- Research Grants
Bachelor's in Biomedical Sciences (1995) and Ph.D. in Molecular Biology (2000) at Federal University of Sao Paulo (UNIFESP-EPM). Pos-Doctoral Fellow at Heart Institute (InCor - University of Sao Paulo Medical School - HCFMUSP), Research Fellow at Brigham and Women´s Hospital and Harvard Medical School (2010-2012) and Research Affiliated at Harvard-MIT Division of Health Sciences and Technology (2010-2012). She is a Principal Investigator in the Laboratory of Genetics and Molecular Cardiology and coordinates the Vascular Biology group focused on mechanotransduction and vascular remodeling. (Source: Lattes Curriculum)
|News published in Agência FAPESP Newsletter about the researcher|
|Protein could extend saphenous vein graft durability|
About 8% of men aged over 65 years show abdominal aortic aneurysms (AAA) and over 80% of patients where and AAA are ruptured die. The AAA formation involves the rupture of extracellular matrix fibers and loss of smooth muscle cells leading to the vascular wall narrowing. The underlying molecular mechanisms of how AAA develops are unknown. During the aneurysm development, there is an inc...
The aortic aneurysm formation is characterized by inflammation with lymphocyte and macrophage infiltration, rupture of elastic and collagen fibers at media and adventitia layers, and loss of smooth muscle cells leading to the vascular wall narrowing. The inflammatory cells secrete cytokines and proteases that induce smooth muscle cell death and extracellular degradation. We have demonst...
Saphenous vein graft is widely used for cardiac revascularization in ischemic myocardium. However, adaptive response to the new hemodynamic condition predisposes the vein graft to occlusion due to the remodeling with increased extracellular matrix and cells expressing ±-SMA. Experimental evidence demonstrates that endothelial to mesenchymal transition (EndMT) is one source of ±-SMA posi...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|