CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Adriana C. Girardi received a B.A. in Pharmacology and Biochemistry (1996) and a Ph.D. (2002) in Physiology at University of São Paulo. From 2002 to 2005, she was a postdoctoral fellow in the Aronson lab (Department of Internal Medicine, Section of Nephrology, Yale University). Currently, she is a principal investigator in the Laboratory of Genetics and Molecular Cardiology, Incor, HC-USP and Professor at FMUSP. She has experience in Renal Physiology, Cardiorenal Pharmacology and Biochemistry. Her major scientific interest is understanding blood pressure regulation and cardiovascular disease. Recently, her research group has investigated how therapies for diabetes affect cardiovascular disease progression and hypertension. javascript:void(0) (Source: Lattes Curriculum)
Clinical evidence indicates that hypertensive patients are highly susceptible to infection and the severity of COVID-19, a disease caused by the new SARS coronavirus SARS-Cov-2. The SARS-CoV-2 requires the host protein angiotensin-converting enzyme-2 (ACE2), as a receptor, and the serine protease TMPRSS2, for S protein priming, to gain intracellular entry in the lungs, among other organs …
Dipeptidyl peptidase 4 (DPP4) inhibitors are antidiabetic agents that exert renoprotective effects, beyond glucose control in humans and in experimental models of cardiovascular and renal diseases. DPP4 inhibition reduces Na+/H+ exchanger isoform 3 (NHE3)-dependent sodium reabsorption in the renal proximal tubule and this inhibitory effect is associated with blood pressure lowering effect…
Collectively, the four subprojects that compose this proposal aim to reveal molecular mechanisms that regulate renal tubular function, elucidate how renal tubule dysfunction contributes to the pathophysiology of hypertension (HAS) and Chronic Kidney Disease (CKD) as well as to reveal the molecular mechanisms of antidiabetic agents along the nephron. The first sub-project aims to define th…
Heart failure (HF) represents a major public health problem and is a major cause of disability and death in the modern world. The raise in worldwide life expectancy and the fact that HF is the final common pathway for a host of cardiac disorders strongly suggest that the substantial healthcare expenditures and social impact associated with this syndrome will continue to escalate. Such asp…
(Only some records are available in English at this moment)
Inhibitors of the enzyme dipeptidyl peptidase IV (DPPIV) are antidiabetic agents which exert renoprotective effects, beyond the glycemic benefit, in humans and experimental models of cardiovascular and renal diseases. Inhibition of DPPIV reduces Na+/H+ exchanger 3 (NHE3)-dependent Na+ reabsorption in proximal renal tubule and this inhibitory effect is associated with the reduction of bloo…
Clinical evidence indicates that hypertensive patients are highly susceptible to infection and the severity of COVID-19, a disease caused by the new SARS coronavirus SARS-Cov-2. The SARS-CoV-2 requires the host protein angiotensin-converting enzyme-2 (ACE2), as a receptor, and the serine protease TMPRSS2, for S protein priming, to gain intracellular entry in the lungs, among other organs …
It is estimated in Brazil that more than 2 million people have Chronic Kidney Disease (CKD) at different stages and approximately 100,000 patients are in renal replacement therapy. However, therapeutic strategies to control the progression of CKD are limited to the control of basal diseases and the use of drugs that block the renin-angiotensin system. Thus there is an avid need for new ag…
(Only some records are available in English at this moment)
The Na+/glucose cotransporter SGLT2 reabsorbs most of the glucose filtered by the kidneys. SGLT2 inhibitors, recently approved as new antidiabetic drugs, reduce reabsorption of glucose by the kidneys, thereby reducing blood glucose levels. Data from clinical studies indicate that patients with type 2 diabetes mellitus treated with SGLT2 inhibitors display a consistent decrease in systolic…
