Marilene Hohmuth Lopes
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Bandeirante de São Paulo (1999) and ph.d. at Cancerology from Fundação Antônio Prudente (2004). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: prpc, vitronectin, neurite outgrowth, axonal growth and sti1. (Source: Lattes Curriculum)
- Prion protein and its partners: emerging targets for glioblastoma stem cell based-therapy, AP.JP2
Abstract
Glioblastoma (GBM), the most aggressive and frequent form of brain malignant tumors in adults, contains a subpopulation of tumor cells called GBM stem cells (GSCs), essential for tumor maintenance, invasion and resistance to therapy. Functionally relevant GSCs plasma membrane markers present potential as a therapeutic target for the treatment of this aggressive disease. Our group has sh...
- Regulation of proteostasis in pluripotent stem cells by the co-chaperone STIP1, AP.R
Abstract
Pluripotent cells have the potential to differentiate into all cell types of an organism and understanding the mechanisms that govern pluripotency status is crucial for regenerative medicine. Evidence indicates the involvement of the proteostasis machinery, regulated by the heat shock organizing protein/stress inducible protein 1 (STIP1) and its ligands, Hsp70 and Hsp90, in embryogenesi...
- Role of prion protein in the dynamic of multiprotein signaling modules related to stemness of glioblastoma stem cells: its functional role and potential therapeutic target, AP.R
Abstract
Glioblastoma (GBM), the most aggressive and frequent form of brain malignant tumors in adults, contains a subpopulation of tumor cells, called GBM stem cells (GSC), essential for tumor maintenance, metastasis and resistance to therapy. GSC plasma membrane markers functionally relevant present potential as a therapeutic target for the treatment of this aggressive disease. Our group has s...
- New insights of stress proteins in health and disease: chaperones and beyond, AO.R
- Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells, PUB.ART
Abstract
Background: Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastomastem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance. GSCs are thereforea promising target for GBM treatment. Our group identified the cellular prion protein (PrPC) and its partner, theco-chaperone Hsp70/90 organizing protein (HOP), as pot...
- Stem cells in developmental biology and cancer, AO.R
(Only some records are available in English at this moment)
- Characterization of intracellular signaling pathways modulated by the cellular prion protein on stemness maintenance in glioblastoma stem cells, BP.PD
Abstract
Among all tumors of the Central Nervous System (CNS), Glioblastoma Multiforme (GBM) is the most aggressive and resistant to standard treatments. Despite many studies, the mean survival of patients is only 15 months. Within the tumor mass, there are groups of cells that have features of stem/progenitor cells, named glioblastoma stem cells (GSCs) and possess large potential for proliferat...
- Analysis of differentially expressed genes in PRNPlow and PRNPhigh patient-derived glioblastoma stem cells, BP.IC
Abstract
The Glioblastoma Multiforme is a highly aggressive tumor, with a high recurrence and death rates. Studies have shown that the GBM is sustained by a subpopulation of cells with stem cells- like characteristics, denominated Glioblastoma Stem Cells. Those cells are resistant to chemo and radiotherapy, and are responsible for the low success rate of treatments in this tumor. Our group has d...
- Evaluation of pluripotency and self-renewal of murine embryonic stem cells with differential expression of STI1, BP.IC
Abstract
Stress Inducible Protein 1 (STI1) is a protein constitutively expressed in differentorganisms since the earliest stages of embryonic development. Among the importantbiological roles played by STI1, its performance as cochaperone, forming a complexbetween the Hsp70-Hsp90 heat shock proteins, is of particular importance, helping inthe activity of these chaperones through the hydrolysis of...
(Only some records are available in English at this moment)
- Study of STI1 function secreted during neuronal differentiation of murine embryonic stem cells, BP.IC
Abstract
The generation of neurons and glial cells during embryonic development comprises a number of networks and complex control mechanisms increasingly studied. There are numerous intrinsic cellular mechanisms (such as transcriptional regulation, cell cycle, internal signaling pathways) and extrinsic (soluble factors, signal molecules secreted by surrounding cells, extracellular matrix, etc.)...
- Impact of the depletion of the co-chaperone STI1 in the control of pluripotency, proliferation and differentiation of murine embryonic stem cells, BP.DD
Abstract
STI1 (Stress Inducible Protein 1) was originally characterized as a co-chaperonin that interacts with heat shock proteins Hsp70 and Hsp90 and regulates its activity in the control of protein folding. However, recent studies demonstrate its broad functional versatility and show its mediation in neurotrophic effects in biological processes such as neuritogenesis, neuroprotection, developm...
- Study of the MAPK/ERK pathway in the proliferation of glioblastoma stem cells induced by the PrPC-STI1 complex, BP.IC
Abstract
Glioblastoma multiforme (GBM) is a tumor derived from glial cells, and is considered one of the most agressive type, with a high rate of recurrence and death. Currently, there is no effective treatment for this disease and its spread pattern prevents the complete removal by surgery.Studies show that the GBM is maintained by a subpopulation of cells with stem cell characteristics, the gl...
