Gustavo Pompermaier Garlet
CV Lattes
ResearcherID
Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor's at Odontology from Universidade Estadual de Ponta Grossa (1999), master's at Imunologia Basica E Aplicada from Faculdade de Medicina de Ribeirao Preto (2002) and doctorate at Imunologia Basica e Aplicada from Faculdade de Medicina de Ribeirao Preto (2005). Has experience in Morphology, focusing on Histology, acting on the following subjects: chemokines, doença periodontal, cytokines, imunologia and quimiocinas. (Source: Lattes Curriculum)
- MSCs and m2 as determinants of the constructive or destructive nature of inflammatory microenvironments associated with bone tissue, AP.TEM
Abstract
Variations in the nature of inflammatory immune response, which include variations in its intensity, extent and the involvement of different cellular subsets and the polarization of immune response, allow the conclusion that the interaction of inflammatory immune response with bone tissue can result in destructive or constructive outcomes. While the destructive responses nature is relat...
- Influence of genetic polymorphisms in the patterns of bacterial colonization and recolonization in chornic periodontitis patients, AP.R
Abstract
Chronic periodontitis is a complex disease involving the interaction between infecting microorganisms and the host´s immune/inflammatory response. Genetic factors can modulate the host´s ability to cope with the bacterial challenge tipping the balance towards a resistant or susceptible phenotype, characterized by the occurrence and extent of irreversible tooth attachment loss. Neverthel...
- In vivo role of CCR2 and CCR5 receptors in the imune and inflammatory response after a classic biomaterial (Ti) grafting, AP.R
Abstract
Studies have shown that the nature (transient or chronic) and the magnitude of the inflammatory and immunological response, generated by a biomaterial, may be decisive in the implant success or failure. Macrophages play a critical role in host response to a biomaterial grafting, and in this context, the chemokines receptors CCR2 and CCR5 play a critical role in this response, since macr...
- The role of Th17 and t regulatory (Tregs) cells in the immunomodulation of experimental periapial lesions, AP.R
Abstract
The establishment, progression and outcome of chronic periapical lesions, albeit dependent on the presence of pathogenic microorganisms, are highly dependent of the nature of host inflammatory immune response in periapical environment. In this scenario, distinct subsets of lymphocytes and its prototypical cytokines have been implicated in such lesions pathogenesis, being recently Th17 a...
(Only some records are available in English at this moment)
- Role of genotypes selected for minimum and maximum inflammatory reactivity in the response to biomaterials (Ti) grafting and in the subsequent osseointegration process in mice, BP.DR
Abstract
Studies suggest that the inflammatory immune response, since presenting a profile of controlled and self-limited nature, is important in the repair and osseointegration process, contributing possibly as a mediator of the chemoattraction, activation and differentiation of several cell types involved in the repair. Among the different cell types recruited during the response, macrophages ...
- Role of macrophage polarization towards M1 profile in the alveolar bone repair and osseointegration processes in mice, BP.DR
Abstract
Bone tissue is a mineralized tissue, characterized by its plasticity, derived from the remodeling process, in which bone resorption followed by neoformation occurs coordinated through a dynamic balance of osteoblast and osteoclast activity, as well as high tissue repair capacity. Recently, the study of the interaction between the immune and skeletal systems has received special attentio...
- Role of macrophage polarization for an M2 profile in the response to the implantation of classical biomaterials (Ti) and its impact on the repair and osseointegration processes, BP.PD
Abstract
The biomaterial implantation leads to an immune / inflammatory response that may be decisive for clinical success. Titanium (Ti) devices, such as osseointegrated implants, when implanted result in a transient low magnitude inflammatory process, compatible with the constructive inflammation, essential for triggering the osseointegration process. Previous results demonstrate the presence ...
(Only some records are available in English at this moment)
- Impact of Slc11a1 gene variants on response standards of the host and the determination of phenotypes resistance and susceptibility to periodontal diseases, BP.MS
Abstract
Periodontitis is initiated by accumulation of bacteria on the surface of the teeth and host factors are involved in the determination of susceptibility/resistance to microbial challenge, being such factors under the influence of multiple genetic loci. Studies in humans and in experimental models have supported the influence of genes in the determination of susceptibility/resistance phen...
- VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase-activating polypeptide) roles in M2 polarization and their impact on the alveolar bone repair process, BP.DR
Abstract
Bone is a mineralized tissue, with support functions, protection, transportation and reserves of minerals; that in the oral cavity, plays an important role in sustaining the teeth. Within the osteoimmunological processes, macrophages (classically pro-inflammatory considered) may present different functional phenotypes, called M1 and M2. The presence or absence of macrophages, as well as...
