CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
The research in my lab is a branch of Integrative Neuroscience, a discipline that seeks to understand how the brain processes specific types of information. The laboratory studies how the mammalian brain regulates respiration and blood pressure, two physiological processes that are dysfunctional in very common diseases (hypertension, obesity, apneic syndromes, heart failure, hypoxia, etc.). These basic homeostatic regulations are orchestrated by the central nervous system that finely tunes pulmonary ventilation along with cardiac and vascular performance through the activity of the respiratory and autonomic outflows. The work consists of identifying relevant neuronal networks in rodents using electrophysiologic and neuroanatomic methods. The main focus is on a region of the brainstem that provides the chemical drive to breathe and contains the neurons that maintain blood pressure. (Source: Lattes Curriculum)
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Breathing automaticity and chemoreception are inseparable neural processes. The retrotrapezoid nucleus (RTN), a group of glutamatergic neurons that express the transcription factor Phox2b, may be a crucial nodal point through which breathing automaticity is regulated to maintain CO2 constant. Additional evidence that RTN neurons have central respiratory chemoreceptor properties is present…
(Only some records are available in English at this moment)
The main physiological function of breathing is the maintenance of blood gases (CO2 and O2) homeostasis. For this fine tuning to take place, the Central Nervous System (CNS) must receive refined and accurate information. Among the neural clusters that control respiratory activity, the ventrolateral region of the brainstem, namely the retrotrapezoid nucleus (RTN) are capable of detecting i…
Inflammation is defined as a biological response caused by numerous agents and is a key element in defense against infections. In the central nervous system, the main defense cell is microglia. Because of the elementary source of inflammatory factors, regulation of microglia may represent the therapeutic potential for neuropsychiatric diseases and, when activated in the ventral respirator…
Ventilation is a physiological process that depends on the integration of neural networks, which is essential for maintaining the internal physiological balance. All this mechanism has the main objective to maintain adequate levels of O2 and CO2 in the blood and tissues. It is well established that central and peripheral chemoreceptors detect changes in arterial blood gas concentrations a…
(Only some records are available in English at this moment)
Guanylyl cyclase D positive (GCD+) neurons are a specialized set of olfactory sensory system. They are thought to play a key role in mediating innate odor preferences, learning and in the CO2 olfactory sensing. GCD+ neurons from olfactory epithelium project their axons to the necklace glomeruli, in the caudal olfactory bulb (OB). They also express other essential components in the CO2 olf…
The opioid epidemic claims more than 50,000 lives every year in North America and contributes to a significant drop in overall life expectancy worldwide. The primary cause of death associated with opioid-based analgesics and drugs of abuse is opioid-induced respiratory depression (OIRD). Although the mortality risk increases in a dose-dependent manner, opioid use is particularly dangerous…
Respiratory activity is maintained unconsciously by the activity of respiratory chemoreceptors, including those located in the retrotrapezoid nucleus (RTN), which control respiratory output in response to changes in tissue CO2/H+. Despite the importance of RTN chemoreceptors, we still do not know about the mechanisms that support their activity, particularly the neuromodulation involving …
The pedunculopontine tegmental nucleus (PPTg) is considered an important nucleus in the mesopontine region and has been shown to have important functions. These neurons exhibit wake- and REM-dependent firing behavior maintenance of the sleep-wake state and are known to participate in a wide range of state-regulating functions including control of breathing. Previous works demonstrate the …
In addition to neurons, astrocytes from ventral medullary surface are highly chemosensitive, contribute to respiratory drive and have a developmental connection with retrotrapezoid nucleus (RTN) neurons. These cells are ideally anatomically positioned, respond to decreases in inspired O2 and decreases in pH, with robust elevations in intracellular Ca2+ and vesicular release of ATP. ATP ac…
The retrotrapezoid nucleus (RTN) contains neurons that regulate breathing in response to changes in tissue CO2/H+ (central chemoreceptors), increasing the inspiration and generating active expiration. Recently, a new rhythm structure breathing-related has been identified in the medulla, a cluster compose by neurons that co-expressing Glutamate and Acetylcholine which displays autonomous b…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 13 / 11 | Completed research grants |
| 26 / 20 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 50 / 41 | All research grants and scholarships |
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