Adriana Castello Costa Girardi
CV Lattes
GoogleMyCitations
ResearcherID
ORCID
Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Adriana C. Girardi received a B.A. in Pharmacology and Biochemistry (1996) and a Ph.D. (2002) in Physiology at University of São Paulo. From 2002 to 2005, she was a postdoctoral fellow in the Aronson lab (Department of Internal Medicine, Section of Nephrology, Yale University). Currently, she is a principal investigator in the Laboratory of Genetics and Molecular Cardiology, Incor, HC-USP and Professor at FMUSP. She has experience in Renal Physiology, Cardiorenal Pharmacology and Biochemistry. Her major scientific interest is understanding blood pressure regulation and cardiovascular disease. Recently, her research group has investigated how therapies for diabetes affect cardiovascular disease progression and hypertension. javascript:void(0) (Source: Lattes Curriculum)
- Molecular bases of renal tubular function and dysfunction, AP.TEM
Abstract
Collectively, the four subprojects that compose this proposal aim to reveal molecular mechanisms that regulate renal tubular function, elucidate how renal tubule dysfunction contributes to the pathophysiology of hypertension (HAS) and Chronic Kidney Disease (CKD) as well as to reveal the molecular mechanisms of antidiabetic agents along the nephron. The first sub-project aims to define ...
- I international cardiorenal meeting, AO.R
- Dipeptidyl peptidase IV as a potential target for the therapy of heart failure, AP.R
Abstract
Heart failure (HF) represents a major public health problem and is a major cause of disability and death in the modern world. The raise in worldwide life expectancy and the fact that HF is the final common pathway for a host of cardiac disorders strongly suggest that the substantial healthcare expenditures and social impact associated with this syndrome will continue to escalate. Such a...
- 2014 Renal Physiology Satellite Symposium, AO.R
(Only some records are available in English at this moment)
- Potential biomarker and therapeutic target of dipeptidyl peptidase IV in Chronic Kidney Disease, BP.DR
Abstract
It is estimated in Brazil that more than 2 million people have Chronic Kidney Disease (CKD) at different stages and approximately 100,000 patients are in renal replacement therapy. However, therapeutic strategies to control the progression of CKD are limited to the control of basal diseases and the use of drugs that block the renin-angiotensin system. Thus there is an avid need for new ...
- Mechanisms mediating the natriuretic and antihypertensive effects of SGLT2 inhibition, BP.IC
Abstract
The Na+/glucose cotransporter SGLT2 reabsorbs most of the glucose filtered by the kidneys. SGLT2 inhibitors, recently approved as new antidiabetic drugs, reduce reabsorption of glucose by the kidneys, thereby reducing blood glucose levels. Data from clinical studies indicate that patients with type 2 diabetes mellitus treated with SGLT2 inhibitors display a consistent decrease in systol...
- Mechanisms responsible for cardioprotective effects of SGLT2 inhibitors: molecular, functional and translational approach, BP.PD
Abstract
Type 2 diabetes mellitus (T2D) is considered one of the main risk factors for cardiovascular diseases (CVD), which are responsible for 80% of the premature mortality of the diabetic population. Among CVD, heart failure is a common complication of T2D, occurring in more than one in 5 patients aged over 65 years. Recently, sodium-glucose cotransporter 2 (SGLT2) inhibitors emerged as promi...
(Only some records are available in English at this moment)
- Role of glucagon-like peptide-1 in the pathophysiology of hypertension, BP.MS
Abstract
A large body of clinical and experimental evidence documents the importance of the kidney in defining the blood pressure (BP) set point and pathogenesis of hypertension. Body fluid volumes and Na+ balance are maintained by the renal regulation of a series of apical Na+ transporters located along the nephron. Changes in the number and/or intrinsic activity of these transporters affect Na...
- Posttranscriptional and posttranslational regulation of the enzyme dypeptidil peptidase IV in heart failure, BP.DR
Abstract
Recent data from our laboratory support the notion that the enzyme dipeptidyl peptidase IV (DPPIV) plays an important role in the pathophysiology of heart failure (HF). DPPIV is a serine protease that cleaves and inactivates a variety of peptides that exert cardioprotective effects, including glucagon-like peptide-1 (GLP-1), brain natriuretic peptide (BNP) and stromal cell-derived facto...
- Effects of Dipeptidyl Peptidase IV inhibition on renal handling of salt and water in rats with congestive heart failure, BP.IC
Abstract
Studies conducted by numerous research laboratories, including ours, underscore the need for undertaking cardiorenal approaches to effectively contain the progression of certain cardiovascular diseases. Edema is the hallmark of congestive heart failure (HF). The most important causes of edema in HF are salt and water retention by the kidneys. The potential causes of altered renal handli...
