CV Lattes
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Ministério da Educação (Brasil). Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Major at Chemistry from Universidade Federal do Rio de Janeiro (2000), master's at Chemistry from Universidade Federal do Rio de Janeiro (2001) and PhD at Molecular Biology from Universidade Federal de São Paulo (2004). Has experience in Biochemistry, focusing on Enzymology, acting on the following subjects: proteolytic enzymes and their inhibitors. (Source: Lattes Curriculum)
Protease inhibitors can directly or indirectly affect the active proteolytic enzyme, limiting or eliminating their ability to catalyze the cleavage of peptide bonds. These molecules may also act selectively or specifically, endogenously controlling various physiological processes. In recent years our group has been working on developing inhibitors for proteases, particularly against human…
The human tissue kallikreins (KLKs) are a group of 15 serine proteases distributed over a wide range of tissues. They appear involved in several pathological events and therefore it is believed that specific inhibitors to these enzymes may represent new therapeutic procedures for certain pathologies. The KLKs also appear differentially expressed in cancer, and for this reason they are poi…
Human kallikreins 5 (KLK5) and 7 (KLK7) are members of the human tissue kallikreins, comprising 15 kallikrein like serine peptidases (KLKs). KLK5 is found in many tissues, including breast, central nervous system, prostate, testis and trachea; and KLK7 was reported to be present at esophagus, kidney, liver and salivary gland. Moreover, both enzymes appear to be most abundantly expressed i…
(Only some records are available in English at this moment)
Protease inhibitors are molecules capable of directly or indirectly affecting the active site of proteolytic enzymes, limiting or eliminating their ability to catalyze the cleavage of peptide bonds. These molecules can still act selectively or specifically, endogenously controlling the most diverse physiological processes. In addition, protease inhibitors also represent a considerable sha…
Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and cells, therefore they are related to a variety of physiological processes. Kallikreins also catch attention for being differentially expressed in cancer tissues, what suggests that they can be used as cancer biomarkers. Several studies with fluorescent peptides have contributed towards the characteri…
Serpin is the name given to the superfamily of proteins with a wide variety of biological functions, and that has as main characteristic the inhibition of serine proteases. Our group recently described and characterized the first of the serpin Sphenophorus levis, popularly known as "bicudo de cana", which attacks the Brazilian sugar cane causing great damage to this crop. Until recently i…
The co-evolution allowed the development of a broad diversity of defense mechanisms in plants against fungi and insects. Different strategies are used by these mechanisms to protect plants, and the proteolytic enzyme inhibitors represent one of the most importants. After decodification of Saccarum officinarum genome, we found a sequence that code for one serpin, a serine peptidase inhibit…
(Only some records are available in English at this moment)
The human tissue kallikreins (KLKs) comprise a family of fifteen serine proteases found in a diversity of biological fluids and tissues. These enzymes are identified as having function in different diseases such as Alzheimer's, cancer, atopic dermatitis, multiple sclerosis, Parkinson's, psoriasis, and others. Thus there is a growing demand for specific inhibitors for each of these kallikr…
The human tissue kallikreins (KLKs) comprise a family of 15 serine proteases distributed over various tissues and biological fluids. These enzymes are indicated as acting in different pathologies such as Alzheimer's disease, cancer, atopic dermatitis, multiple sclerosis, Parkinson's disease, psoriasis, and others. Thus, there is a demand for specific inhibitors for each of the KLKs, and …