The Na+/H+ exchanger isoform 3 (NHE3) is a transport protein responsible for reabsorption of the majority of the filtered NaCl, NaHCO3 and, consequently, water, in renal proximal tubules. This transporter therefore plays an essential role regulating volume and acid-base homeostasis and determining blood pressure levels. The NHE3 activity modulation in response to stimuli is mediated by a …
A large body of clinical and experimental evidence documents the importance of the kidney in defining the blood pressure (BP) set point and pathogenesis of hypertension. Body fluid volumes and Na+ balance are maintained by the renal regulation of a series of apical Na+ transporters located along the nephron. Changes in the number and/or intrinsic activity of these transporters affect Na+ …
(Only some records are available in English at this moment)
A isoforma 3 do trocador Na/H (NHE3) está presente na membrana apical do túbulo proximal renal e medeia a reabsorção da maior parte do NaCl e do NaHCO3 neste segmento do néfron. Dada a sua importância na homeostase dos fluidos corporais, o NHE3 é fortemente regulado por uma ampla gama de efetores através de múltiplos mecanismos moleculares. A rápida regulação da atividade do NHE3 pode oco…
| 3 / 3 | Ongoing research grants |
| 9 / 6 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 28 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 45 / 32 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 31 |
| Citations | 587 |
| Cit./Article | 18.9 |
| Data from Web of Science | |
CRAJOINAS, RENATO O.; POLIDORO, JULIANO Z.; CARNEIRO DE MORAIS, CARLA P. A.; CASTELO-BRANCO, REGIANE C.; GIRARDI, ADRIANA C. C.. Angiotensin II counteracts the effects of cAMP/PKA on NHE3 activity and phosphorylation in proximal tubule cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v. 311, n. 5, p. C768-C776, NOV 1 2016. Web of Science Citations: 6. (12/10146-0, 13/10619-8)
BERALDO, JULIANA ISA; BENETTI, ACARIS; BORGES-JUNIOR, FLAVIO ARAUJO; ARRUDA-JUNIOR, DANIEL F.; MARTINS, FLAVIA LETICIA; JENSEN, LEONARDO; DARIOLLI, RAFAEL; SHIMIZU, MARIA HELOISA; SEGURO, ANTONIO C.; LUCHI, WEVERTON M.; et al. Cardioprotection Conferred by Sitagliptin Is Associated with Reduced Cardiac Angiotensin II/Angiotensin-(1-7) Balance in Experimental Chronic Kidney Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 8, APR 2 2019. Web of Science Citations: 2. (16/22140-7, 13/10619-8)
ARRUDA-JUNIOR, DANIEL F.; MARTINS, FLAVIA L.; DARIOLLI, RAFAEL; JENSEN, LEONARDO; ANTONIO, EDNEI L.; DOS SANTOS, LEONARDO; TUCCI, PAULO J. F.; GIRARDI, ADRIANA C. C.. Dipeptidyl Peptidase IV Inhibition Exerts Renoprotective Effects in Rats with Established Heart Failure. FRONTIERS IN PHYSIOLOGY, v. 7, JUL 12 2016. Web of Science Citations: 8. (13/10619-8)
CRAJOINAS, R. O.; PESSOA, T. D.; RODRIGUES, M. V.; MALNIC, G.; GIRARDI, A. C. C.. Changes in the activity and expression of protein phosphatase-1 accompany the differential regulation of NHE3 before and after the onset of hypertension in spontaneously hypertensive rats. ACTA PHYSIOLOGICA, v. 211, n. 2, p. 395-408, JUN 2014. Web of Science Citations: 6. (12/10146-0)
VEIRAS, LUCIANA C.; GIRARDI, ADRIANA C. C.; CURRY, JOSHUA; PEI, LEI; RALPH, DONNA L.; TRAN, AN; CASTELO-BRANCO, REGIANE C.; PASTOR-SOLER, NURIA; ARRANZ, CRISTINA T.; YU, ALAN S. L.; et al. Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v. 28, n. 12, p. 3504-3517, DEC 2017. Web of Science Citations: 43. (12/10146-0)
GIRARDI, ADRIANA CASTELLO COSTA; FUKUDA, LÍVIA EMY; ROSSONI, LUCIANA VENTURINI; MALNIC, GERHARD; REBOUÇAS, NANCY AMARAL. Dipeptidyl peptidase IV inhibition downregulates Na+-H+ exchanger NHE3 in rat renal proximal tubule. American Journal of Physiology : Renal Physiology, v. 294, n. 2, p. F414-F422, Feb. 2008. (04/01683-5)
GIRARDI, ADRIANA C. C.; DI SOLE, FRANCESCA. Deciphering the mechanisms of the Na+/H+ exchanger-3 regulation in organ dysfunction. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v. 302, n. 11, p. C1569-C1587, JUN 2012. Web of Science Citations: 44.
CRAJOINAS, RENATO O.; ORICCHIO, FELIPE T.; PESSOA, THAISSA D.; PACHECO, BRUNA P. M.; LESSA, LUCILIA M. A.; MALNIC, GERHARD; GIRARDI, ADRIANA C. C.. Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 301, n. 2, p. F355-F363, AUG 2011. Web of Science Citations: 114.
