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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Leonardo dos Reis Silveira in research grants and scholarships supported by FAPESP.
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Skeletal muscle uses a well-regulated transcriptional programs to adapt to environmental inputs through storage or consumption of energy. PPAR² plays a critical role in this process being regulated by its interaction with positive and negative co-regulators. Under NCoR1 overexpression, a well-known PPAR inhibitor, we observed a marked repression of mitochondrial biogenesis in C2C12 cells …
Insulin resistance is a feature associate with type II diabetes but its mechanism is not fully understood. Recently, micro-RNAs (miRNAs) have been described as non-coding molecules associated with post-transcriptional gene regulation and, therefore, regulate several physiological and pathological processes like growth, differentiation, metabolism, cancer and diabetes. It is known that the…
Insulin resistance is a feature associate with type II diabetes but its mechanism is not fully understood. Recently, micro-RNAs (miRNAs) have been described as non-coding molecules associated with post-transcriptional gene regulation and, therefore, regulate several physiological and pathological processes like growth, differentiation, metabolism, cancer and diabetes. It is known that the…
(Only some records are available in English at this moment)
Skeletal muscle uses a well regulated transcriptional programs to adapt to environmental inputs through storage or consumption of energy. PPAR² plays a critical role in this pro-cess being regulated by its interaction with positive and negative co-regulators. Under NCoR1 overexpression, a well known PPAR inhibitor, we observed a marked repression of mitochondrial biogenesis in C2C12 cells…
The mitochondria have fundamental roles in a series of cellular processes, in such a way that their activity level and number in each cell must follow the fuel requirement changes and dysfunctions in the regulation of this processes may lead to conditions like Obesity and Diabetes. Classically, o major regulator of mitochondrial biogenesis is the PGC1-a protein, which by interacting with …
The ability to synchronize mitochondrial signaling pathways to respond to energy fluctuations within the cell is a central aspect of mammalian homeostasis. In this context, mitochondria play a major role. Therefore, the molecular control of mitochondrial function represents a fundamental aspect of mammalian physiology and defects in the integrity of this system can lead to severe perturba…
The nuclear receptor PPAR² is an important transcriptional regulator of the mitochondrial biogenesis process in peripheral tissue cells including skeletal muscle. Recent researches has demonstrated that the expression of hypoxia-inducible transcription factor (HIF-1a) is increased in tissue / muscle cells with high mitochondrial capacity induced by exercise or overexpression of PGC-1a (1,…
(Only some records are available in English at this moment)
The fine-tuning between metabolic demand and supply of metabolites is enabled by the tightly regulation of mitochondrial function both at the posttranslational and transcriptional levels. In the latter, the family of nuclear receptors is largely responsible for translating environmental signals into transcriptional modulation, being orchestrated by the antagonistic action of transcription…
The molecular control of mitochondrial function represents a fundamental aspect of mammalian physiology and defects in the integrity of this system can lead to severe perturbations to cell homeostasis giving rise to a broad range of pathologies, including obesity and type 2 diabetes. The main goal of this project is to develop an integrated screening platform for the identification of tra…
Brown (BAT) and beige adipose cells have the capacity to produce heat (thermogenesis) due to substrate oxidation. This futile cycle is essentially regulated by the action of uncoupling protein 1 (UCP1), a protein located in the inner mitochondrial membrane of brown and beige adipocytes 1. The thermogenesis program is considered a valuable tool to counteract metabolic diseases such as obes…
Skeletal muscle insulin resistance is a common feature in diabetic population. One target that has been given some attention is the transcriptional factor hypoxia inducible factor (HIF-1±). Our proposal was to evaluate the role of HIF-1± in insulin resistant skeletal muscle cells. The skeletal muscle cells will isolated from quadriceps muscle from Wistar rats and cultured in DMEM (Ethics …
| 1 / 1 | Ongoing research grants |
| 7 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 4 / 3 | Completed scholarships abroad |
| 24 / 19 | All research grants and scholarships |
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