptide modulators of protein-protein interactions and of conformational antibodies. . Atualmente é profa. Currently Associate Professor of the Chemistry Institute, Department of Biochemistry of the University of São Paulo, working on signaling pathways related to pain. The main goal of the laboratory is to study signal transduction pathways involved in embriogenesis of the pain pathway, and in the transmission of signals of pain transmitted by nerve growth factor, NGF, activating the kinase TrkA, and the role of the kinase PKMzeta in synaptic remodeling and in chronic pain. (Source: Lattes Curriculum)
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Opioides have an addictive effect generate tolerance upon prolonged use causing unwanted side effects. Thus, there is a great need to search for new analgesic substitutes. To this end, understanding the signaling pathways that lead to pain can help develop new non-opioid analgesics. Inflammatory pain begins with the secretion of nerve growth factor (NGF) and activation of its high affinit…
Physical pain can be subdivided into nociceptive and neuropathic. Nociceptive pain is due to the activation of nociceptors caused by a lesion or disease of the somatosensorial system, considered pathological pain. Both systems can lead to chronic pain, whose treatment is still a great challenge. Thus, it is necessaty to understand the signal transduction pathways that lead to pain to deve…
Data from the literature sugests that one of the problems to study the role of PKCs is the lack of tools that can distinguish specifically the inactive from active forms of the different protein kinase C (PKC) isoenzymes. Differently than other kinases, for example, ERK and JNK in which activation is determined by phosphorylation of the activation loop. Phosphorylations suffered in parti…
In the last years our lab has been characterizing the role of Protein kinase C (PKC) in undifferentiated murine embryonic stem cells (ESC). Our results suggest that most of the PKC²I substrates in undifferentiated ESC are nuclear proteins involved in the regulation of transcription of proteins involved in proliferaation/ diferentiation. Recent studies also have reported nuclear PKC²I i…
(Only some records are available in English at this moment)
Pain plays a key protective role in maintaining tissue integrity and homeostasis, but it is also involved in pathological processes that makes the search for pain treatments of great relevance. Among the mediators secreted when there is tissue damage, the nerve growth factor (NGF) plays a significant role in pain perception through its interaction with its receptor, the tropomyosin recept…
Nociception consists of the process of thermal and mechanical stimuli by peripheral neurons (nociceptors). In an inflammatory context caused by tissue injury, there is the recruitment of immune cells that secrete several pro-inflammatory factors. Amongst them, the nerve growth factor (NGF), acts on the process of hyperalgesia, which is an increased response on stimuli perception of the in…
Chronic pain has become an important health issue for the last few decades, affecting nearly 30% of the population worldwide. The search for analgesics that may help with patient's treatment has increased. TrkA and its associated pathways have proven to be interesting targets for new drugs development. Previous studies from our group, analysed mutations that affect TrkA signaling and thes…
When a tissue injury is produced in the human body, there are several forms of cell signaling of pain. The research interest of our laboratory group is mediated by the dimerization of the TrkA receptor (Tropomyosin kinase A) and a consequent cascade of reactions until neuronal depolarization, through activation of the TRPV1 cation channel.In this inflammatory context, the first step is th…
(Only some records are available in English at this moment)
Following a nerve damage, T cells infiltrate the lesion site to allow tissue repair and homeostatic balance. Locally, T cells release various pro-inflammatory mediators for tissue repair that can influence local neuron activity. We therefore hypothesize that T cells may contribute to chronic pain development after nerve injury through communication with neurons at specific intersectional …
Pain signaling is conducted by nociceptors, which derive from the neural crest and reside in dorsal root ganglia. Inflammatory pain relies on activation of TrkA receptors by NGF, which initiates signaling pathways that trigger action potentials. TrkA activation by NGF also promotes neuronal survival and differentiation during development. Mutations in NTRK1, which encodes TrkA, cause cong…
The ongoing opioid crisis in developed countries has urged the importance of searching for new analgesics. Many pathways have been explored on the therapeutics of this area, but opioids are still the most potent class of drugs for this. Nevertheless, they have limited effects and may lead to addiction, tolerance, and even overdose. Our group, aiming to understand the genetics of a disease…
Cell polarity is essential for differentiation, growth of budding yeast, asymmetric cell division, morphogenesis, transport of molecules across epithelial layers, cell migration and transmission of nerve impulse (enabled by axonal specification and morphological polarity of neurons) amongst other processes. Atypical protein kinase c (aPKC) has been described as a key component in determin…
The Protein Kinase C (PKC) family of serine/ treonine quinases can be divided according to their activation requirements in classical PKCs (cPKCs) that include PKC alpha,beta I, beta II, and gamma, novel PKCs (nPKCs), including PKC delta, PKC epsilon, PKC eta and PKC theta, and atypical PKCs (aPKCs), PKC zeta and lambda/iota. During activation, PKC translocates to membranes and suffers se…
Studies from our laboratory have shown that ²PKC presents a nuclear localization in undifferentiated murine embryonic stem cells. During the process ofdifferentiation occurs a change of subcellular localization of this protein, which shall beexpressed in the cytoplasm of embryonic stem cells (ESC), suggesting that ²PKC canbe an important factor that regulates the differentiation of thes…
| 1 / 1 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 17 / 13 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 32 / 27 | All research grants and scholarships |
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