(Only some records are available in English at this moment)
- Role of myosin IIA in angiotensin II-mediated regulation of NHE3 in the proximal tubule, BE.EP.DR
Abstract
A isoforma 3 do trocador Na/H (NHE3) está presente na membrana apical do túbulo proximal renal e medeia a reabsorção da maior parte do NaCl e do NaHCO3 neste segmento do néfron. Dada a sua importância na homeostase dos fluidos corporais, o NHE3 é fortemente regulado por uma ampla gama de efetores através de múltiplos mecanismos moleculares. A rápida regulação da atividade do NHE3 pode o...
| 1 / 1 | Ongoing research grants |
| 9 / 6 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 26 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 41 / 28 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 25 |
| Citations | 610 |
| Cit./Article | 24.4 |
| Data from Web of Science | |
CRAJOINAS, RENATO O.; POLIDORO, JULIANO Z.; CARNEIRO DE MORAIS, CARLA P. A.; CASTELO-BRANCO, REGIANE C.; GIRARDI, ADRIANA C. C.. Angiotensin II counteracts the effects of cAMP/PKA on NHE3 activity and phosphorylation in proximal tubule cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v. 311, n. 5, p. C768-C776, NOV 1 2016. Web of Science Citations: 7. (13/10619-8, 12/10146-0)
ARRUDA-JUNIOR, DANIEL F.; MARTINS, FLAVIA L.; DARIOLLI, RAFAEL; JENSEN, LEONARDO; ANTONIO, EDNEI L.; DOS SANTOS, LEONARDO; TUCCI, PAULO J. F.; GIRARDI, ADRIANA C. C.. Dipeptidyl Peptidase IV Inhibition Exerts Renoprotective Effects in Rats with Established Heart Failure. FRONTIERS IN PHYSIOLOGY, v. 7, JUL 12 2016. Web of Science Citations: 8. (13/10619-8)
CARNEIRO DE MORAIS, CARLA P.; POLIDORO, JULIANO Z.; RALPH, DONNA L.; PESSOA, THAISSA D.; OLIVEIRA-SOUZA, MARIA; BARAUNA, VALERIO G.; REBOUCAS, NANCY A.; MALNIC, GERHARD; MCDONOUGH, ALICIA A.; GIRARDI, ADRIANA C. C.. Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v. 309, n. 8, p. C541-C550, OCT 15 2015. Web of Science Citations: 5. (13/10619-8, 13/50384-0, 12/10146-0)
CRAJOINAS, R. O.; PESSOA, T. D.; RODRIGUES, M. V.; MALNIC, G.; GIRARDI, A. C. C.. Changes in the activity and expression of protein phosphatase-1 accompany the differential regulation of NHE3 before and after the onset of hypertension in spontaneously hypertensive rats. ACTA PHYSIOLOGICA, v. 211, n. 2, p. 395-408, JUN 2014. Web of Science Citations: 6. (12/10146-0)
INOUE, BRUNA H.; ARRUDA-JUNIOR, DANIEL F.; CAMPOS, LUCIENE C. G.; BARRETO, ANA LUIZA T.; RODRIGUES, MARILIZA V.; KRIEGER, JOSE EDUARDO; GIRARDI, ADRIANA C. C.. Progression of microalbuminuria in SHR is associated with lower expression of critical components of the apical endocytic machinery in the renal proximal tubule. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 305, n. 2, p. F216-F226, JUL 2013. Web of Science Citations: 7. (12/10146-0)
PONTES, ROBERTO B.; CRAJOINAS, RENATO O.; NISHI, ERIKA E.; OLIVEIRA-SALES, ELIZABETH B.; GIRARDI, ADRIANA C.; CAMPOS, RUY R.; BERGAMASCHI, CASSIA T.. Renal nerve stimulation leads to the activation of the Na+/H+ exchanger isoform 3 via angiotensin II type I receptor. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 308, n. 8, p. F848-F856, APR 15 2015. Web of Science Citations: 21. (13/22522-9, 12/10146-0)
QUEIROZ-LEITE, GABRIELLA D.; CRAJOINAS, RENATO O.; NERI, ELIDA A.; BEZERRA, CAMILA N. A.; GIRARDI, ADRIANA C. C.; REBOUCAS, NANCY AMARAL; MALNIC, GERHARD. Fructose Acutely Stimulates NHE3 Activity in Kidney Proximal Tubule. Kidney & Blood Pressure Research, v. 36, n. 1, p. 320-334, 2012. Web of Science Citations: 18. (08/58287-5)
CRAJOINAS, RENATO O.; ORICCHIO, FELIPE T.; PESSOA, THAISSA D.; PACHECO, BRUNA P. M.; LESSA, LUCILIA M. A.; MALNIC, GERHARD; GIRARDI, ADRIANA C. C.. Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 301, n. 2, p. F355-F363, AUG 2011. Web of Science Citations: 117.
