Dr Luis LP da Silva obtained his Bachelors degree in Pharmacy (1999) and his MSc degree (2002) at the University of Sao Paulo, Brazil, and his PhD at the University of Leeds, UK (2006). He was a visiting postdoctoral fellow at the NICHD-National Institutes of Health (NIH) (Bethesda, MD, USA) from 2006 to 2009. He is Associate Professor of Cell Biology at the Ribeirao Preto Medical School at the University of Sao Paulo. Dr. da Silva studies the molecular mechanisms that control the trafficking of proteins within the cell endomembrane system, and how envelope viruses, in particular the HIV and bunyaviruses, manipulate this system to support viral replication and pathogenesis. (Source: Lattes Curriculum)
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The emergence of life diversity and complexity has been facilitated by intercellular communication, which is partially supported by a highly conserved pathway known as the conventional secretory pathway. This pathway involves the secretion of proteins containing a signal peptide through the endoplasmic reticulum-Golgi apparatus-final destination route. Although some questions remain open,…
The Zika virus (ZIKV) and the Oropouche virus (OROV) are emerging arboviruses of great importance to public health, and due to global climate changes, they have the potential to spread to new tropical and subtropical regions. While ZIKV caused a severe epidemic in Brazil, OROV causes recurrent and recent outbreaks in the Caribbean and tropical regions of Latin America. Both viruses, despi…
Although dispensable for HIV replication in vitro, the Nef viral protein is critical for maintaining high viral loads in animal models and progression to AIDS in human patients. Nef interferes with the intracellular transport of host proteins involved in the virus replicative cycle and immunity. Among the targets of Nef is the SERINC5 protein, which, when incorporated into nascent viral p…
(Only some records are available in English at this moment)
The HIV-1 accessory protein Nef downregulates cell surface expression of MHC-I molecules to facilitate virus spreading. The Nef-induced downregulation of MHC-I molecules, such as HLA-A, requires the clathrin adaptor protein 1 (AP-1) complex. The cooperative interaction of Nef, AP-1, and the cytosolic tail (CT) of HLA-A leads to redirection of HLA-A targeting from the trans-Golgi network (…
Oropouche virus (OROV) is one of the most common arboviruses that infects humans in South America. A conservative estimate is that half million people have been infected by OROV in Brazil since the virus was first identified in 1955, although this is likely to be an underestimate due to a resemblance of Oropouche fever with the symptoms of other arbovirus infections including Dengue, Zika…
Nef is an important HIV-1 virulence factor that acts in the maintenance of high viral loads and progression to AIDS. As one the most abundantly produced viral proteins in early infection (first 8-12h), Nef optimizes the cellular environment to maximize viral replication and infectivity of the viral progeny. Nef hijacks the cell machinery that controls the intracellular trafficking of prot…
(Only some records are available in English at this moment)
The Zika virus (ZIKV) and the Oropouche virus (OROV) are emerging arboviruses of great importance to publichealth, and due to global climate changes, they have the potential to spread to new tropical and subtropicalregions. While ZIKV caused a severe epidemic in Brazil, OROV causes recurrent and recent outbreaks in theCaribbean and tropical regions of Latin America. Both viruses, despite …
The interactions between viral factors and the host cell endomembrane system are of fundamental importance for the replication and pathogenesis of SARS-CoV-2. The assembly and externalization of CoVs involve: 1) the invagination of the limiting membrane of the ER-Golgi intermediate compartment (ERGIC) with the consequent budding of nascent viral particles into its interior and 2) the fusi…
Oroupouche virus (OROV) has great epidemiological importance in Brazil and other South American countries such as Ecuador, Panama and Peru. OROV infection causes Oropouche fever, and in some cases may present manifestations of neurological disorders such as meningitis and encephalitis. In fact, studies using murine models and human brain slice cultures showed that OROV exhibits neurotropi…
(Only some records are available in English at this moment)
The adaptor protein (AP) complexes are heterotetrameric complexes that coordinate protein trafficking in the endocytic and secretory pathways. AP-1, a complex of four distinct subunits (gamma, beta1, mi1, and sigma1), is thought to mediate protein trafficking between the trans-Golgi network (TGN) and endosomes and Lysosomes Related Organelles (LROs) though clathrin-coated vesicles (CCV). …
The Oropouche virus (OROV) is the etiological agent of Oropouche fever, a debilitating febrile illness common in South America. Despite its importance in public health, little is known about the biology of the virus in the host cell, especially the relationship between viral and cellular host protein. Our preliminary results from mass spectrometry analysis of the cellular proteome during …
The HIV-1 envelope comprises plasma membrane-derived lipids with inserted viral glycoproteins trimers and host membrane proteins. This complex assembly process is mainly orchestrated by HIV-1 Gag, a structural protein that is key to organize viral assembly and budding domains at the plasma membrane. The interferon-induced transmembrane protein 3 (IFITM3) is a host antiviral protein that m…
Oropouche virus (OROV) is an arbovirus that belongs to the Orthobunyavirus genus, and is the etiological agent of Oropouche fever, a febrile illness common in South America. It has been estimated that approximately half a million people have been infected by OROV in Brazil during the last 50 years. Despite its importance in public health, the replicative cycle of this arbovirus is poorly …
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 10 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 37 / 29 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 59 / 47 | All research grants and scholarships |
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