- Microtomographical, histological and molecular analysis of the role of the CCR5 receptor, and possible cooperative role of CCR2 receptor, in macrophage migration and its impact on the alveolar repair process post extraction in mice, BP.MS
Abstract
Macrophages play important roles in bone repair, including the control of immune response and inflammation, and regulating the transition between granulation tissue to osteogenesis and formation of new bone after an injury. In this context, chemokine receptors, such as CCR5 and CCR2, seems to be key players in the chemotaxis of monocytes/macrophages to sites of tissue injury. Consequent...
(Only some records are available in English at this moment)
- Potential common genetic susceptibility traits shared by chronic and apical periodontitis: focus on SNPs assessment followed by bioinformatics analysis including clinical, microbiological and inflammatory/immunological data, BE.EP.DR
Abstract
Chronic periodontitis and periapical diseases are the leading cause for tooth loss in adults. Both periodontal and periapical lesions seem to share a common pathogenesis in which the establishment of a pathogenic microbiota (either in the gingival sulcus or the periapical region) triggers the host´s immune inflammatory response, which is in turn is responsible for the destruction of the...
- Influence of biomaterial (Ti) experimental biological aging in the outcome of host response to biomaterial grafting in vivo and stem cells (SCAPs) differentiation in vitro, BE.EP.DR
Abstract
The integration and maintenance of permanent biomaterials, such as titanium(Ti)-based devices, depends on its ability to not elicit a damaging immune response and its capacity to trigger and support an appropriate healing process. However, the molecular and cellular basis of immediate and long-term host/biomaterial interaction is poorly understood, even in classical biomaterials such as...
- Role of DAMPs in the modulation on neutrophils and macrophages response to a classic biomaterial (titanium)in vitro, BE.EP.PD
Abstract
SUMMARY: Studies have shown that the nature (transient or chronic) and the magnitude of the inflammatory and immunological response, generated by an implantation, may be decisive in the clinical success or failure of the grafted material. Neutrophils and monocytes/macrophages are described to be recruited to the site of biomaterial implantation, but its role in generation and regulation...
| 1 / 1 | Ongoing research grants |
| 6 / 5 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 21 / 17 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 36 / 31 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 18 |
| Citations | 320 |
| Cit./Article | 17.8 |
| Data from Web of Science | |
MICHELLE DE CAMPOS SORIANI AZEVEDO; NATÁLIA MORTARI RAMUNO; LUCIANA RAQUEL VINCENZI FACHIN; MÔNICA TASSA; PATRÍCIA SAMMARCO ROSA; ANDREA DE FARIA FERNANDES BELONE; SUZANA MADEIRA DIÓRIO; CLEVERSON TEIXEIRA SOARES; GUSTAVO POMPERMAIER GARLET; ANA PAULA FAVARO TROMBONE. qPCR detection of Mycobacterium leprae in biopsies and slit skin smear of different leprosy clinical forms. Brazilian Journal of Infectious Diseases, v. 21, n. 1, p. 71-78, Fev. 2017. Web of Science Citations: 3. (09/06122-5)
ARAUJO-PIRES, ANA CLAUDIA; FRANCISCONI, CAROLINA FAVARO; BIGUETTI, CLAUDIA CRISTINA; CAVALLA, FRANCO; FABIO ARANHA, ANDREZA MARIA; LETRA, ARIADNE; FAVARO TROMBONE, ANA PAULA; FAVERI, MARCELO; SILVA, RENATO MENEZES; GARLET, GUSTAVO POMPERMAIER. Simultaneous analysis of T helper subsets (Th1, Th2, Th9, Th17, Th22, Tfh, Tr1 and Tregs) markers expression in periapical lesions reveals multiple cytokine clusters accountable for lesions activity and inactivity status. Journal of Applied Oral Science, v. 22, n. 4, p. 336-346, Jul. 2014. Web of Science Citations: 43. (13/05994-4, 12/15133-3)
GARLET, GUSTAVO P.; MARTINS JR., WALTER; FONSECA, BENEDITO A. L.; FERREIRA, BEATRIZ R.; SILVA, JOÃO S.. Matrix metalloproteinases, their physiological inhibitors and osteoclast factors are differentially regulated by the cytokine profile in human periodontal disease. Journal of Clinical Periodontology, v. 31, n. 8, p. 671-679, Aug. 2004.
GARLET, GUSTAVO P.; AVILA-CAMPOS, MARIO J.; MILANEZI, CRISTIANE M.; FEREIRA, BEATRIZ R.; SILVA, JOÃO S.. Actinobacillus actinomycetemcomitans-induced periodontal disease in mice: patterns of cytokine, chemokine, and chemokine receptor expression and leukocyte migration. Microbes and Infection, v. 7, n. 4, p. 738-747, Apr. 2004.