| 5 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 6 / 4 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 14 / 11 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 9 |
| Citations | 89 |
| Cit./Article | 9.9 |
| Data from Web of Science | |
FONSECA, FERNANDO P. P.; IKE, PRISCILA T. L.; ASSIS, DIEGO M.; ICIMOTO, MARCELO Y.; JULIANO, MARIA A.; JULIANO, LUIZ; PUZER, LUCIANO; HENRIQUE-SILVA, FLAVIO. Leviserpin: A Serine Peptidase Inhibitor (Serpin) from the Sugarcane Weevil Sphenophorus levis. The Protein Journal, v. 30, n. 6, p. 404-412, AUG 2011. Web of Science Citations: 4. (98/14138-2)
LAUREANO, ANA FLAVIA S.; ZANI, MARCELO B.; SANT'ANA, AQUILES M.; TOGNATO, RAFAEL C.; LOMBELLO, CHRISTIANE B.; DO NASCIMENTO, MONICA HELENA M.; HELMSING, SASKIA; FUEHNER, VIOLA; HUST, MICHAEL; PUZER, LUCIANO. Generation of recombinant antibodies against human tissue kallikrein 7 to treat skin diseases. Bioorganic & Medicinal Chemistry Letters, v. 30, n. 23, DEC 1 2020. Web of Science Citations: 0. (16/21441-3)
BARROS, THALITA G.; SANTOS, JORGE A. N.; DE SOUZA, BRUNO E. G.; SODERO, ANA CAROLINA R.; DE SOUZA, ALESSANDRA M. T.; DA SILVA, DAYANE P.; RODRIGUES, CARLOS RANGEL; PINHEIRO, SERGIO; DIAS, LUIZA R. S.; ABRAHIM-VIEIRA, BARBARA; et al. Discovery of a new isomannide-based peptidomimetic synthetized by Ugi multicomponent reaction as human tissue kallikrein 1 inhibitor. Bioorganic & Medicinal Chemistry Letters, v. 27, n. 2, p. 314-318, JAN 15 2017. Web of Science Citations: 4. (13/10548-3)
SANTOS, JORGE A. N.; KONDO, MARCIA Y.; FREITAS, RENATO F.; DOS SANTOS, MARCELO H.; RAMALHO, TEODORICO C.; ASSIS, DIEGO M.; JULIANO, LUIZ; JULIANO, MARIA A.; PUZER, LUCIANO. The natural flavone fukugetin as a mixed-type inhibitor for human tissue kallikreins. Bioorganic & Medicinal Chemistry Letters, v. 26, n. 5, p. 1485-1489, MAR 1 2016. Web of Science Citations: 4. (13/10548-3)
OLIVEIRA, JOCELIA P. C.; FREITAS, RENATO F.; DE MELO, LEANDRO SILVA; BARROS, THALITA G.; SANTOS, JORGE A. N.; JULIANO, MARIA A.; PINHEIRO, SERGIO; BLABER, MICHAEL; JULIANO, LUIZ; MURI, ESTELA M. F.; et al. Isomannide-Based Peptidomimetics as Inhibitors for Human Tissue Kallikreins 5 and 7. ACS Medicinal Chemistry Letters, v. 5, n. 2, p. 128-132, FEB 2014. Web of Science Citations: 20. (12/50191-4, 11/51297-8)
DE SOUZA, LUCAS R.; MELO, POLLYANA M.; PASCHOALIN, THAYSA; CARMONA, ADRIANA K.; KONDO, MARCIA; HIRATA, IZAURA Y.; BLABER, MICHAEL; TERSARIOL, IVARNE; TAKATSUKA, JOYCE; JULIANO, MARIA A.; et al. Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin. Biochemical and Biophysical Research Communications, v. 433, n. 3, p. 333-337, APR 12 2013. Web of Science Citations: 6. (11/51297-8)
FREITAS, RENATO F.; TEIXEIRA, THIAGO S. P.; BARROS, THALITA G.; SANTOS, JORGE A. N.; KONDO, MARCIA Y.; JULIANO, MARIA A.; JULIANO, LUIZ; BLABER, MICHAEL; ANTUNES, OCTAVIO A. C.; ABRAHAO, JR., ODONIRIO; et al. Isomannide derivatives as new class of inhibitors for human kallikrein 7. Bioorganic & Medicinal Chemistry Letters, v. 22, n. 19, p. 6072-6075, OCT 1 2012. Web of Science Citations: 16. (11/51297-8)
TEIXEIRA, THIAGO S. P.; FREITAS, RENATO F.; ABRAHAO, JR., ODONIRIO; DEVIENNE, KARINA F.; DE SOUZA, LUCAS R.; BLABER, SACHICO I.; BLABER, MICHAEL; KONDO, MARCIA Y.; JULIANO, MARIA A.; JULIANO, LUIZ; et al. Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7. Bioorganic & Medicinal Chemistry Letters, v. 21, n. 20, p. 6112-6115, OCT 15 2011. Web of Science Citations: 35.
DE SOUZA, ACACIO S.; PACHECO, BARBARA D. C.; PINHEIRO, SERGIO; MURI, ESTELA M. F.; DIAS, LUIZA R. S.; LIMA, CAMILO H. S.; GARRETT, RAFAEL; DE MORAES, MARIANA B. M.; DE SOUZA, BRUNO E. G.; PUZER, LUCIANO. 3-Acyltetramic acids as a novel class of inhibitors for human kallikreins 5 and 7. Bioorganic & Medicinal Chemistry Letters, v. 29, n. 9, p. 1094-1098, MAY 1 2019. Web of Science Citations: 0. (16/21441-3)
COMPOSTOS INIBIDORES SELETIVOS DA CALICREÍNA TECIDUAL HUMANA 1 (KLK1), COMPOSIÇÃO, PROCESSO E USOS BR1020140272720 - Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais (IFSULDEMINAS); Universidade Federal do ABC (UFABC); Universidade Federal Fluminense (UFF). Estela Maris Freitas Muri; Thalita Gonçalves Barros; Luciano Puzer; Jorge Alexandre Nogueira Santos; Sérgio Pinheiro - October 2014, 31