(Only some records are available in English at this moment)
- The impact of cellular prion protein depletion in the modulation of signaling pathways and expression of prion-like proteins in glioblastoma stem cell biology, BE.EP.DD
Abstract
The glioblastoma multiforme (GBM) is a tumor composed of glial cells. GBM is by far the most common and most malignant type of glioma, with high rates of recurrence and mortality. Studies have shown that GBM is maintained by stem cells like subpopulation denominated glioblastoma stem cells (GSCs). These cells self-renew, promote angiogenesis and invasion, and are also chemo and radio-re...
- Impact of co-chaperone STIP1 expression in the pluripotency acquision induced by Oct4 in murine fibroblasts, BE.PQ
Abstract
Pluripotent cell have the potential to differentiate into all of the cell typesof an animal. This unique cell state is governed by an interconnected network of transcription factors, being Oct4 a central player in pluripotency induction and maintenance. Evidence pointed out to the participation of proteostase machinary regulated by co-chaperone STIP1 (Stress Inducible Phosphoprotein 1) ...
- Extracellular vesicles function during neural differentiation of mouse embryonic stem cells, BE.EP.DD
Abstract
Within each such microenvironment, stem cells process and sense multiple signals, which can exert influences that collectively regulate cell fate and function in a time-spatial manner. In this context, the stem cells can exert their biologic role transferring genetic information and altering the genetic expression of target cells through extracellular vesicles. MicroRNAs (miRNAs), a cla...
| 3 / 3 | Ongoing research grants |
| 9 / 7 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 15 / 10 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 39 / 32 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 166 |
| Cit./Article | 13.8 |
| Data from Web of Science | |
WASILEWSKA-SAMPAIO, ANA PAULA; SANTOS, TIAGO G.; LOPES, MARILENE HOHMUTH; CAMMAROTA, MARTIN; MARTINS, VILMA REGINA. The growth of glioblastoma orthotopic xenografts in nude mice is directly correlated with impaired object recognition memory. Physiology & Behavior, v. 123, p. 55-61, JAN 17 2014. Web of Science Citations: 4. (09/14027-2)
LOPES, M. H.; SANTOS, T. G.; RODRIGUES, B. R.; QUEIROZ-HAZARBASSANOV, N.; CUNHA, I. W.; WASILEWSKA-SAMPAIO, A. P.; COSTA-SILVA, B.; MARCHI, F. A.; BLEGGI-TORRES, L. F.; SANEMATSU, P. I.; et al. Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival. Oncogene, v. 34, n. 25, p. 3305-3314, JUN 2015. Web of Science Citations: 13. (09/14027-2, 10/20796-6, 12/19019-0, 04/12133-6, 07/08410-2)
SANTOS, TIAGO G.; LOPES, MARILENE H.; MARTINS, VILMA R.. Targeting prion protein interactions in cancer. PRION, v. 9, n. 3, p. 165-173, MAY 4 2015. Web of Science Citations: 14. (09/14027-2, 11/13906-2)
RODRIGUES, BRUNA R.; QUEIROZ-HAZARBASSANOV, NICOLLE; LOPES, MARILENE H.; BLEGGI-TORRES, LUIS F.; SUZUKI, SERGIO; CUNHA, ISABELA W.; SANEMATSU, PAULO; MARTINS, VILMA R.. Nuclear unphosphorylated STAT3 correlates with a worse prognosis in human glioblastoma. PATHOLOGY RESEARCH AND PRACTICE, v. 212, n. 6, p. 517-523, 2016. Web of Science Citations: 6. (09/14027-2, 10/13654-0)
ROMANO, SEBASTIAN A.; CORDEIRO, YRAIMA; LIMA, LUIS MAURICIO T. R.; LOPES, MARILENE H.; SILVA, JERSON L.; FOGUEL, DEBORA; LINDEN, RAFAEL. Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1. FASEB JOURNAL, v. 23, n. 12, p. 4308-4316, DEC 2009. Web of Science Citations: 15. (03/13189-2)
IGLESIA, REBECA PIATNICZKA; PRADO, MARIANA BRANDAO; CRUZ, LILIAN; MARTINS, VILMA REGINA; SANTOS, TIAGO GOSS; LOPES, MARILENE HOHMUTH. Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells. STEM CELL RESEARCH & THERAPY, v. 8, APR 17 2017. Web of Science Citations: 2. (13/19860-0, 09/14027-2, 15/04122-9, 11/13906-2)
CRUZ, LILIAN; AREVALO ROMERO, JENNY ANDREA; PRADO, MARIANA BRANDAO; SANTOS, TIAGO G.; LOPES, MARILENE HOHMUTH. Evidence of Extracellular Vesicles Biogenesis and Release in Mouse Embryonic Stem Cells. STEM CELL REVIEWS AND REPORTS, v. 14, n. 2, p. 262-276, APR 2018. Web of Science Citations: 5. (14/17385-5, 13/22078-1, 11/13906-2)