GIANNOCCO, GISELE; OLIVEIRA, KELEN C.; CRAJOINAS, RENATO O.; VENTURINI, GABRIELA; SALLES, THIAGO A.; FONSECA-ALANIZ, MIRIAM H.; MACIEL, RUI M. B.; GIRARDI, ADRIANA C. C.. Dipeptidyl peptidase IV inhibition upregulates GLUT4 translocation and expression in heart and skeletal muscle of spontaneously hypertensive rats. European Journal of Pharmacology, v. 698, n. 1-3, p. 74-86, JAN 5 2013. Web of Science Citations: 30.
CARRARO-LACROIX, LUCIENE R.; LESSA, LUCILIA M. A.; BEZERRA, CAMILA N. A.; PESSOA, THAISSA D.; SOUZA-MENEZES, JACKSON; MORALES, MARCELO M.; GIRARDI, ADRIANA C. C.; MALNIC, GERHARD. Role of CFTR and ClC-5 in Modulating Vacuolar H+-ATPase Activity in Kidney Proximal Tubule. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 26, n. 4-5, p. 563-576, 2010. Web of Science Citations: 16. (04/01683-5)
CARNEIRO DE MORAIS, CARLA P.; POLIDORO, JULIANO Z.; RALPH, DONNA L.; PESSOA, THAISSA D.; OLIVEIRA-SOUZA, MARIA; BARAUNA, VALERIO G.; REBOUCAS, NANCY A.; MALNIC, GERHARD; MCDONOUGH, ALICIA A.; GIRARDI, ADRIANA C. C.. Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v. 309, n. 8, p. C541-C550, OCT 15 2015. Web of Science Citations: 4. (12/10146-0, 13/50384-0, 13/10619-8)
INOUE, BRUNA H.; ARRUDA-JUNIOR, DANIEL F.; CAMPOS, LUCIENE C. G.; BARRETO, ANA LUIZA T.; RODRIGUES, MARILIZA V.; KRIEGER, JOSE EDUARDO; GIRARDI, ADRIANA C. C.. Progression of microalbuminuria in SHR is associated with lower expression of critical components of the apical endocytic machinery in the renal proximal tubule. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 305, n. 2, p. F216-F226, JUL 2013. Web of Science Citations: 7. (12/10146-0)
QUEIROZ-LEITE, GABRIELLA D.; CRAJOINAS, RENATO O.; NERI, ELIDA A.; BEZERRA, CAMILA N. A.; GIRARDI, ADRIANA C. C.; REBOUCAS, NANCY AMARAL; MALNIC, GERHARD. Fructose Acutely Stimulates NHE3 Activity in Kidney Proximal Tubule. Kidney & Blood Pressure Research, v. 36, n. 1, p. 320-334, 2012. Web of Science Citations: 17. (08/58287-5)
PONTES, ROBERTO B.; CRAJOINAS, RENATO O.; NISHI, ERIKA E.; OLIVEIRA-SALES, ELIZABETH B.; GIRARDI, ADRIANA C.; CAMPOS, RUY R.; BERGAMASCHI, CASSIA T.. Renal nerve stimulation leads to the activation of the Na+/H+ exchanger isoform 3 via angiotensin II type I receptor. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 308, n. 8, p. F848-F856, APR 15 2015. Web of Science Citations: 20. (13/22522-9, 12/10146-0)
DOS SANTOS, DANUBIA SILVA; POLIDORO, JULIANO Z.; BORGES-JUNIOR, FLAVIO A.; GIRARDI, ADRIANA C. C.. Cardioprotection conferred by sodium-glucose cotransporter 2 inhibitors: a renal proximal tubule perspective. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v. 318, n. 2, p. C328-C336, FEB 2020. Web of Science Citations: 1. (16/22140-7)
TAVARES, CAIO A. M.; BAILEY, MATTHEW A.; GIRARDI, ADRIANA C. C.. Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity. FRONTIERS IN PHYSIOLOGY, v. 11, NOV 19 2020. Web of Science Citations: 0. (20/05338-3, 16/22140-7)
