Abstract
Photodocumenter that efficiently captures data from protein gels, nucleic acid gels, chemiluminescent and fluorescent Western blots. (AU)
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Miriam Galvonas Jasiulionis
CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences, medical modality, from Escola Paulista de Medicina (1990) and Master's Degree in Microbiology and Immunology from Escola Paulista de Medicina (1993). She developed her PhD at the Instituto Ludwig de Pesquisas sobre o Cancer through the Graduate Program in Microbiology and Immunology at Escola Paulista de Medicina (1997). She held a Postdoctoral Fellowship in Cell Biology (1998-2000) and Immunology (2002-2007) at Escola Paulista de Medicina. She served as Secretary of International Relations at Unifesp from 2014 to 2019 and as Head of Department from 2020 to 2024. She is currently a Full Professor, Vice-Head of the Department of Pharmacology and Coordinator of the Postgraduate Program in Pharmacology at the Paulista School of Medicine, Unifesp. He has experience in the area of Cellular and Molecular Biology of Cancer, with an emphasis on the role of epigenetic mechanisms (DNA methylation, histone modifications, and ncRNAs) in malignant transformation and tumor progression, particularly in melanoma. (Source: Lattes Curriculum)
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Research grants
- Multi-user equipment approved in grant 2023/17621-0: iBright FL1500 imaging system, AP.EMU
- Multi-user equipment approved in grant 2023/17621-0: QuantStudio Real-Time PCR, AP.EMU
Abstract
Real-time thermal cycler to be routinely used in the thematic project that originated this proposal. Highly sensitive and versatile equipment. (AU)
- Translating non-coding RNA signatures into novel biomarkers and therapeutic targets in Melanoma, AP.TEM
Abstract
Melanoma is one of the most aggressive and therapy-resistant neoplasias. Despite advances achieved through the development of targeted therapies, such as BRAF and MEK inhibitors, and immunotherapies, such as anti-CTLA4 and anti-PD1, which have resulted in increased survival of patients with malignant melanoma, around 50% of these develop resistance to treatments. The characteristic phenot…
- Identification and characterization of ncRNAs playing a role in Melanoma phenotypic plasticity, AP.R
Abstract
Tumor cell plasticity contributes to metastatic competence and is related to tumor heterogeneity, reccurence and treatment failure. Melanomas have high propensity to metastasis and frequently become drug resistant. Although patient survival has significantly increased with the more recent therapeutic modalities, as molecular targeted therapies and immunotherapies, majority patients presen…
- Novel strategies for eliminating residual tumor cells using epigenetic therapy, AP.R SPRINT
Abstract
This proposal aims to strength our hypothesis that epi-drugs, such as demethylating agents, can be an effective treatment for eliminating residual tumor cells by treating both resistant and/or dormant tumor cells (seed) and the microenvironment (soil). The proposal is based on two immunocompetent models: the cellular model of murine melanoma and the model of microenvironment-dependent tum…
- Non-coding RNAs involved with melanoma genesis and progression, AP.R
Abstract
Melanomas are tumors that may frequently progress to their most aggressive form, the metastatic one, been responsible for more than 80% of deaths caused by all types of skin cancers. Considering that, if not early diagnosed and treated, it can rapidly progress and become fatal, the search for tumor markers in tumor samples and biological fluids has received increased attention. It is esti…
(Only some records are available in English at this moment)
Scholarships in Brazil
- Role of histone modifications in melanoma progression and association with oxidative stress, BP.DD
Abstract
Melanoma is a tumor originating from melanocytes and is characterized by its aggressiveness, lethality, and high metastatic potential. Its high plasticity, proliferative capacity, and adaptability present a significant challenge in treating this disease. Both malignant transformation and tumor heterogeneity result from the accumulation of mutations and epigenetic modifications that culmin…
- Identification and analysis of the role of lncRNAs in melanoma development and resistance to immunotherapies, BP.IC
Abstract
Melanoma is the most lethal type of skin cancer due to its high metastatic capacity and frequent resistance to available treatments. Targeted therapies and immunotherapies, including immune checkpoint inhibitors, although currently considered gold standard treatment options, are associated with response failure or resistance in around half of melanoma patients. Therefore, the search for n…
- Identification of lncRNAs with a role in Melanoma progression and resistance to immunotherapy, BP.DD
Abstract
