CV Lattes
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Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor's at Odontology from Universidade Estadual de Ponta Grossa (1999), master's at Imunologia Basica E Aplicada from Faculdade de Medicina de Ribeirao Preto (2002) and doctorate at Imunologia Basica e Aplicada from Faculdade de Medicina de Ribeirao Preto (2005). Has experience in Morphology, focusing on Histology, acting on the following subjects: chemokines, doença periodontal, cytokines, imunologia and quimiocinas. (Source: Lattes Curriculum)
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Variations in the nature of inflammatory immune response, which include variations in its intensity, extent and the involvement of different cellular subsets and the polarization of immune response, allow the conclusion that the interaction of inflammatory immune response with bone tissue can result in destructive or constructive outcomes. While the destructive responses nature is relativ…
Chronic periodontitis is a complex disease involving the interaction between infecting microorganisms and the host´s immune/inflammatory response. Genetic factors can modulate the host´s ability to cope with the bacterial challenge tipping the balance towards a resistant or susceptible phenotype, characterized by the occurrence and extent of irreversible tooth attachment loss. Nevertheles…
Studies have shown that the nature (transient or chronic) and the magnitude of the inflammatory and immunological response, generated by a biomaterial, may be decisive in the implant success or failure. Macrophages play a critical role in host response to a biomaterial grafting, and in this context, the chemokines receptors CCR2 and CCR5 play a critical role in this response, since macrop…
The establishment, progression and outcome of chronic periapical lesions, albeit dependent on the presence of pathogenic microorganisms, are highly dependent of the nature of host inflammatory immune response in periapical environment. In this scenario, distinct subsets of lymphocytes and its prototypical cytokines have been implicated in such lesions pathogenesis, being recently Th17 and…
(Only some records are available in English at this moment)
Studies suggest that the inflammatory immune response, since presenting a profile of controlled and self-limited nature, is important in the repair and osseointegration process, contributing possibly as a mediator of the chemoattraction, activation and differentiation of several cell types involved in the repair. Among the different cell types recruited during the response, macrophages ar…
Bone tissue is a mineralized tissue, characterized by its plasticity, derived from the remodeling process, in which bone resorption followed by neoformation occurs coordinated through a dynamic balance of osteoblast and osteoclast activity, as well as high tissue repair capacity. Recently, the study of the interaction between the immune and skeletal systems has received special attention …
The biomaterial implantation leads to an immune / inflammatory response that may be decisive for clinical success. Titanium (Ti) devices, such as osseointegrated implants, when implanted result in a transient low magnitude inflammatory process, compatible with the constructive inflammation, essential for triggering the osseointegration process. Previous results demonstrate the presence of…
(Only some records are available in English at this moment)
Inflammatory process associated with bone tissue, depending on the cell elements involved and mediators produced, may be destructive or constructive. While most of the knowledge of osteoimmunology derives from chronic inflammatory models that characterize 'destructive inflammation', recent studies have advanced the understanding of 'constructive inflammation' associated with tissue repair…
Periodontitis is initiated by accumulation of bacteria on the surface of the teeth and host factors are involved in the determination of susceptibility/resistance to microbial challenge, being such factors under the influence of multiple genetic loci. Studies in humans and in experimental models have supported the influence of genes in the determination of susceptibility/resistance phenot…
Bone is a mineralized tissue, with support functions, protection, transportation and reserves of minerals; that in the oral cavity, plays an important role in sustaining the teeth. Within the osteoimmunological processes, macrophages (classically pro-inflammatory considered) may present different functional phenotypes, called M1 and M2. The presence or absence of macrophages, as well as c…
(Only some records are available in English at this moment)
Chronic periodontitis and periapical diseases are the leading cause for tooth loss in adults. Both periodontal and periapical lesions seem to share a common pathogenesis in which the establishment of a pathogenic microbiota (either in the gingival sulcus or the periapical region) triggers the host´s immune inflammatory response, which is in turn is responsible for the destruction of the t…
The integration and maintenance of permanent biomaterials, such as titanium(Ti)-based devices, depends on its ability to not elicit a damaging immune response and its capacity to trigger and support an appropriate healing process. However, the molecular and cellular basis of immediate and long-term host/biomaterial interaction is poorly understood, even in classical biomaterials such as T…
SUMMARY: Studies have shown that the nature (transient or chronic) and the magnitude of the inflammatory and immunological response, generated by an implantation, may be decisive in the clinical success or failure of the grafted material. Neutrophils and monocytes/macrophages are described to be recruited to the site of biomaterial implantation, but its role in generation and regulation o…
| 1 / 1 | Ongoing research grants |
| 6 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 22 / 20 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 36 / 33 | All research grants and scholarships |
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