LOPES, NATHALIA R.; MILANEZ, MAYCON I. O.; MARTINS, BEATRIZ S.; VEIGA, AMANDA C.; FERREIRA, GIOVANNA R.; GOMES, GUIOMAR N.; GIRARDI, ADRIANA C.; CARVALHO, POLLIANE M.; NOGUEIRA, FERNANDO N.; CAMPOS, RUY R.; et al. Afferent innervation of the ischemic kidney contributes to renal dysfunction in renovascular hypertensive rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 472, n. 3, JAN 2020. Web of Science Citations: 1. (17/12383-2, 18/02671-3, 15/23858-6, 16/22140-7)
ARRUDA-JUNIOR, DANIEL F.; MARTINS, FLAVIA L.; SALLES, THIAGO ALMEIDA; JENSEN, LEONARDO; DARIOLLI, RAFAEL; ANTONIO, EDNEI L.; DOS SANTOS, LEONARDO; CRAJOINAS, RENATO O.; TUCCI, PAULO J. F.; GOWDAK, LUIS HENRIQUE W.; et al. Postprandial increase in glucagon-like peptide-1 is blunted in severe heart failure. Clinical Science, v. 134, n. 9, p. 1081-1094, MAY 2020. Web of Science Citations: 0. (13/10619-8, 13/17368-0, 16/22140-7)
BENETTI, ACARIS; MARTINS, FLAVIA LETICIA; SENE, LETICIA BARROS; SHIMIZU, MARIA HELOISA M.; SEGURO, ANTONIO C.; LUCHI, WEVERTON M.; GIRARDI, ADRIANA C. C.. Urinary DPP4 correlates with renal dysfunction, and DPP4 inhibition protects against the reduction in megalin and podocin expression in experimental CKD. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 320, n. 3, p. F285-F296, MAR 2021. Web of Science Citations: 0. (16/22140-7)
CARRARO-LACROIX, LUCIENE R.; MALNIC, GERHARD; GIRARDI, ADRIANA C. C.. Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 297, n. 6, p. F1647-F1655, DEC 2009. Web of Science Citations: 73. (04/01683-5)
LUCHI, WEVERTON M.; SHIMIZU, MARIA HELOISA M.; CANALE, DANIELE; GOIS, PEDRO HENRIQUE F.; DE BRAGANCA, ANA CAROLINA; VOLPINI, RILDO A.; GIRARDI, ADRIANA C. C.; SEGURO, ANTONIO C.. Vitamin D deficiency is a potential risk factor for contrast-induced nephropathy. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 309, n. 3, p. R215-R222, AUG 1 2015. Web of Science Citations: 10. (12/10146-0)
SAVIGNANO, FERNANDA A.; CRAJOINAS, RENATO O.; PACHECO, BRUNA P. M.; CAMPOS, LUCIENE C. G.; SHIMIZU, MARIA HELOISA M.; SEGURO, ANTONIO CARLOS; GIRARDI, ADRIANA C. C.. Attenuated diuresis and natriuresis in response to glucagon-like peptide-1 in hypertensive rats are associated with lower expression of the glucagon-like peptide-1 receptor in the renal vasculature. European Journal of Pharmacology, v. 811, p. 38-47, SEP 15 2017. Web of Science Citations: 4. (12/10146-0, 13/10619-8)
CRAJOINAS, RENATO O.; POLIDORO, JULIANO Z.; GIRARDI, ADRIANA C. C.. The potential role of myosin motor proteins in mediating the subcellular distribution of NHE3 in the renal proximal tubule. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 316, n. 5, p. F986-F992, MAY 2019. Web of Science Citations: 0. (16/22140-7)
YOSHIZAKI, AMANDA; ANTONIO, EDNEI LUIZ; SILVA JUNIOR, JOSE ANTONIO; CRAJOINAS, RENATO OLIVEIRA; SILVA, FLAVIO ANDRE; COSTA GIRARDI, ADRIANA CASTELLO; BOCALINI, DANILO SALES; PORTES, LESLIE ANDREWS; NEVES DOS SANTOS, LUIS FELIPE; CARLOS, FERNANDO PEREIRA; et al. Swimming Training Improves Myocardial Mechanics, Prevents Fibrosis, and Alters Expression of Ca2+ Handling Proteins in Older Rats. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 73, n. 4, p. 468-474, APR 2018. Web of Science Citations: 0. (13/10619-8, 15/11028-9)
