Isaias Glezer

• Abstract

  CD36 is a membrane glycoprotein associated with various biological processes, including fatty acids internalization and utilization, and ligand presentation for receptors that activate innate immune system cells. CD36 is a multifunctional receptor due to its presence in varied cell types and also for the diversity of its unrelated ligands. Recently, we characterized CD36 expression in a s…

  Lipid Modification and Signaling through CD36 Receptor in the Nervous System, AP.R
• Post-lesion cell regeneration in the nervous system and functional aspects of genes linked to innate immune response, AP.JP

• Abstract

  Astrocytes are glial cells responsible for neuronal support, and also exert protection against excessive excitation of L-glutamate-responsive neurons through excitatory amino acid transport and protection against reactive oxygen species (ROS). A growing number of studies have shown that astrocytes release extracellular vesicles (EVs) that exert neuroprotective effects. Here we aim to eval…

  Neuroprotective effects of astrocyte-derived extracellular vesicles, BP.IC

• Abstract

  CD36 receptor is a multifunctional molecule involved in diverse cellular functions, including fatty acid cell internalization and metabolism. CD36 expression in a subpopulation of neurononal cells in the nasal neuroepithelium is quite recent, and more studies are necessary to better understand the physiological role of this molecule in the nervous system. Here we propose to investigate t…

  Impact of selective CD36 ablation in the nasal neuroepithelium on gene expression, BP.MS

• Abstract

  The process of hypothalamic adult neurogenesis has been recently described. Although this site has been lesscharacterized compared to the classical adult brain neurogenic niches, there are strong evidences that theneurogenic niche of the hypothalamus is able to generate effector neurons that regulate energy balance. Theneurogenic process of this brain region is likely to be stimulated und…

  The influence of hypothalamic lesions on the implantation of neurosphere-derived cells, BP.IC

(Only some records are available in English at this moment)

• Abstract

  The immune cells are recruited during the regenerative process that takes place after brain injury. The inflammatory reaction associated with this process is essential for pathogen and damaged tissue elimination, as well for tissue recovery. The cells that conduct the innate immune response express Toll-like receptors (TLRs), which transduce signals and induce gene expression following pa…

  Investigation of insulin degrading enzyme (IDE) regulatory role in olfactory sensory neurons regeneration, BE.EP.DD