bachelor's at from Faculdade de Ciências Farmacêuticas de Ribeirão Preto- USP (1998), master's at Farmacologia from Faculdade de Medicina de Ribeirão Preto (2001) and doctorate at Farmacologia from Faculdade de Medicina de Ribeirão Preto (2005). Has experience in Pharmacology, focusing on Cardiorenal Pharmacology, acting on the following subjects: mechanisms, carotid, aorta, ethanol and inhibitory action. (Source: Lattes Curriculum)
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Ethanol consumption is a risk factor for the development of cardiovascular diseases, such as high blood pressure. Ethanol promotes functional and structural changes in the vasculature, in addition to affecting perivascular adipose tissue (PVAT), a biologically active tissue, composed of adipocytes, fibroblasts and cells of the immune system. PVAT has physiological anti-contractile action,…
Testosterone is the main pharmacological approach used by transmasculine individuals during gender-affirming hormone therapy (GAHT-T). Although presenting a safe profile, it can increase cardiovascular risk in this population. Of note, the literature lacks studies addressing the effects of testosterone, and related mechanisms, in the cardiovascular system of biological female organisms, e…
The prevalence of obesity has increased worldwide reaching pandemic levels. Obesity is defined as a chronic disease that induces damage in different organs and systems and is an important risk factor for the development of cardiovascular complications. Obesity is pointed out as one of the main causes of secondary arterial hypertension. It affects the deposition of fat in perivascular adip…
Chronic ethanol consumption induces significant changes in vascular function and is considered as an important risk factor for the development of cardiovascular diseases, such as hypertension. The following mechanisms were proposed to explain ethanol-induced hypertension: 1) changes in vascular contractility in which ethanol consumption induces endothelial dysfunction and increased vascul…
Sepsis is defined as an organ dysfunction, with a potential risk of death, caused by a dysregulated host response to an infection. Sepsis impairs the cardiovascular function with a progressive loss of response to vasoconstrictors, hypotension, myocardial depression and circulatory shock. These responses occur through mechanisms associated with the induction of inducible nitric oxide (NO) …
(Only some records are available in English at this moment)
Arterial hypertension resulting from ethanol consumption affects a significant portion of the world population. This condition is associated with high morbidity and mortality due to its complications. Ethanol consumption activates the renin-angiotensin-aldosterone system (RAAS) and blockade of the angiotensin II AT1 receptor (AT1R) prevents arterial hypertension and vascular dysfunction i…
The prevalence of obesity in Brazil increased from 11.8% in 2006 to 20.3% in 2019. For this reason, this condition is considered a public health problem in Brazil, generating expenses of over R$ 1 billion annually. Obesity is a risk factor for the development of cardiovascular diseases, including high blood pressure. Obesity promotes functional and structural alterations in the vasculatur…
The prevalence of obesity has increased worldwide, reaching pandemic levels and Brazil follows the global trend. Obesity, which is defined as a chronic disease that induces damage to different organs and systems and for this reason it figures as a risk factor in the development of cardiovascular complications. The accumulation of fat in different body regions leads to cardiometabolic chan…
Nitrogen mustards were the first drugs used to treat cancer. Cyclophosphamide is a nitrogen mustard widely used (alone or in combination) in the treatment of neuroblastoma, myeloma, lymphoma and also in ovarian, lung or breast cancer. One factor that limits the use of cyclophosphamide is its toxic effect that affects distinctive organs and tissues including lung, bladder, bone marrow, thy…
Chronic ethanol consumption induces significant changes in vascular function and is considered as an important risk factor for the development of cardiovascular diseases, such as Hypertension. Among the proposed mechanisms to explain ethanol-induced Hypertension are changes in vascular contractility and neuroendrocrine mechanism In fact, it has been shown that RAS plays a role in ethanol-…
(Only some records are available in English at this moment)
Aldosterone is the terminal hormone of the renin-angiotensin-aldosterone system (RAAS) that displays important actions on electrolyte balance and volume control. However, in pathophysiological conditions, aldosterone production can be increased, and activation of the mineralocorticoid receptor (MR) can cause dysfunction and damage to different tissues. In the cardiovascular system, aldost…
Hypertension is a global health condition with significant impacts on morbidity and mortality, often associated with functional and structural changes in perivascular adipose tissue (PVAT). This tissue plays a crucial role in modulating vascular function by regulating vascular tone and contractile response. During hypertension, the renin-angiotensin system, particularly angiotensin II (AN…
The mechanisms underlying ethanol-induced cardiovascular dysfunction include changes in vascular contractility and a neurohumoral response. The renin angiotensin system (RAS) is pointed out as one of the main neurohumoral systems linked to oxidative stress since it regulates oxidative and antioxidant pathways. Perivascular adipose tissue (PVAT) surrounds most blood vessels. In physiologic…
| 2 / 2 | Ongoing grants |
| 16 / 10 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 27 / 18 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 50 / 35 | All research grants and scholarships |
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CV Lattes
ORCID