REPEKE, CARLOS EDUARDO; FERREIRA, JR., SAMUEL BARROS; VIEIRA, ANDREIA ESPINDOLA; SILVEIRA, ELCIA MARIA; AVILA-CAMPOS, MARIO JULIO; DA SILVA, JOAO SANTANA; SANTOS, CARLOS FERREIRA; CAMPANELLI, ANA PAULA; FAVARO TROMBONE, ANA PAULA; GARLET, GUSTAVO POMPERMAIER. Dose-Response Met-RANTES Treatment of Experimental Periodontitis: A Narrow Edge between the Disease Severity Attenuation and Infection Control. PLoS One, v. 6, n. 7, p. e22526, 2011. Web of Science Citations: 21.
GARLET, GUSTAVO POMPERMAIER; GIOZZA, SILVANA PEREIRA; SILVEIRA, ELCIA MARIA; CLAUDINO, MARCELA; SANTOS, SILVANE BRAGA; AVILA-CAMPOS, MARIO JULIO; MARTINS, JR., WALTER; CARDOSO, CRISTINA RIBEIRO; FAVARO TROMBONE, ANA PAULA; CAMPANELLI, ANA PAULA; et al. Association of Human T Lymphotropic Virus 1 Amplification of Periodontitis Severity with Altered Cytokine Expression in Response to a Standard Periodontopathogen Infection. Clinical Infectious Diseases, v. 50, n. 3, p. E11-E18, FEB 1 2010. Web of Science Citations: 21. (07/53940-0)
GARLET, GUSTAVO P.; CARDOSO, CRISTINA R.; MARIANO, FLAVIA S.; CLAUDINO, MARCELA; DE ASSIS, GERSON F.; CAMPANELLI, ANA P.; AVILA-CAMPOS, MARIO J.; SILVA, JOAO S.. Regulatory T cells attenuate experimental periodontitis progression in mice. JOURNAL OF CLINICAL PERIODONTOLOGY, v. 37, n. 7, p. 591-600, JUL 2010. Web of Science Citations: 75. (07/01705-7)
CAVALLA, FRANCO; BIGUETTII, CLAUDIA CRISTINA; COLAVITE, PRISCILA MARIA; SILVEIRA, ELCIA VARISE; MARTINS, JR., WALTER; LETRA, ARIADNE; FAVARO TROMBONE, ANA PAULA; SILVA, RENATO MENEZES; GARLET, GUSTAVO POMPERMAIER. TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic bacterial infection. VIRULENCE, v. 6, n. 3, SI, p. 293-304, APR 2015. Web of Science Citations: 8. (14/03276-0)
FERREIRA, JR., S. B.; REPEKE, C. E.; RAIMUNDO, F. M.; NUNES, I. S.; AVILA-CAMPOS, M. J.; FERREIRA, B. R.; SANTANA DA SILVA, J.; CAMPANELLI, A. P.; GARLET, G. P.. CCR5 Mediates Pro-osteoclastic and Osteoclastogenic Leukocyte Chemoattraction. JOURNAL OF DENTAL RESEARCH, v. 90, n. 5, p. 632-637, MAY 2011. Web of Science Citations: 18. (08/11174-1)
REPEKE, CARLOS EDUARDO; FERREIRA, JR., SAMUEL B.; CLAUDINO, MARCELA; SILVEIRA, ELCIA MARIA; DE ASSIS, GERSON FRANCISCO; AVILA-CAMPOS, MARIO JULIO; SILVA, JOAO SANTANA; GARLET, GUSTAVO POMPERMAIER. Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+and CCR5+in RANKL+ cell migration throughout experimental periodontitis in mice. BONE, v. 46, n. 4, p. 1122-1130, APR 2010. Web of Science Citations: 54. (07/01705-7)
FRANCISCONI, CAROLINA FAVARO; VIEIRA, ANDREIA ESPINDOLA; BIGUETTI, CLAUDIA CRISTINA; GLOWACKI, ANDREW J.; FAVARO TROMBONE, ANA PAULA; LETRA, ARIADNE; SILVA, RENATO MENEZES; SFEIR, CHARLES S.; LITTLE, STEVEN R.; GARLET, GUSTAVO POMPERMAIER. Characterization of the Protective Role of Regulatory T Cells in Experimental Periapical Lesion Development and Their Chemoattraction Manipulation as a Therapeutic Tool. JOURNAL OF ENDODONTICS, v. 42, n. 1, p. 120-126, JAN 2016. Web of Science Citations: 14. (13/05994-4, 12/15133-3)
