CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Bandeirante de São Paulo (1999) and ph.d. at Cancerology from Fundação Antônio Prudente (2004). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: prpc, vitronectin, neurite outgrowth, axonal growth and sti1. (Source: Lattes Curriculum)
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Pluripotent cells have the potential to differentiate into all cell types of an organism and understanding the mechanisms that govern pluripotency status is crucial for regenerative medicine. Evidence indicates the involvement of the proteostasis machinery, regulated by the heat shock organizing protein/stress inducible protein 1 (STIP1) and its ligands, Hsp70 and Hsp90, in embryogenesis …
Glioblastoma (GBM), the most aggressive and frequent form of brain malignant tumors in adults, contains a subpopulation of tumor cells called GBM stem cells (GSCs), essential for tumor maintenance, invasion and resistance to therapy. Functionally relevant GSCs plasma membrane markers present potential as a therapeutic target for the treatment of this aggressive disease. Our group has show…
Glioblastoma (GBM), the most aggressive and frequent form of brain malignant tumors in adults, contains a subpopulation of tumor cells, called GBM stem cells (GSC), essential for tumor maintenance, metastasis and resistance to therapy. GSC plasma membrane markers functionally relevant present potential as a therapeutic target for the treatment of this aggressive disease. Our group has sho…
Background: Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastomastem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance. GSCs are thereforea promising target for GBM treatment. Our group identified the cellular prion protein (PrPC) and its partner, theco-chaperone Hsp70/90 organizing protein (HOP), as poten…
(Only some records are available in English at this moment)
The Glioblastoma Multiforme is a highly aggressive glial tumor, with high recurrence and death rates. Recent studies indicate that the GBM is maintained by a sub-population of cells with stem-cell characteristics, denominated Glioblastoma Stem Cells (GSCs). Recently our group has identified the cellular prion protein as having an important role in the modulation of the GSCs undifferentiat…
Pluripotent stem cells (PSCs), among them as embryonic stem cells(ESCs), have differentiation capacity in all adult somatic lines withoutsenescence, a characteristic known as pluripotency. Pluripotent status is transient inbut can be maintained in vitro by culturing cells in thepathways that regulate differentiation processes, including a leukemia molecule inhibiting factor(LIF). Several …
Glioblatoma Multifome (GBM) is a highly aggressive and lethal type of tumor derived from glial cells. Its high recurrence rate can be attributed to its resistance to conventional treatments and diffuse growth pattern. Studies show that GBM is maintained by a subpopulation of cells with stem cell like characteristics, denominated Glioblastoma Stem Cells (GSCs). These cells can give rise to…
(Only some records are available in English at this moment)
Pluripotent stem cells (PSCs) are capable of self-renewing, in addition to differentiating into any cell type of the adult organism, a characteristic known as pluripotency. These abilities are due, in part, to the network of protein homeostasis, or proteostasis, of which the Stress Inducible Protein 1 (STI1) protein stands out for its dynamism. STI1 is a co-chaperone that assists in many …
The Glioblastoma Multiforme (GBM) is a highly aggressive glial tumor, with a high recurrence and death rates. Within the tumor mass, there are groups of cells that have features of stem/progenitor cells, named glioblastoma stem cells (GSCs) and possess large potential for proliferation and differentiation. GSCs have an important role in growth, maintenance and recurrence of cancer, even a…
Stress Inducible Protein 1 (STI1) corresponds to an evolutionary conserved protein, formed by three repetitive tetratricopeptides domains, and two additional domains rich in aspartate and proline. The structure of STI1 is closely associated with its multifunctionality in cells, being found in the cytoplasm, nucleus and extracellular environment. One of the main functions of STI1 is its ro…
(Only some records are available in English at this moment)
Induced pluripotent stem cells (iPSCs) are one of the most important biological tools for the study of human development, cellular senescence, and neurodegenerative diseases, with a great appeal for patient-specific research and therapy. iPSCs, like embryonic stem cells (ESCs), present increased mechanisms for protein homeostasis (proteostasis) regulation, that added to the other know pat…
The cellular prion protein, a glycoprotein abundantly expressed in central nervous system (CNS), present neurotrophic potential through the formation of multiprotein complexes with several ligands on the cell surface. Glioblastoma, a type of CNS tumor, extremely aggressive and 100% lethal, contains a subpopulation of cells responsible for therapy resistance, the glioblastoma stem cells (G…
The glioblastoma multiforme (GBM) is a tumor composed of glial cells. GBM is by far the most common and most malignant type of glioma, with high rates of recurrence and mortality. Studies have shown that GBM is maintained by stem cells like subpopulation denominated glioblastoma stem cells (GSCs). These cells self-renew, promote angiogenesis and invasion, and are also chemo and radio-resi…
Pluripotent cell have the potential to differentiate into all of the cell typesof an animal. This unique cell state is governed by an interconnected network of transcription factors, being Oct4 a central player in pluripotency induction and maintenance. Evidence pointed out to the participation of proteostase machinary regulated by co-chaperone STIP1 (Stress Inducible Phosphoprotein 1) an…
Within each such microenvironment, stem cells process and sense multiple signals, which can exert influences that collectively regulate cell fate and function in a time-spatial manner. In this context, the stem cells can exert their biologic role transferring genetic information and altering the genetic expression of target cells through extracellular vesicles. MicroRNAs (miRNAs), a class…
| 2 / 2 | Ongoing research grants |
| 10 / 8 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 25 / 20 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 48 / 41 | All research grants and scholarships |
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