CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a degree in Biological Sciences, Biomedicine, from the Federal University of the State of Rio de Janeiro (Uni-Rio) (1988), a masters degree in Biological Sciences (Biophysics) from the Federal University of Rio de Janeiro (1992), and a PhD in Immunology from the Weizmann Institute of Science (1998). She completed a postdoctoral fellowship at Stanford University (19992005). She was a Young Investigator (FAPESP) at the Heart Institute (InCor/HCFMUSP) in the Laboratory of Genetics and Molecular Cardiology (20052009). She has experience in Biochemistry, with an emphasis on Molecular and Cellular Biology, working mainly on the following topics: signal transduction, rational design of peptide modulators of proteinprotein interactions, and conformational antibodies. She obtained her habilitation (Livre-Docência) from the University of São Paulo in July 2015.She is currently an Associate Professor at the Institute of Chemistry, Department of Biochemistry at the University of São Paulo, working on pain signaling pathways. The main goal of the laboratory is to understand the signaling pathways involved in inflammatory pain to support the development of non-opioid analgesics. The lab aims to develop peptide modulators and conformational antibodies to study the signaling pathways involved in the transmission of inflammatory pain signals, identifying and validating new non-opioid therapeutic targets for pain treatment. She is the coordinator of the graduate program in Biological Sciences, Biochemistry (IQ-USP), associate editor of Bioscience Reports and a Scientific Advisor in the Biological Sciences II area at FAPESP. (Source: Lattes Curriculum)
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The primary objective of this proposal is to identify the biological factors underlying the immunological and proinflammatory processes characteristic of chronic pain and specifically to establish whether the impact of chronic pain on gut mucosal homeostasis mediates systemic inflammation. Chronic pain is a refractory health disease that imposes significant economic burden on affected ind…
Opioides have an addictive effect generate tolerance upon prolonged use causing unwanted side effects. Thus, there is a great need to search for new analgesic substitutes. To this end, understanding the signaling pathways that lead to pain can help develop new non-opioid analgesics. Inflammatory pain begins with the secretion of nerve growth factor (NGF) and activation of its high affinit…
Physical pain can be subdivided into nociceptive and neuropathic. Nociceptive pain is due to the activation of nociceptors caused by a lesion or disease of the somatosensorial system, considered pathological pain. Both systems can lead to chronic pain, whose treatment is still a great challenge. Thus, it is necessaty to understand the signal transduction pathways that lead to pain to deve…
Data from the literature sugests that one of the problems to study the role of PKCs is the lack of tools that can distinguish specifically the inactive from active forms of the different protein kinase C (PKC) isoenzymes. Differently than other kinases, for example, ERK and JNK in which activation is determined by phosphorylation of the activation loop. Phosphorylations suffered in parti…
In the last years our lab has been characterizing the role of Protein kinase C (PKC) in undifferentiated murine embryonic stem cells (ESC). Our results suggest that most of the PKC²I substrates in undifferentiated ESC are nuclear proteins involved in the regulation of transcription of proteins involved in proliferaation/ diferentiation. Recent studies also have reported nuclear PKC²I i…
(Only some records are available in English at this moment)
Even though it is an alert of utmost importance for an organism's survival, pain can lead to anguish that requires the use of medication to contain it. Nowadays, the available analgesics do not present the desired efficacy, especially for chronic pain, and cause side effects that affect users in many spheres, underscoring the necessity for developing new strategies to manage pain. In this…
The permeable phosphopeptide TAT-pQYP has been shown to reverse acute nociception in inflammatory models by inhibiting the anchoring of Phospholipase-Cg (PLCg) to the phosphorylated Y785 of Tropomyosin kinase A (TrkA), thereby inhibiting the phosphorylation and activation of the lipase by TrkA and peptide signaling in the nociceptors of the dorsal root ganglion (DRG). The hypothesis of th…
Currently, the search for effective treatments for pain relief is a significant challenge, as many individuals do not experience significant improvements when resorting to anti-inflammatory analgesics and/or opioids available in the market. To address this therapeutic gap, we must have a better understanding of the pathways leading to pain signaling, with particular interest in the pathwa…
(Only some records are available in English at this moment)
Following a nerve damage, T cells infiltrate the lesion site to allow tissue repair and homeostatic balance. Locally, T cells release various pro-inflammatory mediators for tissue repair that can influence local neuron activity. We therefore hypothesize that T cells may contribute to chronic pain development after nerve injury through communication with neurons at specific intersectional …
Pain signaling is conducted by nociceptors, which derive from the neural crest and reside in dorsal root ganglia. Inflammatory pain relies on activation of TrkA receptors by NGF, which initiates signaling pathways that trigger action potentials. TrkA activation by NGF also promotes neuronal survival and differentiation during development. Mutations in NTRK1, which encodes TrkA, cause cong…
The ongoing opioid crisis in developed countries has urged the importance of searching for new analgesics. Many pathways have been explored on the therapeutics of this area, but opioids are still the most potent class of drugs for this. Nevertheless, they have limited effects and may lead to addiction, tolerance, and even overdose. Our group, aiming to understand the genetics of a disease…
(Only some records are available in English at this moment)