FRANCISCONI, C. F.; VIEIRA, A. E.; AZEVEDO, M. C. S.; TABANEZ, A. P.; FONSECA, A. C.; TROMBONE, A. P. F.; LETRA, A.; SILVA, R. M.; SFEIR, C. S.; LITTLE, S. R.; et al. RANKL Triggers Treg-Mediated Immunoregulation in Inflammatory Osteolysis. JOURNAL OF DENTAL RESEARCH, v. 97, n. 8, p. 917-927, JUL 2018. Web of Science Citations: 5. (13/05994-4, 12/15133-3, 15/24637-3)
BIGUETTI, CLAUDIA CRISTINA; CAVALLA, FRANCO; SILVEIRA, ELCIA VARIZE; TABANEZ, ANDRE PETENUCI; FRANCISCONI, CAROLINA FAVARO; TAGA, RUMIO; CAMPANELLII, ANA PAULA; TROMBONE, ANA PAULA FAVARO; RODRIGUES, DANIELI C.; GARLET, GUSTAVO POMPERMAIER. HGMB1 and RAGE as Essential Components of Ti Osseointegration Process in Mice. FRONTIERS IN IMMUNOLOGY, v. 10, APR 5 2019. Web of Science Citations: 0. (14/09590-8, 15/18162-2, 15/24637-3)
COLAVITE, PRISCILA MARIA; VIEIRA, ANDREIA ESPINDOLA; PALANCH REPEKE, CARLOS EDUARDO; DE ARAUJO LINHARI, RAFAELLA PAVANELLI; CARNEIRO SPERA DE ANDRADE, RAISSA GONSALVES; BORREGO, ANDREA; DE FRANCO, MARCELO; TROMBONE, ANA PAULA FAVARO; GARLET, GUSTAVO POMPERMAIER. Alveolar bone healing in mice genetically selected in the maximum (AIRmax) or minimum (AIRmin) inflammatory reaction. CYTOKINE, v. 114, p. 47-60, FEB 2019. Web of Science Citations: 0. (13/25824-6, 15/24637-3)
COLAVITE, PRISCILA MARIA; CAVALLA, FRANCO; GARLET, THIAGO POMPERMAIER; SORIANI AZEVEDO, MICHELLE DE CAMPOS; MELCHIADES, JESSICA LIMA; CAMPANELLI, ANA PAULA; LETRA, ARIADNE; FAVARO TROMBONE, ANA PAULA; SILVA, RENATO MENEZES; GARLET, GUSTAVO POMPERMAIER. TBX21-1993T/C polymorphism association with Th1 and Th17 response at periapex and with periapical lesions development risk. Journal of Leukocyte Biology, v. 105, n. 3, p. 609-619, MAR 2019. Web of Science Citations: 0. (14/17886-4, 15/18163-9, 14/03276-0, 15/24637-3)
CAVALLA, FRANCO; BIGUETTI, CLAUDIA C.; DIONISIO, THIAGO J.; AZEVEDO, MICHELLE C. S.; MARTINS, JR., WALTER; SANTOS, CARLOS F.; TROMBONE, ANA PAULA F.; SILVA, RENATO M.; LETRA, ARIADNE; GARLET, GUSTAVO P.. CCR5 Delta 32 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes. CYTOKINE, v. 103, p. 142-149, MAR 2018. Web of Science Citations: 5. (14/17886-4, 14/03276-0)
BIGUETTI, CLAUDIA CRISTINA; VIEIRA, ANDREIA ESPINDOLA; CAVALLA, FRANCO; FONSECA, ANGELICA CRISTINA; COLAVITE, PRISCILA MARIA; SILVA, RENATO MENEZES; FAVARO TROMBONE, ANA PAULA; GARLET, GUSTAVO POMPERMAIER. CCR2 Contributes to F4/80+Cells Migration Along Intramembranous Bone Healing in Maxilla, but Its Deficiency Does Not Critically Affect the Healing Outcome. FRONTIERS IN IMMUNOLOGY, v. 9, AUG 10 2018. Web of Science Citations: 3. (12/03636-0, 15/24637-3)
SORIANI AZEVEDO, MICHELLE DE CAMPOS; GARLET, THIAGO POMPERMAIER; FRANCISCONI, CAROLINA FAVARO; COLAVITE, PRISCILA MARIA; TABANEZ, ANDRE PETENUCI; MELCHIADES, JESSICA LIMA; FAVARO TROMBONE, ANA PAULA; SFEIR, CHARLES; LITTLE, STEVEN; SILVA, RENATO MENEZES; et al. Vasoactive Intestinal Peptide Immunoregulatory Role at the Periapex: Associative and Mechanistic Evidences from Human and Experimental Periapical Lesions. JOURNAL OF ENDODONTICS, v. 45, n. 10, p. 1228-1236, OCT 2019. Web of Science Citations: 1. (15/25618-2, 15/24637-3)
