CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
Biomedical graduate from the Paulista School of Medicine (UNIFESP), Master in Molecular Biology (Biochemistry) from the Federal University of São Paulo (1997) and Doctor of Science (Biochemistry) from the Federal University of São Paulo (2001). Post-Doctorate at the Butantan Institute and Atheris Laboratoires (Geneva). He is currently a scientific researcher (PqC-VI) of the Butantan Institute. Professor and Advisor in the Post-Graduation Program in Toxinology of the Butantan Institute and also in the Graduate Program in Tropical Diseases of Botucatu Medical School (UNESP). He has experience in the field of Biochemistry, with emphasis on the isolation and characterization of molecules with relevant biological activity from animal poisons and secretions, mainly amphibians and marine organisms, using approaches that involve liquid chromatography and Mass spectrometry (including proteomics ), with a particular focus on peptides and proteins, as well as low molecular weight toxins. Collaborator in research lines in Organic Chemistry, Leishmaniasis, Food Biochemistry, Microbiology, Enzymology, Metabolomics and in the development of sera (antivenoms). Reviewer of indexed journals and advisor to development agencies. (Source: Lattes Curriculum)
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This project aims to update and modernize the institutional mass spectrometry laboratory (facility) of the Butantan Institute. This laboratory is currently equipped with an LC-MS/MS and a MALDI-TOF-MS/MS system, both acquired through FINEP funding, in PRO-INFRA calls in 2007 and 2011, respectively. The equipment continues to function normally, and both have just been approved by the FINEP…
Vaccination is the touchstone of public health policies. The history of vaccination shows that vaccines have been empirically developed; therefore, many studies are still needed for the continuous development of this biological product. The effectiveness of vaccines is evaluated through the reduction of the infection or illness among vaccinated individuals, and it is influenced by many fa…
Leptospirosis is a zoonosis widely distributed in all continents, but prevalent in tropical and sub-tropical regions. The etiological agent is the pathogenic bacteria of the genus Leptospira. In developed countries, the disease in humans is associated with recreational activities with water, while in developing ones, the disease represents a public health problem, with 1 million cases rep…
Part of the Amazon biome is located in the state of Pará, which houses large forests that draw attention due to wood and wild berries - including oilseeds - which are used commercially for oil extraction and biomass generation, which is currently underutilized by industry. The lack of research on the functional potential of the molecules still present in the cake after extraction leads to…
The amphibian skin is comprised by glands that secret a number of bioactive compounds, including peptides and proteins, this projects targets. Chaunus (Bufo) jimi, formerly known as Bufo paracnemis, the popula sapo-cururu is a extremely well adapted bufonid that inhabits the Brazilian semi-arid caatinga. However, it is fairly studied regarding the substances secreted by its skin. The bioc…
Neurodegenerative diseases are characterized by progressive and irreversible loss of neuronal function. They share common features such as mitochondrial dysfunction, oxidative stress, and excitotoxicity. These aspects are primarily associated with the presence of reactive oxygen species resulting from oxidative stress, which leads to cellular damage. Treatment options for these diseases a…
Chemical defense is used by various organisms to avoid predators, parasites, and infections. Besides synthesizing their own chemicals, some animals are able to sequester dietary compounds and use them for their own defense. Among those animals are the "poison frogs", an assemblage of species that represent several distinct phylogenetic lineages. Poison frogs have the ability to sequester …
Conventional serologies can be indicative of immunity, but they can simply be markers of previous contact with a certain agent. Neutralizing antibodies, as the name suggests, are those capable of effectively blocking (neutralizing) the interaction between the pathogenic agent and the host cell. Because of this, the plaque reduction neutralization test is the traditional assay and consider…
Freshwater stingrays are responsible for major accidents in riverside communities, accidents have varied degrees of severity, however, serious events such as necrosis have significant impact in case of accident. As a result, the study of pathophysiological processes and molecules involved in the poisoning has become a goal for scientific research. Some studies have reported the isolation …
Venoms and animal secretions are among the most complex and rich sources of biological materials, i.e., new molecules with potential pharmaceutics and biotechnological applications. Therefore, the secretion of molecules isolated from amphibian skin may be used as alternatives for new drugs, such as combating resistant pathogens. Thus, this project aims to identify and characterize molecul…
Rabies is a zoonosis distributed worldwide, characterized as a lethal progressive acute encephalitis, which affects a wide variety of mammals. The etiologic agent of this disease, Rabies virus (RV), is a bullet-shaped neurotropic enveloped virus. After exposure to the virus, the replication, in muscular tissues, followed by migration of the virus to nerve endings occur, in a process possi…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 9 / 6 | Completed scholarships in Brazil |
| 17 / 14 | All research grants and scholarships |
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