She holds a degree in Biological Sciences (Bachelor's and Bachelor's degrees) from the Federal University of Santa Catarina (1993-1997) and a PhD in Sciences, Area of #8203;#8203;Concentration: Physiology, from the Federal University of São Carlos (2000-2004). She completed her doctoral internship (2002) at the Department of Microbiology, University of Virginia Health System, Charlottesville, VA, USA and a post-doctorate (2005-2006) at the Institute de la Santé et de la Recherche Médicale (INSERM, Unité 553) in Paris, France. She was awarded a Visiting Fellowship (2015) by the University of Nottingham, England. She is currently an Associate Professor at the Federal University of São Carlos. She coordinates the LABEN - Laboratory of Biology of Aging - located in the Department of Gerontology at UFSCar. She leads the research group Biology of Aging registered in the CNPq research groups directory. She is a supervisor in the Graduate Program in Gerontology (PPGGero/UFSCar), which is part of the Network of Interdisciplinary Graduate Programs on Aging (REPRINTE). She also supervises in the Interinstitutional Graduate Program in Physiological Sciences (UFSCar/UNESP). She is a reviewer for several journals in the area of #8203;#8203;Aging, Alzheimer's disease and Cancer and a scientific advisor for Brazilian (CNPq and FAPESP) and foreign funding agencies (Alzheimer's Association, FONDECYT-Chile, Czech Science Foundation-Czech Republic, United States-Israel Binational Science Foundation and The Netherlands Organisation for Health Research and Development). She is a member of the Committee for the Evaluation of Proposals for New Courses (APCN), of the CAPES quadrennial evaluation and of the CAPES Thesis Award in the Interdisciplinary area. He has projects in collaboration with several international institutions such as Trinity College Dublin - Ireland, University of Nottingham - UK, Università degli Studi di Milano - Italy, Universitat de València and Universitat de Barcelona - Spain, Université du Quebec à Montréal - Canada, Olivia Newton John Cancer Research Institute - Australia, University of California in Berkeley, Virginia Commonwealth University and Purdue University - USA. He is a Senior Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute (GBHI) at Trinity College Dublin, Ireland. He has experience in the area of #8203;#8203;Cell Biology and Biochemistry, with an emphasis on Molecular Biology, working mainly on the following topics: aging, elderly, biomarkers for Alzheimer's disease, ADAMs, cancer and mammalian cell culture. E-mail: mcominetti@ufscar.br (Source: Lattes Curriculum)
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Alzheimer's Disease (AD) is a gradual and progressive neurodegenerative disease characterized by extensive neuronal losses and deposits of neurofibrillary tangles and senile plaques. Mild neurocognitive impairment (MCI) is characterized by cognitive decline, but with preservation of functionality, being an intermediate stage between normal AD cognition, but that can be reversed. ADAM10 is…
Alzheimer's disease (AD) is a gradual and progressive neurodegenerative disease characterized by extensive neuronal losses and deposits of neurofibrillary tangles and senile plaques. Mild neurocognitive impairment (MCI) is characterized by cognitive decline, but with preservation of functionality, being an intermediate stage between normal AD cognition, but that can be reversed. ADAM10 is…
AD (Alzheimer's disease) is a progressive neurodegenerative disease predominantly characterized by cortical atrophy in the medial temporal lobe, and microscopically, by extensive neuronal losses and deposits called neurofibrillary tangles and senile plaques. Since the results of the Rotterdam study in 1992, it is known that T2DM (type 2 diabetes mellitus) increases the risk of dementia. …
(Only some records are available in English at this moment)
Cancer, a global concern, is characterized by the uncontrolled growth of cells, often driven by genetic mutations. Breast cancer, notably triple-negative breast cancer (TNBC), represents a significant therapeutic challenge due to its aggressiveness and lack of specific estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2). In this contex…
Alzheimer's disease (AD) is a gradual and progressive neurodegenerative disease characterized by extensive neuronal loss and deposits of neurofibrillary tangles and senile plaques. ADAM10 is the main ±-secretase capable of acting on the non-amyloidogenic pathway of amyloid precursor protein (APP) cleavage and, therefore, preventing the formation of ²-amyloid peptide (A²), one of the patho…
(Only some records are available in English at this moment)
Introduction: The significant increase in the elderly population, concomitant with the growth ofdementia rates, highlights the urgency of effective scientific dissemination actions aboutof these themes. The impact of this condition demands actions aimed at promotingawareness and awareness, aiming to eliminate stigmas and facilitate early diagnosis andhumanized. Therefore, making scientifi…
Introduction: The population growth of the elderly has required greater attention to diseases related to aging and their risk factors. Although there are studies that show the relationship between adiposity and Alzheimer's disease (AD), there is a lack ofconclusive results on the subject, making efficient management impossible. Thus, the proposals analyzed in this study seek to understand…
(Only some records are available in English at this moment)
Alzheimer's disease (AD) is a neurodegenerative condition that affects cognitive abilities, causing dementia. With a prevalence of approximately 50 million people worldwide, which is expected to triple by 2050, the significant social and economic impacts make AD a major concern for healthcare systems worldwide. The pathophysiology of AD includes extracellular aggregates of amyloid 5ý (A5ý…
A disintegrin and metalloprotease 10 (ADAM10), a transmembrane protein, has been investigated as an Alzheimer's disease (AD) blood-based biomarker. Under physiological conditions, it is the major constitutive ±-secretase responsible for the non-amyloidogenic cleavage of amyloid precursor protein (APP), preventing the generation of the amyloid beta peptide (AB). In AD, however, there is a …
The APOE4 allele (so-called µ4) is the strongest genetic risk for sporadic late-onset Alzheimer's disease (LOAD), and is associated with an increase in the levels of amyloid deposition and an early cognitive impairment. To understand the relation between APOE genotype and brain electrical activity, we developed a systematic review, which was recently submitted and is entitled "A systemati…
Cancer is a leading cause of death worldwide. Lung and breast cancer are the most frequent cancer types. In vitro screening methods for antitumor candidate compounds represent a rapid, simple, and reproducible approach to obtain essential data indicative of activity and interaction of new molecules with potential cell targets. In vitro assays based on two-dimensional (2D) monolayer cultur…
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| 2 / 2 | Ongoing grants |
| 15 / 10 | Completed research grants |
| 10 / 10 | Ongoing scholarships in Brazil |
| 34 / 28 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 14 / 13 | Completed scholarships abroad |
| 76 / 64 | All research grants and scholarships |
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CV Lattes
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