Long non-coding RNAs (lncRNAs) are non-protein coding RNAs (ncRNAs) transcripts. It is estimated that 70 to 90% of the human genome is transcribed in ncRNAs. Studies have already demonstrated the importance of lncRNAs in modulating gene expression, making them a significant component of the epigenetic machinery. Melanomas are responsible for about 80% of all deaths related to skin cancers…
(Only some records are available in English at this moment)
- Identification of miRNAs with a role in regulating of phenotype switching in melanoma, BP.MS
Abstract
Melanoma is the most aggressive type of skin cancer due to its ability to generate metastases. It arises from the malignant transformation of melanocytes, the cells responsible for producing melanin, the pigment that gives the skin, eyes, and hair their color. Prolonged exposure to UV light is one of the main factors contributing to the development of melanoma. This aggressiveness and inv…
- Development and characterization of malignant transformation models of prostate epithelial cells, BP.IC
Abstract
Cancer is currently considered a highly prevalent malignant disease for being the second leading cause of death in the world, presenting a difficult early diagnosis and because its treatment, when available, is in many cases expensive and inaccessible. Among the cancers that stand out, we can mention prostate cancer, which is one of the most frequent in the male population. Oncogenesis, t…
- Identification of miRNAs in small extracellular vesicles and their role in melanoma phenotypic plasticity, BP.IC
Abstract
Cutaneous melanoma is characterized by the malignant transformation of melanocytes, cells responsible for the production of melanin pigment, which is located close to the basal layer, between the dermis and epidermis. Despite having a low incidence, it is considered the most aggressive skin cancer due to its high metastatic capacity and resistance to therapies. The change in phenotypes (p…
(Only some records are available in English at this moment)
Scholarships abroad
- Exploring lncRNA-mediated immunotherapy resistance in melanoma through spatial analysis, BE.EP.DD
Abstract
Spatial transcriptomics has emerged as a powerful tool for understanding gene expression dynamics within tissue architecture. This technology is particularly valuable for mapping immune-tumor interactions and gene expression. However, its application remains limited, particularly in the study of long non-coding RNAs (lncRNAs), which are key regulators of gene expression and play critical …
- Investigation of lncRNAs and gene regulatory networks modulated by 5-Aza-2´-deoxycytidine in an murine immune-mediated awakening model of dormant melanoma cells, BE.EP.MS
Abstract
This project aims to examine the role of long non-coding RNAs (lncRNAs) regulated by DNA methylation in melanoma progression and immune-mediated tumor dormancy, focusing on the effects of 5-Aza-2'-deoxycytidine, a DNA demethylating agent, on lncRNA modulation within the tumor microenvironment (TME). Previous studies showed that 5-Aza-2'-deoxycytidine reduces tumor volume and delays tumor …
- Identification of the genomic DNA hydroxymethylation profile during the melanoma progression, BE.EP.DD
Abstract
Our in vitro melanoma progression model employs substrate adhesion blockade as a malignant transforming factor. The cell lines corresponding to steps of melanoma progression are: melan-a (non-tumorigenic melanocytes), 4C (pre-malignant melanocytes), 4C11- (non-metastatic melanoma cells) and 4C11+ (metastatic melanoma cells). The gene and protein levels of TET2 and 5hmC levels are found to…
- The role of miRNA-298 in melanoma metastasis, BE.EP.DR
Abstract
MicroRNAs (miRNAs) are one of the most abundant classes of gene regulatory molecules. They are small non-coding RNAs of approximately 22 nucleotides that have important regulatory function in animals and plants by regulating gene expression negatively and post-transcriptionally. In animals, miRNAs binds to mRNAs leading to its destabilization or its translation repression. It is estimated…
- Identification of important targets associated with stem-like state and epithelial mesenchymal transition along melanocyte malignant transformation, BE.EP.DR
Abstract
Melanoma is an aggressive form of skin cancer that is responsible for the vast majority of skin cancer deaths and its incidence continues to increase worldwide. It is known the existence of many factors that contribute to melanoma development and to increase its incidence, however, there are many questions to be elucidated about the genetics, epigenetics and metabolomics changes that occu…
(Only some records are available in English at this moment)
Total / Available in English
| 4 / 3 | Ongoing grants |
| 24 / 14 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 37 / 30 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 76 / 58 | All research grants and scholarships |
| Associated processes | |