VIEIRA, ANDREIA ESPINDOLA; REPEKE, CARLOS EDUARDO; FERREIRA JUNIOR, SAMUEL DE BARROS; COLAVITE, PRISCILA MARIA; BIGUETTI, CLAUDIA CRISTINA; OLIVEIRA, RODRIGO CARDOSO; ASSIS, GERSON FRANCISCO; TAGA, RUMIO; FAVARO TROMBONE, ANA PAULA; GARLET, GUSTAVO POMPERMAIER. Intramembranous Bone Healing Process Subsequent to Tooth Extraction in Mice: Micro-Computed Tomography, Histomorphometric and Molecular Characterization. PLoS One, v. 10, n. 5, MAY 29 2015. Web of Science Citations: 34. (10/15755-9, 09/11496-1)
ARAUJO-PIRES, ANA CLAUDIA; BIGUETTI, CLAUDIA CRISTINA; REPEKE, CARLOS EDUARDO; RODINI, CAMILA DE OLIVEIRA; CAMPANELLI, ANA PAULA; FAVARO TROMBONE, ANA PAULA; LETRA, ARIADNE; SILVA, RENATO MENEZES; GARLET, GUSTAVO POMPERMAIER. Mesenchymal Stem Cells as Active Prohealing and Immunosuppressive Agents in Periapical Environment: Evidence from Human and Experimental Periapical Lesions. JOURNAL OF ENDODONTICS, v. 40, n. 10, p. 1560-1565, OCT 2014. Web of Science Citations: 15. (12/15133-3)
(References retrieved automatically from State of São Paulo Research Institutions)
GARLET, Gustavo Pompermaier. Participação de citocinas na imunomodulação da doença periodontal experimental induzida por Actinobacillus actinomycetemcomitans. 2005. 177f. Tese (Doutorado) – Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (01/09998-7)
MACHADO, Priscila Maria Colavite. Papel do gene Slc11a1 e de genótipos selecionados para mínima e máxima reatividade inflamatória no processo de reparo ósseo alveolar em camundongos. 2018. Tese (Doutorado) – Faculdade de Odontologia de Bauru. Universidade de São Paulo (USP). Bauru. (13/25824-6)
REPEKE, Carlos Eduardo Palanch. Papel da quimiocina MIP-1 na imunomodulação da severidade da doença periodontal experimental. 2009. Dissertação (Mestrado) - Faculdade de Odontologia de Bauru. Universidade de São Paulo (USP). Bauru. (07/01705-7)
REPEKE, Carlos Eduardo Palanch. Cinética de expressão de moléculas co-estimulatórias de osteoclastos no desenvolvimento da doença periodontal experimental e sua modulação por citocinas. 2012. Tese (Doutorado) – Faculdade de Odontologia de Bauru. Universidade de São Paulo (USP). Bauru. (08/11174-1)
MORTARI, Carolina Fávaro Francisconi. Caracterização morfométrica e molecar do papel da iNOS no processo de reparo ósseo alveolar em condições homeostáticas e infecciosas. 2013. Dissertação (Mestrado) - Faculdade de Odontologia de Bauru. Universidade de São Paulo (USP). Bauru. (10/13626-7)
BIGUETTI, Claudia Cristina. Papel das células CCR2+ no processo de reparo ósseo alveolar em camundongos: caracterização histomorfométrica e molecular. 2014. Dissertação (Mestrado) - Faculdade de Odontologia de Bauru. Universidade de São Paulo (USP). Bauru. (12/03636-0)
VIEIRA, Andreia Espíndola. Caracterização morfométrica e molecular do papel de citocinas pró e anti-inflamatórias no processo de reparo ósseo alveolar em condições homeostáticas e infecciosas. 2013. Tese (Doutorado) – Faculdade de Odontologia de Bauru. Universidade de São Paulo (USP). Bauru. (09/11496-1)
BIGUETTI, Claudia Cristina. Participação de DAMPs na modulação da resposta de macrófagos à implantação de um biomaterial clássico (Ti) e seu impacto no processo de reparo e osseointegração subsequentes. 2018. Tese (Doutorado) – Faculdade de Odontologia de Bauru. Universidade de São Paulo (USP). Bauru. (14/09590-8)