CV Lattes
ResearcherID
ORCID
Google Scholar Citations
Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Adriana C. Girardi received a B.A. in Pharmacology and Biochemistry (1996) and a Ph.D. (2002) in Physiology at University of São Paulo. From 2002 to 2005, she was a postdoctoral fellow in the Aronson lab (Department of Internal Medicine, Section of Nephrology, Yale University). Currently, she is a principal investigator in the Laboratory of Genetics and Molecular Cardiology, Incor, HC-USP and Professor at FMUSP. She has experience in Renal Physiology, Cardiorenal Pharmacology and Biochemistry. Her major scientific interest is understanding blood pressure regulation and cardiovascular disease. Recently, her research group has investigated how therapies for diabetes affect cardiovascular disease progression and hypertension. javascript:void(0) (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Clinical evidence indicates that hypertensive patients are highly susceptible to infection and the severity of COVID-19, a disease caused by the new SARS coronavirus SARS-Cov-2. The SARS-CoV-2 requires the host protein angiotensin-converting enzyme-2 (ACE2), as a receptor, and the serine protease TMPRSS2, for S protein priming, to gain intracellular entry in the lungs, among other organs …
Dipeptidyl peptidase 4 (DPP4) inhibitors are antidiabetic agents that exert renoprotective effects, beyond glucose control in humans and in experimental models of cardiovascular and renal diseases. DPP4 inhibition reduces Na+/H+ exchanger isoform 3 (NHE3)-dependent sodium reabsorption in the renal proximal tubule and this inhibitory effect is associated with blood pressure lowering effect…
Collectively, the four subprojects that compose this proposal aim to reveal molecular mechanisms that regulate renal tubular function, elucidate how renal tubule dysfunction contributes to the pathophysiology of hypertension (HAS) and Chronic Kidney Disease (CKD) as well as to reveal the molecular mechanisms of antidiabetic agents along the nephron. The first sub-project aims to define th…
Heart failure (HF) represents a major public health problem and is a major cause of disability and death in the modern world. The raise in worldwide life expectancy and the fact that HF is the final common pathway for a host of cardiac disorders strongly suggest that the substantial healthcare expenditures and social impact associated with this syndrome will continue to escalate. Such asp…
(Only some records are available in English at this moment)
The Na+ /H+ exchanger isoform 3 (NHE3) is responsible for a large part of the reabsorption of NaCl, NaHCO3, and, consequently, of water, in the renal proximal tubule. As such, this transporter plays an essential role in volume homeostasis, acid-base balance, and blood pressure control. The modulation of NHE3 activity is mediated by a series of molecular mechanisms, including the redistrib…
NHE3 is the most abundant Na+/H+ exchanger isoform at the apical membrane of the proximal tubule, being responsible for the majority of the filtered NaCl and NaHCO3. As such, this NHE isoform plays an essential role in volume homeostasis, acid-base homeostasis, and in determining systemic blood pressure levels. Cummulative evidence indicates that hormones, compounds associated with regula…
Inhibitors of the enzyme dipeptidyl peptidase IV (DPPIV) are antidiabetic agents which exert renoprotective effects, beyond the glycemic benefit, in humans and experimental models of cardiovascular and renal diseases. Inhibition of DPPIV reduces Na+/H+ exchanger 3 (NHE3)-dependent Na+ reabsorption in proximal renal tubule and this inhibitory effect is associated with the reduction of bloo…
(Only some records are available in English at this moment)
Clinical evidence indicates that hypertensive patients are highly susceptible to infection and the severity of COVID-19, a disease caused by the new SARS coronavirus SARS-Cov-2. The SARS-CoV-2 requires the host protein angiotensin-converting enzyme-2 (ACE2), as a receptor, and the serine protease TMPRSS2, for S protein priming, to gain intracellular entry in the lungs, among other organs …
The Na+/glucose cotransporter SGLT2 reabsorbs most of the glucose filtered by the kidneys. SGLT2 inhibitors, recently approved as new antidiabetic drugs, reduce reabsorption of glucose by the kidneys, thereby reducing blood glucose levels. Data from clinical studies indicate that patients with type 2 diabetes mellitus treated with SGLT2 inhibitors display a consistent decrease in systolic…
Type 2 diabetes mellitus (T2D) is considered one of the main risk factors for cardiovascular diseases (CVD), which are responsible for 80% of the premature mortality of the diabetic population. Among CVD, heart failure is a common complication of T2D, occurring in more than one in 5 patients aged over 65 years. Recently, sodium-glucose cotransporter 2 (SGLT2) inhibitors emerged as promisi…
(Only some records are available in English at this moment)
A isoforma 3 do trocador Na/H (NHE3) está presente na membrana apical do túbulo proximal renal e medeia a reabsorção da maior parte do NaCl e do NaHCO3 neste segmento do néfron. Dada a sua importância na homeostase dos fluidos corporais, o NHE3 é fortemente regulado por uma ampla gama de efetores através de múltiplos mecanismos moleculares. A rápida regulação da atividade do NHE3 pode oco…
| 3 / 3 | Ongoing research grants |
| 11 / 6 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 30 / 20 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 49 / 34 | All research grants and scholarships |
| Associated processes | |