CARRARO-LACROIX, LUCIENE R.; LESSA, LUCILIA M. A.; BEZERRA, CAMILA N. A.; PESSOA, THAISSA D.; SOUZA-MENEZES, JACKSON; MORALES, MARCELO M.; GIRARDI, ADRIANA C. C.; MALNIC, GERHARD. Role of CFTR and ClC-5 in Modulating Vacuolar H+-ATPase Activity in Kidney Proximal Tubule. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 26, n. 4-5, p. 563-576, 2010. Web of Science Citations: 16. (04/01683-5)
GIRARDI, ADRIANA C. C.; DI SOLE, FRANCESCA. Deciphering the mechanisms of the Na+/H+ exchanger-3 regulation in organ dysfunction. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v. 302, n. 11, p. C1569-C1587, JUN 2012. Web of Science Citations: 45.
GIRARDI, ADRIANA CASTELLO COSTA; FUKUDA, LÍVIA EMY; ROSSONI, LUCIANA VENTURINI; MALNIC, GERHARD; REBOUÇAS, NANCY AMARAL. Dipeptidyl peptidase IV inhibition downregulates Na+-H+ exchanger NHE3 in rat renal proximal tubule. American Journal of Physiology : Renal Physiology, v. 294, n. 2, p. F414-F422, Feb. 2008. (04/01683-5)
BERALDO, JULIANA ISA; BENETTI, ACARIS; BORGES-JUNIOR, FLAVIO ARAUJO; ARRUDA-JUNIOR, DANIEL F.; MARTINS, FLAVIA LETICIA; JENSEN, LEONARDO; DARIOLLI, RAFAEL; SHIMIZU, MARIA HELOISA; SEGURO, ANTONIO C.; LUCHI, WEVERTON M.; et al. Cardioprotection Conferred by Sitagliptin Is Associated with Reduced Cardiac Angiotensin II/Angiotensin-(1-7) Balance in Experimental Chronic Kidney Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 8, APR 2 2019. Web of Science Citations: 1. (13/10619-8, 16/22140-7)
VEIRAS, LUCIANA C.; GIRARDI, ADRIANA C. C.; CURRY, JOSHUA; PEI, LEI; RALPH, DONNA L.; TRAN, AN; CASTELO-BRANCO, REGIANE C.; PASTOR-SOLER, NURIA; ARRANZ, CRISTINA T.; YU, ALAN S. L.; et al. Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v. 28, n. 12, p. 3504-3517, DEC 2017. Web of Science Citations: 39. (12/10146-0)
GIANNOCCO, GISELE; OLIVEIRA, KELEN C.; CRAJOINAS, RENATO O.; VENTURINI, GABRIELA; SALLES, THIAGO A.; FONSECA-ALANIZ, MIRIAM H.; MACIEL, RUI M. B.; GIRARDI, ADRIANA C. C.. Dipeptidyl peptidase IV inhibition upregulates GLUT4 translocation and expression in heart and skeletal muscle of spontaneously hypertensive rats. European Journal of Pharmacology, v. 698, n. 1-3, p. 74-86, JAN 5 2013. Web of Science Citations: 34.
CARRARO-LACROIX, LUCIENE R.; MALNIC, GERHARD; GIRARDI, ADRIANA C. C.. Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 297, n. 6, p. F1647-F1655, DEC 2009. Web of Science Citations: 77. (04/01683-5)
YOSHIZAKI, AMANDA; ANTONIO, EDNEI LUIZ; SILVA JUNIOR, JOSE ANTONIO; CRAJOINAS, RENATO OLIVEIRA; SILVA, FLAVIO ANDRE; COSTA GIRARDI, ADRIANA CASTELLO; BOCALINI, DANILO SALES; PORTES, LESLIE ANDREWS; NEVES DOS SANTOS, LUIS FELIPE; CARLOS, FERNANDO PEREIRA; et al. Swimming Training Improves Myocardial Mechanics, Prevents Fibrosis, and Alters Expression of Ca2+ Handling Proteins in Older Rats. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 73, n. 4, p. 468-474, APR 2018. Web of Science Citations: 0. (13/10619-8, 15/11028-9)
VIEIRA, STELLA DE SOUZA; ANTONIO, EDNEI LUIZ; DE MELO, BRUNNO LEMES; PORTES, LESLIE ANDREWS; MONTEMOR, JAIRO; OLIVEIRA, HELENITA ANTONIA; MARTINS, FLAVIA LETICIA; ZOGBI, CAMILA; GIRARDI, ADRIANA COSTA; SILVA, JR., JOSE ANTONIO; et al. Exercise Training Potentiates The Cardioprotective Effects of Stem Cells Post-infarction. HEART LUNG AND CIRCULATION, v. 28, n. 2, p. 263-271, FEB 2019. Web of Science Citations: 2. (13/10619-8, 15/11028-9)
