CV Lattes
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ORCID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Bandeirante de São Paulo (1999) and ph.d. at Cancerology from Fundação Antônio Prudente (2004). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: prpc, vitronectin, neurite outgrowth, axonal growth and sti1. (Source: Lattes Curriculum)
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Glioblastoma (GBM), the most aggressive and frequent form of brain malignant tumors in adults, contains a subpopulation of tumor cells called GBM stem cells (GSCs), essential for tumor maintenance, invasion and resistance to therapy. Functionally relevant GSCs plasma membrane markers present potential as a therapeutic target for the treatment of this aggressive disease. Our group has show…
Pluripotent cells have the potential to differentiate into all cell types of an organism and understanding the mechanisms that govern pluripotency status is crucial for regenerative medicine. Evidence indicates the involvement of the proteostasis machinery, regulated by the heat shock organizing protein/stress inducible protein 1 (STIP1) and its ligands, Hsp70 and Hsp90, in embryogenesis …
Glioblastoma (GBM), the most aggressive and frequent form of brain malignant tumors in adults, contains a subpopulation of tumor cells, called GBM stem cells (GSC), essential for tumor maintenance, metastasis and resistance to therapy. GSC plasma membrane markers functionally relevant present potential as a therapeutic target for the treatment of this aggressive disease. Our group has sho…
(Only some records are available in English at this moment)
The glioblastoma (GBM) is a lethal brain tumor with a low life expectancy after diagnosis. It comprises several cell types that communicate through extracellular vesicles (EVs). Through miRNAs, proteins, lipids, and DNA, EVs can mediate cell-to-cell communication. Stem cells/neural precursors (NSCs) are responsible for brain neurogenesis and may be involved in the processes of emergence, …
Glioblastoma Multiforme (GBM) is a highly aggressive glial tumor, with a high recurrence and death rates. Recent studies indicate that the GBM is maintained by a subpopulation of cellswith stem-cell characteristics, denominated Glioblastoma Stem Cells (GSCs). Recently ourgroup has identified the Cellular Prion Protein as having an important role in the modulationof the GSCs undifferentiat…
Patient-derived xenografts (PDX) are a relevant approach to the study of glioblastomas (GBM) since these cells mimic tumor characteristics in vitro. GBM is the most aggressive and difficult-to-treat primary brain tumor, and its high malignancy and resistance to therapy are due, among other factors, to a subpopulation of tumor stem cells known as glioblastoma stem-like cells (GSCs). Althou…
(Only some records are available in English at this moment)
Pluripotent stem cells (PSCs) are capable of self-renewing, in addition to differentiating into any cell type of the adult organism, a characteristic known as pluripotency. These abilities are due, in part, to the network of protein homeostasis, or proteostasis, of which the Stress Inducible Protein 1 (STI1) protein stands out for its dynamism. STI1 is a co-chaperone that assists in many …
The Glioblastoma Multiforme (GBM) is a highly aggressive glial tumor, with a high recurrence and death rates. Within the tumor mass, there are groups of cells that have features of stem/progenitor cells, named glioblastoma stem cells (GSCs) and possess large potential for proliferation and differentiation. GSCs have an important role in growth, maintenance and recurrence of cancer, even a…
Pluripotent stem cells (PSCs), among them as embryonic stem cells(ESCs), have differentiation capacity in all adult somatic lines withoutsenescence, a characteristic known as pluripotency. Pluripotent status is transient inbut can be maintained in vitro by culturing cells in thepathways that regulate differentiation processes, including a leukemia molecule inhibiting factor(LIF). Several …
(Only some records are available in English at this moment)
Induced pluripotent stem cells (iPSCs) are one of the most important biological tools for the study of human development, cellular senescence, and neurodegenerative diseases, with a great appeal for patient-specific research and therapy. iPSCs, like embryonic stem cells (ESCs), present increased mechanisms for protein homeostasis (proteostasis) regulation, that added to the other know pat…
The cellular prion protein, a glycoprotein abundantly expressed in central nervous system (CNS), present neurotrophic potential through the formation of multiprotein complexes with several ligands on the cell surface. Glioblastoma, a type of CNS tumor, extremely aggressive and 100% lethal, contains a subpopulation of cells responsible for therapy resistance, the glioblastoma stem cells (G…
The glioblastoma multiforme (GBM) is a tumor composed of glial cells. GBM is by far the most common and most malignant type of glioma, with high rates of recurrence and mortality. Studies have shown that GBM is maintained by stem cells like subpopulation denominated glioblastoma stem cells (GSCs). These cells self-renew, promote angiogenesis and invasion, and are also chemo and radio-resi…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 11 / 9 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 28 / 23 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 52 / 45 | All research grants and scholarships |
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