Full Professor at Federal University of ABC, UFABC ate Santo André, São Paulo. Graduated in Chemistry from the State University of Campinas (UNICAMP, 1997), PhD in Chemistry from the University of São Paulo (2005) and Ph.D. in Biochimics and Cellular and Molecular Biology - Università di Roma Tor Vergata (2003-2004). She is currently Associate Professor at the Federal University of ABC, and in 2019 was a visiting researcher at the Department of Laboratory Medicine, - Ospedale Fatebenefratelli San Giovanni Calibita, Rome, Italy. She has experience in Biochemistry, acting on the following subjects: transition metal biochemistry (copper, iron and zinc), bioinorganic, free radicals and reactive oxygen species in cell physiology and signaling, development of proactive copper complexes in therapy and cell cultures, neurodegeneration and its relationship with metals and study of new nutraceutical therapies based on metal chelation, oxidative stress generation and cell cycle changes. (Source: Lattes Curriculum)
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Copper is an essential element for the maintenance of life, being considered one of the most important micronutrients necessary for the perfect functioning of a living organism. Copper is present in the active site of numerous essential proteins in the cell, performing important functions in metabolism such as the electron transport chain in the mitochondria, the synthesis of amines, the …
In its normal conformation, the cellular prion protein (PrPC) exerts innumerable cellular and cognitive functions; among them we detach functions as signaling platform and auxiliary in memory fixation. It is a protein anchored in the plasma membrane of all cells and highly present in cells of the brain tissue. With all the knowledge acquired regarding its functions in the last 15 years, t…
Much is known about the oxidation of biomolecules and its relationship with reactive oxygen species (ROS) and intracellular redox imbalance systems. However little is known regarding the transition metals present in trace amounts (such as copper, iron and zinc) in engagement with this type of oxidation mechanism. Our research group has actively contributed to the elucidation of the role o…
(Only some records are available in English at this moment)
Copper is the third most abundant transition metal in the biological environment, and it is an essential element for the maintenance of life. Given its very versatile redox capacity among the elements of the first transition series, copper can assume the most different geometric forms of coordination. Consequently, its high reactivity can be controlled in this way. Thus, being an endogeno…
Copper is an essential trace element for the proper functioning of the human body, but it must have strictly well-regulated homeostasis, otherwise it can play a fundamental role in neurodegenerative diseases that occur due to its deficiency or accumulation in the brain. Alzheimer's Disease is the most common case of dementia, a neurodegenerative disease that presents with symptoms such as…
In its normal conformation, the cellular prion protein (PrPC) exerts innumerable cellular and cognitive functions, among them stand out functions as signaling and auxiliary in memory fixation. It is a protein anchored in the plasma membrane of all cells and highly present in cells of the brain tissue. With all the knowledge acquired regarding its functions in the last 15 years, there are …
(Only some records are available in English at this moment)
Strong evidence in the scientific literature suggests that the deterioration of essential transition metal homeostasis, increasing oxidative damage to biomolecules by redox imbalance, is closely related to the onset, maintenance, and evolution of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Although these connections are r…
This project corresponds to a PhD stage for the student Andreza Candido Matias. In her PhD work, the student has used different commercial chelating agents for copper and zinc, which were membrane permeable. The objective was to study the effects of the imbalance of these metals on cell viability or death and generation of reactive oxygen species (ROS) in cells in culture.She obtained pro…
| 1 / 1 | Ongoing research grants |
| 8 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 25 / 17 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 39 / 30 | All research grants and scholarships |
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CV Lattes
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