Andréa Laurato Sertié
CV Lattes
ResearcherID
Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) (Institutional affiliation for the last research proposal) Birthplace: Brazil
doctorate at Genetics from Universidade de São Paulo (2000). He is currently full professor at Instituto Israelita de Ensino e Pesquisa Albert Einstein. Has experience in Genetics, focusing on Human and Medical Genetics, acting on the following subjects: triagem de mutação, síndrome de knobloch, craniosinostoses, heterogeneidade genética e clínica and genes fgfr. (Source: Lattes Curriculum)
- Functional analysis of rare genetic variants in Autism Spectrum Disorder: an oligonenic mode of inheritance?, AP.R
Abstract
Recent whole-genome-based analyzes have revealed a large number of potentially deleterious genetic variants in patients with Autism Spectrum Disorder (ASD), most of them rare and private. One of the major current challenge is to determine which of these variants are involved in the etiology of the disease and how many variants are required for the complete penetrance of the disorder in ...
- Gene expression analysis on in vitro neuronal models and post-mortem brain tissues to understand Autism Spectrum Disorder, AP.R
Abstract
We propose to combine the complementary expertise of our labs in cellular reprogramming and exome sequencing (Sertié's group) and transcriptome sequencing co-expression network reconstruction (Voineagu lab) to investigate convergent pathophysiology of non-syndromic ASD and Rett syndrome. Dr. Sertie's group is studying the possible role of the complement system in the etiology of ASD, th...
- Elucidating the role of the innate immune complement pathway in brain development and in Autism Spectrum Disorders, AP.R
Abstract
This proposal is aimed to further characterize this important pathway in the developing brain and to understand how it is involved in ASD. The specific objectives include: 1) Further analyze and characterize the complement pathway in the developing brain using mouse models; 2) Expand and validate ASD related variants in the complement pathway; 3) Focus on specific ASD related potentiall...
- Investigation of the cellular and molecular effects of Reln mutations in Autism Spectrum Disorders, AP.R
Abstract
Autism Spectrum Disorders (ASD) are a heterogeneous and highly prevalent group of neurodevelopmental disorders. Whole-genome-based approaches have generated catalogues of thousands of rare and potentially deleterious genetic variants in ASD patients. However, the challenge now is to identify genuine disease-causing/risk variants among the multitude of variants discovered in each exome/g...
(Only some records are available in English at this moment)
- Investigation of the effects of IL-17A cytokine on human neural cells and on Autism Spectrum Disorder, BP.MS
Abstract
Autism Spectrum Disorder (ASD) is a neurodevelopmental disease characterized by deficits in social communication and interaction, as well as by repetitive and stereotyped behaviors. In most cases, the cause of ASD is not completely understood, but it is commonly associated with heterogeneous genetic and environmental backgrounds. Among the most important environmental risk factors for A...
- Molecular and cellular effects of a de novo mutation in the CACNA1H gene in autistic spectrum disorder, BP.MS
Abstract
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by impairment in reciprocal social communication, restricted repetitive and stereotyped patterns of behavior. Recent genomic studies have revealed that the genetic architecture of ASD is extremely complex and heterogeneous, and both rare and common genetic variants may contribute to its etiology. However, mos...
- Study of the involvement of collybistin and gephyrin proteins in the control of translation initiation, BP.MS
Abstract
Collybistin and gephyrin are key proteins implicated in inhibitory synapse development and plasticity that cluster and localize inhibitory neurotransmitter receptors to the neural postsynaptic membrane. Loss of function mutations of collybistin and gephyrin have been identified in patients with neurological diseases such as mental retardation, epilepsy and autism. We have recently repor...
| 1 / 1 | Ongoing research grants |
| 8 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 6 / 2 | Completed scholarships in Brazil |
| 16 / 11 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 2 |
| Citations | 4 |
| Cit./Article | 2.0 |
| Data from Web of Science | |
SANCHEZ-SANCHEZ, SANDRA M.; MAGDALON, JULIANA; GRIESI-OLIVEIRA, KARINA; YAMAMOTO, GUILHERME L.; SANTACRUZ-PEREZ, CAROLINA; FOGO, MARIANA; PASSOS-BUENO, MARIA RITA; SERTIE, ANDREA L.. Rare RELN variants affect Reelin-DAB1 signal transduction in autism spectrum disorder. Human mutation, v. 39, n. 10, p. 1372-1383, OCT 2018. Web of Science Citations: 2. (14/25646-3, 15/50138-4)
ANTONIOLI, ELIANE; TORRES, NATALIA; FERRETTI, MARIO; PICCINATO, CARLA DE AZEVEDO; SERTIE, ANDREA LAURATO. Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells. PLoS One, v. 14, n. 1, JAN 31 2019. Web of Science Citations: 2. (14/25646-3, 12/00831-7)