CV Lattes
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Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
MD from the State University of Campinas (1997), PhD in Medical Sciences from the State University of Campinas (1999) and post-doctoral studies at the Oregon Graduate Institute. Currently a professor at the Department of Biochemistry at the University of São Paulo, a member of the Academy of Sciences of the State of São Paulo and the Brazilian Academy of Sciences. Works in the area of #8203;#8203;energy metabolism. (Source: Lattes Curriculum)
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Mitochondria are the hub of energy metabolism, organelles in which carbohydrate, amino acid and lipid metabolism are completed, and most cellular ATP is produced through oxidative phosphorylation. Because of the dependence on high inner mitochondrial membrane potentials in order to sustain oxidative phosphorylation, ion transport through the inner mitochondrial membrane must be carefully …
The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, pr…
Cardiovascular diseases are important causes of mortality and morbidity. Cardiac infarction (also called cardiac ischemia) could be better managed clinically with a better understanding of stress-related mechanisms involved in cardiac ischemia. Several cardiac protection strategies have mitochondria as a target, including cardiac preconditioning and calorie restriction. Indeed, ischemic d…
(Only some records are available in English at this moment)
Ischemic heart disease is a major cause of morbidity and mortality worldwide. Cardiac protection strategies have highlighted an important role for mitochondrial activities in cardioprotective intervention. Mitochondrial Ca2+ overload leading to loss of oxidative phosphorylation capacity during ischemia is one of the causal mechanisms of the deleterious effects of infarction, and can be pr…
In recent years, amino acid metabolism has been associated with various biological processes and with the pathogenesis of diseases. The urea cycle is a metabolic pathway responsible for converting ammonia excess, derived from the degradation of amino acids, into urea for excretion. To ensure the maintenance of homeostasis and nitrogen balance, the urea cycle enzymes expressions are modula…
Estrogens play crucial roles in various physiological functions, especially in sexualmaturity, reproduction, and post-menopause. Additionally, they play a central role in energymetabolism. This effect is clearly observed in humans and animal models with reduced levels ofestradiol (E2), where E2 replacement reverses several parameters related to the risk ofdeveloping diabetes and cardiovas…
(Only some records are available in English at this moment)
The ability to sense the environment and generate appropriate responses are fundamental features for the survival of living organisms. An important signaling hub and a key controller of cellular metabolism, is the mechanistic target of rapamycin (mTOR). mTOR complex 1 (mTORC1) is primarily involved in cell growth and the availability of amino acids is one of the main stimuli for its acti…
Mitochondrial Ca2+ has an important role in physiology and pathology. Mitochondrial transporters are crucial to maintain Ca2+ homeostasis, and Ca2+ efflux is controlled by the mitochondrial Na+/ Ca2+/ Li+ Exchanger (NCLX).NCLX is important to many physiological cellular processes, such as mitochondrial matrix redox state maintenence, and in different tissues, including brown adipose tissu…
Estradiol receptors (ERs) stimulation shows significant metabolic benefits after menopause. However, it is also related to an increased risk of hormone-dependent cancer and thrombosis. In this sense, the selective activation of the beta-type estradiol receptor (ER²) has shown antitumor action, besides the ability to modulate metabolic indicators of mitochondrial function. Surprisingly, to…
(Only some records are available in English at this moment)
Estrogen signaling is crucial for both reproductive functions and energy metabolism. Estradiol (E2) enhances insulin production and secretion in pancreatic beta cells and insulin signaling in various tissues, including the liver. This project aims to investigate ER²'s impact on liver metabolism, a topic that remains underexplored.Postmenopausal E2 deficiency increases the risk of metaboli…
The ability of mitochondria to transport Ca2+ in a highly regulated manner makes them essential players in Ca2+ signaling. Mitochondrial functions are fine-tuned by changes in both matrix and/or intermembrane space [Ca2+]. Alterations in the composition of the mitochondrial calcium uniporter complex (MCUc) have emerged as an important mechanism to regulate mitochondrial Ca2+ transport eit…
Mitochondrial metabolism and mTORC1 activity are central in nutrient sensing and coordinating an adaptive cellular response. In fact, both pathways are interconnected by different intermediates, providing reciprocal regulation. Given the well-established role of mitochondria in shaping intracellular calcium signals and the clear participation of calcium in mTORC1 regulation, it is rationa…
Brown Adipose Tissue (BAT) displays a central role in non-shivering thermogenesis and cold adaptation in mammals. To do such, potential energy generated in the mitochondria through oxidation of nutrients is dissipated in the form of heat by a specific uncoupling protein, UCP1. Recent data show that this process requires a fine tuning of fusion (union of two separated mitochondria) and fis…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 17 / 11 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 47 / 24 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 8 / 8 | Completed scholarships abroad |
| 81 / 52 | All research grants and scholarships |
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