MD from the State University of Campinas (1997), PhD in Medical Sciences from the State University of Campinas (1999) and post-doctoral studies at the Oregon Graduate Institute. Currently a professor at the Department of Biochemistry at the University of São Paulo, a member of the Academy of Sciences of the State of São Paulo and the Brazilian Academy of Sciences. Works in the area of #8203;#8203;energy metabolism. (Source: Lattes Curriculum)
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Mitochondria are the hub of energy metabolism, organelles in which carbohydrate, amino acid and lipid metabolism are completed, and most cellular ATP is produced through oxidative phosphorylation. Because of the dependence on high inner mitochondrial membrane potentials in order to sustain oxidative phosphorylation, ion transport through the inner mitochondrial membrane must be carefully …
The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, pr…
Cardiovascular diseases are important causes of mortality and morbidity. Cardiac infarction (also called cardiac ischemia) could be better managed clinically with a better understanding of stress-related mechanisms involved in cardiac ischemia. Several cardiac protection strategies have mitochondria as a target, including cardiac preconditioning and calorie restriction. Indeed, ischemic d…
Changes in mitochondrial energy metabolism, ion transport, mtDNA metabolism and redox balance are associated with a variety of physiological and pathological conditions including aging, obesity, heart attack and the toxicity of environmental contaminants. The central aim of this project is to analyze the role of alterations in mitochondrial ion transport, energy and DNA metabolism and/or …
(Only some records are available in English at this moment)
Estrogens play crucial roles in various physiological functions, especially in sexualmaturity, reproduction, and post-menopause. Additionally, they play a central role in energymetabolism. This effect is clearly observed in humans and animal models with reduced levels ofestradiol (E2), where E2 replacement reverses several parameters related to the risk ofdeveloping diabetes and cardiovas…
The transport of calcium in and out of the mitochondrial matrix has critical effects on cellular energy metabolism, signaling, and survival. Briefly, calcium influx into the mitochondrial matrix is controlled by the mitochondrial calcium uniporter (MCU) and calcium efflux by the sodium/calcium exchanger (NCLX). The ability of mitochondria to concentrate large amounts of calcium in a contr…
The ability to sense the environment and generate appropriate responses are fundamental features for the survival of living organisms. An important signaling hub and a key controller of cellular metabolism, is the mechanistic target of rapamycin (mTOR). mTOR complex 1 (mTORC1) is primarily involved in cell growth and the availability of amino acids is one of the main stimuli for its acti…
(Only some records are available in English at this moment)
Mitochondrial Ca2+ has an important role in physiology and pathology. Mitochondrial transporters are crucial to maintain Ca2+ homeostasis, and Ca2+ efflux is controlled by the mitochondrial Na+/ Ca2+/ Li+ Exchanger (NCLX).NCLX is important to many physiological cellular processes, such as mitochondrial matrix redox state maintenence, and in different tissues, including brown adipose tissu…
Ca2+ regulates several aspects of cell behavior, including mitochondrial function. Ca2+ activates several enzymes involved in the tricarboxylic acid cycle, as well as proteins involved in the transport of oxidable substrates. Physiological Ca2+concentrations lead to an increase in the rate of oxidative phosphorylation, and in the production rate of reactive oxygen species (ROS) under cert…
Pyruvate dehydrogenase, isocitrate dehydrogenase, and a-ketoglutarate dehydrogenase of the mitochondrial matrix have been shown to have increased activities in the presence of Ca2+ ions in vitro (Denton and McCormack, 1985; Hansford, 1985). However, these studies were conducted modulating isolated enzyme activity, and show increases in substrate affinity, but not universally in maximum ve…
(Only some records are available in English at this moment)
The ability of mitochondria to transport Ca2+ in a highly regulated manner makes them essential players in Ca2+ signaling. Mitochondrial functions are fine-tuned by changes in both matrix and/or intermembrane space [Ca2+]. Alterations in the composition of the mitochondrial calcium uniporter complex (MCUc) have emerged as an important mechanism to regulate mitochondrial Ca2+ transport eit…
Mitochondrial metabolism and mTORC1 activity are central in nutrient sensing and coordinating an adaptive cellular response. In fact, both pathways are interconnected by different intermediates, providing reciprocal regulation. Given the well-established role of mitochondria in shaping intracellular calcium signals and the clear participation of calcium in mTORC1 regulation, it is rationa…
Brown Adipose Tissue (BAT) displays a central role in non-shivering thermogenesis and cold adaptation in mammals. To do such, potential energy generated in the mitochondria through oxidation of nutrients is dissipated in the form of heat by a specific uncoupling protein, UCP1. Recent data show that this process requires a fine tuning of fusion (union of two separated mitochondria) and fis…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 16 / 10 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 45 / 22 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 77 / 48 | All research grants and scholarships |
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CV Lattes
ORCID