CRAJOINAS, RENATO O.; POLIDORO, JULIANO Z.; GIRARDI, ADRIANA C. C.. The potential role of myosin motor proteins in mediating the subcellular distribution of NHE3 in the renal proximal tubule. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 316, n. 5, p. F986-F992, MAY 2019. Web of Science Citations: 0. (16/22140-7)
SALLES, THIAGO DE ALMEIDA; ZOGBI, CAMILA; DE LIMA, THAIS MARTINS; CARNEIRO, CAMILA DE GODOI; GARCEZ, ALEXANDRE TELES; BARBEIRO, HERMES VIEIRA; ANTONIO, EDNEI LUIZ; DOS SANTOS, LEONARDO; PEREIRA, ALEXANDRE DA COSTA; FERREIRA TUCCI, PAULO JOSE; et al. The contributions of dipeptidyl peptidase IV to inflammation in heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 310, n. 11, p. H1760-H1772, JUN 1 2016. Web of Science Citations: 11. (11/07402-1, 13/10619-8, 09/54225-8)
LUCHI, WEVERTON M.; SHIMIZU, MARIA HELOISA M.; CANALE, DANIELE; GOIS, PEDRO HENRIQUE F.; DE BRAGANCA, ANA CAROLINA; VOLPINI, RILDO A.; GIRARDI, ADRIANA C. C.; SEGURO, ANTONIO C.. Vitamin D deficiency is a potential risk factor for contrast-induced nephropathy. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 309, n. 3, p. R215-R222, AUG 1 2015. Web of Science Citations: 10. (12/10146-0)
DOS SANTOS, LEONARDO; SALLES, THIAGO A.; ARRUDA-JUNIOR, DANIEL F.; CAMPOS, LUCIENE C. G.; PEREIRA, ALEXANDRE C.; BARRETO, ANA LUIZA T.; ANTONIO, EDNEI L.; MANSUR, ALFREDO J.; TUCCI, PAULO J. F.; KRIEGER, JOSE E.; et al. Circulating Dipeptidyl Peptidase IV Activity Correlates With Cardiac Dysfunction in Human and Experimental Heart Failure. Circulation-Heart Failure, v. 6, n. 5, p. 1029-1038, SEP 2013. Web of Science Citations: 76. (09/54225-8, 12/10146-0)
SAVIGNANO, FERNANDA A.; CRAJOINAS, RENATO O.; PACHECO, BRUNA P. M.; CAMPOS, LUCIENE C. G.; SHIMIZU, MARIA HELOISA M.; SEGURO, ANTONIO CARLOS; GIRARDI, ADRIANA C. C.. Attenuated diuresis and natriuresis in response to glucagon-like peptide-1 in hypertensive rats are associated with lower expression of the glucagon-like peptide-1 receptor in the renal vasculature. European Journal of Pharmacology, v. 811, p. 38-47, SEP 15 2017. Web of Science Citations: 4. (13/10619-8, 12/10146-0)
PESSOA, THAISSA DANTAS; GASTALHO CAMPOS, LUCIENE CRISTINA; CARRARO-LACROIX, LUCIENE; GIRARDI, ADRIANA C. C.; MALNIC, GERHARD. Functional Role of Glucose Metabolism, Osmotic Stress, and Sodium-Glucose Cotransporter Isoform-Mediated Transport on Na+/H+ Exchanger Isoform 3 Activity in the Renal Proximal Tubule. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v. 25, n. 9, p. 2028-2039, SEP 2014. Web of Science Citations: 54. (08/58287-5, 12/10146-0)
CARRARO-LACROIX, LUCIENE R.; MALNIC, GERHARD; GIRARDI, ADRIANA C. C.. Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 297, n. 6, p. F1647-F1655, DEC 2009. Web of Science Citations: 77. (04/01683-5)
CRAJOINAS, RENATO O.; POLIDORO, JULIANO Z.; GIRARDI, ADRIANA C. C.. The potential role of myosin motor proteins in mediating the subcellular distribution of NHE3 in the renal proximal tubule. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 316, n. 5, p. F986-F992, MAY 2019. Web of Science Citations: 0. (16/22140-7)
VIEIRA, STELLA DE SOUZA; ANTONIO, EDNEI LUIZ; DE MELO, BRUNNO LEMES; PORTES, LESLIE ANDREWS; MONTEMOR, JAIRO; OLIVEIRA, HELENITA ANTONIA; MARTINS, FLAVIA LETICIA; ZOGBI, CAMILA; GIRARDI, ADRIANA COSTA; SILVA, JR., JOSE ANTONIO; et al. Exercise Training Potentiates The Cardioprotective Effects of Stem Cells Post-infarction. HEART LUNG AND CIRCULATION, v. 28, n. 2, p. 263-271, FEB 2019. Web of Science Citations: 2. (13/10619-8, 15/11028-9)