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Carlos Henrique Tomich de Paula da Silva

CV Lattes ORCID


Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

He is graduate at Chemistry from Universidade Estadual de Campinas (1992), master's at Chemistry from Instituto Militar de Engenharia (1995) and Ph.D. at Chemistry from Universidade de São Paulo (2000), besides 2 postdoctoral stages - Universidade de São Paulo and Barcelona Biomedical Research Park - Spain (2010). Currently, is Associate Professor at the School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - FCFRP / USP, since 2007, where he teaches 3 courses of Graduation and 4 of Post-Graduate. In research, works in the area of Medicinal Chemistry, with emphasis on molecular modeling and QSAR in drug design, including additional enzymatic activity assays with ligands of different therapeutic targets, particularly in cancer, Alzheimer's disease, leishmaniosis and inflammatory diseases. He is coordinator of a current project of medicinal Chemistry in Leishmaniosis and Chagas´disease. He was Director and Vice-Director of two International projects funded by FAPESP and CNPq, as welll as one of the principal investigators (PI) of International project in collaboration with the Nottingham University (PROGRAMA CAPES/UNIVERSIDADE DE NOTTINGHAM - SELEÇÃO DE PROJETOS ESPECIAIS DE PESQUISA EM DRUG DISCOVERY). 
He is also one of the investigators of the Center for Research in Inflammatory Diseases -CRID, FAPESP, as well as of the Medicinal Chemistry Open Acess, SGC-UNICAMP (The Structural Genomics Consortium), and associate researcher of a current FAPESP thematic project. With the private sector, it has established and maintains a University-Company partnership, in the form of scientific advice to assess the toxicological potential of compounds of agrochemical interest, through QSAR (Quantitative Structure-Activity Relationships) and QSTR (Quantitative Structure-Toxicity Relationships) studies. He has 1 patent and 189 publications, including 157 papers, 28 chapters of Medicinal Chemistry, as well as he is editor/co-editor of 4 international books in the field of Medicinal Chemistry. (Source: Lattes Curriculum)

Research grants
Scholarships in Brazil
Scholarships abroad
FAPESP support in numbers * Updated September 19, 2020
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications11
Citations39
Cit./Article3.5
Data from Web of Science

PERNOMIAN, LARISSA; PERNOMIAN, LAENA; GOMES, MAYARA S.; DA SILVA, CARLOS H. T. P.. Pharmacological significance of the interplay between angiotensin receptors: MAS receptors as putative final mediators of the effects elicited by angiotensin ATi receptors antagonists. European Journal of Pharmacology, v. 769, p. 143-146, . Web of Science Citations: 3. (12/00640-7, 13/08216-2, 11/11205-7, 14/17740-0)

PERNOMIAN, LARISSA; GOMES, MAYARA S.; PERNOMIAN, LAENA; MOREIRA, RAFAEL P.; CORREA, FERNANDO M. A.; DE OLIVEIRA, ANA M.. Vasoprotective effects of neurocompensatory response to balloon injury during diabetes involve the improvement of Mas signaling by TGF beta(1) activation. VASCULAR PHARMACOLOGY, v. 64, p. 36-48, . Web of Science Citations: 5. (12/00640-7, 13/08216-2, 09/01005-0, 11/11205-7, 14/17740-0)

PERNOMIAN, LARISSA; GOMES, MAYARA SANTOS; MOREIRA, JOSIMAR DORNELAS; TOMICH DE PAULA DA SILVA, CARLOS HENRIQUE; CAMPOS ROSA, JOAQUIN MARIA; DE BARROS CARDOSO, CRISTINA RIBEIRO. New Horizons on Molecular Pharmacology Applied to Drug Discovery: When Resonance Overcomes Radioligand Binding. CURRENT RADIOPHARMACEUTICALS, v. 10, n. 1, p. 16-20, . Web of Science Citations: 0. (12/00640-7, 14/17740-0, 12/09019-3)

PERNOMIAN, LARISSA; GIMENES, LILIAN R.; GOMES, MAYARA S.; DO VALE, BRUNO N.; CARDOSO, CRISTINA R. B.; DE OLIVEIRA, ANA M.; MOREIRA, JOSIMAR D.. Endothelinergic Contractile Hyperreactivity in Rat Contralateral Carotid to Balloon Injury: Integrated Role for ETB Receptors and Superoxide Anion. BIOMED RESEARCH INTERNATIONAL, . Web of Science Citations: 0. (13/08216-2, 12/00640-7, 14/17740-0, 12/09019-3, 09/01005-0)

