CV Lattes
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Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Química com atribuição tecnológica from Universidade Federal do Rio de Janeiro (2001), master's at Chemistry from Universidade Federal do Rio de Janeiro (2002) and doctorate at Chemistry from Universidade Estadual de Campinas (2006). Has experience in Chemistry, focusing on Organic Synthesis, acting on the following subjects: grupamento acila, glicidóis and ditiana. (Source: Lattes Curriculum)
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Alpha-Heterofunctionalized carbonyl compounds have a wide versatility as synthetic building blocks, due to a variety of transformations that these can participate. However, there are a limited number of asymmetric methodologies to prepare this class of compounds. Therefore, the development of such methodologies is of great importance in the area of organic synthesis. Combining this need w…
The expansion of products that can be obtained through the transformation of vegetal biomass has been a great challenge, especially in the case of complex molecules with high added value. In this case, it is important to develop new methodologies or synthetic transformations that can supply new compounds from raw materials that are easily obtained from the biomass in abundant form (levuli…
Subproject A: Synthesis of prochiral b-cetosulfoxonium ylides and its application in asymmetric insertion reactions catalyzed by gold. Subproject B: The use of Bronsted acids in the organocatalytic decomposition of diazo compounds in the presence of nucleophilic agents. (AU)
Cruzain, the main cysteine protease of Trypanosoma cruzi, is an essential enzyme for the life cycle of the parasite and has been used as a viable target for searching for enzyme inhibitors as drug candidates. The peptide mimetic compound K11777 inhibits cruzain at nanomolar concentrations, and acts by an irreversible inhibition mechanism. Analogs or derivatives K11777 usually contain elec…
(Only some records are available in English at this moment)
Polyurethanes (PUs) are one of the most important types of polymeric materials due to their applications in different fields of industrial chemistry because of their properties. Their main way of obtaining it is trough polyaddition reaction of isocyanates and polyols. The isocyanate monomers that are used as starting material are synthesized from toxic phosgene, therefore, several greener…
Sulfur ylides represent an important synthetic tool for organic chemists since they are used as building blocks in total synthesis, in the materials chemistry, and in the production of drugs, for example. However, there is a great difficulty associated with the alkylation of these compounds, mainly of the stabilized ones, as is the case of the ²-ketosulfoxonium ylides. For this reason, ob…
Alpha-heterofunctionalized carbonyl compounds have a wide versatility as synthetic building blocks, due to a variety of transformations that these can participate. However, there are a limited number of asymmetric methodologies to prepare this class of compounds. Therefore, the development of such methodologies is of great importance in the area of organic synthesis. Combining this need w…
(Only some records are available in English at this moment)
This research project proposes to explore the reactivity of sulfur ylides with ketenes that are generated from diazocarbonyl compounds. This combination aims to obtain functionalized ³-butenolides and butyrolactams. At first, these transformations will be evaluated in the racemic fashion and later it will be extended to the asymmetric version. Currently, there are no reports in the litera…
The research proposed provides a unified catalytic strategy using chiral Brønsted acids to access carbon-oxygen, carbon-nitrogen, carbon-sulfur and carbon-halogen bonds from either diazoketones or sulfoxonium ylides as starting materials.
This project aims to evaluate methodologies for the synthesis of unsaturated bicyclic lactones through the Corey-Chaykovsky reaction, followed by elimination-epoxide opening. The methodology to be evaluated has already been applied in our laboratory for the synthesis of the unsaturated bicyclic lactone 5,5-dimethyltetrahydroisocromen-3(4H)-one, in 35% yield. The project aims to optimize t…
(Only some records are available in English at this moment)
In recent years, sulfur ylides have received significant attention as equivalents of diazo compounds and as precursors of metal-carbene complexes. Although significative advances have been made regarding the use of a-carbonyl metal-carbenes as intermediates in organic synthesis, a less explored type of metal-carbene, containing a-imino group, still have limited sources and few general app…
Our research group have been exploring the chemistry of a,b-unsaturated diazoketones and b-ketosulfoxonium ylides and using these compounds in several relevant chemical transformations. Currently, we are studying enantioselective reactions employing a,b-unsaturated diazoketones, aryl and alkyl diazoketones and b-ketosulfoxonium ylides. In this project, enantioselective reactions will be d…
This project aims at applying the knowledge on the chemistry of alpha,beta-unsaturated diazoketones, developed in our group, to enable the site-selective modification of proteins in collaboration with Prof. Gonçalo Bernardes at University Of Cambridge, UK. Chemical protein modification has emerged as an invaluable tool for understanding natural systems, create therapeutic conjugates with …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 7 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 24 / 21 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 42 / 37 | All research grants and scholarships |
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