Graduated in Biological Sciences (Licentiate and Bachelor's Degree) from the Federal University of Santa Catarina (1993-1997). She has a PhD in Science, Concentration Area: Physiology, from the Federal University of São Carlos (2000-2004). She performed a doctoral 'sandwich' internship (2002) at the Department of Microbiology, University of Virginia Health System, Charlottesville, VA, USA and a post-doctorate (2005-2006) at the Institute de la Santé et de la Recherche Médicale (INSERM, Unité 553) in Paris, France. She was awarded a Visiting Fellowship (2015) by the University of Nottingham, England. She is currently an Associate Professor at the Federal University of São Carlos. She coordinates the LABEN (Laboratory of Biology of Aging) in the Department of Gerontology at UFSCar. She leads the Biology of Aging research group registered in the CNPq directory of research groups. She advises on the Master's course of the Graduate Program in Gerontology (PPGGero / UFSCar), which is part of the REPRINTE (Network of Interdisciplinary Graduate Programs on Aging). She also advises on Masters's and Doctorate courses of the Interinstitutional Graduate Program in Physiological Sciences (UFSCar / UNESP). She is a reviewer for several periodicals in the field of Aging, Alzheimer's Disease and Cancer and a scientific advisor to Brazilian (CNPq and FAPESP) and foreign funding agencies (FONDECYT-Chile, Czech Science Foundation-Czech Republic, United States-Israel Binational Science Foundation and The Netherlands Organization for Health Research and Development). She has projects in collaboration with several international institutions such as Trinity College Dublin - Ireland, University of Nottingham - UK, Università Degli Studi di Milano - Italy, Universitat de València and Universitat de Barcelona - Spain, Université du Quebec à Montréal - Canada, Olivia Newton-John Cancer Research Institute - Australia, University of California in Berkeley, Virginia Commonwealth University and Purdue University - USA. She is a member of the CIBFar (Center for Research and Innovation in Biodiversity and Pharmaceuticals), a program belonging to FAPESP's CEPID (Research, Innovation and Diffusion Centers). She has been selected as an Atlantic Fellow for Equity in Brain Health by the Global Brain Health Institute (GBHI) of Trinity College Dublin, Ireland (2021-2022). She has experience in Cell Biology and Biochemistry, with an emphasis on Molecular Biology, acting on the following topics: ageing, elderly, biomarkers for Alzheimer's disease, ADAMs, cancer and mammalian cell culture. E-mail: mcominetti@ufscar.br / ORCID: https://orcid.org/0000-0001-6385-7392 (Source: Lattes Curriculum)
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Alzheimer's Disease (AD) is a gradual and progressive neurodegenerative disease characterized by extensive neuronal losses and deposits of neurofibrillary tangles and senile plaques. Mild neurocognitive impairment (MCI) is characterized by cognitive decline, but with preservation of functionality, being an intermediate stage between normal AD cognition, but that can be reversed. ADAM10 is…
Alzheimer's disease (AD) is a gradual and progressive neurodegenerative disease characterized by extensive neuronal losses and deposits of neurofibrillary tangles and senile plaques. Mild neurocognitive impairment (MCI) is characterized by cognitive decline, but with preservation of functionality, being an intermediate stage between normal AD cognition, but that can be reversed. ADAM10 is…
AD (Alzheimer's disease) is a progressive neurodegenerative disease predominantly characterized by cortical atrophy in the medial temporal lobe, and microscopically, by extensive neuronal losses and deposits called neurofibrillary tangles and senile plaques. Since the results of the Rotterdam study in 1992, it is known that T2DM (type 2 diabetes mellitus) increases the risk of dementia. …
(Only some records are available in English at this moment)
With the increase in life expectancy, cases of neurodegenerative diseases such as Alzheimer's disease (AD), have also risen. Characterized by a progressive neurodegeneration and cognitive impairment, AD has a major pathological hallmark: the hyperphosphorylated tau protein, which aggregates intracellularly into neurofibrillary tangles, and the beta-amyloid peptide (A²), which forms senile…
Alzheimer's disease (AD) is a gradual and progressive neurodegenerative disease characterized by extensive neuronal loss and deposits of neurofibrillary tangles and senile plaques. ADAM10 is the main ±-secretase capable of acting on the non-amyloidogenic pathway of amyloid precursor protein (APP) cleavage and, therefore, preventing the formation of ²-amyloid peptide (A²), one of the patho…
Alzheimer's disease (AD) is a gradual and progressive neurodegenerative disease characterized by predominant cortical atrophy of the medial temporal lobe and microscopically, by extensive neuronal losses and deposits called neurofibrillary tangles and senile plaques. Since the results of the Rotterdam studies in 1992, type 2 Diabetes mellitus (DM2) has been known to increase the risk of d…
Alzheimer's disease (AD) is a progressive and gradual neurodegenerative disease, whose main characteristic is cortical atrophy, predominant in the medial temporal lobe, in the hippocampus region and at the microscopic level there is evidence of severe neuronal losses, due to the accumulation of senile plaques and neurofibrillary tangles. The results obtained in the Rotterdam study showed …
Dementia caused by Alzheimer's disease (AD) is the most prevalent dementias in Brazil and in the world and several studies have associated the allele µ4 of the Apolipoprotein E (APOE) as the main genetic risk factor for AD at late onset. The evidence of its negative impact on cognitive functions has been demonstrated in different populations, which include healthy individuals from differe…
AD (Alzheimer's disease) is a gradual and progressive neurodegenerative disease characterized by predominant cortical atrophy in the medial temporal lobe, and microscopically, extensive neuronal losses and deposits called neurofibrillary tangles and senile plaques. From the results of the Rotterdam study in 1992, it is known that Diabetes mellitus type 2 (DM) increases the risk of dementi…
(Only some records are available in English at this moment)
The APOE4 allele (so-called µ4) is the strongest genetic risk for sporadic late-onset Alzheimer's disease (LOAD), and is associated with an increase in the levels of amyloid deposition and an early cognitive impairment. To understand the relation between APOE genotype and brain electrical activity, we developed a systematic review, which was recently submitted and is entitled "A systemati…
Cancer is a leading cause of death worldwide. Lung and breast cancer are the most frequent cancer types. In vitro screening methods for antitumor candidate compounds represent a rapid, simple, and reproducible approach to obtain essential data indicative of activity and interaction of new molecules with potential cell targets. In vitro assays based on two-dimensional (2D) monolayer cultur…
Alzheimer's disease (AD) is a neurodegenerative disorder that most affects the elderly population. Classical neuropathological hallmarks of AD include amyloid plaques and neurofibrillary tangles, containing aggregated ²-amyloid (A²) and hyperphosphorylated tau, respectively. In our laboratory, several studies were performed in the area of blood biomarkers for AD, especially focusing on AD…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 15 / 10 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 29 / 23 | Completed scholarships in Brazil |
| 13 / 12 | Completed scholarships abroad |
| 62 / 50 | All research grants and scholarships |
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CV Lattes
ORCID