bachelor's at from Faculdade de Ciências Farmacêuticas de Ribeirão Preto- USP (1998), master's at Farmacologia from Faculdade de Medicina de Ribeirão Preto (2001) and doctorate at Farmacologia from Faculdade de Medicina de Ribeirão Preto (2005). Has experience in Pharmacology, focusing on Cardiorenal Pharmacology, acting on the following subjects: mechanisms, carotid, aorta, ethanol and inhibitory action. (Source: Lattes Curriculum)
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The prevalence of obesity has increased worldwide reaching pandemic levels. Obesity is defined as a chronic disease that induces damage in different organs and systems and is an important risk factor for the development of cardiovascular complications. Obesity is pointed out as one of the main causes of secondary arterial hypertension. It affects the deposition of fat in perivascular adip…
Chronic ethanol consumption induces significant changes in vascular function and is considered as an important risk factor for the development of cardiovascular diseases, such as hypertension. The following mechanisms were proposed to explain ethanol-induced hypertension: 1) changes in vascular contractility in which ethanol consumption induces endothelial dysfunction and increased vascul…
Sepsis is defined as an organ dysfunction, with a potential risk of death, caused by a dysregulated host response to an infection. Sepsis impairs the cardiovascular function with a progressive loss of response to vasoconstrictors, hypotension, myocardial depression and circulatory shock. These responses occur through mechanisms associated with the induction of inducible nitric oxide (NO) …
Total or partial interruption of ethanol consumption by alcoholics can lead to the onset of symptoms of varied intensity. According to the International Classification of Diseases (ICD-10 - 10th Edition; WHO) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV - 4th Edition, American Psychiatric Association) these symptoms are classified as the Alcohol Withdrawal Syndrom…
(Only some records are available in English at this moment)
Nitrogen mustards were the first drugs used to treat cancer. Cyclophosphamide is a nitrogen mustard widely used (alone or in combination) in the treatment of neuroblastoma, myeloma, lymphoma and also in ovarian, lung or breast cancer. One factor that limits the use of cyclophosphamide is its toxic effect that affects distinctive organs and tissues including lung, bladder, bone marrow, thy…
Chronic ethanol consumption induces significant changes in vascular function and is considered as an important risk factor for the development of cardiovascular diseases, such as Hypertension. Among the proposed mechanisms to explain ethanol-induced Hypertension are changes in vascular contractility and neuroendrocrine mechanism In fact, it has been shown that RAS plays a role in ethanol-…
Perivascular adipose tissue (PVAT) is a type of adipose tissue that surrounds large arteries and veins. In addition, to provide mechanical support to the blood vessels, PVAT also functions as a paracrine and endocrine organ. PVAT secretes several bioactive substances that exert an anti-contractile effect thus modulating the vascular response to different vasoactive agents. In obesity, the…
Chronic ethanol consumption is a risk factor for cardiovascular diseases. In this sense, the heart is a main target of the deleterious effects of ethanol in the cardiovascular system. Chronic ethanol consumption induces the expression of the enzyme inducible nitric oxide (NO) synthase (iNOS) and increases the generation of reactive oxygen species (ROS) in the heart and these actions lead …
Sepsis is defined as an organ dysfunction, with a potential risk of death, caused by a dysregulated host response to an infection. Sepsis leads to impaired renal function due to changes in the glomerular structure and a local inflammatory process. The experimental model of cecal ligation and puncture (CLC) is considered the most similar to human sepsis and has been widely used in the stud…
(Only some records are available in English at this moment)
The mechanisms underlying ethanol-induced cardiovascular dysfunction include changes in vascular contractility and a neurohumoral response. The renin angiotensin system (RAS) is pointed out as one of the main neurohumoral systems linked to oxidative stress since it regulates oxidative and antioxidant pathways. Perivascular adipose tissue (PVAT) surrounds most blood vessels. In physiologic…
| 1 / 1 | Ongoing research grants |
| 15 / 9 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 24 / 15 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 43 / 28 | All research grants and scholarships |
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CV Lattes
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