DE LIMA FERNANDES, CAMILA FELIX; IGLESIA, REBECA PIATNICZKA; MELO-ESCOBAR, MARIA ISABEL; PRADO, MARIANA BRANDAO; LOPES, MARILENE HOHMUTH. Chaperones and Beyond as Key Players in Pluripotency Maintenance. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 7, AUG 2 2019. Web of Science Citations: 0. (18/15557-4, 17/26158-0, 18/19320-9, 17/20271-0, 19/12710-9, 19/11097-1)
SANTOS, TIAGO G.; SILVA, IARA R.; COSTA-SILVA, BRUNO; LEPIQUE, ANA PAULA; MARTINS, VILMA R.; LOPES, MARILENE H.. Enhanced Neural Progenitor/Stem Cells Self-Renewal via the Interaction of Stress-Inducible Protein 1 with the Prion Protein. Stem Cells, v. 29, n. 7, p. 1126-1136, JUL 2011. Web of Science Citations: 41. (09/14027-2, 03/13189-2, 07/08410-2)
HAJJ, GLAUCIA N. M.; ARANTES, CAMILA P.; SALLES DIAS, MARCOS VINICIOS; ROFFE, MARTIN; COSTA-SILVA, BRUNO; LOPES, MARILENE H.; PORTO-CARREIRO, ISABEL; RABACHINI, TATIANA; LIMA, FLAVIA R.; BERALDO, FLAVIO H.; et al. The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 70, n. 17, p. 3211-3227, SEP 2013. Web of Science Citations: 21. (09/14027-2, 12/04370-4)
ARANTES, CAMILA; NOMIZ, REGINA; LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; LIMA, FLAVIA R. S.; MARTINS, VILMA R.. Prion Protein and Its Ligand Stress Inducible Protein 1 Regulate Astrocyte Development. Glia, v. 57, n. 13, p. 1439-1449, OCT 2009. Web of Science Citations: 39. (03/13189-2)
CRUZ, LILIAN; ROMERO, JENNY A. A.; IGLESIA, REBECA P.; LOPES, MARILENE H.. Extracellular Vesicles: Decoding a New Language for Cellular Communication in Early Embryonic Development. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 6, AUG 28 2018. Web of Science Citations: 6. (13/19860-0, 14/17385-5, 11/13906-2, 17/20271-0, 13/22078-1)
LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; MURAS, ANGELITA G.; MANCINI, GABRIEL L.; CASTRO, ROSA M. P. S.; RIBEIRO, KARINA C. B.; BRENTANI, RICARDO R.; LINDEN, RAFAEL; MARTINS, VILMA R.. Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways. JOURNAL OF NEUROSCIENCE, v. 25, n. 49, p. 11330-11339, Dec. 2005. (03/13189-2)
COITINHO, ADRIANA S.; LOPES, MARILENE H.; HAJJ, GLAUCIA N. M.; ROSSATO, JANINE I.; FREITAS, ADRIANA R.; CASTRO, CIBELE C.; CAMMAROTA, MARTIN; BRENTANI, RICARDO R.; IZQUIERDO, IVAN; MARTINS, VILMA R.. Short-term memory formation and long-term memory consolidation are enhanced by cellular prion association to stress-inducible protein 1. Neurobiology of Disease, v. 26, n. 1, p. 282-290, Apr. 2007. (03/13189-2)
HAJJ, GLAUCIA N. M.; LOPES, MARILENE H.; MERCADANTE, ADRIANA F.; VEIGA, SILVIO S.; SILVEIRA, RAFAEL B. DA; SANTOS, TIAGO G.; RIBEIRO, KARINA C. B.; JULIANO, MARIA A.; JACCHIERI, SAUL G.; ZANATA, SILVIO M.; et al. Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins. Journal of Cell Science, v. 120, n. 11, p. 1915-1926, May 2007. (03-13189-2, 99/07124-8)
ZANATA, SILVIO M.; LOPES, MARILENE H.; MERCADANTE, ADRIANA F.; HAJJ, GLAUCIA N. M.; CHIARINI, LUCIANA B.; NOMIZO, REGINA; FREITAS, ADRIANA R. O.; CABRAL, ANA L. B.; LEE, KIL S.; JULIANO, MARIA A.; et al. Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. EMBO Journal, v. 21, n. 13, p. 3307-3316, July 2002. (99/07124-8)
(References retrieved automatically from State of São Paulo Research Institutions)
IGLESIA, Rebeca Piatniczka. Estudo da interação entre PrPC e STI1/HOP na biologia de células-tronco de glioblastoma humano in vivo.. 2017. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (13/19860-0)
CRUZ, Lilian. Perfil de miRNAs intracelulares e liberados via vesículas extracelulares na diferenciação neural de células-tronco pluripotentes.. 2017. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (13/22078-1)
ROMERO, Jenny Andrea Arévalo. Impacto da depleção da co-chaperonina STIP1 no controle da pluripotência, proliferação e diferenciação de células-tronco embrionárias murinas.. 2017. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (14/17385-5)