CV Lattes
ORCID
Google Scholar Citations
Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's in Biomedical Sciences (1995) and Ph.D. in Molecular Biology (2000) at Federal University of Sao Paulo (UNIFESP-EPM). Pos-Doctoral Fellow at Heart Institute (InCor - University of Sao Paulo Medical School - HCFMUSP), Research Fellow at Brigham and Women´s Hospital and Harvard Medical School (2010-2012) and Research Affiliated at Harvard-MIT Division of Health Sciences and Technology (2010-2012). She is a Principal Investigator in the Laboratory of Genetics and Molecular Cardiology and coordinates the Vascular Biology group focused on mechanotransduction and vascular remodeling. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Smooth muscle cells (SMCs) are the major cellular component of the media layer of the vascular wall. They control the contractile properties of the vessel thus modulating the blood flow. It is well demonstrated that vascular mechanical stresses are related to the development of diseases such as atherosclerosis, aneurysm and vein graft disease. Our group has demonstrated that cysteine and …
About 8% of men aged over 65 years show abdominal aortic aneurysms (AAA) and over 80% of patients where and AAA are ruptured die. The AAA formation involves the rupture of extracellular matrix fibers and loss of smooth muscle cells leading to the vascular wall narrowing. The underlying molecular mechanisms of how AAA develops are unknown. During the aneurysm development, there is an incre…
The aortic aneurysm formation is characterized by inflammation with lymphocyte and macrophage infiltration, rupture of elastic and collagen fibers at media and adventitia layers, and loss of smooth muscle cells leading to the vascular wall narrowing. The inflammatory cells secrete cytokines and proteases that induce smooth muscle cell death and extracellular degradation. We have demonstra…
Focal adhesions are structures capable of sensing changes in the extracellular matrix (ECM) and modulating the tension of actin fibers, thereby altering cellular phenotype. The factors influencing this process are not fully understood, and in our Fapesp project 2023/03079-9, we are testing the hypothesis that Crp3 modulates signaling in focal adhesions, influencing the contractility of ao…
Saphenous vein graft is widely used for cardiac revascularization in ischemic myocardium. However, adaptive response to the new hemodynamic condition predisposes the vein graft to occlusion due to the remodeling with increased extracellular matrix and cells expressing ±-SMA. Experimental evidence demonstrates that endothelial to mesenchymal transition (EndMT) is one source of ±-SMA positi…
| 1 / 1 | Ongoing grants |
| 3 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 5 / 2 | Completed scholarships in Brazil |
| 11 / 7 | All research grants and scholarships |
| Associated processes | |