CV Lattes
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ORCID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Bandeirante de São Paulo (1999) and ph.d. at Cancerology from Fundação Antônio Prudente (2004). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: prpc, vitronectin, neurite outgrowth, axonal growth and sti1. (Source: Lattes Curriculum)
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Laboratory animals play a crucial role in advancing biomedical research, ensuring the quality and reproducibility of experiments. The essential contribution of these models is underscored by the fact that 186 out of 222 Nobel laureates in Physiology or Medicine utilized laboratory animals in their research. The Covid-19 pandemic has reiterated the critical contribution of laboratory anima…
Glioblastoma (GBM), the most aggressive and frequent form of brain malignant tumors in adults, contains a subpopulation of tumor cells called GBM stem cells (GSCs), essential for tumor maintenance, invasion and resistance to therapy. Functionally relevant GSCs plasma membrane markers present potential as a therapeutic target for the treatment of this aggressive disease. Our group has show…
Pluripotent cells have the potential to differentiate into all cell types of an organism and understanding the mechanisms that govern pluripotency status is crucial for regenerative medicine. Evidence indicates the involvement of the proteostasis machinery, regulated by the heat shock organizing protein/stress inducible protein 1 (STIP1) and its ligands, Hsp70 and Hsp90, in embryogenesis …
(Only some records are available in English at this moment)
Stem cells have the ability to differentiate into various cell types and self-renew, being classified according to their level of specialization. Induced pluripotent stem cells (iPSCs) are pluripotent cells reprogrammed from adult somatic cells through the use of specific transcription factors. The control of pluripotency involves the coordinated function of various components, such as tr…
Autism Spectrum Disorder (ASD) is believed to affect 1 in 100 children worldwide and encompasses a range of neurodevelopmental conditions characterized by impairments in social interaction, communication deficits, and stereotyped behaviors. ASD's etiology involves a complex interplay of genetic, epigenetic, metabolic, immunological and environmental factors. Its heterogeneity further chal…
Mouse embryonic stem cells (mESCs) have long been the subject of biomedical research due to their pluripotency, the ability to give rise to the three embryonic germ layers. Pluripotent status is finely regulated by a complex network of transcription factors, such as the central triad of Oct4, Sox2 and Nanog, as well as by extensive secondary networks that assume a supporting role accordin…
(Only some records are available in English at this moment)
Glioblastoma (GBM) is an extremely aggressive, recurrent, and incurable tumor characterized by significant cellular and molecular heterogeneity, posing a challenge for advancements in its therapy and scientific research modeling. GBM is sustained by a subpopulation of glioblastoma stem cells (GSCs) responsible for promoting angiogenesis, invasion, and therapy resistance. Preclinical model…
The glioblastoma (GBM) is an extremely lethal brain tumor in adults for which there is no effective therapy. Many factors contribute to its aggressiveness, namely the high cellular and molecular heterogeneity and the presence of glioblastoma stem-cells (GSCs), crucial for the treatment resistance and tumor recurrence. Several evidence shows that the gene expression of the cellular prion p…
Pluripotency is the transient ability to differentiate in the three embryonic leaflets, which varies according to the stages of early embryonic development. The pluripotent status characteristic of pluripotent stem cells (PSCs) is regulated by a network of characteristic transcription factors (TFs) that change according to pro-differentiation or pro-pluripotency stimuli. Alongside these T…
(Only some records are available in English at this moment)
Glioblastoma (GBM), sustained by a subpopulation of stem cells (GSCs), continues to confer an unfavorable prognosis, with a median overall survival of 12-18 months, despite implementing a multimodal therapeutic approach. This condition remains a challenge for advancements in therapeutic strategies and research modeling. GBM is a heterogeneous tumor, and the development of high-throughput …
Glioblastoma (GBM) is a deadly brain tumor with a survival rate of less than two years and its high aggressiveness is sustained by a subpopulation of tumor stem cells known as glioblastoma stem-like cells (GSCs). GSCs are involved in chemotherapy resistance and tumor recurrence and have the prion protein (PrPC), a cell surface molecule, as a potential marker and essential player in their …
Induced pluripotent stem cells (iPSCs) are one of the most important biological tools for the study of human development, cellular senescence, and neurodegenerative diseases, with a great appeal for patient-specific research and therapy. iPSCs, like embryonic stem cells (ESCs), present increased mechanisms for protein homeostasis (proteostasis) regulation, that added to the other know pat…
The cellular prion protein, a glycoprotein abundantly expressed in central nervous system (CNS), present neurotrophic potential through the formation of multiprotein complexes with several ligands on the cell surface. Glioblastoma, a type of CNS tumor, extremely aggressive and 100% lethal, contains a subpopulation of cells responsible for therapy resistance, the glioblastoma stem cells (G…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 12 / 10 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 37 / 32 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 62 / 55 | All research grants and scholarships |
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