SANTOS, CLEYDSON B. R.; SANTOS, KELTON L. B.; CRUZ, JORDDY N.; LEITE, FRANCO H. A.; BORGES, ROSIVALDO S.; TAFT, CARLTON A.; CAMPOS, JOAQUIN M.; SILVA, CARLOS H. T. P.. Molecular modeling approaches of selective adenosine receptor type 2A agonists as potential anti-inflammatory drugs. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, . Web of Science Citations: 0. (14/11009-1)

PERNOMIAN, LARISSA; GOMES, MAYARA S.; TOMICH DE PAULA DA SILVA, CARLOS H.; ROSA, JOAQUIN M. C.. Reverse Induced Fit-Driven MAS-Downstream Transduction: Looking for Metabotropic Agonists. Current Medicinal Chemistry, v. 24, n. 39, p. 4360-4367, . Web of Science Citations: 0. (12/00640-7, 13/08216-2, 14/17740-0, 12/09019-3)

PERNOMIAN, LARISSA; MOREIRA, JOSIMAR DORNELAS; GOMES, MAYARA SANTOS. In the View of Endothelial Microparticles: Novel Perspectives for Diagnostic and Pharmacological Management of Cardiovascular Risk during Diabetes Distress. JOURNAL OF DIABETES RESEARCH, . Web of Science Citations: 0. (12/00640-7, 13/08216-2, 09/01005-0, 14/17740-0, 12/09019-3)

MOREIRA, JOSIMAR D.; PERNOMIAN, LARISSA; GOMES, MAYARA S.; PERNOMIAN, LAENA; MOREIRA, RAFAEL P.; DO PRADO, ALEJANDRO F.; DA SILVA, CARLOS H. T. P.; DE OLIVEIRA, ANA M.. Acute restraint stress increases carotid reactivity in type-I diabetic rats by enhancing Nox4/NADPH oxidase functionality. European Journal of Pharmacology, v. 765, p. 503-516, . Web of Science Citations: 10. (11/11205-7, 14/17740-0, 13/08216-2)

PERNOMIAN, LARISSA; DA SILVA, CARLOS H. T. P.. Current basis for discovery and development of aryl hydrocarbon receptor antagonists for experimental and therapeutic use in atherosclerosis. European Journal of Pharmacology, v. 764, p. 118-123, . Web of Science Citations: 6. (13/08216-2, 14/17740-0)

PERNOMIAN, LARISSA; DO PRADO, ALEJANDRO F.; GOMES, MAYARA S.; PERNOMIAN, LAENA; DA SILVA, CARLOS H. T. P.; GERLACH, RAQUEL F.; DE OLIVEIRA, ANA M.. MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality. European Journal of Pharmacology, v. 764, p. 173-188, . Web of Science Citations: 11. (12/00640-7, 13/08216-2, 14/17740-0, 12/09019-3)

RODRIGUES, RICARDO P.; DA SILVA, CARLOS H. T. P.. Discovery of potential neurodegenerative inhibitors in Alzheimer's disease by casein kinase 1 structure-based virtual screening. MEDICINAL CHEMISTRY RESEARCH, v. 26, n. 12, p. 3274-3285, . Web of Science Citations: 4. (10/14929-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ALMEIDA, Jonathan Resende de. Estudos de modelagem molecular e relação estrutura-atividade da acetilcolinesterase e inibidores em Mal de Alzheimer. Dissertação (Mestrado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (08/07248-0

SILVA, Vinicius Barreto da. Modelagem molecular, síntese e avaliação da atividade biológica de potenciais antineoplásicos com a proteína hnRNP K e culturas de células tumorais. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (07/07934-8

RODRIGUES, Ricardo Pereira. Caseína quinase 1 como alvo para o planejamento de fármacos em mal de Alzheimer. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (10/14929-3

SEMIGHINI, Evandro Pizeta. Planejamento racional de inibidores da beta-secretase em mal de Alzheimer. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (08/10805-8

ALMEIDA, Jonathan Resende de. Planejamento, ensaio e otimização in silico de novos protótipos inibidores da enzima acetilcolinesterase. Tese (Doutorado) -  Faculdade de Ciências Farmacêuticas de Ribeirão Preto.  Universidade de São Paulo (USP).  Ribeirão Preto.  (11/01328-4

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