Leonardo dos Reis Silveira
CV Lattes
Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Leonardo dos Reis Silveira in research grants and scholarships supported by FAPESP.
- Identification and functional characterization of protein bound to NCoR1 complex and associated with molecular control of mitochondrial biogenesis process, AP.TEM
Abstract
Skeletal muscle uses a well-regulated transcriptional programs to adapt to environmental inputs through storage or consumption of energy. PPAR² plays a critical role in this process being regulated by its interaction with positive and negative co-regulators. Under NCoR1 overexpression, a well-known PPAR inhibitor, we observed a marked repression of mitochondrial biogenesis in C2C12 cell...
- Effect of miR-696 e miR-let7b on the mitochondrial function in insulin resistant muscle cells, AV.EXT
Abstract
Insulin resistance is a feature associate with type II diabetes but its mechanism is not fully understood. Recently, micro-RNAs (miRNAs) have been described as non-coding molecules associated with post-transcriptional gene regulation and, therefore, regulate several physiological and pathological processes like growth, differentiation, metabolism, cancer and diabetes. It is known that t...
- Effect of miR-696 e miR-let7b on the mitochondrial function in insulin resistant muscle cells, AP.R
Abstract
Insulin resistance is a feature associate with type II diabetes but its mechanism is not fully understood. Recently, micro-RNAs (miRNAs) have been described as non-coding molecules associated with post-transcriptional gene regulation and, therefore, regulate several physiological and pathological processes like growth, differentiation, metabolism, cancer and diabetes. It is known that t...
- Overexpression of genes associated with glucose and fatty acid metabolism in insulin resistant muscle cells, AP.R
(Only some records are available in English at this moment)
- Identification and functional characterization of protein bound to NCoR1 complex and associated with molecular control of mitochondrial biogenesis process, BP.PD
Abstract
Skeletal muscle uses a well regulated transcriptional programs to adapt to environmental inputs through storage or consumption of energy. PPAR² plays a critical role in this pro-cess being regulated by its interaction with positive and negative co-regulators. Under NCoR1 overexpression, a well known PPAR inhibitor, we observed a marked repression of mitochondrial biogenesis in C2C12 cel...
- Search and characterization of novel transcriptional regulators of mitochondrial biogenesis associated genes, BP.DR
Abstract
The mitochondria have fundamental roles in a series of cellular processes, in such a way that their activity level and number in each cell must follow the fuel requirement changes and dysfunctions in the regulation of this processes may lead to conditions like Obesity and Diabetes. Classically, o major regulator of mitochondrial biogenesis is the PGC1-a protein, which by interacting wit...
- Molecular control of HIF1-A expression and response to insulin mediated by PPAR in muscle cells, BP.IC
Abstract
The nuclear receptor PPAR² is an important transcriptional regulator of the mitochondrial biogenesis process in peripheral tissue cells including skeletal muscle. Recent researches has demonstrated that the expression of hypoxia-inducible transcription factor (HIF-1a) is increased in tissue / muscle cells with high mitochondrial capacity induced by exercise or overexpression of PGC-1a (...
- High throughput screening (HTS) biological platform for mitochondrial homeostasis evaluation in adherent cells, BP.PD
Abstract
The ability to synchronize mitochondrial signaling pathways to respond to energy fluctuations within the cell is a central aspect of mammalian homeostasis. In this context, mitochondria play a major role. Therefore, the molecular control of mitochondrial function represents a fundamental aspect of mammalian physiology and defects in the integrity of this system can lead to severe pertur...
- ATM protein as an important molecular regulator of mitochondrial function and glucose metabolism in muscle cells, BP.PD
Abstract
Insulin resistance in skeletal muscle is a common characteristic of diabetic patients. It was recently demonstrated a strong association between ATM deficiency and oxidative stress , a favorable condition for the development of neurodegenerative, metabolic and oncogenic diseases. Under oxidative stress state, the transcription of PGC1-± is downregulated, increasing evidence that activat...
(Only some records are available in English at this moment)
- Screening platform for the identification of molecular targets involved in mitochondrial homeostasis, BE.EP.PD
Abstract
The molecular control of mitochondrial function represents a fundamental aspect of mammalian physiology and defects in the integrity of this system can lead to severe perturbations to cell homeostasis giving rise to a broad range of pathologies, including obesity and type 2 diabetes. The main goal of this project is to develop an integrated screening platform for the identification of t...
- INTER-ORGAN communication between BAT and muscle: role of batokines in whole body energy homeostasis, BE.EP.PD
Abstract
Brown (BAT) and beige adipose cells have the capacity to produce heat (thermogenesis) due to substrate oxidation. This futile cycle is essentially regulated by the action of uncoupling protein 1 (UCP1), a protein located in the inner mitochondrial membrane of brown and beige adipocytes 1. The thermogenesis program is considered a valuable tool to counteract metabolic diseases such as ob...
- Regulation of mitochondrial function by hypoxia inducible factor (HIF-1) in insulin resistant muscle cells, BE.EP.PD
Abstract
Skeletal muscle insulin resistance is a common feature in diabetic population. One target that has been given some attention is the transcriptional factor hypoxia inducible factor (HIF-1±). Our proposal was to evaluate the role of HIF-1± in insulin resistant skeletal muscle cells. The skeletal muscle cells will isolated from quadriceps muscle from Wistar rats and cultured in DMEM (Ethic...
| 1 / 1 | Ongoing research grants |
| 7 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 9 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 2 | Completed scholarships abroad |
| 23 / 18 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 3 |
| Citations | 18 |
| Cit./Article | 6.0 |
| Data from Web of Science | |
LIMA, TANES I.; ARAUJO, HYGOR N.; MENEZES, EVELINE S.; SPONTON, CARLOS H.; ARAUJO, MICHEL B.; BOMFIM, LUCAS H. M.; QUEIROZ, ANDRE L.; PASSOS, MADLA A.; AMARAL E SOUSA, THAIS; HIRABARA, SANDRO M.; et al. Role of microRNAs on the Regulation of Mitochondrial Biogenesis and Insulin Signaling in Skeletal Muscle. Journal of Cellular Physiology, v. 232, n. 5, p. 958-966, MAY 2017. Web of Science Citations: 14. (13/22733-0)
LIMA, TANES I.; VALENTIM, RAFAEL R.; ARAUJO, HYGOR N.; OLIVEIRA, ANDRE G.; FAVERO, BIANCA C.; MENEZES, EVELINE S.; ARAUJO, RAFAELA; SILVEIRA, LEONARDO R.. Role of NCoR1 in mitochondrial function and energy metabolism. Cell Biology International, v. 42, n. 6, SI, p. 734-741, JUN 2018. Web of Science Citations: 3. (16/23008-5)
LIMA, I, TANES; SILVEIRA, LEONARDO R.. A microplate assay for measuring cell death in C2C12 cells. BIOCHEMISTRY AND CELL BIOLOGY, v. 96, n. 5, p. 702-706, OCT 2018. Web of Science Citations: 1. (16/23008-5)