VIEIRA, STELLA DE SOUZA; ANTONIO, EDNEI LUIZ; DE MELO, BRUNNO LEMES; PORTES, LESLIE ANDREWS; MONTEMOR, JAIRO; OLIVEIRA, HELENITA ANTONIA; MARTINS, FLAVIA LETICIA; ZOGBI, CAMILA; GIRARDI, ADRIANA COSTA; SILVA, JR., JOSE ANTONIO; et al. Exercise Training Potentiates The Cardioprotective Effects of Stem Cells Post-infarction. HEART LUNG AND CIRCULATION, v. 28, n. 2, p. 263-271, FEB 2019. Web of Science Citations: 3. (15/11028-9, 13/10619-8)
SALLES, THIAGO DE ALMEIDA; ZOGBI, CAMILA; DE LIMA, THAIS MARTINS; CARNEIRO, CAMILA DE GODOI; GARCEZ, ALEXANDRE TELES; BARBEIRO, HERMES VIEIRA; ANTONIO, EDNEI LUIZ; DOS SANTOS, LEONARDO; PEREIRA, ALEXANDRE DA COSTA; FERREIRA TUCCI, PAULO JOSE; et al. The contributions of dipeptidyl peptidase IV to inflammation in heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 310, n. 11, p. H1760-H1772, JUN 1 2016. Web of Science Citations: 10. (11/07402-1, 13/10619-8, 09/54225-8)
PESSOA, THAISSA DANTAS; GASTALHO CAMPOS, LUCIENE CRISTINA; CARRARO-LACROIX, LUCIENE; GIRARDI, ADRIANA C. C.; MALNIC, GERHARD. Functional Role of Glucose Metabolism, Osmotic Stress, and Sodium-Glucose Cotransporter Isoform-Mediated Transport on Na+/H+ Exchanger Isoform 3 Activity in the Renal Proximal Tubule. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v. 25, n. 9, p. 2028-2039, SEP 2014. Web of Science Citations: 49. (12/10146-0, 08/58287-5)
SALLES, THIAGO A.; DOS SANTOS, LEONARDO; BARAUNA, VALERIO G.; GIRARDI, ADRIANA C. C.. Potential Role of Dipeptidyl Peptidase IV in the Pathophysiology of Heart Failure. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 16, n. 2, p. 4226-4249, FEB 2015. Web of Science Citations: 11. (13/10619-8)
FARAH, LIVIA X. S.; VALENTINI, VANESSA; PESSOA, THAISSA D.; MALNIC, GERHARD; MCDONOUGH, ALICIA A.; GIRARDI, ADRIANA C. C.. The physiological role of glucagon-like peptide-1 in the regulation of renal function. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 310, n. 2, p. F123-F127, JAN 15 2016. Web of Science Citations: 31. (12/10146-0, 13/10619-8)
DOS SANTOS, LEONARDO; SALLES, THIAGO A.; ARRUDA-JUNIOR, DANIEL F.; CAMPOS, LUCIENE C. G.; PEREIRA, ALEXANDRE C.; BARRETO, ANA LUIZA T.; ANTONIO, EDNEI L.; MANSUR, ALFREDO J.; TUCCI, PAULO J. F.; KRIEGER, JOSE E.; et al. Circulating Dipeptidyl Peptidase IV Activity Correlates With Cardiac Dysfunction in Human and Experimental Heart Failure. Circulation-Heart Failure, v. 6, n. 5, p. 1029-1038, SEP 2013. Web of Science Citations: 70. (12/10146-0, 09/54225-8)
MACHADO BERGER, REBECA CALDEIRA; VASSALLO, PAULA FRIZERA; CRAJOINAS, RENATO DE OLIVEIRA; OLIVEIRA, MARILENE LUZIA; MARTINS, FLAVIA LETICIA; NOGUEIRA, BRENO VALENTIM; MOTTA-SANTOS, DAISY; ARAUJO, ISABELLA BINOTTI; FORECHI, LUDIMILA; COSTA GIRARDI, ADRIANA CASTELLO; et al. Renal Effects and Underlying Molecular Mechanisms of Long-Term Salt Content Diets in Spontaneously Hypertensive Rats. PLoS One, v. 10, n. 10, OCT 23 2015. Web of Science Citations: 7. (12/10146-0, 13/10619-8)
MARTINS, FLAVIA L.; BAILEY, MATTHEW A.; GIRARDI, ADRIANA C. C.. Endogenous Activation of Glucagon-Like Peptide-1 Receptor Contributes to Blood Pressure Control Role of Proximal Tubule Na+/H(+)Exchanger Isoform 3, Renal Angiotensin II, and Insulin Sensitivity. Hypertension, v. 76, n. 3, p. 839-848, SEP 2020. Web of Science Citations: 0. (16/22140-7)