Dario Simões Zamboni in research grants and scholarships supported by FAPESP.
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Leishmaniasis are a group of diseases to pose a major public health problem worldwide, affecting mainly less favored individuals from emerging countries. The diseases are caused by protozoan parasites of the Leishmania spp genus, presenting different known clinical forms: cutaneous, mucocutaneous and visceral. In the mammalian host these parasites preferentially infect phagocytic cells, p…
Differential recognition of pathogenic versus non-pathogenic microbes is essential to ensure rapid and effective immune responses that limit the replication of pathogenic microbes in cells and tissues. This differential recognition occurs through receptors located in the cytoplasm of innate immune cells. Among these receptors is a family of cytoplasmic proteins that contain NBD and LRR do…
Leishmaniasis is a devastating parasitic disease that targets the poorest of society and is the 9th largest global infectious disease burden (WHO). It is truly a Neglected Infectious Disease as the combined financial support of basic and clinical research equates to <2% of infectious disease R&D resources available. Consequently, there are no vaccines available currently and the limited a…
(Only some records are available in English at this moment)
COVID-19, caused by the new coronavirus (SARS-CoV-2) has become a worldwide health problem, with more than one million confirmed cases and 50,000 deaths by early April 2020. In its most severe forms, COVID-19 symptoms includes fever, cough, fatigue, headache and may progress to respiratory distress syndrome and death. The severe cases of COVID-19 are characterized by an intense inflammato…
The SpectraMax i3 Platform support development of assays that measure absorbance, fluorescence, luminescence in real time. The equipment will be equipped with the SpectraMax Minimax, which allows the imaging of the cultures in real time. The equipment is multifunctional and support development of several assays, thus favoring several users of different laboratories. (AU)
Legionella species are the causative agents of Legionnaires' disease, a potentially fatal infection spread through aerosolized water. The majority of our understanding of Legionella is based on the predominant pathogen L. pneumophila. However, a significant proportion of Legionnaires' disease, particularly in the southern hemisphere, is caused by the poorly understood pathogen L. longbeac…
(Only some records are available in English at this moment)
Protozoan parasites of the Leishmania genus cause leishmaniasis by establishing their replicative niche in the interior of macrophage's phagolysosomes. In this interaction, diverse responses that limit parasite growth are triggered, such as activating the multimeric protein complex inflammasome. The Nod-like receptor Pyrin domain 3 (NLRP3) inflammasome is involved in processing pro-IL-1² …
(Only some records are available in English at this moment)
Leishmaniasis is caused by the obligate intracellular protozoan of the genus Leishmania, a disease that affects more than one million people and causes 70,000 deaths per year. The parasites replicate within macrophages and negatively modulate several signaling pathways and cell death in these cells, as an important evasion mechanism. Members of the NOD family of receptors, including NLRP3…
(Only some records are available in English at this moment)
Coxiella burnetii is a Gram-negative bacterium and causative agent of Q fever in humans. The bacterium is highly adapted to infect alveolar macrophages and subvert their functions, including the avoidance of TLR recognition, the inhibition of apoptosis and the modulation of diverse vesicle traffic pathways. Its virulence is dependent on the translocation of bacterial proteins (called effe…
The innate immune system is composed of several sensors and effectors widely expressed in macrophages, dendritic cells and epithelial cells. These molecules can rapidly induce inflammatory responses by triggering the production of cytokines, chemokines and release of danger signals present in the cytoplasm. In this context, host cell death has been reemerged as an important effector mecha…
Autophagy is a process of cellular degradation that captures and degrades organelles and intracellular pathogens and delivers them to autolysosomes for destruction. The role of autophagy in Trypanosoma cruzi infection is still largely unknown. During the development of the Ph.D. project, we found that autophagy is induced in response to T. cruzi favoring restriction of parasite replicatio…
| 5 / 5 | Ongoing research grants |
| 8 / 6 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 71 / 47 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 92 / 66 | All research grants and scholarships |
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